Introduction. Electronic commerce has been a very important business model within the COVID-19 pandemic. In our region, this model has not yet been fully established because the customer still mistrusts it. Target. Analyze the effects that eCommerce is causing due to the impact of the pandemic on MSMEs in the region 6. Methodology. The research design started from the positivist research paradigm, non-experimental and transectional field design with documentary support, descriptive research level, the population was 77,289 and the sample 471, the questionnaire instrument was used, it was validated by trial of experts with experience in the employment area and methodology, rating validity, clarity, coherence, and relevance. Results. Among the most frequently required results through electronic commerce in the presence of the coronavirus, were food 30.13%, supermarkets 26.10%, pharmacies 19.39%, sports sector 8.64%, which includes equipment such as electronic treadmills, bicycles , clothing, shoes, among others; others 7.87%, which includes audiovisual content, tablets, computers, cell phones, and other articles; and minor tools, laundry 4.41% and liquor stores 3.45%, in short, the clearest change is that more people have made the decision to opt for online purchases to avoid going out and exposing themselves. Conclution. The effects of a globalized world, where the digital age is everything today, give way to new consumption patterns and strengthening the value chain of online sales, are just some of the balances that the coronavirus has thrown that, although it has affected health and multiple economic activities, it is also stimulating creativity and the development of business solutions that will contribute to the growth of electronic commerce in the short term that business generates.