CA 15-3 Tumor Marker in Invasive Breast Carcinoma of non-special type (ductal)

Abstract

Abstract

Introduction: CA 15-3 is one of the tumor markers used in breast cancer for: early detection of subclinical metastasis, control and evolution of the disease, oncological therapeutic support, prognosis. The aim of this study is to establish the relationship of this biomarker with biological variables such as age, immunohistochemical (histological grade, progesterone receptors, estrogen receptors, HER2, tumor type) and therapeutic variables associated with non-special type invasive carcinoma of the breast. Methods: Analytical study that was conducted with ninety-four records of oncological patients diagnosed with invasive breast carcinoma of No Special Type, extracted from the Anatomical Pathology service of the “Hospital de Specialties José Carrasco Arteaga” (IESS) that works with the AS400 computer system, in Cuenca, Ecuador, during the period 2018 - 2020. The research related the CA 15-3 marker with biological, immunohistochemical and therapeutic variables pre- and post-treatment. Results: The universe consisted of ninety-four patient records. The mean age was 52 years. CA 15-3 levels were significantly reduced after oncologic treatments in the patients. Their preintervention values ranged from 5.11 - 416.5 U/mL with a mean of 33.12 U/mL and a standard deviation of 67.65 U/mL and their postintervention values ranged from 4.41 - 121.5 U/mL with a mean of 16.54 and a standard deviation of 16.97 U/mL (T-test 2.67, p= 0.009). Statistical association was found between biomarker and progesterone receptors (p=0.009, RR= 6.8, LC: 1.3 - 34.2) and KI-67 (p=0.001, RR= 8.55, LC= 2.0 - 36.4). Conclusions: The CA 15-3 biomarker decreases in levels after oncologic treatments and has statistical association with progesterone receptors and the KI-67 marker.