Introduction: root perforations are a frequent complication in endodontic practice. The prognosis of these teeth depends on several factors, such as the location, size, and the time elapsed since the perforation occurred. In recent years, treatment has evolved with the introduction of bioceramic materials, which provide superior sealing ability compared with traditional filling materials. Objective: to present a clinical case on the successful management of root perforation using bioceramic materials, including clinical and radiographic follow-up. Methodology: a clinical case is reported involving the surgical selling of a root perforation in the middle third of a previously treated tooth using bioceramic materials. Clinical and radiographic follow-ups were performed for 15 days, 1 month, 3, 6, and 9 months. Results: The patient remained asymptomatic, without signs of inflammation or dental mobility. Radiographic evaluation revealed appropriate periradicular tissue regeneration. Conclusions: although extensive root perforations are often considered lesions with poor prognosis, they do not necessarily imply the definitive loss of the tooth. This case demonstrates that, through timely intervention, the use of bioceramic materials and the correct application of biological protocols, it is possible to restore and maintain the functionality of the affected tooth. General Area of Study: Odontology. Specific area of study: Endodontic. Type of study: Clinical case.

Introduction. Physical activity has been shown to be an effective strategy for the non-pharmacological management of gestational diabetes, contributing to glycemic control, reducing maternal-fetal complications, and improving quality of life. Therefore, it is important to compile and analyze current scientific evidence demonstrating the benefits of physical exercise in women diagnosed with this condition, thus promoting its therapeutic use by physical therapists as an integral part of treatment during pregnancy. Objective. To synthesize the available scientific evidence on the effects of physical exercise in pregnant women with gestational diabetes, considering its impact on glycemic control and its role as a therapeutic strategy. Methodology. A systematic review that followed the guidelines of the PRISMA declaration. Results. Structured and supervised exercise consistently improves glycemic control in GDM. Additionally, resistance exercise may have a slight advantage in postprandial glycemia. Professional supervision enhances the metabolic and psychosocial benefits of exercise-based interventions, improving quality of life. Conclusion. Aerobic and resistance exercise improve fasting and postprandial glycemia, with the latter being more sensitive to resistance training. However, unsupervised activities, such as postprandial walking without personalization, can be ineffective or counterproductive. Professional supervision ensures an adequate therapeutic dose and optimizes metabolic effects. General Area of Study: Health Sciences. Specific area of study: Physiotherapy. Type of study: Systematic bibliographic review.

Introduction: Antiparasitic resistance to anthelmintics in humans is a health problem that compromises the effectiveness of pharmacological treatments, caused by self-medication and the inappropriate use of these drugs, which promotes parasite resistance. Evaluating antiparasitic resistance and its implications on treatment efficacy is essential to understand the magnitude of the problem and to design effective strategies. Therefore, the collection and analysis of data on anthelmintic resistance will allow healthcare professionals to make informed decisions about the most appropriate treatments, ensuring better outcomes for patients and reducing the spread of resistant parasites. Objective: This study aims to analyze anthelmintic resistance in humans, as well as the mechanisms involved. Methodology: This was conducted through a literature review using various databases and reliable sources such as PubMed, ProQuest, Scopus, Taylor & Francis, and ScienceDirect, employing Boolean operators and key terms to obtain high-quality information. The PRISMA method was used to facilitate data collection and analysis. Results: Studies have shown that anthelmintic resistance in humans occurs due to mutations in the beta-tubulin gene, which affects the action of the drugs. This, combined with environmental factors such as their inappropriate use, leads to modifications in their mechanisms of action, rendering them ineffective for treatment. Conclusion: This research promotes the rational use of medications, avoiding self-medication and the overuse of anthelmintics by raising awareness among the population and healthcare professionals about the importance of a responsible approach to the treatment of parasitic infections. Study area: Parasitology. Type of study: Systematic bibliographic review.

Introduction: Dentoalveolar trauma (DAT), with reported incidence rates ranging from 6% to 59% (1), is one of the most frequent reasons for consultation today and is the cause of multiple injuries affecting different structures, including dental and pulpal involvement. One such case involves an immature apex, where the root portion never achieves closure, leading to pulpal pathologies. Objective: To evaluate the effectiveness of the combined use of A-PRF and I-PRF in the regeneration of a permanent tooth with an immature apex resulting from dentoalveolar trauma. Methodology: A clinical case with a diagnosis of pulpal necrosis accompanied by a chronic apical abscess and the presence of an open apex is presented. Regenerative endodontic therapy is performed using platelet concentrates A-PRF and I-PRF. Results: The combined use of platelet concentrates enhances the regenerative process of teeth with an immature apex. Radiographic and tomographic follow-ups showed considerable progress in bone formation and lesion repair, in addition to obtaining signs of pulpal revitalization. Conclusions: Regenerative endodontics with the use of platelet concentrates as a therapy represents one of the most promising innovations in the treatment of immature teeth with pulpal necrosis, as it aims to restore pulpal vitality, promote continuous root development, and achieve apical closure, appreciating scaffolding aspects (2), which offer an optimal microenvironment for the regeneration of pulpal tissue. General Area of Study: Odontology. Specific area of study: Endodontic. Type of study: Clinical case.

Introduction: Apical sealing is the key to success in an endodontic treatment, this study seeks to compare the apical sealing capacity between the AH Plus sealant and the BioRoot sealant with and without the use of gutta-percha, 20 acrylic teeth were used that went through a complete endodontic treatment,  following the appropriate guidelines and procedures, AH plus with gutta-percha, HA plus without gutta-percha, BioRoot with gutta-percha and BioRoot without gutta-percha were divided into 4 groups, after completing the filling, apical filtration was evaluated by immersing the teeth in methylene blue and taking data on its penetration. Objectives: To compare the apical sealing capacity between bioceramic sealants and HA plus with and without gutta-percha in endodontic treatments by means of an in vitro study. Methodology: The study is in vitro and seeks to compare the apical sealing capacity between the AH Plus sealant (based on epoxy resin) and the BioRoot RCS sealant (bioceramic), with and without the use of gutta-percha. 20 acrylic teeth were used and received complete endodontic treatment. These were divided into four experimental groups: AH Plus with gutta-percha, AH Plus without gutta-percha, BioRoot with gutta-percha, and BioRoot without gutta-percha. The evaluation of apical filtration was performed by immersing the teeth in methylene blue and measuring its penetration. Results: the text does not present the numerical or descriptive data of the results. The results are expected to compare microfiltration between the four groups to determine the most effective combination for optimal apical sealing and to analyze the influence of gutta-percha on the efficacy of both sealants. The aim is to determine whether the simplification of the gutta-percha technique, especially with bioceramic sealants, offers a comparable or superior seal. Conclusions: The conclusions of the study, once conducted, will focus on identifying the combination (sealant and use/absence of gutta-percha) that offers the best performance in the prevention of apical leaks. It will be concluded about the real need for gutta-percha in root canal filling when using modern sealants such as bioceramics (BioRoot RCS) compared to a traditional sealant such as AH Plus. General area of study: Dentistry. Specific area of study: Endodontics. Type of item: original.

Introduction: Multifocal and monovision contact lenses are designed to provide unique features to the wearer to focus images at different distances without the need to wear frame lenses. Objectives: The effectiveness of the two adaptation techniques was evaluated: conventional monovision and multifocal contact lenses in presbyopic patients. Methodology: This is an analytical and descriptive study, conducted over a period of 6 months, and 9 patients aged 47 to 57 years who attended the optometric consultation were evaluated. Results: In both techniques, adaptation was performed with monthly contact lenses made of comfilcon A material, initially applying the Schirmer I test, the lacrimal meniscus, the BUT (Break-Up Time) test; in addition, the contrast test and the pre- and post-adaptation decimal visual acuity were used to obtain accurate results of both techniques. Statistical analysis was conducted with Student and Wilcoxon t-tests with a 95% confidence interval. Conclusions: A variation was observed in relation to the two techniques. It was determined in a statistically significant way that multifocal contact lenses in near visual acuity are more effective than monovision (Student's paired test P=0.430) (Wilcoxon's paired test P=0.686). In addition, it was found that monovision is more effective in distance visual acuity than multifocal monovision in a statistically significant way (Paired Student t-test P=0.341) (Wilcoxon paired test P=0.317). General area of study: Health. Specific area of study: Optometry. Item type: Original.

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that represents a serious global public health problem. It is characterized by the presence of hyperglycemia and insulin resistance, which can lead to severe complications such as blindness, heart attacks, strokes, kidney failure, and/or amputations. Its symptoms usually include polydipsia, polyuria, polyphagia, blurred vision, asthenia, and unintentional weight loss, which become evident over the course of several years. This is why the need persists in studying biomarkers that assist in the early detection of T2DM. For example, adiponectin, which has anti-inflammatory and insulin-sensitizing effects, plays a fundamental role in energy metabolism and glycemic homeostasis. It is a hormone secreted by adipose tissue, composed of 244 amino acids and with a molecular weight of approximately 28 kDa. Objective: Evaluate the clinical usefulness of adiponectin as an early marker in the detection of T2DM and its direct relationship with other biochemical parameters. Methodology: Systematic review of the literature with a qualitative and descriptive approach, using inclusion and exclusion criteria and based on the PRISMA methodology. Results: Adiponectin has been shown to have an inverse association with risk factors related to the development of T2DM, including obesity and hypertriglyceridemia. Normal adiponectin levels have been observed in patients with normoglycemia, but decreased levels in prediabetic and diabetic patients, which positions adiponectin as a strong marker for the early detection of T2DM, thereby allowing better disease management. Conclusion: Based on scientific evidence, adiponectin is considered a clinically relevant marker for the early detection of T2DM. Its decrease reflects an unfavorable metabolic profile, thus reinforcing its protective role and its potential usefulness in screening strategies and in the improved management of T2DM. General Area of Study: Clinical Laboratory. Specific area of study: Clinical Biochemistry. Type of study: Systematic bibliographic review.