Prematurity, worldwide, is the leading cause of neonatal mortality and morbidity, making it a real challenge for the Ecuadorian health system. The main objective of the research is to establish the prevalence of prematurity and its associated factors, in the Neonatology area of the Vicente Corral Moscoso Hospital, between 2011-2015, applying an analytical, cross-sectional observational methodology, reviewing a number of 447 clinical records of newborns, who met the inclusion criteria, statistically analyzing, reporting Odds ratio, with a confidence interval of (95%) and accepting the pi value, the relevant bioethical foundations were applied, within the results it is given that the prevalence of prematurity was (29.4%), the percentage of adolescent mothers was ( 30.3%), (56.1%) have secondary education, (36.4%) are married and (72.7%) spend the night in urban areas. The predominant sex of premature infants was male with (52.3%), (70.5%) were late preterm infants and 79.5% were small for gestational age. The risk factors that show a statistical variation relationship were: age younger than 19 years old and older than 35 years old (OR: 1.71; CI: 1.12-2.59 p: 0.01), hypertensive disorders (OR: 1.81; CI: 1.08-3.03 p: 0.02 ), intrauterine growth restriction (OR: 4.89 CI: 3.17-7.55 p: 0.000), and multiple pregnancy (OR: 2.79; CI: 1.45-5.34 p: 0.001), concluding that the prevalence of prematurity was high, a relationship was found statistically significant with: age, hypertensive disorders, intrauterine growth retardation and multiple pregnancy