Emesis induced by tranexamic acid administration in cats

Abstract

Introduction: although the effectiveness of using emetics for decontamination in cases of poisoning in humans has been questioned, in veterinary medicine, it has been observed that exposure to substances such as pharmaceuticals, onions, chocolates, tobacco, insecticides, pesticides, and others Foreign elements that can be eliminated by vomiting without causing harm, could benefit significantly by induced emesis in an adequate period of time. In the present study, the efficacy of tranexamic acid in inducing vomiting was evaluated in randomly selected cats in optimal health. Careful monitoring of drug effects was carried out with the aim of achieving emesis in a controlled manner. Aim. The objective of the present investigation was to evaluate the efficacy with two experiments: one increasing the doses with repetitions of five minutes between doses and the other with a single dose until emesis was obtained. Methodology. This research had a descriptive quantitative experimental approach where 10 cats were exposed to two experiments in the first (T1), three doses of 10 mg/kg, 20 mg/kg and 30 mg/kg were applied, with intervals of 5 minutes to assess the effective dose. In the second experiment (T2), exposure to a single dose was carried out with one-week intervals for the next dose to determine at which (single) dose emesis occurs. Results: 90% of the cats had induced emesis in a period of no more than 230 seconds and with a maximum of three events per cat. Conclusion: Tranexamic acid proved to be effective in inducing vomiting, observing that emesis occurred with an increase in the dose of the drug, reaching this effect even with a single dose of 40 mg/kg. Study area: Veterinary Medicine.