Synthesis of N-decyl-4 - ((3-formyl-4-hydroxyphenoxy) methyl) benzamide by reaction of 4-bromomethylbenzoic acid, decylamine and 2,5-dihydroxybenzaldehyde.
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Introduction: Current vaccines based on protein subunits require immunoadjuvants to reach optimal efficiency, for this, compounds have been synthesized that can achieve this capacity without affecting the human being. These types of vaccines offer significant advantages over traditional vaccines that use complete pathogens. Objective: To develop a synthetic route to obtain an organic compound that has the immuno-potentiating capacity for the human system. Methodology: The research is experimental in normal laboratory conditions. A synthetic route is designed in two stages, the first has the purpose of giving the resulting molecule solubility in an apolar medium, through the formation of an amide by the reaction between decylamine with 4-bromomethylbenzoic acid, allowing the molecule to pass through the cell membrane, unlike the second stage, which is to obtain the structure responsible for the immuno-potentiating capacity. Thin-layer chromatography isolation systems are used to define the solvent systems that were used in liquid chromatography and reaction guides to facilitate the formation of specific functional groups Results: The first stage of the synthesis of N-decyl-4 - ((3-formyl-4-hydroxyphenoxy) methyl) benzamide achieves a reaction yield of 78.66% and in the second stage 53.22%. Conclusion: The compound N-decyl-4 - ((3-formyl-4-hydroxyphenoxy) methyl) benzamide is synthesized according to the characterized NMR spectrum.
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