Carbapenemic resistant enterobacteria in the hospital Vicente Corral Moscoso in the year 2019-2020

Abstract

Introduction. Resistance to carbapenems is defined as the production of enzymes capable of inactivating the action of antibiotics. However, due to the alarming increase in resistance, they are used more frequently, leading to increased resistance. Carbapenems are broad-spectrum β-lactams with bactericidal activity against Gram-positive and Gram-negative bacteria. And they are considered as reserve antibiotics. Objetive: The objective of this research is to describe the frequency of carbapenem-resistant Enterobacteriaceae from the results of antibiograms in clinical isolates. of the Vicente Corral Moscoso Hospital during the 2019-2020 period. Methods: The study is descriptive, secondary documentary. Results: The investigation compiled a total universe of 3732 positive cultures, those that presented resistance to carbapenems were 400, which corresponds to 10.7% of isolates, the male gender was the most representative with 60.2% compared to 39.75% of the Female gender. The frequency analysis showed that the emergency area was the most representative with 59.8% followed by hospitalization with 31.3% and ICU with 7.9%. In the analysis by type of sample, resistance was observed in respiratory secretions with 54.2%. Regarding the bacterial species, the predominance of Klebsiella pneumoniae was evidenced with 86%, compared to 14% of other species. Conclusions: In the present work, it suggests an increase in cases of resistance to carbapenems in comparison with the different types of samples studied, with a predominance of respiratory secretions, with the dominance of Klebsiella pneumonia against the other bacterial species.