Introduction: fine needle aspiration has played an essential role in the evaluation of the patient with thyroid nodule, being a fast, minimally invasive method and the patient will quickly be reintegrated into his activities. Objective: to determine the validity of the Fine Needle Aspiration Puncture (FNAP) guided by ultrasound in the diagnosis of thyroid cancer in patients of the José Carrasco Arteaga Hospital in 2017. Methodology: validation study of diagnostic tests that compared fine needle aspiration puncture guided by ultrasound with histopathology (gold standard); 236 patients accomplished inclusion criteria. For the analysis, frequencies and percentages, standard deviation and mean were applied, according to quantitative and qualitative variables respectively; for the validation of the FNAP, tests of sensitivity, specificity, positive and negative predictive value were performed. The respective bioethical processes were applied. Results: 73.78% of patients were over 48 years old (mean of 56.52, SD +/- 13.51). According to the Bethesda classification, most patients presented atypia with 27.1%, followed by 26.3% of follicular neoplasia. By histopathology, 53.8% were benign with 43.2% of papillary carcinomas. The sensitivity was 73.39%; specificity 57.48%, validity index 64.83%; positive predictive value 59.7%; negative predictive value 71.57%; positive likelihood ratio 1.73, negative likelihood ratio 0.46; Youden index 0.31, Cohen's Kappa index 0.31. Conclusions:  The FNAP had a greater sensitivity than specificity; however, it could nCot be decisive at the time of diagnosis and decision-making.

Introduction: Vaccination-related myocarditis has been reported as a major side effect of the mRNA COVID-19 vaccine. In this review article, a series of 15 global case reports of laboratory-confirmed myocarditis post COVID-19 vaccination were summarized. Objectives: The main objective of this article is to critically analyze and summarize published case reports on vaccination-associated myocarditis. Methodology: Google Scholar was used to search for confirmed cases of vaccination-associated myocarditis from 2021 to 2022. Results: It was found that there is a higher prevalence of immunization-related myocarditis in young adults, especially in male patients (94%). Genetic defects, environmental aspects and dietary habits were discovered as other factors that could have stimulated the development of myocarditis. Troponin and C-reactive protein levels were elevated in most cases (93%). Conclusions: vaccination-associated myocarditis case reports are very rare and only represent a minimal fraction of the total population that has been vaccinated. The benefits offered by the COVID-19 vaccine far outweigh the effects a COVID-19 infection. It is recommended to continue administering the mRNA vaccine to manage the COVID-19 pandemic.