Intentional replantation with I-PRF for periapical healing

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Joel Alejandro Cherres Quiroz
Felipe Guido Rodriguez Reyes

Abstract

Introduction: Post-treatment Apical Periodontitis (PAPT) is a frequent cause of endodontic failure, strongly associated with the persistence of intraradicular infection. In cases where conventional retreatment or periapical surgery are contraindicated due to anatomical limitations, Intentional Reimplantation (IR) emerges as a conservative therapeutic alternative. The complementary use of Injectable Platelet-Rich Fibrin (i-PRF) provides an additional benefit, by promoting tissue regeneration through the sustained release of growth factors. Objectives: This report describes the management of an upper second molar (2.7) with PAPT and critical proximity to the maxillary sinus. Methodology: A descriptive report corresponding to a clinical case report aimed at documenting the clinical management and postoperative evolution of a tooth with post-treatment apical periodontitis by intentional reimplantation supplemented with injected platelet-rich fibrin (I-PRF). Results: An IR was performed with extraoral apicoectomy, retrograde obturation with bioceramics and application of i-PRF in the alveolus. The extraoral time was 10 minutes and 20 seconds, respecting the established operating protocols. At six months, clinical and tomographic controls showed significant bone healing, recovery of the periodontal ligament space, and adequate functional integration of the specimen, without recurrence of the lesion. Conclusions: The present case highlights the viability of IR complemented with i-PRF as an effective option to preserve teeth with PAPT in complex situations, where conventional surgery is not feasible, integrating microsurgical techniques and regenerative biomaterials in current endodontic practice. General area of study: Dentistry. Specific area of study: Endodontics. Type of article: Clinical case.

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How to Cite
Cherres Quiroz, J. A., & Rodriguez Reyes, F. G. (2026). Intentional replantation with I-PRF for periapical healing. Anatomía Digital, 9(1), 82-95. https://doi.org/10.33262/anatomiadigital.v9i1.3577
Section
Articulos de revisión bibliográfica

References

1. Rufasto-Goche KS, Vigo-Ayasta ER, Lizarbe-Castro MV, Salazar-Rodríguez MR. Etiología, fisiopatología y tratamiento de la periodontitis apical. Revisión de la literatura. Avances en Odontoestomatología [Internet]. 2023 [citado 2025 septiembre 13]; 39(1): 9-16. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0213-12852023000100003&lng=es

2. Siqueira JF, Rôças IN, Ricucci D, Hülsmann M. Causes, and management of post-treatment apical periodontitis. British Dental Journal [Internet]. 2014 [cited 2025 September 13]; 216(6): 305-312. Available in: https://pubmed.ncbi.nlm.nih.gov/24651336/

3. Blanco-Fuentes BY, Moreno-Monsalve JO, Mesa-Herrera U. Asociación entre calidad del tratamiento endodóntico y periodontitis apical, evaluada mediante Tomografía computarizada de haz cónico en una población colombiana. Universidad y Salud [Internet]. 2023 [citado 2025 septiembre 13]; 25(1): 1-5. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-71072023000100007&lng=en.

4. Siqueira JF, Rôças IN. Present status and future directions: microbiology of endodontic infections. International Endodontic Journal [Internet]. 2022 [cited 2025 September 13]; 55(3):512-530. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34958494/

5. Ragua Antolinez SA. Análisis histopatológico periapical de dientes con Enfermedad Periapical Post Tratamiento (EPP), sometidos a microcirugía endodoncia en pacientes atendidos en el posgrado de endodoncia de la Universidad Nacional de Colombia [Tesis de especialista, Universidad Nacional de Colombia, Bogotá, Colombia] [Internet]. 2017 [citado 2025 septiembre 13]. Disponible en: https://repositorio.unal.edu.co/items/b1842c13-e832-44b6-8ed3-453cd7593535

6. Siqueira JF, Rôças IN. Clinical implications and microbiology of bacterial persistence after treatment procedures. Journal of Endodontics [Internet]. 2008 [cited 2025 September 13]; 34(11): 1291-1301. Available in: https://doi.org/10.1016/j.joen.2008.07.028

7. Alharbi MA. The Outcome of Contemporary Intentional Replantation: a retrospective study. Medical Research Archives [Internet]. 2023 [cited 2025 September 13]; 11(8). Available in: https://esmed.org/MRA/mra/article/view/4228

8. Herrera D, Quintero J, Castellanos M, Velásquez A, López B. Beneficios de la descompresión y enucleación en lesiones quísticas de gran tamaño en la mandíbula. Revista Vive [Internet]. 2024 [citado 2025 septiembre 13]; 7(19):194-206. Disponible en: https://revistavive.org/index.php/revistavive/article/view/429

9. Jakovljevic A, Nikolic N, Jacimovic J, Pavlovic O, Milicic B, Beljic-Ivanovic K, et al. Prevalence of apical periodontitis and conventional nonsurgical root canal treatment in general adult population: an updated systematic review and meta-analysis of cross-sectional studies published between 2012 and 2020. Journal of Endodontics [Internet]. 2020 [cited 2025 September 13]; 46(10):1371-1386.e8. Available in: http://dx.doi.org/10.1016/j.joen.2020.07.007

10. Yu YH, Kim M, Kratchman S, Karabucak B. Surgical management of lateral lesions with intentional replantation in single-rooted mandibular first premolars with radicular groove: 2 case reports. Journal of the American Dental Association [Internet]. 2022 [cited 2025 September 13];153(4): 371-381. Available in: https://pubmed.ncbi.nlm.nih.gov/35078591/

11. Santos JM, Marques JA, Esteves M, Sousa V, Palma PJ, Matos S. Intentional replantation as a starting approach for a multidisciplinary treatment of a mandibular second molar: a case report. Journal of Clinical Medicine [Internet]. 2022 [cited 2025 September 13];11(17):5111. Available in: http://dx.doi.org/10.3390/jcm11175111

12. Liang Y, Ma R, Chen L, Dai X, Zuo S, Jiang W, et al. Efficacy of i-PRF in regenerative endodontics therapy for mature permanent teeth with pulp necrosis: study protocol for a multicentre randomised controlled trial. Trials [Internet]. 2021 [cited 2025 September 13]; 22:436. Available in: http://dx.doi.org/10.1186/s13063-021-05401-7

13. Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clinical Oral Investigations [Internet]. 2017 [cited 2025 September 13]; 21(8):2619-2627. Available in: http://dx.doi.org/10.1007/s00784-017-2063-9

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