Characterization of glycosylatedhemoglobin A1c in healthypregnancies

Abstract

Introduction: in pregnant women with pregestational diabetes mellitus (type 1 or 2) and gestational diabetes the determination of glycosylatedhemoglobinisparticularlyimportantbecauseitscorrelationalvalue has been seen with the development of maternal and fetal complications. Objective: to characterize the glycosylated hemoglobin in the different trimesters of pregnancy.

Methods: cross-sectional analytical observational study in the Manuel Fajardo Gyneco-Obstetric Hospital during he second semester of 2016 to 100 healthy pregnancies that attended the prenatal control; and a control group of 150 healthy non-pregnant women older than 17 years in the population corresponding to the municipality of Güines whomt the inclusion and exclusion criteria. Determinations of glycosylated hemoglobin and fasting glycemia were made.

Results: the healthy pregnant women the average glycosylated hemoglobin was lower than in non-pregnant women, respectively 4.50 % (4.41-4.49) versus 5.21 % (5.16-5.26), P <0.001. In the healthy pregnant group, glycosylated hemoglobin increased with the trimester of pregnancy p <0.05, first trimester: 4.35 (4.20 - 4.47), second trimester: 4.58 (4.45 - 4.70), third trimester: 4.61 (4.14 - 5.08).

Conclusions: during pregnancy the percentage of Hb A1c increases with the trimester of pregnancy, so it is important to determine its reference value for better metabolic control of pregnant women