New therapies for the management of vasomotor symptoms in menopause

Abstract

Introduction. Menopause brings physical and psychological changes that can affect personal and family relationships. Many women do not seek medical help due to lack of information, access difficulties, and concerns about the side effects of hormonal therapies. New non-hormonal treatments, such as neurokinin B antagonists, show promise in effectively relieving vasomotor symptoms. Objective. To analyze the impact of menopause on women's lives, identifying the barriers they face in seeking medical help and evaluating the effectiveness of recent non-hormonal treatments, such as neurokinin B antagonists, in improving vasomotor symptoms and quality of life. Methodology. This bibliographic review serves as the basis for a retrospective study that critically evaluates the selected literature under various criteria. Results. Several studies have investigated the effectiveness of neurokinin B antagonists, such as fezolinetant, in the treatment of menopausal hot flashes. Research has shown that the neurokinin B pathway regulates the secretion of GnRH and therefore plays a crucial role in the control of hot flashes. Conclusion. For decades, hormone therapy has been effective in relieving menopause symptoms such as hot flashes, although it carries risks such as venous thromboembolism and endometrial cancer. This has led to the search for safer and more effective alternatives, such as NK3R and neurokinin B antagonists, which are being evaluated in terms of efficacy, safety and tolerability compared to traditional hormone therapy.