Use of PRF and IPRF in endodontic revascularization and revitalization treatments. Literature review
Main Article Content
Abstract
Introduction: regenerative endodontics has incorporated biomaterials such as platelet-rich fibrin (PRF) and its injectable variant (i-PRF), which function as bioactive scaffolds that promote the regeneration of the dentin–pulp complex through the sustained release of growth factors. Objective: To evaluate the clinical and radiographic efficacy of PRF and i-PRF in endodontic revascularization and revitalization procedures.
Methodology: a narrative review was conducted, covering studies published between 2020 and 2025 in recognized scientific databases. Clinical trials, systematic reviews, and meta-analyses in English and Spanish were included, analyzing clinical and radiographic outcomes in permanent teeth. Results: PRF and i-PRF showed favorable results in periapical healing, apical closure, and postoperative pain reduction. i-PRF stood out for its improved clinical handling, greater penetration capacity, and higher release of growth factors. However, some studies did not show significant differences compared with the blood clot. Conclusion: both biomaterials are effective in regenerative endodontics, with the potential advantages of i-PRF. Standardized studies and long-term follow-up are required. General area of study: Dentistry. Specific area of study: Endodontics. Type of study: Literature review.
Downloads
Download data is not yet available.
Article Details
How to Cite
Cevallos Brito, A. E., Piedra Andrade, R. B., & Rodriguez Reyes, F. G. (2026). Use of PRF and IPRF in endodontic revascularization and revitalization treatments. Literature review. Anatomía Digital, 9(2), 137 - 151. https://doi.org/10.33262/anatomiadigital.v9i2.3685
Section
Articulos de revisión bibliográfica
References
1. Sarraf P, Goldani B, Khoshkhounejad M, Hamidzadeh F. PRF ‐assisted regenerative endodontic retreatment of an immature tooth: a 4‐year follow‐up. Clinical Case Reports [Internet]. 2025 [cited 2026Jan7];13(10): e9611. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12537540/
2. Kingra S, Singla M, Kaur H, Gupta S. Heal and seal using injectable blood derivative: case series. Journal of Conservative Dentistry and Endodontics [Internet]. 2025 [cited 2026 Jan 7];28(5):491-5. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12129293/
3. Pan J, Luo L, Jiang Z, Huang H, Jiang B. The effect of injectable plateletrich fibrin and platelet-rich fibrin in regenerative endodontics: a comparative in vitro study. Journal of Applied Oral Science [Internet]. 2024 [cited 2026Jan7];32: e20230327. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11178352/
4. Liang Y, Ma R, Chen L, Dai X, Zuo S, Jiang W, et al. Efficacy of i-PRF in regenerative endodontics therapy for mature permanent teeth with pulp necrosis: study protocol for a multicentre randomised controlled trial. Trials [Internet]. 2021 [cited 2026Jan7];22(1):581. Available from: https://link.springer.com/article/10.1186/s13063-021-05401-7
5. De Lima Barbosa R, Stellet Lourenço E, de Azevedo dos Santos JV, Rodrigues Santiago Rocha N, Mourão CF, Gomez Alves G. The effects of platelet-rich fibrin in the behavior of mineralizing cells related to bone tissue regeneration. A scoping review of in vitro evidence. Journal of Functional Biomaterials [Internet]. 2023 [cited 2026Jan7];14(10):515. Available from: https://pubmed.ncbi.nlm.nih.gov/37888168/
6. Dos Reis-Prado AH, Benetti F, Bottino MC, Dal-Fabbro R. Optimizing methods for regenerative endodontics. Regenerative Medicine [Internet]. 2025 [cited 2026 Jan 7];20(1):339-351. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12408052/
7. Huang R, Chen W, Fang M, Peters OA, Hosseinpour S. Clinical and radiographic outcomes of autologous platelet-rich products in regenerative endodontics: a systematic review and meta-analysis. Dentistry Journal [Internet]. 2025 [cited 2026 Jan 7];13(6):261. Available from: https://pubmed.ncbi.nlm.nih.gov/40559139/
8. Tsiolaki A, Theocharis D, Tsitsipas N, Fardi A, Kodonas K. Evaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis. Restorative Dentistry & Endodontics [Internet]. 2025 Nov [cited 2026Jan7];50(4): e41. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12707569/
9. Rebimbas Guerreiro S, Marto CM, Paula A, de Azevedo Pereira JR, Carrilho E, Marques-Ferreira M, et al. Platelet-rich plasma and platelet-rich fibrin in endodontics: a scoping review. International Journal of Molecular Sciences [Internet]. 2025 [cited 2026Jan7];26(11):4759. Available from: https://pubmed.ncbi.nlm.nih.gov/40564941/
10. Turjanski D, Lisjak D, Bucevic Sojcic P, Valpotic J, Borojevic T, Gorseta K, et al. Advanced platelet-rich fibrin plus sealed exclusively with glass ionomer cement: setting a new standard for healing, aesthetics and predictive modeling in regenerative endodontics. Journal of Functional Biomaterials [Internet]. 2025 [cited 2026 Jan 7];16(1):47. Available from: https://pubmed.ncbi.nlm.nih.gov/41010262/
11. Salah T, Hussein W, Abdelkafy H. Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial. BDJ Open [Internet]. 2025 [cited 2026 Jan 7];11(1):21. Available from: https://pubmed.ncbi.nlm.nih.gov/39900647/
12. Abo-Heikal MM, El-Shafei JM, Shouman SA, Roshdy NN. Evaluation of the efficacy of injectable platelet-rich fibrin versus platelet-rich plasma in the regeneration of traumatized necrotic immature maxillary anterior teeth: a randomized clinical trial. Dental Traumatology [Internet]. 2024 Feb [cited 2026 Jan 7];40(1):61-75. Available from: https://pubmed.ncbi.nlm.nih.gov/37612879/
13. Morina LL, Muratovska I, Hajdari B, Agani Z, Leci B, Bimbashi V. Platelet-rich fibrin in oral surgery and endodontic procedures as a regenerative biomaterial: a review article. International Journal of Biomedicine [Internet]. 2023 [cited 2026Jan7];13(4):213-220. Available from: https://www.ijbm.org/articles/i52/ijbm_13(4)_ra3.pdf
14. Goswami P, Chaudhary V, Arya A, Verma R, Vijayakumar G, Bhavani M. Platelet Rich Fibrin (PRF) and its application in dentistry: a literature review. Journal of Pharmacy and Bioallied Sciences [Internet]. 2024 [cited 2026 Jan 7];16(Suppl 1): S5-7. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11000897/
15. Pandey J, Nagpal R, Sinha DJ, Gupta A. Clinical efficacy of platelet rich fibrin, injectable platelet rich fibrin, and advanced platelet rich fibrin in regenerative endodontics: a case series. Journal of Conservative Dentistry and Endodontics [Internet]. 2024 [cited 2026 Jan 7];27(11):1196-200. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11702872/
16. El-Hady AYA, Badr AES. The Efficacy of advanced platelet-rich fibrin in revascularization of immature necrotic teeth. The Journal of Contemporary Dental Practice [Internet]. 2022 Jul [cited 2026 Jan 7];23(7):725-32. Available from: https://pubmed.ncbi.nlm.nih.gov/36440520/
17. Kandemir Demirci G, Güneri P, Çalışkan MK. Regenerative endodontic therapy with platelet rich fibrin: case series. The Journal of Clinical Pediatric Dentistry [Internet]. 2020 [cited 2026 Jan 7];44(1):15-9. Available from: https://pubmed.ncbi.nlm.nih.gov/31995420/
18. Major M, Polyák M, Würsching T, Kammerhofer G, Kocsis É, Németh Z, et al. PRF membranes enhance postoperative recovery after periapical surgery: a single-blind randomized pilot trial using 3D imaging. Journal of Clinical Medicine [Internet]. 2025 [cited 2026Jan7];14(3):1052. Available from: https://colab.ws/articles/10.3390%2Foral5040098
19. Darwish OB, Aziz SMA, Sadek HS. Healing potentiality of blood clot, S-PRF and A-PRF as scaffold in treatment of non-vital mature single rooted teeth with chronic peri-apical periodontitis following regenerative endodontic therapy: randomized clinical trial. BMC Oral Health [Internet]. 2025 [cited 2026 Jan 7];25(1):164. Available from: https://pubmed.ncbi.nlm.nih.gov/39789544/
20. Pham VK, Pham TLK, Pham AT, Le HLA, Tran TB Van, Huynh KK, et al. Platelet-rich fibrin as an apical barrier for MTA placement in the treatment of teeth with open apices: a pilot study. Journal of Translational Medicine [Internet]. 2024 [cited 2026 Jan 7];22(1):495. Available from: https://pubmed.ncbi.nlm.nih.gov/38796431/
21. Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B. Regenerative endodontics: a comprehensive review. International Endodontic Journal [Internet]. 2018 [cited 2026 Jan 7];51(12):1367–1388. Available from: http://dx.doi.org/10.1111/iej.12954
22. Mousavi E, Nasrabadi N, Jamali S, Haddadi A. Evaluation of the clinical outcomes of regenerative endodontic procedures using autologous platelet concentrate: a systematic review and meta-analysis. Pesquisa Brasileira em Odontopediatria e Clínica Integrada [Internet]. 2025 [cited 2026Jan7]; 25:e230113. Available from: https://www.scielo.br/j/pboci/a/jdHCtY3HWpvdzcCTWc9CskC/?lang=en&format=pdf
23. Rizk HM, Salah Al-Deen MSM, Emam AA. Comparative evaluation of Platelet Rich Plasma (PRP) versus Platelet Rich Fibrin (PRF) scaffolds in regenerative endodontic treatment of immature necrotic permanent maxillary central incisors: A double blinded randomized controlled trial. The Saudi Dental Journal [Internet]. 2020 [cited 2026Jan7];32(5):224-231. Available from: https://pubmed.ncbi.nlm.nih.gov/32647469/
24. You JS, Jung GW, Oh JS, Moon SY, Lee WP, Jo HH. Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial. BMC Oral Health [Internet]. 2023 Dec [cited 2026Jan7];23(1):821. Available from: https://pubmed.ncbi.nlm.nih.gov/37899448/
25. Rani M, Singh B, Nanda T, Ohri T, Aggarwal K, Bhasker A, Kaur A. Never-ending journey of platelet concentrates. Journal of Current Medical Research and Opinion [Internet]. 2022 M [cited 2026Jan7];5(4):1192-202. Available from: https://cmro.in/index.php/jcmro/article/view/509/704
26. Ray HL, Marcelino J, Braga RG, Horwat R, Lisien M, Khaliq S. Long-term follow up of revascularization using platelet-rich fibrin. Dental traumatology: official publication of International Association for Dental Traumatology. [Internet]2016 [cited 2026 Jan 7];32(1):80–84. Available from: https://www.semanticscholar.org/paper/Long-term-follow-up-of-revascularization-using-Ray-Marcelino/903cdc988a878d185e4053ae1b7a42a4fa42b0f0
27. Thamaraiselvan M, Jayakumar ND, Dhanraj G. Role of injectable platelet Rich Fibrin (iPRF) in Periodontal Therapy - A report on current evidence. Journal of Population Therapeutics and Clinical Pharmacology [Internet]. 2023 [cited 2026Jan7];30(16):154-162. Available from: http://jptcp.com/index.php/jptcp/article/view/1944/2022
28. González Guachizaca GV, Morocho Morocho NP, Lugo Pinto MA, Rodriguez Reyes FG. Endodontic regeneration with A-PRF and I-PRF in a permanent tooth with immature apex: a clinical case report. Anatomía Digital [Internet]. 2025Nov.13 [cited 2026Jan.07];8(4):57-63. Available from: https://doi.org/10.33262/anatomiadigital.v8i4.3558
29. Alberca Gaona N del C, Sarmiento Tigre PB, Oviedo Delgado AN, Rodríguez Reyes FG. Pulp regenerative therapy in permanent teeth with closed apex using I-PRF and A-PRF as biological scaffolds. Anatomía Digital [Internet]. 2026Mar.23 [cited 2026Jan.07];9(1):96-115. Available from: https://doi.org/10.33262/anatomiadigital.v9i1.3624
30. Soto Zumbana JA, Piedra Andrade RB, Lugo Pinto MA, Rodriguez Reyes FG. Applied regenerative endodontics: periapical surgery and sealing of root drilling with A-PRF and photodynamic therapy. Case Report. Anatomía Digital [Internet]. 2025Apr.22 [cited 2026Jan.07];8(2):89-101. Available from: https://doi.org/10.33262/anatomiadigital.v8i2.3402
31. Cherres Quiroz JA, Rodriguez Reyes FG. Intentional replantation with I-PRF for periapical healing. Anatomía Digital [Internet]. 2026Jan.5 [cited 2026Jan.07];9(1):82-85. Available from: https://doi.org/10.33262/anatomiadigital.v9i1.3577
2. Kingra S, Singla M, Kaur H, Gupta S. Heal and seal using injectable blood derivative: case series. Journal of Conservative Dentistry and Endodontics [Internet]. 2025 [cited 2026 Jan 7];28(5):491-5. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12129293/
3. Pan J, Luo L, Jiang Z, Huang H, Jiang B. The effect of injectable plateletrich fibrin and platelet-rich fibrin in regenerative endodontics: a comparative in vitro study. Journal of Applied Oral Science [Internet]. 2024 [cited 2026Jan7];32: e20230327. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11178352/
4. Liang Y, Ma R, Chen L, Dai X, Zuo S, Jiang W, et al. Efficacy of i-PRF in regenerative endodontics therapy for mature permanent teeth with pulp necrosis: study protocol for a multicentre randomised controlled trial. Trials [Internet]. 2021 [cited 2026Jan7];22(1):581. Available from: https://link.springer.com/article/10.1186/s13063-021-05401-7
5. De Lima Barbosa R, Stellet Lourenço E, de Azevedo dos Santos JV, Rodrigues Santiago Rocha N, Mourão CF, Gomez Alves G. The effects of platelet-rich fibrin in the behavior of mineralizing cells related to bone tissue regeneration. A scoping review of in vitro evidence. Journal of Functional Biomaterials [Internet]. 2023 [cited 2026Jan7];14(10):515. Available from: https://pubmed.ncbi.nlm.nih.gov/37888168/
6. Dos Reis-Prado AH, Benetti F, Bottino MC, Dal-Fabbro R. Optimizing methods for regenerative endodontics. Regenerative Medicine [Internet]. 2025 [cited 2026 Jan 7];20(1):339-351. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12408052/
7. Huang R, Chen W, Fang M, Peters OA, Hosseinpour S. Clinical and radiographic outcomes of autologous platelet-rich products in regenerative endodontics: a systematic review and meta-analysis. Dentistry Journal [Internet]. 2025 [cited 2026 Jan 7];13(6):261. Available from: https://pubmed.ncbi.nlm.nih.gov/40559139/
8. Tsiolaki A, Theocharis D, Tsitsipas N, Fardi A, Kodonas K. Evaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis. Restorative Dentistry & Endodontics [Internet]. 2025 Nov [cited 2026Jan7];50(4): e41. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12707569/
9. Rebimbas Guerreiro S, Marto CM, Paula A, de Azevedo Pereira JR, Carrilho E, Marques-Ferreira M, et al. Platelet-rich plasma and platelet-rich fibrin in endodontics: a scoping review. International Journal of Molecular Sciences [Internet]. 2025 [cited 2026Jan7];26(11):4759. Available from: https://pubmed.ncbi.nlm.nih.gov/40564941/
10. Turjanski D, Lisjak D, Bucevic Sojcic P, Valpotic J, Borojevic T, Gorseta K, et al. Advanced platelet-rich fibrin plus sealed exclusively with glass ionomer cement: setting a new standard for healing, aesthetics and predictive modeling in regenerative endodontics. Journal of Functional Biomaterials [Internet]. 2025 [cited 2026 Jan 7];16(1):47. Available from: https://pubmed.ncbi.nlm.nih.gov/41010262/
11. Salah T, Hussein W, Abdelkafy H. Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial. BDJ Open [Internet]. 2025 [cited 2026 Jan 7];11(1):21. Available from: https://pubmed.ncbi.nlm.nih.gov/39900647/
12. Abo-Heikal MM, El-Shafei JM, Shouman SA, Roshdy NN. Evaluation of the efficacy of injectable platelet-rich fibrin versus platelet-rich plasma in the regeneration of traumatized necrotic immature maxillary anterior teeth: a randomized clinical trial. Dental Traumatology [Internet]. 2024 Feb [cited 2026 Jan 7];40(1):61-75. Available from: https://pubmed.ncbi.nlm.nih.gov/37612879/
13. Morina LL, Muratovska I, Hajdari B, Agani Z, Leci B, Bimbashi V. Platelet-rich fibrin in oral surgery and endodontic procedures as a regenerative biomaterial: a review article. International Journal of Biomedicine [Internet]. 2023 [cited 2026Jan7];13(4):213-220. Available from: https://www.ijbm.org/articles/i52/ijbm_13(4)_ra3.pdf
14. Goswami P, Chaudhary V, Arya A, Verma R, Vijayakumar G, Bhavani M. Platelet Rich Fibrin (PRF) and its application in dentistry: a literature review. Journal of Pharmacy and Bioallied Sciences [Internet]. 2024 [cited 2026 Jan 7];16(Suppl 1): S5-7. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11000897/
15. Pandey J, Nagpal R, Sinha DJ, Gupta A. Clinical efficacy of platelet rich fibrin, injectable platelet rich fibrin, and advanced platelet rich fibrin in regenerative endodontics: a case series. Journal of Conservative Dentistry and Endodontics [Internet]. 2024 [cited 2026 Jan 7];27(11):1196-200. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11702872/
16. El-Hady AYA, Badr AES. The Efficacy of advanced platelet-rich fibrin in revascularization of immature necrotic teeth. The Journal of Contemporary Dental Practice [Internet]. 2022 Jul [cited 2026 Jan 7];23(7):725-32. Available from: https://pubmed.ncbi.nlm.nih.gov/36440520/
17. Kandemir Demirci G, Güneri P, Çalışkan MK. Regenerative endodontic therapy with platelet rich fibrin: case series. The Journal of Clinical Pediatric Dentistry [Internet]. 2020 [cited 2026 Jan 7];44(1):15-9. Available from: https://pubmed.ncbi.nlm.nih.gov/31995420/
18. Major M, Polyák M, Würsching T, Kammerhofer G, Kocsis É, Németh Z, et al. PRF membranes enhance postoperative recovery after periapical surgery: a single-blind randomized pilot trial using 3D imaging. Journal of Clinical Medicine [Internet]. 2025 [cited 2026Jan7];14(3):1052. Available from: https://colab.ws/articles/10.3390%2Foral5040098
19. Darwish OB, Aziz SMA, Sadek HS. Healing potentiality of blood clot, S-PRF and A-PRF as scaffold in treatment of non-vital mature single rooted teeth with chronic peri-apical periodontitis following regenerative endodontic therapy: randomized clinical trial. BMC Oral Health [Internet]. 2025 [cited 2026 Jan 7];25(1):164. Available from: https://pubmed.ncbi.nlm.nih.gov/39789544/
20. Pham VK, Pham TLK, Pham AT, Le HLA, Tran TB Van, Huynh KK, et al. Platelet-rich fibrin as an apical barrier for MTA placement in the treatment of teeth with open apices: a pilot study. Journal of Translational Medicine [Internet]. 2024 [cited 2026 Jan 7];22(1):495. Available from: https://pubmed.ncbi.nlm.nih.gov/38796431/
21. Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B. Regenerative endodontics: a comprehensive review. International Endodontic Journal [Internet]. 2018 [cited 2026 Jan 7];51(12):1367–1388. Available from: http://dx.doi.org/10.1111/iej.12954
22. Mousavi E, Nasrabadi N, Jamali S, Haddadi A. Evaluation of the clinical outcomes of regenerative endodontic procedures using autologous platelet concentrate: a systematic review and meta-analysis. Pesquisa Brasileira em Odontopediatria e Clínica Integrada [Internet]. 2025 [cited 2026Jan7]; 25:e230113. Available from: https://www.scielo.br/j/pboci/a/jdHCtY3HWpvdzcCTWc9CskC/?lang=en&format=pdf
23. Rizk HM, Salah Al-Deen MSM, Emam AA. Comparative evaluation of Platelet Rich Plasma (PRP) versus Platelet Rich Fibrin (PRF) scaffolds in regenerative endodontic treatment of immature necrotic permanent maxillary central incisors: A double blinded randomized controlled trial. The Saudi Dental Journal [Internet]. 2020 [cited 2026Jan7];32(5):224-231. Available from: https://pubmed.ncbi.nlm.nih.gov/32647469/
24. You JS, Jung GW, Oh JS, Moon SY, Lee WP, Jo HH. Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial. BMC Oral Health [Internet]. 2023 Dec [cited 2026Jan7];23(1):821. Available from: https://pubmed.ncbi.nlm.nih.gov/37899448/
25. Rani M, Singh B, Nanda T, Ohri T, Aggarwal K, Bhasker A, Kaur A. Never-ending journey of platelet concentrates. Journal of Current Medical Research and Opinion [Internet]. 2022 M [cited 2026Jan7];5(4):1192-202. Available from: https://cmro.in/index.php/jcmro/article/view/509/704
26. Ray HL, Marcelino J, Braga RG, Horwat R, Lisien M, Khaliq S. Long-term follow up of revascularization using platelet-rich fibrin. Dental traumatology: official publication of International Association for Dental Traumatology. [Internet]2016 [cited 2026 Jan 7];32(1):80–84. Available from: https://www.semanticscholar.org/paper/Long-term-follow-up-of-revascularization-using-Ray-Marcelino/903cdc988a878d185e4053ae1b7a42a4fa42b0f0
27. Thamaraiselvan M, Jayakumar ND, Dhanraj G. Role of injectable platelet Rich Fibrin (iPRF) in Periodontal Therapy - A report on current evidence. Journal of Population Therapeutics and Clinical Pharmacology [Internet]. 2023 [cited 2026Jan7];30(16):154-162. Available from: http://jptcp.com/index.php/jptcp/article/view/1944/2022
28. González Guachizaca GV, Morocho Morocho NP, Lugo Pinto MA, Rodriguez Reyes FG. Endodontic regeneration with A-PRF and I-PRF in a permanent tooth with immature apex: a clinical case report. Anatomía Digital [Internet]. 2025Nov.13 [cited 2026Jan.07];8(4):57-63. Available from: https://doi.org/10.33262/anatomiadigital.v8i4.3558
29. Alberca Gaona N del C, Sarmiento Tigre PB, Oviedo Delgado AN, Rodríguez Reyes FG. Pulp regenerative therapy in permanent teeth with closed apex using I-PRF and A-PRF as biological scaffolds. Anatomía Digital [Internet]. 2026Mar.23 [cited 2026Jan.07];9(1):96-115. Available from: https://doi.org/10.33262/anatomiadigital.v9i1.3624
30. Soto Zumbana JA, Piedra Andrade RB, Lugo Pinto MA, Rodriguez Reyes FG. Applied regenerative endodontics: periapical surgery and sealing of root drilling with A-PRF and photodynamic therapy. Case Report. Anatomía Digital [Internet]. 2025Apr.22 [cited 2026Jan.07];8(2):89-101. Available from: https://doi.org/10.33262/anatomiadigital.v8i2.3402
31. Cherres Quiroz JA, Rodriguez Reyes FG. Intentional replantation with I-PRF for periapical healing. Anatomía Digital [Internet]. 2026Jan.5 [cited 2026Jan.07];9(1):82-85. Available from: https://doi.org/10.33262/anatomiadigital.v9i1.3577