Applications and considerations of FRP in endodontic surgery: a literature review

Abstract

Introduction: Fibrin-rich plasma (FRP) is a biomaterial—a natural fibrous clot enriched with platelets, leukocytes, and a high concentration of endogenous growth factors. It is used in dentistry and maxillofacial surgery for bone regeneration, bone graft covering, among other applications. Objective: To characterize the efficacy and safety of FRP in endodontic surgery. Methodology: Searches were conducted on various database platforms, including Elsevier, Springer Link, and PubMed, using keywords and Boolean operators (AND and OR) to optimize results. The PRISMA 2020 model was used to screen articles based on predefined eligibility criteria. Articles were assessed for risk of bias using the ROB-2 tool for randomized trials. Results: A total of nine studies were included in this review. The total sample size was approximately 290 patients, all of whom were adults. The differences between the total sample and the control groups were negligible. Efficacy was measured using the following parameters: total hemostasis, mean pain score, changes in the root canal area, reduction in apical diameter, periradicular healing, and palatal mucosal thickness. Conclusion: Overall, the use of FRP showed superior results compared with other therapeutic methods; however, very few articles reported significant differences in the efficacy measurement parameters. Regarding adverse effects, the intervention groups experienced no complications, while complications were minimal in the control groups. General Area of Study: Odontology. Specific area of study: endodontics. Type of study: A literature review.