Analgesic evaluation of xylazine and dexmedetomidine by continuous infusion in OVH surgeries in canines
Article Sidebar
Main Article Content
Abstract
Objective: To evaluate intraoperative and immediate postoperative analgesia by continuous infusion of xylazine and dexmedetomidine in ovariohysterectomy (OVH) surgeries in undifferentiated breed dogs, at the Snap veterinary clinic in the city of Ambato, December-January 2022-2023. Methodology: fifty female canines are entered into a blind, prospective, and randomized study with prior informed consent from the owners. They are divided into two groups: twenty-five canines for the xylazine (X) group and twenty-five canines for the dexmedetomidine (D) group. Vital signs are taken heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), capillary refill time (TLLC), and temperature (T) before beginning neuroleptanalgesia and throughout the surgical procedure plus capnography. (eTCO2) at 5, 10 and 15 minutes, for group (X) the premedication is xylazine 0.3mg/kg and tramadol 3mg/kg, for group (D) the premedication is dexmedetomidine 3ug/kg and tramadol 3mg/kg. The induction for the two groups is the same 3mg/kg ketamine and 3mg/kg propofol applied slowly intravenously in 2 minutes, maintenance is immediately performed with continuous infusion propofol as well as the alpha two adrenergic drugs proposed by syringe pumps. In addition, propofol consumption and anesthetic recovery time are assessed. In the postoperative period with the animal recovered from anesthesia, pain was assessed using the modified Glasgow scale. This research was of a descriptive experimental type, and a quantitative approach. Results: in the 2 study groups, the measured variables did not present statistically significant changes, but for group (X) a greater consumption of propofol close to 20% was observed to obtain a good anesthetic plane, in the postoperative period the analgesic awakening it happens during the 10 minutes after and the Glasgow scale is not statistically significant. Conclusion: including alpha two adrenergic drugs provide one more tool to improve pain relief during and after a surgical procedure.
Downloads
Article Details
References
Botella, C. (2004). Administración parenteral de medicamentos: la vía intravenosa (el goteo intravenoso). 1–5. https://www.fisterra.com/material/tecnicas/parenteral/viaIV.pdf
Burkitt, J., & Davis, H. (2012). Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care. WILEY-BLACKWELL.
Dent, B., Aarnes, T., Wavreille, V., Lakritz, J., Lerche, P., KuKanich, B., Riccó Pereira, C., & Bednarski, R. (2019). Pharmacokinetics and pharmacodynamic effects of oral transmucosal and intravenous administration of dexmedetomidine in dogs. 80(10), 969–975. https://doi.org/10.2460/ajvr.80.10.969
Firth, A. M., & Haldane, S. L. (1999). Development of a scale to evaluate postoperative pain in dogs. Journal of the American Veterinary Medical Association, 214(5), 651–659. https://pubmed.ncbi.nlm.nih.gov/10088012/
Grimm, K. A., Leigh A, L., William J, T., Stephen A, G., & Robertson, S. A. (2015). Veterinary anesthesia and analgesia, 5th Edition of Lumb and Jones. WILEY-BLACKWELL.
Holton, L., Reid, J., Scott, E. M., Pawson, P., & Nolan, A. (2001). Articles- Development of a behavior-based scale to measure acute pain in dogs.
Kuusela, E., Raekallio, M., Väisänen, M., Mykkänen, K., Ropponen, H., & Vainio, O. (2001). Comparison of medetomidine and dexmedetomidine as premedicates in dogs undergoing propofol-isoflurane anesthesia. 62(7). https://doi.org/10.2460/ajvr.2001.62.1073
Mahmoud, M., Mason, K., & Barbi, E. (2015). Dexmedetomidine: review, update, and future considerations of pediatric perioperative and periprocedural applications and limitations. British Journal of Anaesthesia, 115(2), 171–182. https://doi.org/10.1093/bja/aev226
Muir, W. (2008). Manual de Anestesia Veterinaria (Cuarta). Elsevier.
Murrell, J. C., Psatha, E. P., Scott, E. M., Reid, J., & Hellebrekers, L. J. (2008). Application of a modified form of the Glasgow pain scale in a veterinary teaching center in the Netherlands. Veterinary Record, 162(13), 403–408. https://doi.org/10.1136/vr.162.13.403
Pan, S. Y., Liu, G., Lin, J. H., & Jin, Y. P. (2021). Efficacy and safety of dexmedetomidine premedication in balanced anesthesia: A systematic review and meta-analysis in dogs. Animals, 11(11). https://doi.org/10.3390/ani11113254
Plumb, D. C. (2008). Veterinary Drug Handbook (Sexta). Blackwell.
Ruano Puente, B. (2017). Dolor crónico en el perro (primera). Servet.
Sández Cordero, I. (2019). Manual clínico de monitorización anestésica en pequeños animales (primera). Servet.