Immunohistochemistry, a renewing tool for therapeutic selection in breast cancer

Abstract

Introduction: Breast cancer is a group of tumors that can show similar clinical and homogeneous histological aspects, however, with a very diverse biological behavior and a great variability in the response to treatment. The current histological classification based on hematoxylin eosin does not allow to identify the patients who will present better responses and benefits with the different therapeutic modalities. Immunohistochemistry is related to the chemical activity of cells and tissues. Objective: To explain the importance of immunohistochemistry in therapeutic selection in breast cancer. Methodology: We consulted the literature related to the topic and carried out this review. Results and discussion: Taking into account the advances obtained with the immunohistochemistry technique, it is possible to have a more accurate prediction of behavior, allow a personalized therapy with better control of the disease, relapse-free survival and overall survival. Conclusions: The development of immunohistochemistry allows personalized therapies according to subtypes in breast cancer, achieving significant benefits in disease control and survival.