Insulinización en adultos mayores con diabetes mellitus tipo 2
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Introducción. La insulinización es un tratamiento destinado a pacientes con diabetes mellitus (DM). En especial, en edades tempranas y a pacientes con DM tipo 1. Sin embargo, su uso también se ha probado en pacientes con DM tipo 2, en cualquier grupo etario incluyendo adultos mayores. Objetivo. Detallar la insulinización en adultos mayores con diabetes mellitus tipo 2. Metodología. Se realizó una revisión bibliográfica tipo narrativa basada en el uso de artículos científicos como fuentes bibliográficas. La búsqueda de dichos artículos se realizó en plataformas digitales y bases de datos exclusivamente de áreas de salud: Springer, Elsevier, Pubmed Central, entre otros. Para perfeccionar las búsquedas, se utilizaron palabras clave a modo de descriptores, tanto en idioma inglés como español. Para mejorar los resultados, se apoyó la búsqueda con operadores booleanos como AND Y OR. Se utilizó el modelo PRISMA para el cribado de los artículos. Resultados. De un total de 80 artículos revisados, 15 cumplieron con los requisitos de la presente revisión. Las indicaciones para iniciar la insulinización en adultos mayores es el fracaso a tratamientos con antidiabéticos orales, enfermedades cardiovasculares con falta de control, enfermedad renal o hepática crónicas, y en aquellos pacientes hospitalizados bajo vigilancia médica. Conclusión. Las ventajas de la insulinización tienen que ver con la facilidad de autoadministración, incluso en edades avanzadas. Las complicaciones más importantes son hipoglucemia, aumento de peso y en menor porcentaje hematomas locales. Área de estudio general: medicina. Área de estudio específica: medicina general.
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Agliata, A., Giordano, D., Bardozzo, F., Bottiglieri, S., Facchiano, A., & Tagliaferri, R. (2023, April 5). Machine Learning as a Support for the Diagnosis of Type 2 Diabetes. International Journal of Molecular Sciences, 24(7), 6775. https://www.mdpi.com/1422-0067/24/7/6775
Alexopoulos, A. S., Kahkoska, A. R., Pate, V., Bradley, M. C., Niznik, J., Thorpe, C., ... & others. (2021, November 2). Deintensification of Treatment With Sulfonylurea and Insulin After Severe Hypoglycemia Among Older Adults With Diabetes. JAMA Network Open, 4(11), e2132215. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785666
Aminde, L. N., Tindong, M., Ngwasiri, C. A., Aminde, J. A., Njim, T., Fondong, A. A., ... & others. (2019). Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon. BMC Endocr Disord, 19(1), 35. https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-019-0360-9
Ballesta, S., Chillaron, J., & Flores, J. (2018). Abordaje y tratamiento de la diabetes tipo 2 a partir de los 80 años. FMC. Recuperado de: https://atencionprimaria.almirallmed.es/cientificos/abordaje-y-tratamiento-de-la-diabetes-tipo-2-a-partir-de-los-80-anos/
Bayked, E. M., Kahissay, M. H., & Workneh, B. D. (2022). Barriers and facilitators to insulin treatment: a phenomenological inquiry. J Pharm Policy Pract, 15(1), 45. https://joppp.biomedcentral.com/articles/10.1186/s40545-022-00441-z
Blanco Naranjo, E. G., Chavarría Campos, G. F., & Garita Fallas, Y. M. (2021, January 1). Insulinización práctica en la diabetes mellitus tipo 2. Revista Médica Sinergia, 6(1), e628. https://revistamedicasinergia.com/index.php/rms/article/view/628
Bozanic, A., Toro, P., Bello-Lepe, S., Hurtado-Oliva, J., Beyle, C., Valdés, C., ... & others. (2023, January 19). Cognitive impairment with Type 2 Diabetes Mellitus among community-dwelling older adults in Chile: Prevalence, risk factors and cognitive characteristics. Frontiers in Human Neuroscience, 16, 1070611. https://www.frontiersin.org/articles/10.3389/fnhum.2022.1070611/full
Cai, Y. H., Wang, Z., Feng, L. Y., & Ni, G. X. (2022). Effect of Exercise on the Cognitive Function of Older Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Frontiers in Human Neuroscience, 16, 876935. https://www.frontiersin.org/articles/10.3389/fnhum.2022.876935/full
Chagas, T. A., dos Reis, M. A., Leivas, G., Santos, L. P., Gossenheimer, A. N., Melo, G. B., ... & others. (2023, March 2). Prevalence of diabetic retinopathy in Brazil: a systematic review with meta-analysis. Diabetology & Metabolic Syndrome, 15(1), 34. https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-023-01003-2
Che, S., Meng, M., Jiang, Y., & Ye, X. (2022). Perceptions of exercise and exercise instruction in patients with type 2 diabetes mellitus and sarcopenia: A qualitative study. BMC Geriatrics, 22(1), 892. https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-03519-0
Chothia, M. Y., Humphrey, T., Schoonees, A., Chikte, U. M. E., & Davids, M. R. (2022). Hypoglycaemia due to insulin therapy for the management of hyperkalaemia in hospitalised adults: A scoping review. PLOS ONE, 17(5), e0268395. https://dx.plos.org/10.1371/journal.pone.0268395
Correr, C. J., Coura-Vital, W., Frade, J. C. Q. P., Nascimento, R. C. R. M., Nascimento, L. G., Pinheiro, E. B., ... & others. (2020, December). Prevalence of people at risk of developing type 2 diabetes mellitus and the involvement of community pharmacies in a national screening campaign: a pioneer action in Brazil. Diabetology & Metabolic Syndrome, 12(1), 89. https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-020-00593-5
Cruz, M. S., Silva, I. C. F. da, Miguez, J. S. G., & Machado, M. P. R. (2022). Prevalence of hypertension and obesity in patients with type 2 Diabetes Mellitus. Brazilian Journal of Pharmaceutical Sciences, 58, e20497. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100778&tlng=en
Czupryniak, L., Dicker, D., Lehmann, R., Prázný, M., & Schernthaner, G. (2021, October 1). The management of type 2 diabetes before, during and after Covid-19 infection: what is the evidence? Cardiovascular Diabetology, 20(1), 198. https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01389-1
Daly, A., & Hovorka, R. (2021). Technology in the management of type 2 diabetes: Present status and future prospects. Diabetes, Obesity and Metabolism, 23(8), 1722-1732. https://onlinelibrary.wiley.com/doi/10.1111/dom.14418
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., ... & others. (2022, December). Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia, 65(12), 1925-1966. https://link.springer.com/10.1007/s00125-022-05787-2
Díaz Torres, A. E., & Duran Urdiales, T. A. (2021). Frecuencia y factores asociados a la inercia terapéutica en inicio de insulinización en pacientes con Diabetes Mellitus II en el Hospital José Carrasco Arteaga, Cuenca, 2018. Revista Médica del Hospital José Carrasco Arteaga, 13(3), 153-7. https://revistamedichjca.iess.gob.ec/ojs/index.php/HJCA/article/view/668
Edens, M. A., van Dijk, P. R., Hak, E., & Bilo, H. J. G. (2023). Determinants of excessive weight gain after the initiation of insulin therapy in type 2 diabetes mellitus: Retrospective inception cohort study (ZODIAC 60). Diabetes Research and Clinical Practice, 200, 110719. https://linkinghub.elsevier.com/retrieve/pii/S0168822723004825
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., ... & others. (2023). 13. Older Adults: Standards of Care in Diabetes—2023. Diabetes Care, 46(Supplement_1), S216-29. https://diabetesjournals.org/care/article/46/Supplement_1/S216/148044/13-Older-Adults-Standards-of-Care-in-Diabetes-2023
Escourrou, E., Laurent, S., Leroux, J., Oustric, S., & Gardette, V. (2022, January 11). The shift from old age to very old age: an analysis of the perception of aging among older people. BMC Primary Care, 23(1), 3. https://bmcfampract.biomedcentral.com/articles/10.1186/s12875-021-01616-4
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., ... & others. (2020). Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 21(17), 6275. https://www.mdpi.com/1422-0067/21/17/6275
Gentile, S., Guarino, G., Della Corte, T., Marino, G., Satta, E., Romano, C., ... & others. (2021). Bruising: A Neglected, Though Patient-Relevant Complication of Insulin Injections Coming to Light from a Real-Life Nationwide Survey. Diabetes Ther, 12(4), 1143-1157. http://link.springer.com/10.1007/s13300-021-01026-w
Gomezcoello Vásquez, V., Caza, M., & Jácome Sánchez, E. (2021, January 4). Prevalencia de diabetes Mellitus y sus complicaciones. Revista Médica Vozandes, 31(2), 49-55. https://revistamedicavozandes.com/wp-content/uploads/2021/01/06_A0_06.pdf
Hampson, G., Elder, G. J., Cohen-Solal, M., Abrahamsen, B. (2021). A review and perspective on the assessment, management and prevention of fragility fractures in patients with osteoporosis and chronic kidney disease. Endocrine, 73(3), 509-29. https://link.springer.com/10.1007/s12020-021-02735-9
Hu, X., Meng, L., Wei, Z., Xu, H., Li, J., Li, Y., ... & others. (2022, December 16). Prevalence and potential risk factors of self-reported diabetes among elderly people in China: A national cross-sectional study of 224,142 adults. Frontiers in Public Health, 10, 1051445. https://www.frontiersin.org/articles/10.3389/fpubh.2022.1051445/full
Ikegami, H., Hiromine, Y., & Noso, S. (2022, August). Insulin‐dependent diabetes mellitus in older adults: Current status and future prospects. Geriatrics & Gerontology International, 22(8), 549-553. https://onlinelibrary.wiley.com/doi/10.1111/ggi.14414
Illescas, K., Castro, C., & Carrera, M. (2018). Insulinoterapia en pacientes con diabetes mellitus tipo 2. Revista Científica de Investigación Actualizando el Mundo de las Ciencias, 3(2). Recuperado de: https://reciamuc.com/index.php/RECIAMUC/article/view/370/383
Instituto Mexicano del Seguro Social. (n.d.). Diagnóstico y Tratamiento de diabetes mellitus en el Adulto Mayor Vulnerable. Retrieved from https://www.imss.gob.mx/sites/all/statics/guiasclinicas/657GRR.pdf
Jmenez Montero, J. G., Villegas Barakat, M., & Carvajal Solórzano, M. L. (2022). Conceptos Actuales de la Terapia Con Insulina. Revista de Ciencias de la Salud Integrando Conocimiento, 6(3), 65-78.
Jude, E. B., Malecki, M. T., Gomez Huelgas, R., Prazny, M., Snoek, F., Tankova, T., ... & otros. (2022). Expert Panel Guidance and Narrative Review of Treatment Simplification of Complex Insulin Regimens to Improve Outcomes in Type 2 Diabetes. Diabetes Therapy, 13(4), 619-34. https://link.springer.com/10.1007/s13300-022-01222-2
Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2019). Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends. Journal of Epidemiology and Global Health, 10(1), 107. https://www.atlantis-press.com/article/125921499
Langerman, C., Forbes, A., & Robert, G. (2022). The experiences of insulin use among older people with Type 2 diabetes mellitus: A thematic synthesis. Primary Care Diabetes, 16(5), 614-26. https://linkinghub.elsevier.com/retrieve/pii/S175199182200136X
Law, M. F., Ho, R., Law, K. W. T., & Cheung, C. K. M. (2021). Gastrointestinal and hepatic side effects of potential treatment for COVID-19 and vaccination in patients with chronic liver diseases. World Journal of Hepatology, 13(12), 1850-1874. https://www.wjgnet.com/1948-5182/full/v13/i12/1850.htm
LeRoith, D., Biessels, G. J., Braithwaite, S. S., Casanueva, F. F., Draznin, B., Halter, J. B., ... & others. (2019). Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 104(5), 1520-1574. https://academic.oup.com/jcem/article/104/5/1520/5413486
Li, Z., Li, S., Xiao, Y., Zhong, T., Yu, X., & Wang, L. (2022). Nutritional intervention for diabetes mellitus with Alzheimer’s disease. Frontiers in Nutrition, 9, 1046726. https://www.frontiersin.org/articles/10.3389/fnut.2022.1046726/full
Liu, C., De Roza, J., Ooi, C. W., Mathew, B. K., Elya, & Tang, W. E. (2022). Impact of patients’ beliefs about insulin on acceptance and adherence to insulin therapy: a qualitative study in primary care. BMC Primary Care, 23(1), 15. https://bmcfampract.biomedcentral.com/articles/10.1186/s12875-022-01627-9
Llamas-Saez, C., Saez-Vaquero, T., Jiménez-García, R., López-de-Andrés, A., Carabantes-Alarcón, D., Zamorano-León, J. J., ... & others. (2023, March 22). Cross Sectional and Case-Control Study to Assess Time Trend, Gender Differences and Factors Associated with Physical Activity among Adults with Diabetes: Analysis of the European Health Interview Surveys for Spain (2014 & 2020). Journal of Clinical Medicine, 12(6), 2443. https://www.mdpi.com/2077-0383/12/6/2443
Machry, R. V., Cipriani, G. F., Pedroso, H. U., Nunes, R. R., Pires, T. L. S., Ferreira, R., ... & otros. (2021). Pens versus syringes to deliver insulin among elderly patients with type 2 diabetes: A randomized controlled clinical trial. Diabetology & Metabolic Syndrome, 13(1), 64. https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-021-00675-y
Menassa, M., Stronks, K., Khatmi, F., Roa Díaz, Z. M., Espinola, O. P., Gamba, M., ... & others. (2023, February). Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models. eClinicalMedicine, 56, 101821. https://linkinghub.elsevier.com/retrieve/pii/S2589537022005508
Mendes, R., Martins, S., & Fernandes, L. (2019). Adherence to Medication, Physical Activity and Diet in Older Adults With Diabetes: Its Association With Cognition, Anxiety and Depression. J Clin Med Res, 11(8), 583-592. http://www.jocmr.org/index.php/JOCMR/article/view/3894
Morros-González, E., Chacón-Valenzuela, E., Vargas-Beltrán, M. P., Gómez, A. M., Chavarro-Carvajal, D., Cano-Gutiérrez, C. A., ... & others. (2022). Falls, hospitalizations, and poor self-rated health in older people with diabetes and frailty: A secondary analysis of SABE-Colombia. Frontiers in Clinical Diabetes and Healthcare, 3, 895313. https://www.frontiersin.org/articles/10.3389/fcdhc.2022.895313/full
Morros-González, E., Chacón-Valenzuela, E., Vargas-Beltrán, M. P., Gómez, A. M., Chavarro-Carvajal, D., Cano-Gutiérrez, C. A., ... & others. (2023, June). Falls, hospitalizations, and poor self-rated health in older people with diabetes and frailty: A secondary analysis of SABE-Colombia. In Review.
Munshi, M. N., Slyne, C., Greenberg, J. M., Greaves, T., Lee, A., Carl, S., ... & others. (2019). Nonadherence to Insulin Therapy Detected by Bluetooth-Enabled Pen Cap Is Associated With Poor Glycemic Control. Diabetes Care, 42(6), 1129-1131. https://diabetesjournals.org/care/article/42/6/1129/35987/Nonadherence-to-Insulin-Therapy-Detected-by
Nabrdalik, K., Skonieczna-Żydecka, K., Irlik, K., Hendel, M., Kwiendacz, H., Łoniewski, I., ... & others. (2022). Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials. Frontiers in Endocrinology, 13, 975912. https://www.frontiersin.org/articles/10.3389/fendo.2022.975912/full
Nain, R. A., & Thomas, D. C. (2022). Lipohypertrophy prevalence and its associated risk factors in insulin-treated patients with type 2 diabetes in North Borneo, Malaysia. Belitung Nurs J, 8(6), 521-528. https://www.belitungraya.org/BRP/index.php/bnj/article/view/2246
Nakhleh, A., Shehadeh, N. (2021). Hypoglycemia in diabetes: An update on pathophysiology, treatment, and prevention. World Journal of Diabetes, 12(12), 2036-49. https://www.wjgnet.com/1948-9358/full/v12/i12/2036.htm
Ni, X., Zhang, L., Feng, X., Tang, L. (2022). New Hypoglycemic Drugs: Combination Drugs and Targets Discovery. Frontiers in Pharmacology, 13, 877797. https://www.frontiersin.org/articles/10.3389/fphar.2022.877797/full
Ohiagu, F. O., Chikezie, P. C., & Chikezie, C. M. (2021, March 31). Pathophysiology of diabetes mellitus complications: Metabolic events and control. Biomedical Research and Therapy, 8(3), 4243-57. http://www.bmrat.org/index.php/BMRAT/article/view/663
Orces, C. H., & Lorenzo, C. (2018, April). Prevalence of prediabetes and diabetes among older adults in Ecuador: Analysis of the SABE survey. Diabetes Metabolic Syndrome: Clinical Research & Reviews, 12(2), 147-153. https://linkinghub.elsevier.com/retrieve/pii/S1871402117303776
Pimenta, N., Félix, I. B., Monteiro, D., Marques, M. M., & Guerreiro, M. P. (2022). Promoting Physical Activity in Older Adults With Type 2 Diabetes via an Anthropomorphic Conversational Agent: Development of an Evidence and Theory-Based Multi-Behavior Intervention. Frontiers in Psychology, 13, 883354. https://www.frontiersin.org/articles/10.3389/fpsyg.2022.883354/full
Pradeepa, R., & Mohan, V. (2021). Epidemiology of type 2 diabetes in India. Indian Journal of Ophthalmology, 69(11), 2932. https://journals.lww.com/ijo/Fulltext/2021/11000/Epidemiology_of_type_2_diabetes_in_India.6.aspx
Rahman, M. M., Hamiduzzaman, M., Akter, Mst. S., Farhana, Z., Hossain, M. K., Hasan, M. N., ... & others. (2021). Frailty indexed classification of Bangladeshi older adults’ physio-psychosocial health and associated risk factors- a cross-sectional survey study. BMC Geriatrics, 21(1), 3. https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01970-5
Ramírez-Alvarado, C. (2023, July 5). Aerobic exercise as a protective factor in older adults with type 2 diabetes mellitus. Mexican Journal of Medical Research ICSA, 11(22), 54-60. https://repository.uaeh.edu.mx/revistas/index.php/MJMR/article/view/10631
Reed, J., Bain, S., & Kanamarlapudi, V. (2021, August). A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives. Diabetes Metabolic Syndrome Obesity: Targets and Therapy, 14, 3567-3602. https://www.dovepress.com/a-review-of-current-trends-with-type-2-diabetes-epidemiology-aetiology-peer-reviewed-fulltext-article-DMSO
Rocca, J., Calderón, M., La Rosa, A., Seclén, S., Castillo, O., Pajuelo, J., ... & others. (2021, December). Type 2 diabetes mellitus in Peru: A literature review including studies at high-altitude settings. Diabetes Research and Clinical Practice, 182, 109132. https://linkinghub.elsevier.com/retrieve/pii/S0168822721004915
Sandoval Benalcázar, D. C., Socasi Dioses, E. G., Vera Navarrete, E. M., & Poaquiza Pacheco, D. J. (2023). El uso de insulina en pacientes con diabetes tipo II. RECIAMUC, 7(2), 124-133. Recuperado de: https://reciamuc.com/index.php/RECIAMUC/article/view/1098
Santos, K. B. M., Reis, R. C. P. dos, Duncan, B. B., D’Avila, O. P., & Schmidt, M. I. (2023, March 22). Access to diabetes diagnosis in Brazil based on recent testing and consultation: The Brazilian national health survey, 2013 and 2019. Frontiers in Endocrinology, 14, 1122164. https://www.frontiersin.org/articles/10.3389/fendo.2023.1122164/full
Sanz-Cánovas, J., López-Sampalo, A., Cobos-Palacios, L., Ricci, M., Hernández-Negrín, H., Mancebo-Sevilla, J. J., ... & others. (2022). Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia. International Journal of Environmental Research and Public Health, 19(14), 8677. https://www.mdpi.com/1660-4601/19/14/8677
Sarker, A., Das, R., Ether, S., Saif-Ur-Rahman, K. M. (2020). Non-pharmacological interventions for the prevention of type 2 diabetes mellitus in low and middle-income countries: protocol for a systematic review and meta-analysis of randomized controlled trials. Systematic Reviews, 9(1), 288. https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-020-01550-z
Seguí Díaz, M. (2010). Aspectos prácticos en la insulinización del paciente anciano con diabetes. Avances en Diabetología, 26(5), 320-5. https://linkinghub.elsevier.com/retrieve/pii/S1134323010650041
Sendekie, A. K., Teshale, A. B., & Tefera, Y. G. (2022, May 26). Glycemic control in newly insulin-initiated patients with type 2 diabetes mellitus: A retrospective follow-up study at a university hospital in Ethiopia. PLOS ONE, 17(5), e0268639. https://dx.plos.org/10.1371/journal.pone.0268639
Shi, Q., Nong, K., Vandvik, P. O., Guyatt, G. H., Schnell, O., Rydén, L., ... & others. (2023). Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ, e074068. https://www.bmj.com/lookup/doi/10.1136/bmj-2022-074068
Shi, Q., Nong, K., Vandvik, P. O., Guyatt, G. H., Schnell, O., Rydén, L., ... & others. (2023). Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ. https://www.bmj.com/lookup/doi/10.1136/bmj-2022-074068
Sinclair, A. J., Abdelhafiz, A. H. (2022). Metabolic Impact of Frailty Changes Diabetes Trajectory. Metabolites, 13(2), 295. https://www.mdpi.com/2218-1989/13/2/295
Sinclair, A. J., Pennells, D., Abdelhafiz, A. H. (2022). Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus—a choice determined by metabolic phenotype. Aging Clinical and Experimental Research, 34(9), 1949-67. https://link.springer.com/10.1007/s40520-022-02142-8
Strain, W. D., Down, S., Brown, P., Puttanna, A., & Sinclair, A. (2021). Diabetes and Frailty: An Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes. Diabetes Ther, 12(5), 1227-1247. https://link.springer.com/10.1007/s13300-021-01035-9
Sy, S. L., Munshi, M. M., & Toschi, E. (2022). Can Smart Pens Help Improve Diabetes Management? J Diabetes Sci Technol, 16(3), 628-634. http://journals.sagepub.com/doi/10.1177/1932296820965600
Teixeira, J., Pedrozo Campos Antunes, T., Carlos de Abreu, L., Lucas Souza Ramos, J., Mende de Castro, J., Batista Francalino da Rocha, J., ... & others. (2023, March 23). Prevalência de pé diabético e seus fatores de risco no Estado do Espirito Santo, Brasil. Journal of Human Growth and Development, 33(1), 33-43. https://revistas.marilia.unesp.br/index.php/jhgd/article/view/14295
Thaiss, C. A., Levy, M., Grosheva, I., Zheng, D., Soffer, E., Blacher, E., ... & others. (2018). Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection. Science, 359(6382), 1376-1383. https://www.science.org/doi/10.1126/science.aar3318
Thewjitcharoen, Y., Prasartkaew, H., Tongsumrit, P., Wongjom, S., Boonchoo, C., Butadej, S., ... & others. (2020). Prevalence, Risk Factors, and Clinical Characteristics of Lipodystrophy in Insulin-Treated Patients with Diabetes: An Old Problem in a New Era of Modern Insulin. Diabetes Metab Syndr Obes Targets Ther, 13, 4609-4620. https://www.dovepress.com/prevalence-risk-factors-and-clinical-characteristics-of-lipodystrophy--peer-reviewed-article-DMSO
Tiedemann, L. J., Meyhöfer, S. M., Francke, P., Beck, J., Büchel, C., & Brassen, S. (2022). Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters. eLife, 11, e76835. https://elifesciences.org/articles/76835
Toschi, E., & Munshi, M. N. (2020). Benefits and Challenges of Diabetes Technology Use in Older Adults. Endocrinology and Metabolism Clinics of North America, 49(1), 57-67. https://linkinghub.elsevier.com/retrieve/pii/S0889852919300830
Toschi, E., Slyne, C., Greenberg, J. M., Greaves, T., Atakov-Castillo, A., Carl, S., ... & others. (2020). Examining the Relationship Between Pre- and Postprandial Glucose Levels and Insulin Bolus Timing Using Bluetooth-Enabled Insulin Pen Cap Technology and Continuous Glucose Monitoring. Diabetes Technology & Therapeutics, 22(1), 19-24. https://www.liebertpub.com/doi/10.1089/dia.2019.0186
Weiner, J. Z., Gopalan, A., Mishra, P., Lipska, K. J., Huang, E. S., Laiteerapong, N., ... & others. (2019, December 1). Use and Discontinuation of Insulin Treatment Among Adults Aged 75 to 79 Years With Type 2 Diabetes. JAMA Internal Medicine, 179(12), 1633. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2751518
Widyahening, I. S., Khunti, K., Vos, R. C., & Chew, B. H. (2022, March 17). Achieving Effective Management and Treatment of Diabetes Mellitus in Future Primary Care. Frontiers in Endocrinology, 13, 854244. https://www.frontiersin.org/articles/10.3389/fendo.2022.854244/full
Wolosowicz, M., Prokopiuk, S., Kaminski, T. W. (2022). Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle? Medicina (Mex), 58(4), 472. https://www.mdpi.com/1648-9144/58/4/472
Xie, J., Wang, M., Long, Z., Ning, H., Li, J., Cao, Y., ... & others. (2022, December 7). Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019. BMJ, e072385. https://www.bmj.com/lookup/doi/10.1136/bmj-2022-072385
Yan, Y., Wu, T., Zhang, M., Li, C., Liu, Q., Li, F., ... & others. (2022, December). Prevalence, awareness and control of type 2 diabetes mellitus and risk factors in Chinese elderly population. BMC Public Health, 22(1), 1382. https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-022-13759-9
Yang, Y., Cai, Z., & Zhang, J. (2021). Insulin Treatment May Increase Adverse Outcomes in Patients With COVID-19 and Diabetes: A Systematic Review and Meta-Analysis. Frontiers in Endocrinology, 12, 696087. https://www.frontiersin.org/articles/10.3389/fendo.2021.696087/full
Zheng, Y., Ley, S. H., & Hu, F. B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, 14(2), 88-98. https://www.nature.com/articles/nrendo.2017.151