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Indicadores hematológicos de leucemia viral felina en gat= os asintomáticos

Hematological indicators of feline viral leukemia in apparently healthy cats

3D"Interfaz

= ¹=	Jessica Paola Moyano Morocho	https://orcid.org/0000-0002-9640-4354
<= /span>	Maestría en Medicina Veterinaria, Universidad Católica de Cuenca, Ecuador. jessica.moyano.5= 5@est.ucacue.edu.ec=
= ²=	Pablo Giovanny Rubio Arias	https://orcid.org/0000-0002-9185-4823
<= /span>	Maestría en Medicina Veterinaria, Universidad Católica de Cuenca, Ecuador. prubioa@ucacue.edu.ec

	Artículo de Investigación Científica y Tecnológi= ca Enviado: 08/01/2023 Revisado: 16/02/2023 Aceptado: 13/03/2023 Publicado:20/04/2023 DOI: https://doi= .org/10.33262/concienciadigital.v6i2.2544
<= /u>
&= nbsp; Cítese= :	&= nbsp;	&= nbsp; Moyano Morocho, J. P., & Rubio Arias, P. G. (2023). Indicadores hematológico= s de leucemia viral felina en gatos asintomáticos. ConcienciaDigital, 6(2), 103-114. https://doi.org/10.33262/concienciadigital.v6i2.2544=
<= !--[if gte vml 1]> <= /o:p>	&= nbsp;	CONCIENCIA DIGITAL, es una revista multidisciplina= r, trimestral, que se publicará en soporte electrónico tiene como misión contribu= ir a la formación de profesionales competentes con visión humaníst= ica y crítica que sean capaces de exponer sus resultados investigativos y científicos en la misma medida que se promueva mediante su intervención cambios positivos en la sociedad. https://concienciadigital.org<= span style=3D'font-size:8.0pt;font-family:"Times New Roman",serif;mso-fareast-= font-family: "Times New Roman";mso-fareast-language:ES'> La revista es editada por la Editorial Ciencia Digital (Editorial de prestigio registrada en la Cámara Ecuatoriana de Libro con No de Afiliación 663) www.celibro.org.= ec
<= /o:p>	&= nbsp;	Esta revista está protegida bajo una licencia Creative Commons Attribution Non Commercial No Derivatives 4.0 International. Copia de la licencia: http://creativec= ommons.org/licenses/by-nc-nd/4.0/

Palabras claves:=

leucemia, asintomático, hemograma, inmunocromatográfica, signos.

Resumen =

Introducción. Hoy en día los perfiles hematológicos veterinarios en todas las especies, principalmente= en felinos, han tomado una gran importancia en clínica como ayuda diagnóstic= a en la valoración del paciente, siendo esto un objeto de investigación. Objetivo. Identi= ficar parámetros hematológicos en gatos aparentemente sanos que acudieron a consulta veterinaria con sospecha de signos clínicos a leucemia felina.<= span style=3D'font-size:12.0pt;line-height:115%;font-family:"Times New Roman",= serif'> Metodología. Se analizó los resultados hematológicos obtenidos por el método mecánico de extracción de sangre a 27 gatos aparentemente sanos que acudieron a consulta, a cada paciente se realizó hemograma y test de inmunocromatografía a leucemia vi= ral felina. Resultados. De acuerdo con el análisis estadístico se determina que, si un paciente que se encuentra por debajo de los valores normales en Hematocrito, Plaquetas y Leucocitos o a= lo mucho el máximo de lo normal y el valor de Linfocitos es mayor a su rango normal, el paciente va a tener la enfermedad. Conclusión. De acuerdo con el presente estudio se concluye que, si un paciente felino presenta valores por debajo de los valores normales en hematocrito, plaqu= etas y leucocitos y un valor superior al valor normal de linfocitos juntos con signos referentes a leucemia viral felina durante la consulta veterinaria= , se puede determinar que es un gato con leucemia viral felina asintomático comprobando con el test de inmunocromatográfia.<= /span>

&= nbsp;

Keywords:

Leukemia, Asymptomatic, Hemogram, Immunochromatography, Signs.

Abstract

Introduction. Nowadays, veterinary hematological profiles in all species, in felines, have taken a significa= nt importance in clinical practice as a diagnostic aid in the evaluation of = the patient, being this the object of research. Objective. To identify hematologic parameters in healthy cats that attended veterinary consultat= ion with clinical suspicion of feline leukemia. Methodology. The hematologic results obtained by the mechanical method of blood collection from twenty-seven healthy cats attending for consultation were analyzed. = Each patient underwent hemogram and immunochromatography test for feline viral leukemia. Results. According to the statistical analysis it is determined that if a patient is below the normal values in hematocrit, pl= atelets, and leukocytes or at most the maximum of normal and the value of lymphocy= tes is higher than its normal range, the patient has the disease. Conclusi= ons. According to the present patient study, it is concluded that, if a fe= line presents values below the normal values in hematocrit, platelets and leukocytes and a value above the normal value of lymphocytes together with signs referring to feline viral leukemia during the consultation veterina= ry, it can be determined that it is a cat with asymptomatic feline viral leuk= emia by checking with the immunochromatographic test.=

Introducción<= /b>

Hoy en día los perfiles hematológicos veterinarios en todas las especies, principalmente en felinos, han tomado u= na gran importancia en clínica como ayuda diagnóstica en la valoración del paciente, siendo esto un objeto de investigación (Grandía, 2019).

En nuestro país actualmente la atención médi= ca en felinos domésticos ha mostrado una mayor demanda, exigiendo que los médi= cos veterinarios brinden un servicio de mejor calidad (Herencia, 2018)<= !--[if supportFields]>. Por ello es necesario que el diagnóstico= del paciente sea de forma integral, en el que además de una buena anamnesis y un examen físico detallado, se realicen exámenes complementarios como un perfil hemático, bioquímica sanguínea, prueba para la detección de virus tales como Leucemia Viral Felina (FeLV) e Inmunodeficiencia Viral Felina (FVI), exámen= es coprológicos y diagnóstico por imágenes entre otros.

En el Ecuador y en general en toda Latinoamérica, existen pocos estudios sobre el hemograma en felinos, por lo= que resulta necesario establecer parámetros más acordes a la situación y condiciones del país que permitan llegar a un diagnóstico efectivo y rápido= , ya que los hemogramas brindan una idea básica del estado de salud del paciente= . El hecho de que no se cuente con parámetros, obliga a que se utilice estándare= s de felinos de diferentes

edades que pueden con llevar a un mal diagnóstico en el paciente (Llumiquinga, 2021; Vet, 2018).

La hematología clínica durante mucho tiempo = ha sido uno de los criterios más empleados como medida de diagnóstico de la sa= lud, pues, además que permite evaluar cambios resultantes de demandas fisiológic= as (Herencia, 2018; Orbegos, 2016).

Las variaciones de especies animales han jug= ado un papel fundamental en el estudio de la hematopoyesis, tanto en condiciones normales como en condiciones de estrés fisiológico, la mayoría de pacientes felinos, en muchas ocasiones, requieren de un manejo especial para llevar a cabo cualquier tipo de procedimiento (García, 2022).

El FeLV es un gama retovirus oncogénico con capacidad de transformar las células que infectan en neoplás= icas (Zanna et al., 2018), por compleji= dad de la afección producida por este virus es necesario analizar detalladamente la patogenia y curso de la misma (Nelson & Couto, 2020); esta enfermedad se transmite por vía horizontal (saliva, orina, heces, leche) y vía vertical (intrauterina) en conclusión cualquier gato positivo que elimine virus en la saliva u otras secreciones es una fuente de contagio para otros gatos en contacto directo y para su propia descendencia (Camacho, 2017).

Las alteraciones hematológicas más comunes que se producen por el virus de FeLV es la anemia, neutropenia y alteraciones plaquetarias, debido a que son causadas por el efecto supresor del virus sobre la médula ósea, afectando tanto a las célul= as madre hematopoyéticas como a las células estromales (Cortés, 2019); también induc= en alteraciones en la médula ósea mediante la destrucción celular ocasionada p= or la expresión de antígenos en la superficie de las células (Arrieta, 2022; S= pada, 2018).

Existen diversas pruebas diagnós= ticas de FeLV que deben interpretarse de forma conjunta y siempre en función de si estamos ante un gato sano o enfermo, se pueden encontrar algunas diferencias hematológicas y bioquímicas entre leucemia e inmunodeficiencia (Thompson, 2= 018; Zanna et al., 2018).

El uso de pruebas ELI= SA o inmunocromatográficas es la técnica más utilizada en clínica debido a su fá= cil accesibilidad y pronta respuesta, un resultado ELISA es suficiente para establecer el diagnostico ya que el cuadro clínico aumenta el valor predict= ivo positivo de la prueba debido a que la sensibilidad y especificidad es (> 95%) siendo muy buenas (Dechra, 2019).

Estas pruebas serológ= icas son utilizadas como método tamiz, debiendo ser confirmados los resultados positivos a través de otras pruebas como Western Blot o PCR (Westm= an, 2019).

Metodología

La investigación correspondió a un estudio c= uasi experimental, de tipo observacional donde se analizaron los resultados hematológicos obtenidos por el método mecánico de extracción de sangre a 27 gatos aparentemente sanos, que acudieron a consulta en el periodo comprendido de agosto 2022 hasta enero 2023, a cada paciente se realizó el test de inmunocromatográfia a leucemia viral felina Anigen Rapid= FIV Ab/FeLV Ag Test Kit (SensPERT) como método de verificación de la enfermedad= .

Las muestras obtenidas fueron tomadas en un ambiente controlado con igualdad de condiciones y con un mane= jo adecuado en la toma de muestra sanguínea en el paciente, para evitar alteraciones en los resultados. Los parámetros sanguíneos fueron evaluados = por el método sistémico de análisis de analitos (Hemaray 51Vet Auto Vet Hematol= ogy Analyzer). Para el análisis estadístico se aplicó diagramas de frecuencia c= on el uso del software Estadístico R.

Resultados

Los siguientes result= ados se obtienen a partir de un análisis estadístico por frecuencias de rangos, = los rangos fueron establecidos según la bibliografía de rangos normales de anal= itos en felinos domésticos (Herencia, 2018)<= !--[if supportFields]>.

Fig= ura 1

Hematocrito

Nota: Porcentajes de Hematocritos de las 27 muestras hematológicas

De la figura 1, se puede concluir que si los Hematocritos están tanto en el rango normal o por debajo de lo normal el paciente puede tener la enfermedad.

Fig= ura 2

Leucocitos

Nota: Porcentajes de Leucocitos de las 27 muestras hematológic= as

De la figura 2, se pu= ede observar que si los Leucocitos están por debajo de lo normal o están dentro= del rango normal el paciente puede tener la enfermedad. Sin embargo, hay que recalcar que es más probable que se encuentren dentro del rango normal.

Fig= ura 3

Plaquetas

Nota: Porcentajes de Plaquetas de las 27 muestras hematológica= s

De la figura 3, podemos observar que un paciente p= uede tener la enfermedad a pesar de tener sus plaquetas en el rango adecuado, ap= enas el 22% de los pacientes con la enfermedad están por debajo del rango normal= .

Fig= ura 4

Linfocitos

Nota: Porcentajes de Linfocitos de las 27 muestras hematológic= as

De la figura 4, se pu= ede concluir que cuando un paciente tiene los Linfocitos elevados (mayor a 6) seguramente va a tener la enfermedad.

Según la bibliografía cuando los siguiente 4 analitos: Hematocrito + Plaquetas + Linfocitos + Leu= cocitos están fuera de su rango normal, el paciente posee la enfermedad.=

Para probar esto se realizaron todas las combinaciones entre los 4 analitos que se encuentren p= or debajo de lo normal y se obtuvieron los siguientes Test:<= /p>
Test 1: Hematocrito + Plaquetas + Linfocitos + Leucocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los= 4 analitos.

Resultado: 1 paciente tiene los 4 analitos por encima o debajo de los valores normales= .

Test 2: Linfocitos: En este Test se toman en cuenta los exámenes que tienen valores= que están por encima o debajo del analito Linfocitos.

Resultado: 10 pacientes tienen el analito Linfocitos por encima o debajo de los valores normales, mientras el resto se mantiene en rangos normales.

Test 3: Hematocrito + Linfocitos + Leucocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los analitos H= ematocrito, Linfocitos y Leucocitos.

Resultado: 7 pacientes tienen los 3 analitos por encima o debajo de los valores normal= es, mientras que el analito Plaquetas se mantiene en rangos normales.

Test 4: Hematocrito + Plaquetas + Linfocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los analitos H= ematocrito, Plaquetas y Linfocitos.

Resultado: 3 pacientes tienen los 3 analitos por encima o debajo de los valores normal= es, mientras que el analito Leucocitos se mantiene en rangos normales.

Test 5: Hematocrito + Linfocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los analitos Hematocrito y = Linfocitos.

Resultado: 2 pacientes tienen los 2 analitos por encima o debajo de los valores normal= es, mientras que el resto de analitos se mantienen en rangos normales.

Test 6: Linfocitos + Leucocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los analitos Linfocitos y Leucocitos.

Resultado: 2 pacientes tienen los 2 analitos por encima o debajo de los valores normal= es, mientras que el resto de analitos se mantienen en rangos normales.

Test 7: Plaquetas + Linfocitos: En este Test se toman en cuenta los exámenes que ti= enen valores que están por encima o debajo de los analitos Plaquetas y Linfocito= s.

Resultado: 1 paciente tiene los 2 analitos por encima o debajo de los valores normales, mientras que el resto de analitos se mantienen en rangos normales.

Test 8: Hematocrito + Plaquetas + Leucocitos: En este Test se toman en cuenta los exámenes que tienen valores que están por encima o debajo de los analitos h= ematocrito, Plaquetas, Leucocitos.

Resultado: 1 paciente tiene los 3 analitos por encima o debajo de los valores normales, mientras que el analito Linfocitos se mantiene en rangos normales.

A partir de estos resultados, se tiene la figura 5.

Fig= ura 5

Podemos concluir que siempre que tengan el analito Linfocitos alterado (mayor a 6) es más probab= le que el paciente tenga la enfermedad.

De todo lo mostrado anteriormente se obtiene el siguiente resultado para un test acertado.=

Tab= la 1

Parámetros para determinar paciente con FeLV en hemograma

Analito

Rango normal

Test

Hematocrito

33% - 56%

<=3D59,6

Leucocitos

5,5-19,5

<=3D20

Plaquetas

117 - 490

<=3D420

Linfocito

0,83 - 4,91

>6

La lectura nos muestra que, si un paciente está poder debajo de lo normal en Hematocrito, Plaqueta= s y Leucocitos o a lo mucho el máximo de lo normal y el Linfocitos es mayor a su rango normal, el paciente posea la enfermedad.

Conclusión

·&nb= sp; De acuerdo con el presen= te estudio se concluye que, si un paciente felino presenta valores por debajo = de los valores normales en hematocrito, plaquetas y leucocitos y un valor supe= rior al valor normal de linfocitos juntos con signos referentes a leucemia viral felina durante la consulta veterinaria, se puede determinar que es un gato = con leucemia viral felina asintomático comprobando con el test de inmunocromatográfia= .

Conflicto de intereses

Los autores declaramos que no existe conflicto de intereses en relación con el artículo presentado= .

Referencias Bibliográficas=
Arrieta, M. (2022). = Una mirada a las enfermedades retrovirales felinas. Universidad Nacional de Río Negro. https://rid.unrn.edu.ar/bitstream/20.500.12049/8667/1/Macarena%20Arrieta%= 20-Informe%20Final%20de%20Grado%20versi%C3%B3n%20final.pdf
Camacho, W. (2017). Leucemia e inmunodeficiencia felina. Reporte de un caso. REDVET. https://www.redalyc.org/pdf/636/63653470033.pdf

Cortés, N. (2019). Procedimientos en Medicina de Urgencias. Espańa: Gráfica IN Multimédica.<= /span>

Dechra. (2019). SensPERT. https://www.senspert.com.br/fiv-felv.html

García, N. M. (2022). Virus de la leucemia e inmunodeficiencia felina: un estudio retrospectivo en clínicas veterinarias particulares en Bogotá y Chía. Revista de la Facultad de Medicina Veterinaria y de Zootecnia. https://revistas.unal.edu.co/index.php/remevez/article/view/103264

Grandía, R. (2019). Hallazgos hematológicos en perros y gatos en Lima, Perú. Revista de Investigaciones Veterinar= ias del Perú, 1395-1413. https://dx.doi.org/10.15381/rivep.v30i4.17154=

Herencia, Y. (2018). Determinación de parámetros hematológicos en gatos domésticos (Felis catus) en el altiplan= o. Universidad Nacional del Altiplano (Perú). https://repositorioslatinoamericanos.uchile.cl/handle/2250/3278840

Llumiquinga, T. (2021). Evaluación de parám= etros hematológicos y bioquímicos en neonatos caninos al destete suplementados = con Glutamina y BCCA’s. Universidad Central del Ecuador. http://www.dspace.uce.edu.ec/handle/25000/25412

Nelson, R., & Couto, G., (2020). M= edicina Interna de pequeńos animales. Espańa: Asis Biomedia.

Orbegos, B. Z. (2016). Determinación de valores hematológicos referenciales en felis catus adultos. Universidad Privada Antenor Orrego: https://repositorio.upao.edu.pe/bitstream/20.500.12759/5783/1/REP_MED.VET= E_ZULMI.OLANO_DETERMINACI%C3%93N.VALORES.HEMATOL%C3%93GICOS.REFERENCIALES.F= ELIS.CATUS.ADULTOS.CIUDAD.TRUJILLO.2016.pdf

Spada, E. (2018). Survival time and effect of selected predictor variables on survival in owned. ELSEVIER. https://doi.org/10.1016/j.prevetmed.2017.12.001

Thompson, M. (2018). Diagnóstico Diferen= cial Clínico en Pequeńos Animales. Espańa: Elsevier.<= /p>
Vet, S. (2018). Hematología. http://www.suizavet.com/manuales/hematologia.pdf

Westman, M. (2019). Diagnosing feline immunodeficiency virus (FIV) and feline leukaemia. Australian Veterinary Journal. https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/30809813/

Zanna, G., Aybar, V., Casamián, D., Cerón, J., Clemente, F., Fatjó, J., & Si= lva, S. (2018). Manual Clínico de Medicina Felina. Espańa: 5M Publishing.

El artíc= ulo que se publica es de exclusiva responsabilidad de los autores y no necesariamente reflejan el pensamiento de la Revista Conciencia Digital.

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El artíc= ulo queda en propiedad de la revista y, por tanto, su publicación parcial y/o t= otal en otro medio tiene que ser autorizado por el director de la Revista Conciencia Digital.<= /o:p>

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Analito	Rango normal	Test
Hematocrito	33% - 56%	<=3D59,6
Leucocitos	5,5-19,5	<=3D20
Plaquetas	117 - 490	<=3D420
Linfocito	0,83 - 4,91	>6