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Evaluación del efecto del cortisol provocado por hipoxia sobre algunos parámetros inmunológicos de tilapias de comercializ= ación de la ciudad de Sucúa – Ecuador

 

Evaluation of the effect of cortisol caused by hypoxia on some immunological parameter= s of tilapia commercialization from the city of Sucua – Ecuador

 

Javier Ignacio Briones García.[1]

 

 

Recibido: 30-01-2021 / Revisado: 04-02-2021 /Aceptado: 28-02-2021/ Publicado: 05-03-2021

 

Abstract. =                                      DOI: https://doi.org/10.33262/concienciadigital.v4i1.2.1611

 

Introduction. The fish organism responds to any effect of stres= s by activating corticosteroid hormones, an increase in cortisol in the fish org= anism destabilizes the state of cellular and humoral immunity factors, depletion = of the immune system, continuous stress in fish It can have serious and harmful consequences on your health, they are generally related to the environmental conditions that exist in the environment, in tilapia commercial aquariums i= t is observed that the most common is hypoxia. Objective. To evaluate the effect of hypoxic stress on some immunological parameters of tilapia. Methodology. The eval= uation of the changes in some parameters of the immune system in tilapia under the influence of endogenous cortisol was carried out due to the effects of hypo= xia, experimenting with 10 fish, control (5) and experimental (5) group taking b= lood samples for 3 days, the evaluation of the state of cellular immunity was determined by the phagocytic activity of blood cells (erythrocytes, leukocy= tes and thrombocytes). Results. Wh= en analyzing the changes in the phagocytic activity of the blood cells of the tilapia, a growth of the phagocytic activity is observed in all the blood c= ells in the fish of the control group; in the fish of the experimental group, the phagocytic activity of the erythrocytes only increased, while the thrombocy= tes and leukocytes decreased. Cortisol levels in the blood increased while oxyg= en levels were reduced in the aquarium, in the experimental group. Conclusions. It was found that, w= ith an increase in the level of cortisol, the activity of cellular immunity in fish increases, created by leukocytes, likewise it was determined that some indicators of the immune status decrease with an increase in this hormone.<= o:p>

 

Keywords: Effect, Cortis= ol, Tilapia, Phagocytic Activity

 

Resumen.

 

Introducción. El organismo de los peces responde a cualquier efecto del estrés activando las hormonas corticosteroides, un aumento del cortisol en el organismo de los p= eces desestabiliza el estado de los factores de inmunidad celular y humoral, el agotamiento del sistema inmunológico, el estrés continuo en los peces pue= de acarrear consecuencias graves y perjudiciales en su salud, generalmente est= án relacionadas a las condiciones ambientales que existen en el entorno, en acuarios de comercialización de tilapias se observa que el más común es = la hipoxia. Objetivo. Evaluar el efecto del estrés p= or hipoxia sobre algunos parámetros inmunológicos de tilapias. Metodología. La evaluación de los cambios en algunos parámetros del sistema inmunológico en la tilapia bajo la influencia del cortisol endóge= no se realizó por efectos de hipoxia, experimentando con 10 peces, grupo control= (5) y experimental (5) tomando muestras de sangre durante 3 días, la evaluaciÃ= ³n del estado de la inmunidad celular, se determinó mediante la actividad fagocí= tica de las células sanguíneas (eritrocitos, leucocitos y trombocitos).  Resultados. Al analizar los cambios= en la actividad fagocítica de las células sanguíneas de la tilapia, se observa= un crecimiento de la actividad fagocítica en todas las células sanguíneas e= n los peces del grupo de control; en los peces del grupo experimental, la activid= ad fagocítica de los eritrocitos solo aumentó, mientras que los trombocitos = y los leucocitos disminuyeron. Los niveles de cortisol en sangre aumentaban mientras se reducía los nivel= es de oxígeno en el acuario, en el grupo experimental. Conclusi= ones. Se encontró que, con un aumento en el nivel de cortisol, aumenta la actividad= de la inmunidad celular en los peces, creada por los leucocitos, así mismo se determinó que algunos indicadores del estado inmunológico disminuyen con = un aumento de esta hormona.

 

Palabras claves: Efecto, Cortisol, Tilapia, Actividad Fagocítica

Introducción.

Es importante conocer la condiciÃ= ³n del sistema inmunológico de los peces durante la evaluación de su estado inmunológico, determinar el potencial del organismo de los peces para resi= stir los efectos de factores ambientales agresivos y establecer la naturaleza del efecto de los agentes inmunomoduladores. Según (Peres= toronina, 2018), esto se logra mediante un análisis de los factores de inmunidad cel= ular y humoral. El factor congénito inespecífico de defensa inmune más antiguo filogenéticamente es la fagocitosis, por lo que ( Passantino . et al., 2002)=   recomienda su estudio para eval= uar el estado inmunológico de los peces, ya que sus células sanguíneas (eritroc= itos, leucocitos y trombocitos) tienen la capacidad de fagocitosis.

 

El organismo de los peces respond= e a cualquier efecto del estrés activando las hormonas corticosteroides y las catecolaminas ( Barcellos y Nicolaiewsky, 1999), un aumento en el contenido de co= rtisol en el organismo de los peces desestabiliza el estado de los factores de inmunidad celular y humoral, el agotamiento del sistema inmunológico (Magnadóttir, 2006), siendo uno de estos factores de = estrés la hipoxia.

 

En estudios realizados por (Mikryakov, 2002) se observa el efecto del transporte = en la reducción de la resistencia inmunitaria en los peces estableciendo que la regulación del número de leucocitos se lleva a cabo mediante hormonas, principalmente corticosteroides, por lo que podría ser un motivo para cree= r que el cortisol puede desempeñar un papel importante en la supresión de la ac= tividad fagocítica, (Tort, 2011) sostiene que, si bien= el estrés crónico es en última instancia  puede considerarse inmunosupresor, el estrés agudo o  trauma pueden ayudar a mejorar los componentes celulares y humorales de las defensas innatas del cuerpo en momentos de necesidad. (Ortuño y Esteban, 2001) observaron la depresión d= e la actividad fagocítica y del complemento bajo la influencia del estrés, que= se recuperó a los 3 días.

 

Los datos disponibles muestran que, independientem= ente de los parámetros inmunitarios que se evalúen, los estresores ambientales= tanto naturales como artificiales suprimen las funciones inmunitarias. Muchas cuestiones de las reacciones del organismo de los peces a los cambios exter= nos aún no han sido suficientemente estudiadas, por lo que es necesario estudi= ar la dinámica de los parámetros sanguíneos teniendo en cuenta los principales factores de su entorno. Es importante conocer la condición del sistema inmunológico de los peces durante la evaluación de su estado inmu= nológico, determinar el potencial del organismo de los peces para resistir los efecto= s de factores ambientales agresivos y establecer la naturaleza del efecto de los agentes inmunomoduladores. Según (Perestoronina, 2018), esto se logra mediante un análisis de los factores de inmunidad cel= ular y humoral. El factor congénito inespecífico de defensa inmune más antiguo filogenéticamente es la fagocitosis, por lo que (Passantino . et al.,= 2002) recomienda su estudio para evaluar el estado inmunológico de los peces, ya= que sus células sanguíneas (eritrocitos, leucocitos y trombocitos) tienen la capacidad de fagocitosis.

 

El organismo de los peces responde a cualquier efecto= del estrés activando las hormonas corticosteroides y las catecolaminas ( Barcellos y Nicolaiewsky, 1999), un aumento en el contenido de cortisol en el organismo de los peces desestabiliza el estado de los factores de inmunidad celular y humoral, el agotamiento del sistema inmunológico (Magnadóttir, 2006), siendo uno de estos factores de estrés la hipoxia.

 

En estudios realizados por (Mikr= yakov, 2002) se observa el efecto del transporte en la reducción de la resistencia inmunitaria en los peces estableciendo que la regulación del número de leucocitos se lleva a cabo mediante hormonas, principalmente corticosteroid= es, por lo que podría ser un motivo para creer que el cortisol puede desempeñ= ar un papel importante en la supresión de la actividad fagocítica, (Tort, 2011) sostiene que, si bien el estrés crónico= es en última instancia  puede considera= rse inmunosupresor, el estrés agudo o  trauma pueden ayudar a mejorar los componentes celulares y humorales de las defens= as innatas del cuerpo en momentos de necesidad. (Ortuño y Esteban, 2001) observaron la depresión de la actividad fagocítica y del complemento bajo= la influencia del estrés, que se recuperó a los 3 días.

 

Los datos disponibles muestran que, independientement= e de los parámetros inmunitarios que se evalúen, los estresores ambientales ta= nto naturales como artificiales suprimen las funciones inmunitarias. Muchas cuestiones de las reacciones del organismo de los peces a los cambios exter= nos aún no han sido suficientemente estudiadas, por lo que es necesario estudi= ar la dinámica de los parámetros sanguíneos teniendo en cuenta los principales= factores de su entorno.

 

Metodologia.

El traba= jo se realizó en el mercado<= /span> “Primero de Mayo, de la ciudad de Sucúa, se experimentó c= on 10 tilapias (Oreochromis mossambicus), que previamente se dividieron en grupos de c= ontrol y experimental.

 

Los peces tanto del grupo de control y experimental se mantuvieron en acuarios <= span class=3DSpellE>aireados con un nivel de = oxígeno de 5mg/L, un PH de 7,8 y con una temperatura= de 25 grados centígrados. Después de un período d= e adaptación, los peces del grupo= experimental (5) se estresaron (los niveles de oxígeno se redujeron gradualmente). = Se obtuvo sangre de la vena = de la cola. El muestreo de sangr= e de los animales que partic= iparon en el experimento se realizó inmediatamente después de la aclimataciÃ= ³n, y luego 24 y 48 horas después de la influencia del factor de estrés (hipoxia) (Perestronina, 2018) y se enviaron al lab= oratorio clínico “Astudillo†de la ciudad de Sucua.

 

Para eva= luar el estado de la inmunidad<= /span> celular, se determinó la= actividad fagocítica de las cé= lulas sanguíneas (eritrocitos, leucocitos y trombocitos)= (Girón-Pérez y Zaitseva,= 2004). La concentración de cortisol en el plasma sanguíneo se determinó = mediante el Método de El= isa en fase sólida y para la obt= ención de proteínas (albumina y globulina) se utilizó el = Método Colorimétrico con Reactivo Spinreact.

 

La capac= idad fagocitica de las células= se expresó mediante los siguientes indicadores: FA - act= ividad fagocítica; FI - índice = fagocítico; FN: número fagocítico

 

Los resu= ltados obtenidos durante el estudio se procesaron con el software Microsoft= Excel y se presentan como medià y error estandar. Para evaluar las diferenci= as en muestras dependientes (grupo de control y grupo experimental) con una distribución normal, se = utilizó la prueba t de S= tudent para muestras dependientes= , con una distribución anormal, se utilizó la prueba de Wilcoxon.

 

Resultados.

Uno de los factores de estrés es= la hipoxia. La dinámica de la concentración de oxígeno en los acuarios de c= ontrol y experimentales se presenta en el grafico 1.

&nbs= p;

Grafico 1. Dinámica de la concentración de oxígeno en los acuarios de la investigación.

Fuente: Elaboración propia.

&nbs= p;

Como resultado del experimento, se observó que el nivel de cortisol en el suero sanguíneo de las tilapias ca= mbia significativamente según los grupos evaluados como se observa en la tabla = 1.

 

 

GRUPO EXPERIMENTAL, n=3D5<= /o:p>

GRUPO CONTROL, n=3D5=

 

Día 1

Día 2

Día 3

Día 1

Día 2

Día 3

Cortisol,  ng/ml

1= 18.8 ± 20.4

2= 28.6  ± 50.2

2= 57.5 ± 35.4

1= 15.4 ± 14.6

2= 58.07 ± 23.6

2= 02.07 ± 17.32

 

Tabla 1: Dinámica de los marcadores de estrés du= rante el experimento.

Fuente: Elaboración propia.

 

Al analizar los datos de la tabla, se puede observar un aumento en el nivel de cortisol en la sangre de los peces de los grupos de control y experimentale= s en el segundo día del experimento, que puede deberse a la reacción de los pe= ces a las manipulaciones de muestras de sangre, pero en el tercer día este indic= ador continúa aumentando en los peces del grupo experimental y disminuye en los peces de control (grafico 2).

 

Grafico 2: Dinámica del cortisol en el plasma sanguí= neo de los peces.

Fuente: Elaboración propia.

 

La tarea principal en la evaluación del estado inmunitario son los inmunodiagnósticos de los trastornos del sistema inmunitario que predicen = la gravedad del proceso patológico (Girón-Pérez, et. Al, 2006). Una disminu= ción en el nivel de oxígeno es un factor de estrés, si el sistema inmunológico no funciona correctamente, puede provocar la muerte de los peces según (Perestronina, 2018). Al estudiar los factores celular= es de la inmunidad inespecífica de las tilapias, se estableció que no solo los leucocitos, sino también los eritrocitos con los trombocitos poseen activi= dad fagocítica en los peces.

 Al evaluar la actividad fagocítica de = los leucocitos, eritrocitos y trombocitos antes y después de apagar el compres= or de oxígeno, se obtuvo los resultados presentados en la tabla 2.

 

 

Leucocitos

Eritrocitos

Trombocitos

=

 

FA

FI

FN

FA

FI

FN

FA

FI

FN

Día 1

Grupo control

0.67 ± 0.31

0.65  ± 0.28

0.01 ± 0.02

80.24 ± 1.23

8.0 ± 0.62

6.47 ± 0.5

7.80 ± 0.6

2.38 ± 0.3

0.15 ± 0.3

Grupo = exper.

1.08 ± 0.61

1.25 ± 0.50

0.038 ± 0.01

86.50 ± 1.48

8.52 ± 0.15

7.40 ± 0.3

10.34 ± 0.9

2.05 ± 0.29

0.21 ± 0.60

Día 2

Grupo control

2.24 ± 0.64

1.87 ± 0.45

0.07 ± 0.02

89.45 ± 1.4

5.2 ± 0.14

4.70 ± 0.30

10.89 ± 0.89

2.80 ± 0.25

0.34 ± 0.04

Grupo = exper.

0.68 ± 0.38

0.75 ± 0.45

0.02 ± 0.01

6.34 ± 0.3

6.40 ± 0.5

5.39 ± 0.45

10.6 ± 1.54

3.06 ± 0.3

0.34 ± 0.04

Día 3

Grupo control

0.17 ± 0.1

0.4  ± 0.34

0.00

85,98  ± 1.35

6.98  ± 0.34

6.08  ± 0.38

9.35  ± 0.78

1.90  ± 0.16

0.19  ± 0.02

Grupo = exper.

0.87  ± 0.46

0.98  ± 0.46

0.02  ± 0.001

88.67  ± 1.45

7.08  ± 0.46

6.29  ± 0.46

10.68  ± 0.85

1.89  ± 0.17

0.22  ± 0.03

&n= bsp;

Tabla 2= : Actividad fagocítica de las células sanguíneas de las tilapias en los grupos control y experimental.

Fuente: Elaboración propia.

 

Al analizar los cambios en la actividad fagocítica de las células sanguínea= s de la tilapia según la tabla 2, se puede observar la misma dinámica de fagocito= sis de todas las células sanguíneas en los peces del grupo de control: crecimien= to de la actividad en el segundo día del estudio; en los peces del grupo experimental, en el segundo día, la actividad fagocítica de los eritrocit= os solo aumentó, mientras que los trombocitos y los leucocitos disminuyeron notablemente. Al tercer día, los índices de fagocitosis volvieron a su va= lor original.                        =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â                          =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                            

 

Para evaluar el estado de inmunidad humoral, se determinó la concentración de inmunoglobulinas en suero (Zhang, Wang, Liu, y Fu, 2019), siendo la base bioquímica de la inmunidad humoral específica, las cuales realizan la fun= ción de anticuerpos específicos contra antígenos específicos, son sintetizada= s por las células plasmáticas (linfocitos B) y se secretan en la sangre o los f= luidos tisulares (Olabuenaga, 2000). Su parte principa= l se refiere a la fracción de suero de sangre gamma-globulina.

 

En el estudio de la inmunidad humoral antes y después de apagar el compresor = de oxígeno, obtuvimos los resultados presentados en la tabla 3.

 

Parámetros

Grupo experimental, n=3D 5<= o:p>

Grupo control, n=3D5

Día 1

Día 3

Día 1

Día 3

Albumina,=

4.8 ± 1.1

2.7 ± 0.65

4.5 ± 1.5

2.3 ± 0.4

Globulina α

4.1 ± 0.5

1.8 ± 1.2

2.7 ± 0.5

1.4 ± 0.3

Globulina β

1.2 ± 0.2

0.65 ± 0.25

0.4 ± 0.1

0.5 ± 0.1

Globulina γ

0.95 ± 0.25

0.4 ± 0.04

0.67 ± 0.2

0.32 ± 0.05

Proteínas totales

36.4 ± 3.5

24.5 ± 2.5

28.3 ± 2.4

22.3 ± 1.7

 

Tabla 3: Indicadores de inmunidad humoral durante = el experimento.

Fuente: Elaboración propia.

 

Analizando los resultados, podemos notar diferencias significativas solo en el número de β-globulinas en el = primer día del estudio, los indicadores restantes cambiaron unidireccionalmente, = lo que puede estar asociado con el muestreo de sangre en peces. El análisis de correlación reveló una correlación moderada a cercana entre el nivel de cortisol y los parámetros inmunológicos de la sangre de los peces (tabla = 4).

 

Par= ámetro

Tro= mbocitos

Leu= cocitos

Eri= trocitos

Inm= unidad humoral

FA<= o:p>

FN<= o:p>

FA<= o:p>

FN<= o:p>

FA<= o:p>

FN<= o:p>

Album.

Glo. α

Glo. β

Glo.γ

Cor= tisol

-0.3

-0.3

0.5

0.5

-0.74

-0.3

-0.4

-0.6

-0.6

-0.4

 =

Tabla 4: Coefi= cientes de correlación entre cortisol y parámetros inmunológicos de sangre de ti= lapias

Fuente: Elaboración propia.

 

En base a los resultados obtenido= s, es posible observar la presencia de un coeficiente de correlación positivo= para cortisol solo con actividad leucocitaria, los coeficientes restantes tienen valores negativos.

 

Conclusiones.

·      =    Al estudiar los efectos complejos de los factores de estr= és, incluida la hipoxia aguda y la manipulación, se descubrió que los niveles= de cortisol en la sangre de los peces de los grupos de control y experimentales aumentaron el segundo día del experimento, lo que puede estar asociado con= la reacción de los peces a las manipulaciones de muestras de sangre, pero al tercer día, este indicador continúa aumentando en los peces del grupo experimental y disminuye en los peces del control.

·      =    Al analizar los cambios en la actividad fagocítica de las células sanguíneas de la tilapia, se puede observar la misma dinámica de fagocitosis de todas las células sanguíneas en los peces del grupo de con= trol: un aumento de la actividad en el segundo día del estudio y una fuerte disminución en el tercer día, que coincide con la dinámica del cortisol = en ellos. En los peces del grupo experimental, la actividad fagocítica de los eritrocitos solo aumentó el segundo día, y las plaquetas y los leucocitos disminuyeron significativamente. Al tercer día, los índices de fagocitosis volvieron a su valor original.

·      =    En el estudio del vínculo de inmunidad humoral, solo se pueden observar diferencias significativas en el número de globulinas β el primer día del estudio, los indicadores restantes cambiaron unidireccionalmente, lo que puede estar asociado con el muestreo de sangre = en peces.

·      =    Con base en el análisis de correlación y regresión, encontramos la presencia de una correlación moderada a cercana entre el ni= vel de cortisol y los parámetros inmunológicos de la sangre de los peces. Ade= más, cuanto mayor es el nivel de cortisol, mayor es la actividad de la inmunidad celular creada por los glóbulos blancos. Otros indicadores del estado inmunológico de los peces disminuyen con un aumento de esta hormona.<= /o:p>

 

 

Referencias bibliográficas.=

Barcellos, L., & Nicolaiewsky, S. (1999). Plasma levels of cortisol in the response to acute stress in Nile tilapia, Oreochromis niloticus (L.), previously exposed to chronic stress. Aquaculture Researc= h, 30, (6), 437-444.

Chen, W. H., Sun, L. T., Tsai, C. L., Song, Y. L., & Chang, C. F. (2002). Col= d-stress induced the modulation of catecholamines, cortisol, immunoglobulin M, and leukocyte phagocytosis in tilapia. General and comparative endocrinology, 126(1), 90-100.

Girón-Pérez, M. I.,= & Zaitseva, G. P. (2004). La contaminación acuática y la inmunidad de los peces. Luz María Villarreal de Puga, 83.

Girón-Pérez, M. I., Barcelos-Ga= rcia, R.,et al. (2006). Effect of chlorpyrifos on the hematology and phagocytic activity of Nile tilapia cells (Oreochromis niloticus). Toxicology mechanisms and me= thods16(9), 495-499.

Magnadóttir, B. (2006). Innate immunity of fish (overview). Fish & shellfish immunology, 20 (3), 2, 137-151.=

Mikryakov, V. (2007). Effect of transportation on the composition of peripheral blood leukocytes of carp. Voprosy rybolov= stva, 2(30), 209-214.

Passantino, L., Altamura, M. et al. (2002). Binding and engulfment of Candida albicans = by erythrocytes of Rainbow trout (Salmo gairdneri Richardson) Immunopharmacolo= gy and immunotoxicology. Fish immunolo= gy, 24 (4), 665- 678.

Perestoro= nina, E. (2018). The dependence of immunological parameters of fish on the

oxygen content in water. Vologda-Molochnoye, 3(2), 148-152.

Olabuenaga, S. E. (20= 00). Sistema inmune en peces. Gayana (Concepción)64(2= ), 205-215.

Ortuño, = J., & Esteban, M. (2001). Effects of short-term crowding stress on the gilthead seabream (Sparus aurata L.) innate immune response. Fish & shellfish immunology, 11 (2), 187-197.

Tort, L. (2011). Stress and immune modulation in fish. Developmental & Comparative Immunology, 35 (12), 1366-1375.=

Zhang, L., Wang, C., Liu, H., & Fu, P. (2019). The important role of phagocyto= sis and interleukins for nile tilapia (Oreochromis niloticus) to defense infect= ion of Aeromonas hydrophila based on transcriptome analysis. Fish & shellfish immunology92, 54-63.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

PARA CITAR EL ARTÃCULO INDEXADO.

 

 

Briones García, J. I. (2021). Evaluación del efecto del cortisol provocado por hi= poxia sobre algunos parámetros inmunológicos de tilapias de comercialización d= e la ciudad de Sucúa – Ecuador. ConcienciaDigital, 4(1.2), 446-456. https://doi= .org/10.33262/concienciadigital.v4i1.2.1611

 

 


 

 

 

El artículo que se publica es de exclusiva responsabilidad de los autores y no necesariamente reflejan el pensamiento de la Revi= sta Conciencia Digital.

 

El artículo queda en propiedad de la revista y, por tanto, su publicación pa= rcial y/o total en otro medio tiene que ser autorizado por el director de la Revista Conciencia Digital.<= /o:p>

 

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[1] Escuela Superior Politécnica de Chimborazo, Maestría en Ingeniería Química Aplicada, Rio= bamba, javier.briones @espoch.edu.ec, https://orcid.org/0000-0002-2675-3495

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www.concienciadigital.org

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Educación ambiental       Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â =                            =                                      Â=  Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â  Página 9

 

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