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V=
ol.
3, N°3.4, p. 49 - 59, septiembre, 201
North American blastomicosis in a poorly
controlled diabetic patient case report
Lizbeth Karolina Vivanco
Balcazar[1], =
Thalia Alexandra Feijóo Velepucha.[2], =
Leonardo
Santiago Sivisaka Satama.[3] &=
amp;
Ramiro Andrés Guerrero Ińiguez.[4]=
span>
Recibido:
24-06-2019 / Revisado: 29-07-209 /Aceptado: 10-08-2019/ Publicado: 10-09-20=
19
Blastomycosis is a
relatively rare and potentially lethal fungal infectious disease, which is
mainly diagnosed in South Central and Midwest United States. Its presence in
Latin America is exceptional. Pulmonary affection can vary from an asymptom=
atic
infection to a severe and fatal disease, presented as acute or chronic
pneumonia, or as a pulmonary mass.
We present the case of a patient who shown sympt=
oms,
such as a cough, mucopurulent expectoration, hemoptics, progressive dyspnea,
unquantified fever and a weight loss over a period of three months, which
despite the use of antibiotics did not remit. There are later complications
with signs of septic shock, including respiratory difficulty with intercost=
al
retractions, alteration of thoracic expandability and bilateral crackling of
pulmonary fields.
On the radiograph, bilateral cottony infiltrates=
are
observed and the study was complemented with culture, where the etiological
microorganism could be visualized. The treatment with 200 mg itraconazole is
initiated, with favorable evolution of the patient, subsequently completely
remitting the lung disease. On pulmonary
pathology, a member of the Fungi group should be considered, focusing on the
immunosuppressed patients to avoid future complications.
Keywords: Blastomycosis; Blastomyces dermatitidis; lung disea=
ses,
fungal.
Resumen
La blastomicosis es una enfermedad infecci=
osa
micótica relativamente rara y potencialmente letal, que se diagnostica
principalmente en el centro sur y medio oeste de Estados Unidos; siendo
excepcional su presencia en Latinoamérica. La afectación pulmonar puede var=
iar
desde una infección asintomática hasta la enfermedad grave y mortal,
presentándose como neumonía aguda o crónica, o bien como una masa pulmonar =
Se presenta el caso de un paciente con el
cuadro de tos, expectoración mucopurulenta, hemoptoica, disnea progresiva,
fiebre no cuantificada y pérdida de peso de 3 meses de evolución que a pesar
del uso de antibióticos no remite; complicándose posteriormente con signos =
de
shock séptico abarcando dificultad respiratoria con retracciones intercosta=
les,
alteración de la expansibilidad torácica y crepitantes bilaterales de campos
pulmonares, requiriendo el uso de inotrópicos. En la radiografía se observa=
ron
infiltrados algodonosos bilaterales y se complementó el estudio con cultivo,
donde se pudo visualizar el microorganismo etiológico. Se inició el tratami=
ento
con itraconazol de 200 mg, con evolución favorable del paciente, remitiendo
posteriormente completamente la enfermedad pulmonar. Se deben considerar a
pesar de no ser comunes en el medio, para patología pulmonar, los
microorganismos fúngicos, haciendo un enfoque a los pacientes inmunodeprimi=
dos
para evitar las complicaciones a futuro.
Palabras
claves: B=
lastomicosis,
Blastomyces dermatitidis, enfermedades pulmonares, fúngica.
INTRODUCCIÓN
La blastomicosis es una infección micótica endémic=
a,
grave, poco frecuente, causada por el hongo dimórfico, Blastomyces
dermatitidis. La presentación inicial se produce a través de los pulmones y
suele ser subclínica. Se caracteriza por ser una enfermedad progresiva que
implica múltiples órganos y sistemas y en el peor de los casos una infección
pulmonar aguda fulminante.
El microorganismo responsable habita
generalmente en climas templados húmedos, con suelos ricos y ácidos,
relacionado con la madera en descomposición, y se encuentra en las cercanía=
s de
los ríos o lagos o en las zonas sujetas a inundaciones periódicas. Es propi=
a de
los trabajadores rurales; agricultores y campesinos y la vía de entrada más
frecuente es a través de inhalación de esporas.
Epidemiológicamente la blastomicosis es
endémica en el continente norteamericano. Se extiende desde Canadá, Estados
Unido y México. A nivel mundial la incidencia varía según las áreas afectad=
as,
siendo alta en las áreas endémicas. La incidencia es menos de 1 caso por
100,000 habitantes norteamericanos. A nivel local los reportes de esta
patología son relativamente escasos.
Es frecuente a los 30 y 50 ańos (prome=
dio
cuarta década). Los hombres adultos tienen la mayor probabilidad de desarro=
llar
la patología.
El cuadro se caracteriza por un mal es=
tado
general, anorexia, pérdida de peso, sudores nocturnos, disnea, tos
mucopurulenta o hemoptisis y dolor torácico. En el estudio radiológico se
comprueban infiltrados de diversos tamańos, por lo general densos y
parahiliares.
En ocasiones, su diagnóstico es tardío
precisamente por sus características clínicas y radiológicas que muchas vec=
es
inducen al diagnóstico erróneo de neumonía bacteriana y viral.
Hay que tener en cuenta que la enferme=
dad
pulmonar tiende a ser más grave en huéspedes inmunocomprometidos ya que el
curso clínico es más agresivo, y hay una tasa de mortalidad más alta.
El diagnóstico se basa fundamentalment=
e en
la clínica, el tratamiento tórpido a los antibióticos y especialmente al
hallazgo microscópico y el aislamiento en cultivos de B. Dermatitidis en
muestras de esputo, lavados bronquiales, pus, biopsias, y rara vez
hemocultivos. Las opciones de tratamiento para los pacientes con blastomico=
sis
incluyen anfotericina B o uno de los azoles por lo general itraconazol.
La importancia radica que, al tratarse=
de
una afección pulmonar relativamente rara y potencialmente letal, se debe
ampliar el conocimiento de la presentación de esta patología especialmente =
en
pacientes inmunocomprometidos con el fin de plantear un diagnóstico precoz y
prevenir complicaciones severas.
Se presenta un caso de en un paciente =
de
sexo masculino inmunodeprimido (Diabetes Mellitus tipo II mal controlada) c=
on
manifestaciones características de un cuadro de Neumonía, en el cual se aís=
la
B. Dermatitidis.
PRESENTACIÓN
DEL CASO CLÍNICO
Paciente
masculino de 53 ańos de edad residente del Cantón Calvas de la provincia de
Loja. Con antecedentes de Diabetes Mellitus tipo II de 10 ańos de evolución,
patología mal controlada. Dedicado a la agricultura y albańilería.
Refirió
antecedente de pérdida de peso de 3 meses de evolución que se acompańó de t=
os
con expectoración mucopurulenta, hemoptoica. Posteriormente presentó disnea
progresiva de grandes a pequeńos esfuerzos, además 9 días previo al ingreso
presenta fiebre no cuantificada, motivo por el cual acude al hospital Isidro
Ayora de la Cuidad de Loja con el diagnóstico presuntivo de diabetes
descompensada, neumonía grave adquirida en la comunidad y shock séptico de =
foco
pulmonar. Recibió soporte con inotrópicos.
Al
examen físico de ingreso: caquéctico, diaforética piel caliente, mucosas
pálidas y secas, Frecuencia respiratoria: 37 rpm, Frecuencia cardíaca: 130 =
lpm,
Temperatura: 38,4, Saturación de oxígeno: 84%, Tensión arterial: 85/55 mmHg=
şC,
tos con abundante expectoración herrumborsa, dificultad respiratoria marcad=
a al
reposo, tiraje intercostal, retracciones intercostales, alteración de la
expansibilidad torácica, crepitantes bilaterales en ambos campos pulmonares=
, e
hipoventilación. Glasgow:14/15
Se
decidió ingreso a críticos en virtud del cuadro clínico que cursa y los
siguientes datos de laboratorio: Glucemia: 299 mg/dl, Neutrófilos: 85,2
K/uL VES: 25mm/Hg, Gasometría: PCo=
2:
13.10 mmHg, Ph: 7.41, Sat:94.4% (Alcalosis respiratoria), Rx simple de tóra=
x:
Infiltrados algodonosos bilaterales (Ver imagen 1), TAC simple tórax:
infiltrado mixto en vidrio delustrado (Ver imagen 2) Índice SOFA: 5 APACHE:=
12
Índice de mortalidad: 15%. Se plantea el uso de Ventilación asistida.
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">
Ima=
gen
1. Radiografía simple de Tórax <=
span
style=3D'mso-spacerun:yes'> Imagen 2. TAC simple de Tórax
Posteriormente
debido al aspecto herrumbroso del esputo (Ver imagen 3) se realiza examen
directo de la muestra y se evidencia la presencia hifas tabicadas con
microconidias y levaduras +++
Imagen 3. Características del Esputo
El resultado del cultivo mostró abundant=
es
blastosporas redondeadas de gran tamańo con aspecto similar a un hongo
dimórfico, el mismo que requirió de una temperatura de 37ş para su aislamie=
nto
óptimo. Compatible con Blastomyces
dermatitis.
Imagen
4 y 5. Estudio microscópico de la muestra
Debido
a los resultados característicos se planteó el diagnóstico de Blastomicosis
Pulmonar y se inició tratamiento antifúngico con Itraconazol de 200 mg vía =
oral
cada 12 horas durante 6 meses. Evolucionó favorablemente. Así mismo se real=
izó
controles seriados de la función suprarrenal ya que las dosis elevadas de e=
ste
agente terapéutico pueden causar dańos colaterales.
Luego de tres meses el paciente evoluciona
clínicamente favorable y la placa de control muestra cambios significativos=
.
Imagen
6. Rx de tórax de control
DISCUSIÓN
La blastomicosis es una infección causada por el h=
ongo
dimórfico Blastomyces dermatitidis, considerada endémica en áreas de
América del Norte, aunque se=
ha
distribuido ampliamente en el continente africano y en regiones del
Medio Oriente y la India
Se cree que el mecanismo causal inicial de la infección pulmonar es =
la
inhalación de los conidios de B. dermatitidis. En la
naturaleza, el hongo existe en forma micelial y la inhalación de esporas da
como resultado una infección pulmonar primaria. Las esporas se inoculan en =
las
células alveolares y se produce la germinación en formas de levadura. Aunque
los macrófagos pulmonares eliminan la mayoría de las esporas antes de que
ocurra la infección, las que sobreviven producen neumonitis. Desde el pulmó=
n,
puede haber diseminación hematógena y, con menos frecuencia, diseminación
linfática. La respuesta inmune a la infección consiste en la migración de
macrófagos neutrófilos hacia el tejido infectado, lo que induce una respues=
ta
granulomatosa y supurativa con necrosis y fibrosis asociadas a la blastomic=
osis
B dermatitidis puede producir una variedad de síndromes clínicos,
desde una infección asintomática hasta el síndrome de dificultad respirator=
ia
aguda fulminante
Las
manifestaciones radiológicas de la infección pulmonar son muy diversas y
principalmente incluyen consolidación del espacio aéreo, lesiones similares=
a
masas, infiltración intersticial y miliar, y lesiones cavitarias. La
consolidación es el hallazgo radiográfico más común y a menudo se confunde =
con
una neumonía bacteriana. Las imágenes sugestivas de masas en el tórax
constituyen el segundo hallazgo radiográfico más común, y se han se han
reportado hasta en un 31% de los casos; típicamente en pacientes con u=
na
presentación crónica de la enfermedad
Para
establecer un diagnóstico definitivo de blastomicosis pulmonar, B.
dermatitidis debe aislarse en un cultivo de esputo o en un espécimen de
aspirado bronquial, u observarse en el examen histológico del tejido obteni=
do
por biopsia (bronquio o pulmón). <=
span
style=3D'color:black;background:white'>Aunque el rendimiento diagnóstico de=
las
preparaciones húmedas del esputo es bajo, debe considerarse dado el bajo co=
sto
y la simplicidad. El diagnóstico se realiza mediante la observa=
ción
de la característica levadura incipiente de paredes gruesas y de base amplia
después de tinciones especiales
La
resolución espontánea de la blastomicosis no parece ocurrir y la enfermedad=
no
tratada puede asociarse con tasas de mortalidad cercanas al 60%
CONCLUSIONES
ˇ&nb=
sp;
Se presentó=
un
caso de un paciente masculino de 53 ańos agricultor que inicialmente cursa =
con
clínica compatible de neumonía adquirida en la comunidad, descompensada
metabólicamente por una diabetes mellitus tipo II mal controlada. Recibió
tratamiento con antimicrobiano de amplio espectro cuya evolución no fue
satisfactoria. Por lo que se adicionó empíricamente anti fúngico dada a la
presentación clínicas y a las características macroscópicas del esputo. Una=
vez
realizados los exámenes pertinentes (examen directo y cultivo) de donde res=
ulto
el aislamiento de B. Dermatitis, se diagnosticó una micosis profunda de ori=
gen
pulmonar.
ˇ&nb=
sp;
Es importan=
te que,
ante un paciente con los factores de riesgo epidemiológico aunado a la
presentación clínica tórpida y rápidamente progresiva, se debe tomar en cue=
nta
otras etiologías de neumonías adquirida en la comunidad como las de origen
micótico.
ˇ&nb=
sp;
Por tal mot=
ivo es
muy relevante para el medico conocer que, ante la evolución desfavorable, o=
de
una infección respiratoria baja, en un paciente con los factores de riesgo =
ya
descritos debe tomarse en cuenta la etiología micótica tal como lo seńala la
literatura. (Schwartz, Embil, Sharma, Goulet, & Bruce, 2016)
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PARA
CITAR EL ARTÍCULO INDEXADO.
Vivanco Balcazar, L., Feijóo Velepuch=
a,
T., Sivisaka Satama, L., & Guerrero Ińiguez, R. (2019). Blastomicosis
norteamericana en un paciente diabético mal controlado, caso. Cienc=
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Digital, 3(3.4.), 49-59. https://doi.org=
/10.33262/cienciadigital.v3i3.4.834
El artículo que se publica es de
exclusiva responsabilidad de los autores y no necesariamente reflejan el
pensamiento de la Revista Ciencia
Digital.
El artículo qu=
eda
en propiedad de la revista y, por tanto, su publicación parcial y/o total en
otro medio tiene que ser autorizado por el director de la Revista Ciencia Digital.
[1] Hospital-Clínica San Agustín,
Loja, Ecuador, karovi@hotmail.es
[2] Hospital Eugenio Espe=
jo,
Quito, Ecuador, thaly.45@gmail.com
[3] Hospital Carlos Andrade Marín, Quito, Ecuador, santiago-santiagos@hotamil.com
[4] Hospital-Clínica San Agustín, Loja, Ecuador, raguerrero_93@hotmail.com