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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472= c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1= o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:ab= solute" /></span><span class=3D"awspan" style=3D"color:#ffffff">ISSN: </spa= n><span class=3D"awspan" style=3D"font-weight:bold; color:#ffffff">2697-339= 1</span><span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2, pp. 69= =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3=A9dicas, salud p= =C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span><svg font-= family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" version=3D"1.1= " width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"width:209.= 31px; height:41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:= xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0= L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"evenodd" /><= /g></g></svg></span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margi= n-left:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font-family:Ebr= ima; font-size:11pt; color:#ffffff">www.anatomiadigital.org</span></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weig= ht:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c= 4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o= ) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c= 4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight= :bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = ;        </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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position:absolute" /></span><span sty= le=3D"height:0pt; display:block; position:absolute; z-index:34"><img src=3D= "data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAAAASCAYAAABWzo5XAAAABHNC= SVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFUOI1VlM1PIkkYxn/VTdMNDUI= M4jIxozsBD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1EPyMrAyofY2tBde2C6d3yTSi= VV9T71vE89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJycxDAMhxI9DBPgeUkosy6Jar= VIul7m6usKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnpyeOjo4olUo0m01c10UIAQIE= Ao81QCKRYH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCqKtMz0wTUALe3t9i2DUCz2WR= nZwcpJfl8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVkA9Ho9Dg4OmJqaGgENh0NOT0= +p1+s+SCgUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+fkI6PX1lbOzM1+DeDzOysoKo= XAYx3GIRCI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azCUA4HGZ1dRVN04hEIqiKyvbv= 2xT2C1jPFo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z26RO9bpd/W00K+3/w3H+i+e0= bX76UkVIihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHFxQTab5f7+/n//CDFiFIvFUF= XVX/Q2pJTEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOpqm8dTv02630TSNYDCIUEYm9= SIej49KMwyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4fX3xmWmaxvT09AgoEAiQy+Wo= VCrUajUcx6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4cjAYcHx8zPb2Nt1uF0VRfA2= 8XvNKd10XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRVP2B+FNk2Tzc1NFhcX0TRtdM= b7jKSU2LbN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQog3QN7c7Xa5vr6mWq3SaDQQQ= pBKpchkMqTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC" width=3D"18" height=3D= "18" alt=3D"" style=3D"margin-left:5.66pt; position:absolute" /></span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight= :bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1= o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y = 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00= 593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><a= href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a= ></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-si= ze:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoratio= n:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt= ; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</span><= /a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><a href=3D"http://www.cienciadig= italeditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv= " style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"ht= tp://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-we= ight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.or= g</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8p= t"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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position:ab= solute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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text-decoration:underline; color:#0563c1">www.cienciadigitaled= itorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; posi= tion:absolute; z-index:57"><img src=3D"data:image/png;base64,iVBORw0KGgoAAA= ANSUhEUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBl= SsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0h= uWAqFAUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdr= tNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRk= dHicViCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSC= hEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvG= bDabrKysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tv= bIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9Pn= HD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYT= dt1yeVuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185= OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPp= oQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT= 9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0= zSj5nMXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfL= SE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQ= a3PjmBjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKR= QKPHnyhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9Tr= VZZW1ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXc= KidnAAAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-l= eft:-1pt; 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font= -weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. 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text-decoration:underline; color:#0563c1">www.cienciadigitaled= itorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; posi= tion:absolute; z-index:60"><img src=3D"data:image/png;base64,iVBORw0KGgoAAA= ANSUhEUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBl= SsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0h= uWAqFAUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdr= tNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRk= dHicViCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSC= hEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvG= bDabrKysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tv= bIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9Pn= HD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYT= dt1yeVuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185= OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPp= oQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT= 9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0= zSj5nMXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfL= SE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQ= a3PjmBjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKR= QKPHnyhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9Tr= VZZW1ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXc= KidnAAAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-l= eft:-1pt; 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font= -weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"= text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org= " style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1">www.an= atomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1= pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= </a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font= -size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline; color:#0563c1">www.cienciadigitaled= itorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; posi= tion:absolute; z-index:63"><img src=3D"data:image/png;base64,iVBORw0KGgoAAA= ANSUhEUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBl= SsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0h= uWAqFAUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdr= tNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRk= dHicViCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSC= hEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvG= bDabrKysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tv= bIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9Pn= HD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYT= dt1yeVuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185= OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPp= oQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT= 9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0= zSj5nMXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfL= SE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQ= a3PjmBjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKR= QKPHnyhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9Tr= VZZW1ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXc= KidnAAAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-l= eft:-1pt; 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Dig= ital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuad= or (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><a href=3D"http://www.anatomiadigital.org" styl= e=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right= :1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigita= l.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1">w= ww.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-l= eft:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><a= href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:n= one"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt;= font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; 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width=3D"77" height=3D"28" alt=3D"" style=3D"margin-left:441.05pt; position= :absolute" /></span><span class=3D"awspan" style=3D"font-size:18pt; font-we= ight:bold">Restricci=C3=B3n cal=C3=B3rica y mim=C3=A9ticos en el envejecimi= ento</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:14pt"><span class=3D"awspan" style=3D"font-size:14pt; font-sty= le:italic">Calorie restriction and mimetics in aging</span></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:6.5pt"><span c= lass=3D"awspan" style=3D"font-size:6.5pt; font-weight:bold">1</span></p><p = class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"= ><span class=3D"awspan" style=3D"font-size:10pt">Kevin Pa=C3=BAl D=C3=ADaz = N=C3=BA=C3=B1ez</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:10pt"><span class=3D"awspan" style=3D"font-size:10p= t">https://orcid.org/0009-0003-2719-5848</span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><span class=3D"awspa= n" style=3D"font-size:10pt">Estudiante de la carrera de medicina, Universid= ad T=C3=A9cnica de Ambato, Ambato, Ecuador.</span></p><p class=3D"awdiv" st= yle=3D"margin-right:1pt; margin-left:1pt"><a href=3D"mailto:kdiaz95852@uta.= edu.ec" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font= -size:10pt; text-decoration:underline; color:#0563c1">kdiaz95852@uta.edu.ec= </span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:10p= t"><span class=3D"awspan" style=3D"font-size:10pt">  </span></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:6.5pt"><= span class=3D"awspan" style=3D"font-size:6.5pt; font-weight:bold">2</span><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size= :10pt"><span class=3D"awspan" style=3D"font-size:10pt">Andrea Carolina Ceva= llos Teneda</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:10pt"><span class=3D"awspan" style=3D"font-size:10pt">h= ttps://orcid.org/0000-0002-9512-9274 </span></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:10pt"><span class=3D"awspan" = style=3D"font-size:10pt">Universidad T=C3=A9cnica de Ambato, Ambato, Ecuado= r.</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><a href=3D"mailto:ac.cevallos@uta.edu.ec" style=3D"text-decoration:none"><= span class=3D"awspan" style=3D"font-size:10pt; text-decoration:underline; c= olor:#0563c1">ac.cevallos@uta.edu.ec</span></a></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><span class=3D"awspa= n" style=3D"font-size:10pt; font-weight:bold">Art=C3=ADculo de Investigaci= =C3=B3n Cient=C3=ADfica y Tecnol=C3=B3gica</span></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><span class=3D"aws= pan" style=3D"font-size:10pt">Enviado: 18/01/2025</span></p><p class=3D"awd= iv" style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><span class= =3D"awspan" style=3D"font-size:10pt">Revisado: 16/02/2025</span></p><p clas= s=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><sp= an class=3D"awspan" style=3D"font-size:10pt">Aceptado: 05/03/2025</span></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 0pt"><span class=3D"awspan" style=3D"font-size:10pt">Publicado:22/04/2025</= span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:10pt"><span class=3D"awspan" style=3D"font-size:10pt">DOI:</span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:10pt"> </span><= a href=3D"https://doi.org/10.33262/anatomiadigital.v8i2.3395" style=3D"text= -decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:10pt"><a href=3D"https://doi.org/10.33262/anatomiad= igital.v8i2.3395" style=3D"text-decoration:none"><span class=3D"awspan" sty= le=3D"font-size:10pt; font-weight:bold; text-decoration:underline; color:#0= 563c1">https://doi.org/10.33262/anatomiadigital.v8i2.3395</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:10pt">   &#x= a0;          </span></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><s= pan class=3D"awspan" style=3D"font-size:10pt">C=C3=ADtese: </span></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:10pt"><= span class=3D"awspan" style=3D"font-size:10pt">D=C3=ADaz</span><span class= =3D"awspan" style=3D"font-size:10pt; letter-spacing:2.95pt"> </span><span c= lass=3D"awspan" style=3D"font-size:10pt">N=C3=BA=C3=B1ez,</span><span class= =3D"awspan" style=3D"font-size:10pt; letter-spacing:2.95pt"> </span><span c= lass=3D"awspan" style=3D"font-size:10pt">K.</span><span class=3D"awspan" st= yle=3D"font-size:10pt; letter-spacing:2.95pt"> </span><span class=3D"awspan= " style=3D"font-size:10pt">P.,</span><span class=3D"awspan" style=3D"font-s= ize:10pt; letter-spacing:2.95pt"> </span><span class=3D"awspan" style=3D"fo= nt-size:10pt">&</span><span class=3D"awspan" style=3D"font-size:10pt; l= etter-spacing:2.95pt"> </span><span class=3D"awspan" style=3D"font-size:10p= t">Cevallos</span><span class=3D"awspan" style=3D"font-size:10pt; letter-sp= acing:2.95pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">Tened= a,</span><span class=3D"awspan" style=3D"font-size:10pt; letter-spacing:2.9= 5pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">A.</span><span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:2.95pt"> </span><= span class=3D"awspan" style=3D"font-size:10pt">C.</span><span class=3D"awsp= an" style=3D"font-size:10pt; letter-spacing:2.95pt"> </span><span class=3D"= awspan" style=3D"font-size:10pt">(2025).</span><span class=3D"awspan" style= =3D"font-size:10pt; letter-spacing:2.95pt"> </span><span class=3D"awspan" s= tyle=3D"font-size:10pt">Restricci=C3=B3n</span><span class=3D"awspan" style= =3D"font-size:10pt; letter-spacing:2.95pt"> </span><span class=3D"awspan" s= tyle=3D"font-size:10pt">cal=C3=B3rica</span><span class=3D"awspan" style=3D= "font-size:10pt; letter-spacing:2.95pt"> </span><span class=3D"awspan" styl= e=3D"font-size:10pt">y mim=C3=A9ticos</span><span class=3D"awspan" style=3D= "font-size:10pt; letter-spacing:11.95pt"> </span><span class=3D"awspan" sty= le=3D"font-size:10pt">en</span><span class=3D"awspan" style=3D"font-size:10= pt; letter-spacing:11.95pt"> </span><span class=3D"awspan" style=3D"font-si= ze:10pt">el</span><span class=3D"awspan" style=3D"font-size:10pt; letter-sp= acing:11.95pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">enve= jecimiento.</span><span class=3D"awspan" style=3D"font-size:10pt; letter-sp= acing:11.95pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">Anat= om=C3=ADa</span><span class=3D"awspan" style=3D"font-size:10pt; letter-spac= ing:11.95pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">Digita= l,</span><span class=3D"awspan" style=3D"font-size:10pt; letter-spacing:11.= 95pt"> </span><span class=3D"awspan" style=3D"font-size:10pt">8(2),</span><= span class=3D"awspan" style=3D"font-size:10pt; letter-spacing:11.95pt"> </s= pan><span class=3D"awspan" style=3D"font-size:10pt">69-88. </span><a href= =3D"https://doi.org/10.33262/anatomiadigital.v8i2.3395" style=3D"text-decor= ation:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-le= ft:1pt; font-size:10pt"><a href=3D"https://doi.org/10.33262/anatomiadigital= .v8i2.3395" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"= font-size:10pt; text-decoration:underline; color:#0563c1">https://doi.org/1= 0.33262/anatomiadigital.v8i2.3395</span></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" s= tyle=3D"font-size:8pt">ANATOM=C3=8DA</span><span class=3D"awspan" style=3D"= font-size:8pt; letter-spacing:0.45pt"> </span><span class=3D"awspan" style= =3D"font-size:8pt">DIGITAL,</span><span class=3D"awspan" style=3D"font-size= :8pt; letter-spacing:0.45pt"> </span><span class=3D"awspan" style=3D"font-s= ize:8pt">es</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spa= cing:0.45pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">una</sp= an><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:0.45pt"> <= /span><span class=3D"awspan" style=3D"font-size:8pt">Revista</span><span cl= ass=3D"awspan" style=3D"font-size:8pt; letter-spacing:0.45pt"> </span><span= class=3D"awspan" style=3D"font-size:8pt">Electr=C3=B3nica,</span><span cla= ss=3D"awspan" style=3D"font-size:8pt; letter-spacing:0.45pt"> </span><span = class=3D"awspan" style=3D"font-size:8pt">Trimestral,</span><span class=3D"a= wspan" style=3D"font-size:8pt; letter-spacing:0.45pt"> </span><span class= =3D"awspan" style=3D"font-size:8pt">que</span><span class=3D"awspan" style= =3D"font-size:8pt; letter-spacing:0.45pt"> </span><span class=3D"awspan" st= yle=3D"font-size:8pt">se</span><span class=3D"awspan" style=3D"font-size:8p= t; letter-spacing:0.45pt"> </span><span class=3D"awspan" style=3D"font-size= :8pt">publicar=C3=A1</span><span class=3D"awspan" style=3D"font-size:8pt; l= etter-spacing:0.45pt"> </span><span class=3D"awspan" style=3D"font-size:8pt= ">en</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:0.= 45pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">soporte</span>= <span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:0.45pt"> </sp= an><span class=3D"awspan" style=3D"font-size:8pt">electr=C3=B3nico tiene</s= pan><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.5pt"> = </span><span class=3D"awspan" style=3D"font-size:8pt">como</span><span clas= s=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span c= lass=3D"awspan" style=3D"font-size:8pt">misi=C3=B3n</span><span class=3D"aw= span" style=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span class=3D= "awspan" style=3D"font-size:8pt">contribuir</span><span class=3D"awspan" st= yle=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span class=3D"awspan"= style=3D"font-size:8pt">a</span><span class=3D"awspan" style=3D"font-size:= 8pt; letter-spacing:-0.5pt"> </span><span class=3D"awspan" style=3D"font-si= ze:8pt">la</span><span class=3D"awspan" style=3D"font-size:8pt">  </sp= an><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.5pt">&#= xa0;</span><span class=3D"awspan" style=3D"font-size:8pt">formaci=C3=B3n</s= pan><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.5pt"> = </span><span class=3D"awspan" style=3D"font-size:8pt">de</span><span class= =3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span cl= ass=3D"awspan" style=3D"font-size:8pt">profesionales</span><span class=3D"a= wspan" style=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span class= =3D"awspan" style=3D"font-size:8pt">competentes</span><span class=3D"awspan= " style=3D"font-size:8pt; letter-spacing:-0.5pt"> </span><span class=3D"aws= pan" style=3D"font-size:8pt">con</span><span class=3D"awspan" style=3D"font= -size:8pt; letter-spacing:-0.5pt"> </span><span class=3D"awspan" style=3D"f= ont-size:8pt">visi=C3=B3n</span><span class=3D"awspan" style=3D"font-size:8= pt; letter-spacing:-0.5pt"> </span><span class=3D"awspan" style=3D"font-siz= e:8pt">human=C3=ADstica</span><span class=3D"awspan" style=3D"font-size:8pt= ; letter-spacing:-0.5pt"> </span><span class=3D"awspan" style=3D"font-size:= 8pt">y</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:= -0.5pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">cr=C3=ADtica= que</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.= 65pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">sean</span><sp= an class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.65pt"> </span>= <span class=3D"awspan" style=3D"font-size:8pt">capaces</span><span class=3D= "awspan" style=3D"font-size:8pt; letter-spacing:1.65pt"> </span><span class= =3D"awspan" style=3D"font-size:8pt">de exponer</span><span class=3D"awspan"= style=3D"font-size:8pt; letter-spacing:1.65pt"> </span><span class=3D"awsp= an" style=3D"font-size:8pt">sus</span><span class=3D"awspan" style=3D"font-= size:8pt; letter-spacing:1.65pt"> </span><span class=3D"awspan" style=3D"fo= nt-size:8pt">resultados</span><span class=3D"awspan" style=3D"font-size:8pt= ; letter-spacing:1.65pt"> </span><span class=3D"awspan" style=3D"font-size:= 8pt">investigativos</span><span class=3D"awspan" style=3D"font-size:8pt; le= tter-spacing:1.65pt"> </span><span class=3D"awspan" style=3D"font-size:8pt"= >y</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.65= pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">cient=C3=ADficos= </span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.65pt= "> </span><span class=3D"awspan" style=3D"font-size:8pt">en</span><span cla= ss=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.65pt"> </span><span = class=3D"awspan" style=3D"font-size:8pt">la</span><span class=3D"awspan" st= yle=3D"font-size:8pt; letter-spacing:1.65pt"> </span><span class=3D"awspan"= style=3D"font-size:8pt">misma</span><span class=3D"awspan" style=3D"font-s= ize:8pt; letter-spacing:1.65pt"> </span><span class=3D"awspan" style=3D"fon= t-size:8pt">medida</span><span class=3D"awspan" style=3D"font-size:8pt; let= ter-spacing:1.65pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">= que</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.6= 5pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">se promueva med= iante su intervenci=C3=B3n cambios positivos en la sociedad. </span><a href= =3D"https://anatomiadigital.org" style=3D"text-decoration:none"></a></p><p = class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <a href=3D"https://anatomiadigital.org" style=3D"text-decoration:none"><spa= n class=3D"awspan" style=3D"font-size:8pt; text-decoration:underline; color= :#0563c1">https://anatomiadigital.org</span></a></p><p style=3D"margin-righ= t:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font= -size:8pt"> </span><span class=3D"awspan" style=3D"font-size:8pt; colo= r:#0563c1"> </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-size:8pt">La= </span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"= > </span><span class=3D"awspan" style=3D"font-size:8pt">revista</span><span= class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"> </span><sp= an class=3D"awspan" style=3D"font-size:8pt">es</span><span class=3D"awspan"= style=3D"font-size:8pt; letter-spacing:1.4pt"> </span><span class=3D"awspa= n" style=3D"font-size:8pt">editada</span><span class=3D"awspan" style=3D"fo= nt-size:8pt; letter-spacing:1.4pt"> </span><span class=3D"awspan" style=3D"= font-size:8pt">por</span><span class=3D"awspan" style=3D"font-size:8pt; let= ter-spacing:1.4pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">l= a</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt= "> </span><span class=3D"awspan" style=3D"font-size:8pt">Editorial</span><s= pan class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"> </span>= <span class=3D"awspan" style=3D"font-size:8pt">Ciencia</span><span class=3D= "awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"> </span><span class= =3D"awspan" style=3D"font-size:8pt">Digital</span><span class=3D"awspan" st= yle=3D"font-size:8pt; letter-spacing:1.4pt"> </span><span class=3D"awspan" = style=3D"font-size:8pt">(Editorial</span><span class=3D"awspan" style=3D"fo= nt-size:8pt; letter-spacing:1.4pt"> </span><span class=3D"awspan" style=3D"= font-size:8pt">de</span><span class=3D"awspan" style=3D"font-size:8pt; lett= er-spacing:1.4pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">pr= estigio</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing= :1.4pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">registrada</= span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"> = </span><span class=3D"awspan" style=3D"font-size:8pt">en</span><span class= =3D"awspan" style=3D"font-size:8pt; letter-spacing:1.4pt"> </span><span cla= ss=3D"awspan" style=3D"font-size:8pt">la</span><span class=3D"awspan" style= =3D"font-size:8pt; letter-spacing:1.4pt"> </span><span class=3D"awspan" sty= le=3D"font-size:8pt">C=C3=A1mara Ecuatoriana de Libro con No de Afiliaci=C3= =B3n 663) </span><a href=3D"http://www.celibro.org.ec" style=3D"text-decora= tion:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:8pt"><a href=3D"http://www.celibro.org.ec" style=3D"text-d= ecoration:none"><span class=3D"awspan" style=3D"font-size:8pt; text-decorat= ion:underline; color:#0563c1">www.celibro.org.ec</span></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span cla= ss=3D"awspan" style=3D"font-size:8pt">Esta</span><span class=3D"awspan" sty= le=3D"font-size:8pt; letter-spacing:-0.05pt"> </span><span class=3D"awspan"= style=3D"font-size:8pt">revista</span><span class=3D"awspan" style=3D"font= -size:8pt; letter-spacing:-0.05pt"> </span><span class=3D"awspan" style=3D"= font-size:8pt">est=C3=A1</span><span class=3D"awspan" style=3D"font-size:8p= t; letter-spacing:-0.05pt"> </span><span class=3D"awspan" style=3D"font-siz= e:8pt">protegida</span><span class=3D"awspan" style=3D"font-size:8pt; lette= r-spacing:-0.05pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">b= ajo</span><span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.= 05pt"> </span><span class=3D"awspan" style=3D"font-size:8pt">una</span><spa= n class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.05pt"> </span>= <span class=3D"awspan" style=3D"font-size:8pt">licencia</span><span class= =3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.05pt"> </span><span c= lass=3D"awspan" style=3D"font-size:8pt">Creative</span><span class=3D"awspa= n" style=3D"font-size:8pt; letter-spacing:-0.05pt"> </span><span class=3D"a= wspan" style=3D"font-size:8pt">Commons</span><span class=3D"awspan" style= =3D"font-size:8pt; letter-spacing:-0.05pt"> </span><span class=3D"awspan" s= tyle=3D"font-size:8pt">Atribuci=C3=B3n-NoComercial-CompartirIgual 4.0 Inter= national. Copia de la licencia: </span><a href=3D"https://creativecommons.o= rg/licenses/by-nc-sa/4.0/deed.es" style=3D"text-decoration:none"></a></p><p= class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"= ><a href=3D"https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es" styl= e=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-size:8pt; t= ext-decoration:underline; color:#0563c1">https://creativecommons.org/licens= es/by-nc-sa/4.0/deed.es</span></a></p><p style=3D"margin-right:1pt; margin-= left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-size:8pt">&#x= a0;</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><span style=3D"height:0pt; display:block; position:absolu= te; z-index:74"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABg= AAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0= dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh= 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color:#ffffff">P=C3=A1gina</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#fffff= f"> 70 | 88</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:9pt"><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digit= al</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador= (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Tels. 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position:absolute" /></s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"color:#ff= ffff">ISSN: </span><span class=3D"awspan" style=3D"font-weight:bold; color:= #ffffff">2697-3391</span><span class=3D"awspan" style=3D"color:#ffffff">Vol= . 8 No. 2, pp. 69 =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3= =A9dicas, salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fi= ca</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><span><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.3= 3" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" st= yle=3D"width:209.31px; height:41.33px; font-family:'Times New Roman'; font-= size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path= d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rul= e=3D"evenodd" /></g></g></svg></span></p><p class=3D"awdiv" style=3D"margin= -right:1pt; margin-left:1pt; font-size:11pt"><span class=3D"awspan" style= =3D"font-family:Ebrima; 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=AD= a Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 = Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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Directo (00593) 0998-235-485</= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><a href=3D"http://www= .anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.anatomiadigital.org" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; color:#0563c1">www.anatomiadigital.org</span></a></p><p style=3D"= margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" = style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-r= ight:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadig= italeditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#44= 72c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn A= mbate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">         </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593= ) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:8pt">         </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. = Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoratio= n:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1= pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.= org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:= 8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><a href=3D"http://www= .cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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evidad</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:= 1pt"><span class=3D"awspan" style=3D"font-weight:bold; color:#767171">Resum= en</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><span class=3D"awspan" style=3D"font-weight:bold">Introducci=C3=B3n.</span= ><span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:0.8pt"> <= /span><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"lette= r-spacing:0.8pt"> </span><span class=3D"awspan">envejecimiento</span><span = class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awsp= an">de</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:0.8pt"> </span><span class=3D"awspan">poblaci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">m= undial</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span>= <span class=3D"awspan">ha impulsado</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.2pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">= b=C3=BAsqueda</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.2pt"> </span><span class=3D"awspan">estrategias</span><span = class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"aws= pan">para</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </s= pan><span class=3D"awspan">prolongar</span><span class=3D"awspan" style=3D"= letter-spacing:-0.2pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">= salud</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span>= <span class=3D"awspan">y retrasar enfermedades relacionadas con la edad. La= restricci=C3=B3n cal=C3=B3rica</span><span class=3D"awspan" style=3D"lette= r-spacing:0.4pt"> </span><span class=3D"awspan">(RC),</span><span class=3D"= awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">que</= span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span cl= ass=3D"awspan">reduce</span><span class=3D"awspan" style=3D"letter-spacing:= 0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">ingesta</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"aw= span">cal=C3=B3rica</span><span class=3D"awspan" style=3D"letter-spacing:0.= 4pt"> </span><span class=3D"awspan">sin</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">desnutrici=C3=B3n,= es</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><s= pan class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacin= g:0.65pt"> </span><span class=3D"awspan">intervenci=C3=B3n</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan"= >diet=C3=A9tica</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt= "> </span><span class=3D"awspan">geroprotectora</span><span class=3D"awspan= " style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">m=C3=A1s</= span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span c= lass=3D"awspan">estudiada.</span><span class=3D"awspan" style=3D"letter-spa= cing:0.65pt"> </span><span class=3D"awspan">Sin embargo,</span><span class= =3D"awspan" style=3D"letter-spacing:7.85pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:7.85pt"> </span><sp= an class=3D"awspan">dificultad</span><span class=3D"awspan" style=3D"letter= -spacing:7.85pt"> </span><span class=3D"awspan">de</span><span class=3D"aws= pan" style=3D"letter-spacing:7.85pt"> </span><span class=3D"awspan">mantene= rla</span><span class=3D"awspan" style=3D"letter-spacing:7.85pt"> </span><s= pan class=3D"awspan">ha</span><span class=3D"awspan" style=3D"letter-spacin= g:7.85pt"> </span><span class=3D"awspan">dirigido</span><span class=3D"awsp= an" style=3D"letter-spacing:7.85pt"> </span><span class=3D"awspan">la inves= tigaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt">= </span><span class=3D"awspan">hacia</span><span class=3D"awspan" style=3D"= letter-spacing:-0.7pt"> </span><span class=3D"awspan">f=C3=A1rmacos</span><= span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt= "> </span><span class=3D"awspan">imiten</span><span class=3D"awspan" style= =3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">sus</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awsp= an">efectos,</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> = </span><span class=3D"awspan">conocidos como</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">mim=C3=A9tico= s</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= 0.95pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">restricci=C3=B3n= </span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span= class=3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" style=3D"lette= r-spacing:0.95pt"> </span><span class=3D"awspan">(MRC).</span><span class= =3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan" = style=3D"font-weight:bold">Objetivo. </span><span class=3D"awspan">Examinar= </span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span = class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.= 5pt"> </span><span class=3D"awspan">potencial</span><span class=3D"awspan" = style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">de</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"aw= span">la</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </spa= n><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-sp= acing:0.5pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" = style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">sus</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"a= wspan">mim=C3=A9ticos</span><span class=3D"awspan" style=3D"letter-spacing:= 0.5pt"> </span><span class=3D"awspan">para</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">retrasar el</spa= n><span class=3D"awspan" style=3D"letter-spacing:4.95pt"> </span><span clas= s=3D"awspan">envejecimiento,</span><span class=3D"awspan" style=3D"letter-s= pacing:4.95pt"> </span><span class=3D"awspan">evaluando</span><span class= =3D"awspan" style=3D"letter-spacing:4.95pt"> </span><span class=3D"awspan">= su</span><span class=3D"awspan" style=3D"letter-spacing:4.95pt"> </span><sp= an class=3D"awspan">impacto</span><span class=3D"awspan" style=3D"letter-sp= acing:4.95pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan= " style=3D"letter-spacing:4.95pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:4.95pt"> </span><span class= =3D"awspan">salud</span><span class=3D"awspan" style=3D"letter-spacing:4.95= pt"> </span><span class=3D"awspan">y longevidad,</span><span class=3D"awspa= n" style=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">y</span><= span class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span class= =3D"awspan">analizando</span><span class=3D"awspan" style=3D"letter-spacing= :3.85pt"> </span><span class=3D"awspan">sus</span><span class=3D"awspan" st= yle=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">bases</span><s= pan class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span class=3D= "awspan">cient=C3=ADficas</span><span class=3D"awspan" style=3D"letter-spac= ing:3.85pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" s= tyle=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">posibles apli= caciones</span><span class=3D"awspan" style=3D"letter-spacing:20.05pt"> </s= pan><span class=3D"awspan">terap=C3=A9uticas.</span><span class=3D"awspan" = style=3D"letter-spacing:20.05pt"> </span><span class=3D"awspan" style=3D"fo= nt-weight:bold">Metodolog=C3=ADa.</span><span class=3D"awspan" style=3D"fon= t-weight:bold; letter-spacing:20.05pt"> </span><span class=3D"awspan">Revis= i=C3=B3n bibliogr=C3=A1fica</span><span class=3D"awspan" style=3D"letter-sp= acing:0.15pt"> </span><span class=3D"awspan">cualitativa</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= basada</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span= ><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spa= cing:0.15pt"> </span><span class=3D"awspan">literatura</span><span class=3D= "awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">sob= re</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><sp= an class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing= :0.15pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">MRC en</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class=3D"= awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:= 2.35pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">el</span><span = class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class=3D"aws= pan">envejecimiento.</span><span class=3D"awspan" style=3D"letter-spacing:2= .35pt"> </span><span class=3D"awspan">Se</span><span class=3D"awspan" style= =3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">recopilaron</span= ><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class= =3D"awspan">datos</span><span class=3D"awspan" style=3D"letter-spacing:2.35= pt"> </span><span class=3D"awspan">de bases</span><span class=3D"awspan" st= yle=3D"letter-spacing:6.3pt"> </span><span class=3D"awspan">cient=C3=ADfica= s</span><span class=3D"awspan" style=3D"letter-spacing:6.3pt"> </span><span= class=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing= :6.3pt"> </span><span class=3D"awspan">PubMed,</span><span class=3D"awspan"= style=3D"letter-spacing:6.3pt"> </span><span class=3D"awspan">LILACS</span= ><span class=3D"awspan" style=3D"letter-spacing:6.3pt"> </span><span class= =3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:6.3pt"> = </span><span class=3D"awspan">Cochrane, centrados</span><span class=3D"awsp= an" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">en</span>= <span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">estudios</span><span class=3D"awspan" style=3D"letter-spacing:0= .8pt"> </span><span class=3D"awspan">cl=C3=ADnicos</span><span class=3D"aws= pan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">de</span= ><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"= > </span><span class=3D"awspan">=C3=BAltimos</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">cinco</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"= awspan">a=C3=B1os.</span><span class=3D"awspan" style=3D"letter-spacing:0.8= pt"> </span><span class=3D"awspan">Los hallazgos</span><span class=3D"awspa= n" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">se</span><= span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D= "awspan">sintetizan</span><span class=3D"awspan" style=3D"letter-spacing:0.= 6pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">una</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan= ">revisi=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"= > </span><span class=3D"awspan">narrativa.</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan" style=3D"font-we= ight:bold">Resultados.</span><span class=3D"awspan"> La RC mostr=C3=B3 mejo= ras significativas en salud y longevidad en modelos</span><span class=3D"aw= span" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">experim= entales</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span= ><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spac= ing:0.4pt"> </span><span class=3D"awspan">humanos,</span><span class=3D"aws= pan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">reducien= do</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><spa= n class=3D"awspan">peso,</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.4pt"> </span><span class=3D"awspan">niveles de</span><span class=3D"aw= span" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">insuli= na,</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><s= pan class=3D"awspan">temperatura</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.2pt"> </span><span class=3D"awspan">corporal</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan"= >y</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><sp= an class=3D"awspan">estr=C3=A9s</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.2pt"> </span><span class=3D"awspan">oxidativo.</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan= ">Promovi=C3=B3 la</span><span class=3D"awspan" style=3D"letter-spacing:0.6= pt"> </span><span class=3D"awspan">autofagia</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">mediante</span= ><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt">= </span><span class=3D"awspan">inhibici=C3=B3n</span><span class=3D"awspan"= style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">de</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"a= wspan">mTOR</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </= span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-= spacing:0.6pt"> </span><span class=3D"awspan">activaci=C3=B3n</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspa= n">de AMPK.</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> <= /span><span class=3D"awspan">Los</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.4pt"> </span><span class=3D"awspan">MRC,</span><span class=3D= "awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">com= o</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><spa= n class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:= -0.4pt"> </span><span class=3D"awspan">metformina</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">y</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class= =3D"awspan">rapamicina,</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.4pt"> </span><span class=3D"awspan">tambi=C3=A9n demostraron</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.65pt"> </span><span class=3D"= awspan">efectos</span><span class=3D"awspan" style=3D"letter-spacing:2.65pt= "> </span><span class=3D"awspan">antienvejecimiento</span><span class=3D"aw= span" style=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">al</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.65pt"> </span><span cla= ss=3D"awspan">modular</span><span class=3D"awspan" style=3D"letter-spacing:= 2.65pt"> </span><span class=3D"awspan">v=C3=ADas</span><span class=3D"awspa= n" style=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">de detecc= i=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:-0.15pt"> </span><span class=3D"awspan">nutrientes</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan= ">y</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><= span class=3D"awspan">reducir</span><span class=3D"awspan" style=3D"letter-= spacing:-0.15pt"> </span><span class=3D"awspan">el</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">da=C3= =B1o</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span>= <span class=3D"awspan">oxidativo,</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.15pt"> </span><span class=3D"awspan">sugiriendo su</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"= awspan">potencial</span><span class=3D"awspan" style=3D"letter-spacing:0.35= pt"> </span><span class=3D"awspan">como</span><span class=3D"awspan" style= =3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">alternativas</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span clas= s=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"= > </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"le= tter-spacing:0.35pt"> </span><span class=3D"awspan">RC.</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan" = style=3D"font-weight:bold">Conclusi=C3=B3n.</span><span class=3D"awspan" st= yle=3D"font-weight:bold; letter-spacing:0.35pt"> </span><span class=3D"awsp= an">La</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span= ><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spa= cing:0.35pt"> </span><span class=3D"awspan">y sus</span><span class=3D"awsp= an" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">mim=C3=A9= ticos,</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span>= <span class=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-sp= acing:0.9pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan"= style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">rapamicina,<= /span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span c= lass=3D"awspan">mejoran</span><span class=3D"awspan" style=3D"letter-spacin= g:0.9pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">longevidad</span= ><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class= =3D"awspan">y la</span><span class=3D"awspan" style=3D"letter-spacing:3.55p= t"> </span><span class=3D"awspan">calidad</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">muscular</span><= span class=3D"awspan" style=3D"letter-spacing:3.55pt"> </span><span class= =3D"awspan">activando</span><span class=3D"awspan" style=3D"letter-spacing:= 3.55pt"> </span><span class=3D"awspan">v=C3=ADas</span><span class=3D"awspa= n" style=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">clave</sp= an><span class=3D"awspan" style=3D"letter-spacing:3.55pt"> </span><span cla= ss=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:3.5= 5pt"> </span><span class=3D"awspan">AMPK</span><span class=3D"awspan" style= =3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">y SIRT1.</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">Aunque</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt">= </span><span class=3D"awspan">act=C3=BAan</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">de</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspa= n">manera</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </sp= an><span class=3D"awspan">distinta,</span><span class=3D"awspan" style=3D"l= etter-spacing:0.4pt"> </span><span class=3D"awspan">ambos</span><span class= =3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">p= romueven la</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt"> <= /span><span class=3D"awspan">autofagia</span><span class=3D"awspan" style= =3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><= span class=3D"awspan">protecci=C3=B3n</span><span class=3D"awspan" style=3D= "letter-spacing:2.25pt"> </span><span class=3D"awspan">antioxidante,</span>= <span class=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class= =3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt"= > </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"l= etter-spacing:2.25pt"> </span><span class=3D"awspan">sugiere</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspa= n">la necesidad</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:0.4pt"> </span><span class=3D"awspan">enfoques</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan"= >combinados</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">para</span><span class=3D"awspan" style=3D"lett= er-spacing:0.4pt"> </span><span class=3D"awspan">optimizar</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">= los</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><sp= an class=3D"awspan">efectos antienvejecimiento.</span><span class=3D"awspan= " style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan" style=3D"f= ont-weight:bold">=C3=81rea</span><span class=3D"awspan" style=3D"font-weigh= t:bold; letter-spacing:-0.6pt"> </span><span class=3D"awspan" style=3D"font= -weight:bold">de</span><span class=3D"awspan" style=3D"font-weight:bold; le= tter-spacing:-0.6pt"> </span><span class=3D"awspan" style=3D"font-weight:bo= ld">estudio</span><span class=3D"awspan" style=3D"font-weight:bold; letter-= spacing:-0.6pt"> </span><span class=3D"awspan" style=3D"font-weight:bold">g= eneral:</span><span class=3D"awspan" style=3D"font-weight:bold; letter-spac= ing:-0.6pt"> </span><span class=3D"awspan">Medicina.</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan" style= =3D"font-weight:bold">=C3=81rea de</span><span class=3D"awspan" style=3D"fo= nt-weight:bold; letter-spacing:4.1pt"> </span><span class=3D"awspan" style= =3D"font-weight:bold">estudio</span><span class=3D"awspan" style=3D"font-we= ight:bold; letter-spacing:4.1pt"> </span><span class=3D"awspan" style=3D"fo= nt-weight:bold">espec=C3=ADfica:</span><span class=3D"awspan" style=3D"font= -weight:bold; letter-spacing:4.1pt"> </span><span class=3D"awspan">Endocrin= olog=C3=ADa.</span><span class=3D"awspan" style=3D"letter-spacing:4.1pt"> <= /span><span class=3D"awspan" style=3D"font-weight:bold">Tipo</span><span cl= ass=3D"awspan" style=3D"font-weight:bold; letter-spacing:4.1pt"> </span><sp= an class=3D"awspan" style=3D"font-weight:bold">de</span><span class=3D"awsp= an" style=3D"font-weight:bold; letter-spacing:4.1pt"> </span><span class=3D= "awspan" style=3D"font-weight:bold">estudio:</span><span class=3D"awspan" s= tyle=3D"color:#333333">  </span><span class=3D"awspan">Revisi=C3=B3n B= ibliogr=C3=A1fica.</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; = margin-left:1pt"><span class=3D"awspan" style=3D"font-weight:bold">Keywords= : </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><span class=3D"awspan">Restriction, calories, mimetics, aging, drugs, long= evity</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1= pt"><span class=3D"awspan" style=3D"font-weight:bold; color:#767171">Abstra= ct</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt;= margin-bottom:10pt"><span class=3D"awspan" style=3D"font-weight:bold">Intr= oduction.</span><span class=3D"awspan" style=3D"font-weight:bold; letter-sp= acing:5.55pt"> </span><span class=3D"awspan">The</span><span class=3D"awspa= n" style=3D"letter-spacing:5.55pt"> </span><span class=3D"awspan">aging</sp= an><span class=3D"awspan" style=3D"letter-spacing:5.55pt"> </span><span cla= ss=3D"awspan">of</span><span class=3D"awspan" style=3D"letter-spacing:5.55p= t"> </span><span class=3D"awspan">the</span><span class=3D"awspan" style=3D= "letter-spacing:5.55pt"> </span><span class=3D"awspan">world's</span><span = class=3D"awspan" style=3D"letter-spacing:5.55pt"> </span><span class=3D"aws= pan">population</span><span class=3D"awspan" style=3D"letter-spacing:5.55pt= "> </span><span class=3D"awspan">has prompted</span><span class=3D"awspan" = style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">the</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"a= wspan">search</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> = </span><span class=3D"awspan">for</span><span class=3D"awspan" style=3D"let= ter-spacing:0.4pt"> </span><span class=3D"awspan">strategies</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan= ">to</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">prolong</span><span class=3D"awspan" style=3D"letter-s= pacing:0.4pt"> </span><span class=3D"awspan">health</span><span class=3D"aw= span" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">and</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span clas= s=3D"awspan">delay age-related</span><span class=3D"awspan" style=3D"letter= -spacing:1.6pt"> </span><span class=3D"awspan">diseases.</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">C= alorie</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span>= <span class=3D"awspan">restriction</span><span class=3D"awspan" style=3D"le= tter-spacing:1.6pt"> </span><span class=3D"awspan">(CR),</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">w= hich</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><s= pan class=3D"awspan">reduces caloric</span><span class=3D"awspan" style=3D"= letter-spacing:5.4pt"> </span><span class=3D"awspan">intake</span><span cla= ss=3D"awspan" style=3D"letter-spacing:5.4pt"> </span><span class=3D"awspan"= >without</span><span class=3D"awspan" style=3D"letter-spacing:5.4pt"> </spa= n><span class=3D"awspan">malnutrition,</span><span class=3D"awspan" style= =3D"letter-spacing:5.4pt"> </span><span class=3D"awspan">is</span><span cla= ss=3D"awspan" style=3D"letter-spacing:5.4pt"> </span><span class=3D"awspan"= >the</span><span class=3D"awspan" style=3D"letter-spacing:5.4pt"> </span><s= pan class=3D"awspan">most</span><span class=3D"awspan" style=3D"letter-spac= ing:5.4pt"> </span><span class=3D"awspan">studied </span></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span styl= 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letter-spacing:3pt; color:#ffffff">Procedimientos= M=C3=A9dicos</span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:11pt; letter-spacing:3pt; color:#ffffff">  </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing:3p= t; color:#ffffff">       </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing:3p= t; color:#ffffff">P=C3=A1gina</span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:11pt; color:#ffffff"> 71 | 88</span></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span 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position:abso= lute" /></span><span class=3D"awspan" style=3D"color:#ffffff">ISSN: </span>= <span class=3D"awspan" style=3D"font-weight:bold; color:#ffffff">2697-3391<= /span><span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2, pp. 69 = =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3=A9dicas, salud p= =C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span><svg font-= family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" version=3D"1.1= " width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"width:209.= 31px; height:41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:= xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0= L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"evenodd" /><= /g></g></svg></span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margi= n-left:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font-family:Ebr= ima; 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anat= om=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Tel. 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"= text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org= " style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:11pt; text-decoration:underline">www.anatomiadigital.o= rg</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8= pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><a href=3D"http://www.= cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p clas= s=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a = href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:no= ne"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; te= xt-decoration:underline">www.cienciadigitaleditorial.com</span></a></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.or= g</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8p= t"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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0dXVSWN9A3pVT1RUFHPm30bTxYsUP1OMwWCgqKgIq9V6+eCvZaj6q+kf/vAHDhw4wK1TbmVK7mT= a7XY8bjeKgAGSR4R4qjC9gbBIQ8iOo6MTR0f7zWjMQTYEqtARGW7tjyOc3d04u7sJ0VzX4WTlIA= gBIiyWECoet4umC67LZKtEDGJ8Oto7Q+CpWkBScbSChvoG9Ho902bMYOKkSSxYeCf/2P53nlm7l= qamJubPn8/w4cNDESeEIBAIYLfbOXbsGG+//Taf7t/HLdm3cNePFtLb66KsrIy271oHAXa97V/J= kF6PnP6/071S62b6nZ1d3LN4MQCqpgWJweZLzQB0dHQSFRPD9Jn/QVRUJP/4cAcvvvgCZWVl5OT= kkJGRQVxcHB6Ph4sXL3Ly5Mlgg9rZTt70fG6bN4+ICCsfbt1G+f6D9Hl9VyyuqiqpqakAoaoppa= Szs5Po6GgCgQBdXV03dN5oNBIREYHD4QgRmC6Xi+TkZBRF4dKlS6H8eyMJDw8nLS2Nzs5Ompub0= ev1IZqpr6/vJpoCKbiy5YBgY/nBu++x6sFV5ORMYEhsHIcOHOJ4xXFOnvwavd6AXq9H07TgAkKQ= mmpjyQ+Xckv2OExGI9u3lXLwOoABxMXF8corr1BfX09vby9VVVVMmjQp9Hh/8803OXHixA3dHjN= mDKtWreKtt94iOzubnp4ePB4Pd999N36/n927d7Nr165Qz3g9KS4uxu/3o6oqW7ZswWQysXr1al= 566SVOnDhx3R5ysFwDmuYPUHP2LP/98susWLGCsWPH8pMlP2HOvDk0NjTSdOkidrsdnaLDZrMxL= NVGSnIK4eZwXK5e/ra5hH2f7MPnvf6JBWlyK8ePHycrK4uamhqKiop49dVXkVJSXV19U4fNZjNj= xoxh+fLlOJ1OWlpamDBhAps2baKtrY2IiAh0Ot1NbUyfPp2dO3dy+vRpuru7mTlzJhaLhby8PKq= rq783Uq8BrR+4pvoLvLjhJebcNoeC2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tve= JhfrVIKVFVlaioKBITEzEYDPz+97/niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2tr= XR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdH= Pv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iX= q6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAo= waNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi= 4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0= Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhO= K/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D= " width=3D"77" height=3D"28" alt=3D"" style=3D"margin-left:441.05pt; positi= on:absolute" /></span><span class=3D"awspan">geroprotective</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan"= >dietary</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </spa= n><span class=3D"awspan">intervention.</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">However,</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"a= wspan">the</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </s= pan><span class=3D"awspan">difficulty</span><span class=3D"awspan" style=3D= "letter-spacing:0.4pt"> </span><span class=3D"awspan">of maintaining</span>= <span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class= =3D"awspan">it</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"= > </span><span class=3D"awspan">has</span><span class=3D"awspan" style=3D"l= etter-spacing:0.55pt"> </span><span class=3D"awspan">directed</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awsp= an">research</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> = </span><span class=3D"awspan">towards</span><span class=3D"awspan" style=3D= "letter-spacing:0.55pt"> </span><span class=3D"awspan">drugs</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspa= n">that</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </spa= n><span class=3D"awspan">mimic its</span><span class=3D"awspan" style=3D"le= tter-spacing:3.25pt"> </span><span class=3D"awspan">effects,</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class=3D"awspa= n">known</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </sp= an><span class=3D"awspan">as</span><span class=3D"awspan" style=3D"letter-s= pacing:3.25pt"> </span><span class=3D"awspan">calorie</span><span class=3D"= awspan" style=3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">rest= riction</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </spa= n><span class=3D"awspan">mimetics</span><span class=3D"awspan" style=3D"let= ter-spacing:3.25pt"> </span><span class=3D"awspan">(CRMs). </span><span cla= ss=3D"awspan" style=3D"font-weight:bold">Objective.</span><span class=3D"aw= span" style=3D"font-weight:bold; letter-spacing:-0.05pt"> </span><span clas= s=3D"awspan">To</span><span class=3D"awspan" style=3D"letter-spacing:-0.05p= t"> </span><span class=3D"awspan">examine</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan">the</span><span= class=3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"a= wspan">potential</span><span class=3D"awspan" style=3D"letter-spacing:-0.05= pt"> </span><span class=3D"awspan">of</span><span class=3D"awspan" style=3D= "letter-spacing:-0.05pt"> </span><span class=3D"awspan">CR</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan= ">and</span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> </span= ><span class=3D"awspan">its</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.05pt"> </span><span class=3D"awspan">mimetics</span><span class=3D= "awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan">to= delay</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </spa= n><span class=3D"awspan">aging,</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.65pt"> </span><span class=3D"awspan">assessing</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspa= n">their</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </s= pan><span class=3D"awspan">impact</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.65pt"> </span><span class=3D"awspan">on</span><span class=3D= "awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">he= alth</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span>= <span class=3D"awspan">and</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.65pt"> </span><span class=3D"awspan">longevity,</span><span class= =3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan"= >and analyzing</span><span class=3D"awspan" style=3D"letter-spacing:5.95pt"= > </span><span class=3D"awspan">their</span><span class=3D"awspan" style=3D= "letter-spacing:5.95pt"> </span><span class=3D"awspan">scientific</span><sp= an class=3D"awspan" style=3D"letter-spacing:5.95pt"> </span><span class=3D"= awspan">basis</span><span class=3D"awspan" style=3D"letter-spacing:5.95pt">= </span><span class=3D"awspan">and</span><span class=3D"awspan" style=3D"le= tter-spacing:5.95pt"> </span><span class=3D"awspan">possible</span><span cl= ass=3D"awspan" style=3D"letter-spacing:5.95pt"> </span><span class=3D"awspa= n">therapeutic applications.</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.5pt"> </span><span class=3D"awspan" style=3D"font-weight:bold">Me= thodology.</span><span class=3D"awspan" style=3D"font-weight:bold; letter-s= pacing:-0.5pt"> </span><span class=3D"awspan">Qualitative</span><span class= =3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">= literature</span><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </= span><span class=3D"awspan">review</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.5pt"> </span><span class=3D"awspan">based on</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspa= n">literature</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt">= </span><span class=3D"awspan">on</span><span class=3D"awspan" style=3D"let= ter-spacing:1.25pt"> </span><span class=3D"awspan">CR</span><span class=3D"= awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">and<= /span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span = class=3D"awspan">CRM</span><span class=3D"awspan" style=3D"letter-spacing:1= .25pt"> </span><span class=3D"awspan">in</span><span class=3D"awspan" style= =3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">relation</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D= "awspan">to</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> <= /span><span class=3D"awspan">aging.</span><span class=3D"awspan" style=3D"l= etter-spacing:1.25pt"> </span><span class=3D"awspan">Data</span><span class= =3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">= was collected</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> = </span><span class=3D"awspan">from</span><span class=3D"awspan" style=3D"le= tter-spacing:0.7pt"> </span><span class=3D"awspan">scientific</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspa= n">databases</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> <= /span><span class=3D"awspan">such</span><span class=3D"awspan" style=3D"let= ter-spacing:0.7pt"> </span><span class=3D"awspan">as</span><span class=3D"a= wspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">PubMed= ,</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span= class=3D"awspan">LILACS and</span><span class=3D"awspan" style=3D"letter-s= pacing:1.3pt"> </span><span class=3D"awspan">Cochrane,</span><span class=3D= "awspan" style=3D"letter-spacing:1.3pt"> </span><span class=3D"awspan">focu= sing</span><span class=3D"awspan" style=3D"letter-spacing:1.3pt"> </span><s= pan class=3D"awspan">on</span><span class=3D"awspan" style=3D"letter-spacin= g:1.3pt"> </span><span class=3D"awspan">clinical</span><span class=3D"awspa= n" style=3D"letter-spacing:1.3pt"> </span><span class=3D"awspan">studies</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.3pt"> </span><span cla= ss=3D"awspan">from</span><span class=3D"awspan" style=3D"letter-spacing:1.3= pt"> </span><span class=3D"awspan">the</span><span class=3D"awspan" style= =3D"letter-spacing:1.3pt"> </span><span class=3D"awspan">last</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.3pt"> </span><span class=3D"awspa= n">five years.</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"= > </span><span class=3D"awspan">The</span><span class=3D"awspan" style=3D"l= etter-spacing:2.95pt"> </span><span class=3D"awspan">findings</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awsp= an">are</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </spa= n><span class=3D"awspan">summarized</span><span class=3D"awspan" style=3D"l= etter-spacing:2.95pt"> </span><span class=3D"awspan">in</span><span class= =3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">= a</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><spa= n class=3D"awspan">narrative</span><span class=3D"awspan" style=3D"letter-s= pacing:2.95pt"> </span><span class=3D"awspan">review. </span><span class=3D= "awspan" style=3D"font-weight:bold">Results.</span><span class=3D"awspan" s= tyle=3D"font-weight:bold; letter-spacing:1.55pt"> </span><span class=3D"aws= pan">CR</span><span class=3D"awspan" style=3D"letter-spacing:1.55pt"> </spa= n><span class=3D"awspan">showed</span><span class=3D"awspan" style=3D"lette= r-spacing:1.55pt"> </span><span class=3D"awspan">significant</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span class=3D"awspa= n">improvements</span><span class=3D"awspan" style=3D"letter-spacing:1.55pt= "> </span><span class=3D"awspan">in</span><span class=3D"awspan" style=3D"l= etter-spacing:1.55pt"> </span><span class=3D"awspan">health</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span class=3D"awspan= ">and longevity</span><span class=3D"awspan" style=3D"letter-spacing:-0.45p= t"> </span><span class=3D"awspan">in</span><span class=3D"awspan" style=3D"= letter-spacing:-0.45pt"> </span><span class=3D"awspan">experimental</span><= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">and</span><span class=3D"awspan" style=3D"letter-spacing:-0.45p= t"> </span><span class=3D"awspan">human</span><span class=3D"awspan" style= =3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">models,</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">reducing</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.45pt"> </span><span class=3D"awspan">weight, insulin</span><span class=3D= "awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"awspan">lev= els,</span><span class=3D"awspan" style=3D"letter-spacing:5.05pt"> </span><= span class=3D"awspan">body</span><span class=3D"awspan" style=3D"letter-spa= cing:5.05pt"> </span><span class=3D"awspan">temperature</span><span class= =3D"awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"awspan">= and</span><span class=3D"awspan" style=3D"letter-spacing:5.05pt"> </span><s= pan class=3D"awspan">oxidative</span><span class=3D"awspan" style=3D"letter= -spacing:5.05pt"> </span><span class=3D"awspan">stress.</span><span class= =3D"awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"awspan">= It promoted</span><span class=3D"awspan" style=3D"letter-spacing:2.85pt"> <= /span><span class=3D"awspan">autophagy</span><span class=3D"awspan" style= =3D"letter-spacing:2.85pt"> </span><span class=3D"awspan">through</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.85pt"> </span><span class=3D"= awspan">mTOR</span><span class=3D"awspan" style=3D"letter-spacing:2.85pt"> = </span><span class=3D"awspan">inhibition</span><span class=3D"awspan" style= =3D"letter-spacing:2.85pt"> </span><span class=3D"awspan">and</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.85pt"> </span><span class=3D"awsp= an">AMPK activation.</span><span class=3D"awspan" style=3D"letter-spacing:3= .1pt"> </span><span class=3D"awspan">MRCs,</span><span class=3D"awspan" sty= le=3D"letter-spacing:3.1pt"> </span><span class=3D"awspan">such</span><span= class=3D"awspan" style=3D"letter-spacing:3.1pt"> </span><span class=3D"aws= pan">as</span><span class=3D"awspan" style=3D"letter-spacing:3.1pt"> </span= ><span class=3D"awspan">metformin</span><span class=3D"awspan" style=3D"let= ter-spacing:3.1pt"> </span><span class=3D"awspan">and</span><span class=3D"= awspan" style=3D"letter-spacing:3.1pt"> </span><span class=3D"awspan">rapam= ycin,</span><span class=3D"awspan" style=3D"letter-spacing:3.1pt"> </span><= span class=3D"awspan">also demonstrated</span><span class=3D"awspan" style= =3D"letter-spacing:6.4pt"> </span><span class=3D"awspan">anti-aging</span><= span class=3D"awspan" style=3D"letter-spacing:6.4pt"> </span><span class=3D= "awspan">effects</span><span class=3D"awspan" style=3D"letter-spacing:6.4pt= "> </span><span class=3D"awspan">by</span><span class=3D"awspan" style=3D"l= etter-spacing:6.4pt"> </span><span class=3D"awspan">modulating</span><span = class=3D"awspan" style=3D"letter-spacing:6.4pt"> </span><span class=3D"awsp= an">nutrient-sensing</span><span class=3D"awspan" style=3D"letter-spacing:0= .9pt"> </span><span class=3D"awspan">pathways</span><span class=3D"awspan" = style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">and</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"a= wspan">reducing</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"= > </span><span class=3D"awspan">oxidative</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">damage,</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"a= wspan">suggesting their</span><span class=3D"awspan" style=3D"letter-spacin= g:1.2pt"> </span><span class=3D"awspan">potential</span><span class=3D"awsp= an" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">as</span>= <span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class= =3D"awspan">alternatives</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.2pt"> </span><span class=3D"awspan">to</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">CR.</span><span= class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"aws= pan" style=3D"font-weight:bold">Conclusion.</span><span class=3D"awspan" st= yle=3D"font-weight:bold; letter-spacing:1.2pt"> </span><span class=3D"awspa= n">CR</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><= span class=3D"awspan">and</span><span class=3D"awspan" style=3D"letter-spac= ing:1.2pt"> </span><span class=3D"awspan">its mimetics,</span><span class= =3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">= such</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><= span class=3D"awspan">as</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.45pt"> </span><span class=3D"awspan">rapamycin,</span><span class=3D"a= wspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">impro= ve</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><sp= an class=3D"awspan">longevity</span><span class=3D"awspan" style=3D"letter-= spacing:1.45pt"> </span><span class=3D"awspan">and</span><span class=3D"aws= pan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">muscle = quality</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </spa= n><span class=3D"awspan">by</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.1pt"> </span><span class=3D"awspan">activating</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= key</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><s= pan class=3D"awspan">pathways</span><span class=3D"awspan" style=3D"letter-= spacing:-0.1pt"> </span><span class=3D"awspan">such</span><span class=3D"aw= span" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">as</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span cla= ss=3D"awspan">AMPK</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 1pt"> </span><span class=3D"awspan">and</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">SIRT1. Although</= span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span c= lass=3D"awspan">they</span><span class=3D"awspan" style=3D"letter-spacing:2= .45pt"> </span><span class=3D"awspan">act</span><span class=3D"awspan" styl= e=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">differently,</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span cla= ss=3D"awspan">both</span><span class=3D"awspan" style=3D"letter-spacing:2.4= 5pt"> </span><span class=3D"awspan">promote</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">autophagy</spa= n><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span clas= s=3D"awspan">and antioxidant</span><span class=3D"awspan" style=3D"letter-s= pacing:4.45pt"> </span><span class=3D"awspan">protection,</span><span class= =3D"awspan" style=3D"letter-spacing:4.45pt"> </span><span class=3D"awspan">= suggesting</span><span class=3D"awspan" style=3D"letter-spacing:4.45pt"> </= span><span class=3D"awspan">the</span><span class=3D"awspan" style=3D"lette= r-spacing:4.45pt"> </span><span class=3D"awspan">need</span><span class=3D"= awspan" style=3D"letter-spacing:4.45pt"> </span><span class=3D"awspan">for<= /span><span class=3D"awspan" style=3D"letter-spacing:4.45pt"> </span><span = class=3D"awspan">combined approaches</span><span class=3D"awspan" style=3D"= letter-spacing:1.95pt"> </span><span class=3D"awspan">to</span><span class= =3D"awspan" style=3D"letter-spacing:1.95pt"> </span><span class=3D"awspan">= optimize</span><span class=3D"awspan" style=3D"letter-spacing:1.95pt"> </sp= an><span class=3D"awspan">anti-aging</span><span class=3D"awspan" style=3D"= letter-spacing:1.95pt"> </span><span class=3D"awspan">effects.</span><span = class=3D"awspan" style=3D"letter-spacing:1.95pt"> </span><span class=3D"aws= pan" style=3D"font-weight:bold">General</span><span class=3D"awspan" style= =3D"font-weight:bold; letter-spacing:1.95pt"> </span><span class=3D"awspan"= style=3D"font-weight:bold">Area</span><span class=3D"awspan" style=3D"font= -weight:bold; letter-spacing:1.95pt"> </span><span class=3D"awspan" style= =3D"font-weight:bold">of Study:</span><span class=3D"awspan" style=3D"font-= weight:bold; letter-spacing:3.5pt"> </span><span class=3D"awspan">Medicine.= </span><span class=3D"awspan" style=3D"letter-spacing:3.5pt"> </span><span = class=3D"awspan" style=3D"font-weight:bold">Specific</span><span class=3D"a= wspan" style=3D"font-weight:bold; letter-spacing:3.5pt"> </span><span class= =3D"awspan" style=3D"font-weight:bold">area</span><span class=3D"awspan" st= yle=3D"font-weight:bold; letter-spacing:3.5pt"> </span><span class=3D"awspa= n" style=3D"font-weight:bold">of</span><span class=3D"awspan" style=3D"font= -weight:bold; letter-spacing:3.5pt"> </span><span class=3D"awspan" style=3D= "font-weight:bold">study:</span><span class=3D"awspan" style=3D"font-weight= :bold; letter-spacing:3.5pt"> </span><span class=3D"awspan">Endocrinology. = </span><span class=3D"awspan" style=3D"font-weight:bold">Type of study:</sp= an><span class=3D"awspan" style=3D"color:#333333"> </span><span class=3D"aw= span">Bibliography Review.</span></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weight:bold; = color:#767171">1.Introducci=C3=B3n</span></p><p class=3D"awdiv" style=3D"ma= rgin-right:1pt; margin-left:1pt"><span class=3D"awspan">El</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan"= >r=C3=A1pido</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> = </span><span class=3D"awspan">crecimiento</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">de</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awsp= an">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span= ><span class=3D"awspan">poblaci=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">mundial</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"= awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> <= /span><span class=3D"awspan">envejece</span><span class=3D"awspan" style=3D= "letter-spacing:-0.4pt"> </span><span class=3D"awspan">ha</span><span class= =3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">= generado</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </sp= an><span class=3D"awspan">motivaci=C3=B3n</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">para la</span><s= pan class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D= "awspan">investigaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:2.15pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan= " style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">los</span>= <span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class= =3D"awspan">mecanismos</span><span class=3D"awspan" style=3D"letter-spacing= :2.15pt"> </span><span class=3D"awspan">subyacentes</span><span class=3D"aw= span" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">al</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span cla= ss=3D"awspan">envejecimiento</span><span class=3D"awspan" style=3D"letter-s= pacing:2.15pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan= " style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class= =3D"awspan">b=C3=BAsqueda</span><span class=3D"awspan" style=3D"letter-spac= ing:2.15pt"> </span><span class=3D"awspan">de posibles</span><span class=3D= "awspan" style=3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">medi= das</span><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><sp= an class=3D"awspan">para</span><span class=3D"awspan" style=3D"letter-spaci= ng:4.9pt"> </span><span class=3D"awspan">ampliar</span><span class=3D"awspa= n" style=3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><span class=3D= "awspan">duraci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing= :4.9pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">salud</span><span= class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><span class=3D"aws= pan">y</span><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span>= <span class=3D"awspan">retrasar</span><span class=3D"awspan" style=3D"lette= r-spacing:4.9pt"> </span><span class=3D"awspan">la</span><span class=3D"aws= pan" style=3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">aparici= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span= ><span class=3D"awspan">de enfermedades</span><span class=3D"awspan" style= =3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">relacionadas</span= ><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class= =3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"= > </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"le= tter-spacing:1.8pt"> </span><span class=3D"awspan">edad</span><span class= =3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">(= 1).</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><sp= an class=3D"awspan">Concepto</span><span class=3D"awspan" style=3D"letter-s= pacing:1.8pt"> </span><span class=3D"awspan">conocido</span><span class=3D"= awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">como<= /span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span c= lass=3D"awspan">envejecimiento saludable que integra campos de fisiolog=C3= =ADa del envejecimiento y modulaci=C3=B3n molecular.</span></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><spa= n class=3D"awspan">En</span><span class=3D"awspan" style=3D"letter-spacing:= 0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">actualidad</span><= span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D= "awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">envejecimiento</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">se</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspa= n">reconoce</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">como</span><span class=3D"awspan" style=3D"lett= er-spacing:0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"aw= span" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">contrac= ci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </sp= an><span class=3D"awspan">gradual</span><span class=3D"awspan" style=3D"let= ter-spacing:0.4pt"> </span><span class=3D"awspan">del</span><span class=3D"= awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">espac= io homeodin=C3=A1mico</span><span class=3D"awspan" style=3D"letter-spacing:= 0.2pt"> </span><span class=3D"awspan">(2).</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">Expresi=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span cl= ass=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:0.2= pt"> </span><span class=3D"awspan">surge</span><span class=3D"awspan" style= =3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">de</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan"= >la</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><sp= an class=3D"awspan">homeodin=C3=A1mica,</span><span class=3D"awspan" style= =3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">t=C3=A9rmino</span= ><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class= =3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt">= </span><span class=3D"awspan">boga</span><span class=3D"awspan" style=3D"l= etter-spacing:0.2pt"> </span><span class=3D"awspan">que</span><span class= =3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">h= a reemplazado</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> = </span><span class=3D"awspan">al</span><span class=3D"awspan" style=3D"lett= er-spacing:1.7pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">homeost= asis,</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><= span class=3D"awspan">fundamentado</span><span class=3D"awspan" style=3D"le= tter-spacing:1.7pt"> </span><span class=3D"awspan">en</span><span class=3D"= awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">que</= span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span cl= ass=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:1.7= pt"> </span><span class=3D"awspan">sistemas</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">biol=C3=B3gicos= </span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span = class=3D"awspan">no</span><span class=3D"awspan" style=3D"letter-spacing:1.= 7pt"> </span><span class=3D"awspan">son </span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span style=3D"heigh= t:0pt; display:block; position:absolute; z-index:210"><img src=3D"data:imag= 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position:absolute" /></= span><span class=3D"awspan" style=3D"color:#ffffff">ISSN: </span><span clas= s=3D"awspan" style=3D"font-weight:bold; color:#ffffff">2697-3391</span><spa= n class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2, pp. 69 =E2=80=93 8= 8, abril - junio 2025Revista en ciencias m=C3=A9dicas, salud p=C3=BAblicaAr= t=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span></p><p class=3D"awdiv= " style=3D"margin-right:1pt; margin-left:1pt"><span><svg font-family=3D"Tim= es New Roman" font-size=3D"16" height=3D"41.33" version=3D"1.1" width=3D"20= 9.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"width:209.31px; height:= 41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:xlink=3D"http= ://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0 L209,0 L209,= 41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"evenodd" /></g></g></svg>= </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><span class=3D"awspan" style=3D"font-family:Ebrima; 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline">www.anatomiadigital.org</span></a></p= ><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline">www.cienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" = style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span style=3D"h= eight:0pt; display:block; position:absolute; z-index:246"><img src=3D"data:= image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICA= gIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpE= pNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZ= afT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dl= hdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAy= AMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1= Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL= 16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQ= kSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0z= QZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtu= xGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJyc= AKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++= TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraR= AwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6= fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h= 4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx= 2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFL= quUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl= 0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFTkSuQmCC" width=3D"19" height=3D= "19" alt=3D"" style=3D"margin-left:3.84pt; 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position:absolute" /></span><span style=3D"hei= ght:0pt; display:block; position:absolute; z-index:244"><img src=3D"data:im= age/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAAAASCAYAAABWzo5XAAAABHNCSVQICAgI= fAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFUOI1VlM1PIkkYxn/VTdMNDUIM4jIxozs= BD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1EPyMrAyofY2tBde2C6d3yTSiVV9T71vE= 89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJycxDAMhxI9DBPgeUkosy6JarVIul7m6u= sKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnpyeOjo4olUo0m01c10UIAQIEAo81QCKR= YH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCqKtMz0wTUALe3t9i2DUCz2WRnZwcpJfl= 8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVkA9Ho9Dg4OmJqaGgENh0NOT0+p1+s+SC= gUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+fkI6PX1lbOzM1+DeDzOysoKoXAYx3GIR= CI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azCUA4HGZ1dRVN04hEIqiKyvbv2xT2C1jP= Fo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z26RO9bpd/W00K+3/w3H+i+e0bX76UkVI= ihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHFxQTab5f7+/n//CDFiFIvFUFXVX/Q2pJ= TEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOpqm8dTv02630TSNYDCIUEYm9SIej49KM= wyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4fX3xmWmaxvT09AgoEAiQy+WoVCrUajUc= x6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4cjAYcHx8zPb2Nt1uF0VRfA28XvNKd10= XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRVP2B+FNk2Tzc1NFhcX0TRtdMb7jKSU2L= bN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQog3QN7c7Xa5vr6mWq3SaDQQQpBKpchkM= qTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC" width=3D"18" height=3D"18" alt= =3D"" style=3D"margin-left:5.66pt; position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; color:#0563c1">www.cienciadigitaleditorial.com</span></a></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><= span style=3D"height:0pt; display:block; position:absolute; z-index:249"><i= mg src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABMAAAATCAYAAAByUDb= MAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJREFUOI1tlM1PG0cYxn= 8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICjUKglBgndWq0/ljbC= Nbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5imiZSSj4vIQRCCKFf= NCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGEYKgDP89jf32dpaYm= DgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3vD8+XMqlQpKKSzLwh= 4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgzkSemZmH5G7fRkqJ7= /skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz+H6AEJK9vb/Z3t7h= zPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A8j1QqxbWhIbLXr2M= YBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiYQRrYZBZiTD4T8HZC= yLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFKkcV1tfXeLrwlH8/v= Odb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhbn4l8MBhEsGQyeXnY= dTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZnJZEin0wA4jsNxvc7= du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD2qIFD0el06nQ7/1e= t43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRBw8ekkql0HWNP5bLv= H27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kghaDQdPtY+0mw2CcMQ= TdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5QyMrqKCqUU7Xabcrn= M+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR5KKeLxOLZtUyqVKB= QKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFTkSuQmCC" width= =3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-1pt; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = ;        </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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positi= on:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digit= al</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador= (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Tels. 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= position:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa= Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#447= 2c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80= =93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista = Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; colo= r:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">         </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold= ; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Am= bato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Tels. 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position:absolute" /><= /span><span> </span></p><p class=3D"awdiv" style=3D"font-size:8pt; bac= kground-color:#ffffff"><span class=3D"awspan" style=3D"font-size:8pt; font-= style:italic">Esta revista est=C3=A1 protegida bajo una licencia Creative C= ommons en la 4.0 International. Copia de la licencia: </span><a href=3D"htt= p://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:no= ne"></a></p></div><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt; font-size:8pt"><a href=3D"http://creativecommons.org/licenses/by-nc-s= a/4.0/" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font= -size:8pt; text-decoration:underline; color:#0563c1">http://creativecommons= .org/licenses/by-nc-sa/4.0/</span></a></p><p style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-size:8pt"= > </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt"><span style=3D"height:0pt; display:block; position:absolute; z-index:= 277"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAE0AAAAcCAYA= AAAk2zLiAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAEz9JREFUaIHlmHt= 01NW1xz/nN7+ZzCOZPMkTJgmvBCIhgBAS4EICCI1FpXJLReBiEasVWWrrWnZpG2lRV8HHtauWWh= 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pvoLvLjhJebcNoeC2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlai= oKBITEzEYDPz+97/niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vq= IoFBcXk5+fz8qVK9m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkC= GJiYggzGdECAXp6nDRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz= 0dnZycaNG1m7di0Oh4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2t= JTU0lMzOTL7/88sawSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+= 4cJ06cwOv1snjxYkpKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp= 0/n4sWLNDcHC2BlZSU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/= FXvXmzN47GY2nnvuOXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77= " height=3D"28" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" = /></span><span class=3D"awspan">permanentes</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">o</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspa= n">inmutables,</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt">= </span><span class=3D"awspan">ni</span><span class=3D"awspan" style=3D"let= ter-spacing:2.3pt"> </span><span class=3D"awspan">se</span><span class=3D"a= wspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">hallan= </span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span = class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.= 3pt"> </span><span class=3D"awspan">equilibrio,</span><span class=3D"awspan= " style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">sino</span>= <span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class= =3D"awspan">son</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"= > </span><span class=3D"awspan">un</span><span class=3D"awspan" style=3D"le= tter-spacing:2.3pt"> </span><span class=3D"awspan">ajuste</span><span class= =3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">c= ontinuo</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span= ><span class=3D"awspan">y din=C3=A1mico,</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">donde</span><span = class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awsp= an">la</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span>= <span class=3D"awspan">capacidad</span><span class=3D"awspan" style=3D"lett= er-spacing:0.5pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">amortig= uaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.5pt"> </span><span class=3D"awspan">los</span><span class=3D"aws= pan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">sistemas= </span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span = class=3D"awspan">biol=C3=B3gicos</span><span class=3D"awspan" style=3D"lett= er-spacing:0.5pt"> </span><span class=3D"awspan">determina</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">= la salud</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </sp= an><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.1pt"> </span><span class=3D"awspan">un</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">organismo= .</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><spa= n class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-spacing:= -0.1pt"> </span><span class=3D"awspan">entendimiento</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span cl= ass=3D"awspan">este</span><span class=3D"awspan" style=3D"letter-spacing:-0= .1pt"> </span><span class=3D"awspan">aspecto</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">del</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"= awspan">envejecimiento</span><span class=3D"awspan" style=3D"letter-spacing= :-0.1pt"> </span><span class=3D"awspan">ha</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">llevado</span><= span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class= =3D"awspan">a adoptar estrategias enfocadas en la prevenci=C3=B3n (3). </sp= an></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span= class=3D"awspan">En</span><span class=3D"awspan" style=3D"letter-spacing:0= .85pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style= =3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">campo</span><span= class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"aw= span">de</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </sp= an><span class=3D"awspan">dichas</span><span class=3D"awspan" style=3D"lett= er-spacing:0.85pt"> </span><span class=3D"awspan">intervenciones</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"a= wspan">preventivas,</span><span class=3D"awspan" style=3D"letter-spacing:0.= 85pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">reducci=C3=B3n</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span cl= ass=3D"awspan">sostenida</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"a= wspan">ingesta cal=C3=B3rica sin desnutrici=C3=B3n denominada restricci=C3= =B3n cal=C3=B3rica RC, se ha consolidado como la intervenci=C3=B3n</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"= awspan">diet=C3=A9tica</span><span class=3D"awspan" style=3D"letter-spacing= :1.4pt"> </span><span class=3D"awspan">geroprotectora</span><span class=3D"= awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">mejor= </span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span = class=3D"awspan">estudiada</span><span class=3D"awspan" style=3D"letter-spa= cing:1.4pt"> </span><span class=3D"awspan">(4).</span><span class=3D"awspan= " style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">La</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"= awspan">restricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.4pt"> </span><span class=3D"awspan">cal=C3=B3rica</span><span class=3D= "awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">tien= e como</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span= ><span class=3D"awspan">objetivo</span><span class=3D"awspan" style=3D"lett= er-spacing:1.65pt"> </span><span class=3D"awspan">principal</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan= ">incrementar</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:1.65pt"> </span><span class=3D"awspan">longevidad</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awsp= an">o</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span>= <span class=3D"awspan">esperanza</span><span class=3D"awspan" style=3D"lett= er-spacing:1.65pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">vida,= </span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span= class=3D"awspan">pudiendo</span><span class=3D"awspan" style=3D"letter-spa= cing:1.65pt"> </span><span class=3D"awspan">las intervenciones</span><span = class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"aw= span">diet=C3=A9ticas</span><span class=3D"awspan" style=3D"letter-spacing:= -0.25pt"> </span><span class=3D"awspan">reducir</span><span class=3D"awspan= " style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">incidencia</span><span class=3D"awspan" style=3D"letter-spacing= :-0.25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">enfermedades<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span= class=3D"awspan">cr=C3=B3nicas</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.25pt"> </span><span class=3D"awspan">no</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">tran= smisibles (5). </span><span class=3D"awspan"> </span><span class=3D"aw= span">Principalmente</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.55pt"> </span><span class=3D"awspan">aquellas</span><span class=3D"awspan= " style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">asociadas= </span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><spa= n class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.55pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">hipernutrici=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span>= <span class=3D"awspan">cr=C3=B3nica</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.55pt"> </span><span class=3D"awspan">(4).</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan= ">Uno</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span= ><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.55pt"> </span><span class=3D"awspan">los</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">factores= m=C3=A1s</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </s= pan><span class=3D"awspan">relevantes</span><span class=3D"awspan" style=3D= "letter-spacing:0.15pt"> </span><span class=3D"awspan">en</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= el</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><sp= an class=3D"awspan">surgimiento</span><span class=3D"awspan" style=3D"lette= r-spacing:0.15pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">enferm= edades</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span= ><span class=3D"awspan">cr=C3=B3nicas</span><span class=3D"awspan" style=3D= "letter-spacing:0.15pt"> </span><span class=3D"awspan">asociadas</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"a= wspan">con</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </= span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter= -spacing:0.15pt"> </span><span class=3D"awspan">edad,</span><span class=3D"= awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">como= obesidad, diabetes mellitus tipo II y enfermedades cardiovasculares (6). <= /span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><s= pan class=3D"awspan">Hoy</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.8pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">d=C3=ADa</span>= <span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class= =3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt">= </span><span class=3D"awspan">encuentran</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">en</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan= ">investigaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1= .8pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">desarrollo</span><= span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D= "awspan">algunos</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt= "> </span><span class=3D"awspan">f=C3=A1rmacos</span><span class=3D"awspan"= style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">dirigidos</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span cla= ss=3D"awspan">a retrasar</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" = style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">mecanismos</= span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span c= lass=3D"awspan">celulares</span><span class=3D"awspan" style=3D"letter-spac= ing:0.85pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">moleculares</= span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span c= lass=3D"awspan">asociados</span><span class=3D"awspan" style=3D"letter-spac= ing:0.85pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan"= style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">el</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D= "awspan">envejecimiento,</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">tales como</span><span class=3D"a= wspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">la</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span cl= ass=3D"awspan">disminuci=C3=B3n</span><span class=3D"awspan" style=3D"lette= r-spacing:0.15pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span cla= ss=3D"awspan">remodelaci=C3=B3n</span><span class=3D"awspan" style=3D"lette= r-spacing:0.15pt"> </span><span class=3D"awspan">y</span><span class=3D"aws= pan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">la</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span clas= s=3D"awspan">autofagia</span><span class=3D"awspan" style=3D"letter-spacing= :0.15pt"> </span><span class=3D"awspan">o</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">el</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awsp= an">incremento</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:0.15pt"> </span><span class=3D"awspan">metilaci=C3=B3n</span><= span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class= =3D"awspan">de prote=C3=ADnas,</span><span class=3D"awspan" style=3D"letter= -spacing:1.9pt"> </span><span class=3D"awspan">estos</span><span class=3D"a= wspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">f=C3= =A1rmacos</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </sp= an><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-s= pacing:1.9pt"> </span><span class=3D"awspan">conocen</span><span class=3D"a= wspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">como</= span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span cl= ass=3D"awspan">imitadores</span><span class=3D"awspan" style=3D"letter-spac= ing:1.9pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">restricci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><s= pan class=3D"awspan">o</span><span class=3D"awspan" style=3D"letter-spacing= :1.9pt"> </span><span class=3D"awspan">mim=C3=A9ticos</span><span class=3D"= awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">de re= stricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt">= </span><span class=3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">MRC,</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"a= wspan">que</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </s= pan><span class=3D"awspan">surgen</span><span class=3D"awspan" style=3D"let= ter-spacing:1.4pt"> </span><span class=3D"awspan">como</span><span class=3D= "awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">una<= /span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span c= lass=3D"awspan">opci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:1.4pt"> </span><span class=3D"awspan">relevante</span><span class=3D"= awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">a</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span clas= s=3D"awspan">considerar</span><span class=3D"awspan" style=3D"letter-spacin= g:1.4pt"> </span><span class=3D"awspan">ante</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">la dificultad<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span= class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">mantener</span><span class=3D"awspan= " style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">de</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class= =3D"awspan">forma</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= 5pt"> </span><span class=3D"awspan">consistente</span><span class=3D"awspan= " style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class= =3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt= "> </span><span class=3D"awspan">(7).</span><span class=3D"awspan" style=3D= "letter-spacing:-0.15pt"> </span><span class=3D"awspan">Estos</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aws= pan">compuestos</span><span class=3D"awspan" style=3D"letter-spacing:-0.15p= t"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.15pt"> </span><span class=3D"awspan">pesar</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspa= n">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span= ><span class=3D"awspan">tener niveles</span><span class=3D"awspan" style=3D= "letter-spacing:0.05pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= evidencia</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </s= pan><span class=3D"awspan">limitada</span><span class=3D"awspan" style=3D"l= etter-spacing:0.05pt"> </span><span class=3D"awspan">y</span><span class=3D= "awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">no<= /span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span = class=3D"awspan">haber</span><span class=3D"awspan" style=3D"letter-spacing= :0.05pt"> </span><span class=3D"awspan">iniciado</span><span class=3D"awspa= n" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">ensayos</= span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span c= lass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:0.0= 5pt"> </span><span class=3D"awspan">humanos,</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">merecen</span= ><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class= =3D"awspan">especial atenci=C3=B3n como campo de investigaci=C3=B3n, por lo= cual se incluyen en este estudio. </span></p><p class=3D"awdiv" style=3D"m= argin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weig= ht:bold; color:#767171">2.Metodolog=C3=ADa</span></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">Estudio</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span cla= ss=3D"awspan">dise=C3=B1ado</span><span class=3D"awspan" style=3D"letter-sp= acing:2.35pt"> </span><span class=3D"awspan">con</span><span class=3D"awspa= n" style=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">un</span>= <span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class= =3D"awspan">enfoque</span><span class=3D"awspan" style=3D"letter-spacing:2.= 35pt"> </span><span class=3D"awspan">cualitativo</span><span class=3D"awspa= n" style=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">basado</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span cl= ass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.35= pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan" style= =3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">revisi=C3=B3n</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span cla= ss=3D"awspan">narrativa</span><span class=3D"awspan" style=3D"letter-spacin= g:2.35pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">la literatura<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span= class=3D"awspan">cient=C3=ADfica,</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.25pt"> </span><span class=3D"awspan">con</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >el</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><= span class=3D"awspan">prop=C3=B3sito</span><span class=3D"awspan" style=3D"= letter-spacing:-0.25pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >analizar</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </= span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-= spacing:-0.25pt"> </span><span class=3D"awspan">sintetizar</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span>= <span class=3D"awspan">evidencia</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.25pt"> </span><span class=3D"awspan">disponible</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"aws= pan">sobre la</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt">= </span><span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan= " style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">cal=C3=B3r= ica</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><s= pan class=3D"awspan">(RC)</span><span class=3D"awspan" style=3D"letter-spac= ing:1.85pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">sus</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"= awspan">mim=C3=A9ticos</span><span class=3D"awspan" style=3D"letter-spacing= :1.85pt"> </span><span class=3D"awspan">(MRC)</span><span class=3D"awspan" = style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">en</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"= awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:= 1.85pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">los</span><span= class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"aw= span">procesos</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"= > </span><span class=3D"awspan">de envejecimiento</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">y</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span class= =3D"awspan">determinar</span><span class=3D"awspan" style=3D"letter-spacing= :-0.5pt"> </span><span class=3D"awspan">si</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">existe</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span class=3D= "awspan">una</span><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> = </span><span class=3D"awspan">correlaci=C3=B3n</span><span class=3D"awspan"= style=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">positiva</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span cl= ass=3D"awspan">entre</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">restricci=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span = class=3D"awspan">cal=C3=B3rica o</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.2pt"> </span><span class=3D"awspan">el</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">uso</= span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span c= lass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 2pt"> </span><span class=3D"awspan">mim=C3=A9ticos</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span clas= s=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt= "> </span><span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">cal=C3= =B3rica</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </spa= n><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.2pt"> </span><span class=3D"awspan">un</span><span class=3D"awspan"= style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">envejecimie= nto</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><s= pan class=3D"awspan">saludable.</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.2pt"> </span><span class=3D"awspan">Con</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">el</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span cl= ass=3D"awspan">fin de</span><span class=3D"awspan" style=3D"letter-spacing:= 0.55pt"> </span><span class=3D"awspan">validar</span><span class=3D"awspan"= style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">o</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"= awspan">descartar</span><span class=3D"awspan" style=3D"letter-spacing:0.55= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:0.55pt"> </span><span class=3D"awspan">mencionada</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"= awspan">hip=C3=B3tesis</span><span class=3D"awspan" style=3D"letter-spacing= :0.55pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">llev=C3=B3</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span clas= s=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"= > </span><span class=3D"awspan">cabo</span><span class=3D"awspan" style=3D"= letter-spacing:0.55pt"> </span><span class=3D"awspan">una</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= b=C3=BAsqueda</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt">= </span><span class=3D"awspan">exhaustiva de</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">informaci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><= span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.95pt"> </span><span class=3D"awspan">bases</span><span class=3D"awspan= " style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class= =3D"awspan">datos</span><span class=3D"awspan" style=3D"letter-spacing:0.95= pt"> </span><span class=3D"awspan">cient=C3=ADficas</span><span class=3D"aw= span" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">recono= cidas,</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span= ><span class=3D"awspan">incluidas</span><span class=3D"awspan" style=3D"let= ter-spacing:0.95pt"> </span><span class=3D"awspan">PubMed,</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan"= >LILACS, Cochrane</span><span class=3D"awspan" style=3D"letter-spacing:1.5p= t"> </span><span class=3D"awspan">Library,</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">Scopus</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"a= wspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </spa= n><span class=3D"awspan">Web</span><span class=3D"awspan" style=3D"letter-s= pacing:1.5pt"> </span><span class=3D"awspan">of</span><span class=3D"awspan= " style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">Science.</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span cla= ss=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt= "> </span><span class=3D"awspan">estrategia</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awsp= an">b=C3=BAsqueda</span><span class=3D"awspan" style=3D"letter-spacing:1.5p= t"> </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"= letter-spacing:1.5pt"> </span><span class=3D"awspan">construy=C3=B3 utiliza= ndo</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><sp= an class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing= :0.7pt"> </span><span class=3D"awspan">algoritmo</span><span class=3D"awspa= n" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">((Aging)</= span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span cl= ass=3D"awspan">OR</span><span class=3D"awspan" style=3D"letter-spacing:0.7p= t"> </span><span class=3D"awspan">(Envejecimiento))</span><span class=3D"aw= span" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">AND</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span clas= s=3D"awspan">((Caloric</span><span class=3D"awspan" style=3D"letter-spacing= :0.7pt"> </span><span class=3D"awspan">Restriction)</span><span class=3D"aw= span" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">OR (Res= tricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:5.25pt">= </span><span class=3D"awspan">cal=C3=B3rica))</span><span class=3D"awspan"= style=3D"letter-spacing:5.25pt"> </span><span class=3D"awspan">AND</span><= span class=3D"awspan" style=3D"letter-spacing:5.25pt"> </span><span class= =3D"awspan">((Caloric</span><span class=3D"awspan" style=3D"letter-spacing:= 5.25pt"> </span><span class=3D"awspan">Restriction</span><span class=3D"aws= pan" style=3D"letter-spacing:5.25pt"> </span><span class=3D"awspan">Mimetic= s)</span><span class=3D"awspan" style=3D"letter-spacing:5.25pt"> </span><sp= an class=3D"awspan">OR</span><span class=3D"awspan" style=3D"letter-spacing= :5.25pt"> </span><span class=3D"awspan">(Mim=C3=A9ticos</span><span class= =3D"awspan" style=3D"letter-spacing:5.25pt"> </span><span class=3D"awspan">= de restricci=C3=B3n cal=C3=B3rica)).</span><span class=3D"awspan">  </= span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; mar= gin-bottom:10pt"><span class=3D"awspan">Los</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">criterios</span= ><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt">= </span><span class=3D"awspan">inclusi=C3=B3n</span><span class=3D"awspan" = style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">considerados<= /span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span c= lass=3D"awspan">fueron:</span><span class=3D"awspan" style=3D"letter-spacin= g:1.5pt"> </span><span class=3D"awspan">publicaciones</span><span class=3D"= awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span cla= ss=3D"awspan">ingl=C3=A9s</span><span class=3D"awspan" style=3D"letter-spac= ing:1.5pt"> </span><span class=3D"awspan">o</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">espa=C3=B1ol</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span cla= ss=3D"awspan">que abordaran</span><span class=3D"awspan" style=3D"letter-sp= acing:0.95pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan= " style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">RC,</span>= <span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class= =3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt= "> </span><span class=3D"awspan">MRC</span><span class=3D"awspan" style=3D"= letter-spacing:0.95pt"> </span><span class=3D"awspan">y</span><span class= =3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">= su</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><sp= an class=3D"awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"let= ter-spacing:0.95pt"> </span><span class=3D"awspan">con</span><span class=3D= "awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">el<= /span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span = class=3D"awspan">envejecimiento;</span><span class=3D"awspan" style=3D"lett= er-spacing:0.95pt"> </span><span class=3D"awspan">estudios</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan"= >realizados</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> <= /span><span class=3D"awspan">en poblaciones</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">adultas</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span clas= s=3D"awspan">sanas;</span><span class=3D"awspan" style=3D"letter-spacing:-0= .45pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">trabajos</span><= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">publicados</span><span class=3D"awspan" style=3D"letter-spacing= :-0.45pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">revistas</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span cla= ss=3D"awspan">cient=C3=ADficas</span><span class=3D"awspan" style=3D"letter= -spacing:-0.45pt"> </span><span class=3D"awspan">entre</span><span class=3D= "awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">di= ciembre</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </sp= an><span class=3D"awspan">de 2019</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.65pt"> </span><span class=3D"awspan">y</span><span class=3D"= awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">dic= iembre</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.65pt"> </span><span class=3D"awspan">2024.</span><span class=3D"aw= span" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">Por</= span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span = class=3D"awspan">otro</span><span class=3D"awspan" style=3D"letter-spacing:= -0.65pt"> </span><span class=3D"awspan">lado,</span><span class=3D"awspan" = style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">se</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class= =3D"awspan">excluyeron</span><span class=3D"awspan" style=3D"letter-spacing= :-0.65pt"> </span><span class=3D"awspan">aquellos</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">estudio= s</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><sp= an class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.65pt"> </span><span class=3D"awspan">combinaban intervenciones</span><= span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span class= =3D"awspan">diet=C3=A9ticas,</span><span class=3D"awspan" style=3D"letter-s= pacing:2.75pt"> </span><span class=3D"awspan">como</span><span class=3D"aws= pan" style=3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">el</spa= n><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span clas= s=3D"awspan">ayuno</span><span class=3D"awspan" style=3D"letter-spacing:2.7= 5pt"> </span><span class=3D"awspan">intermitente</span><span class=3D"awspa= n" style=3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">o</span><= span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span class= =3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:2.75pt"= > </span><span class=3D"awspan">ejercicio,</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">sin</span><span= class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span class=3D"aw= span">un</span><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </sp= an><span class=3D"awspan">an=C3=A1lisis </span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span style=3D"heigh= 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline">www.anatomiadigital.org</span></a></p= ><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline">www.cienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" = style=3D"margin-right:1pt; 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position:absolute" /></span><span style=3D"hei= ght:0pt; display:block; position:absolute; z-index:312"><img src=3D"data:im= age/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAAAASCAYAAABWzo5XAAAABHNCSVQICAgI= fAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFUOI1VlM1PIkkYxn/VTdMNDUIM4jIxozs= BD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1EPyMrAyofY2tBde2C6d3yTSiVV9T71vE= 89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJycxDAMhxI9DBPgeUkosy6JarVIul7m6u= sKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnpyeOjo4olUo0m01c10UIAQIEAo81QCKR= YH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCqKtMz0wTUALe3t9i2DUCz2WRnZwcpJfl= 8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVkA9Ho9Dg4OmJqaGgENh0NOT0+p1+s+SC= gUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+fkI6PX1lbOzM1+DeDzOysoKoXAYx3GIR= CI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azCUA4HGZ1dRVN04hEIqiKyvbv2xT2C1jP= Fo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z26RO9bpd/W00K+3/w3H+i+e0bX76UkVI= ihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHFxQTab5f7+/n//CDFiFIvFUFXVX/Q2pJ= TEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOpqm8dTv02630TSNYDCIUEYm9SIej49KM= wyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4fX3xmWmaxvT09AgoEAiQy+WoVCrUajUc= x6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4cjAYcHx8zPb2Nt1uF0VRfA28XvNKd10= XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRVP2B+FNk2Tzc1NFhcX0TRtdMb7jKSU2L= bN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQog3QN7c7Xa5vr6mWq3SaDQQQpBKpchkM= qTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC" width=3D"18" height=3D"18" alt= =3D"" style=3D"margin-left:5.66pt; position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; color:#0563c1">www.cienciadigitaleditorial.com</span></a></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><= span style=3D"height:0pt; display:block; position:absolute; z-index:317"><i= mg src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABMAAAATCAYAAAByUDb= MAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJREFUOI1tlM1PG0cYxn= 8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICjUKglBgndWq0/ljbC= Nbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5imiZSSj4vIQRCCKFf= NCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGEYKgDP89jf32dpaYm= DgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3vD8+XMqlQpKKSzLwh= 4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgzkSemZmH5G7fRkqJ7= /skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz+H6AEJK9vb/Z3t7h= zPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A8j1QqxbWhIbLXr2M= YBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiYQRrYZBZiTD4T8HZC= yLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFKkcV1tfXeLrwlH8/v= Odb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhbn4l8MBhEsGQyeXnY= dTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZnJZEin0wA4jsNxvc7= du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD2qIFD0el06nQ7/1e= t43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRBw8ekkql0HWNP5bLv= H27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kghaDQdPtY+0mw2CcMQ= TdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5QyMrqKCqUU7Xabcrn= M+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR5KKeLxOLZtUyqVKB= QKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFTkSuQmCC" width= =3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-1pt; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = ;        </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Tel. 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positi= on:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digit= al</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador= (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Tels. 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= position:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa= Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#447= 2c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80= =93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista = Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; colo= r:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">         </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold= ; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Am= bato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Tels. 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position:absolute" /><= /span><span> </span></p><p class=3D"awdiv" style=3D"font-size:8pt; bac= kground-color:#ffffff"><span class=3D"awspan" style=3D"font-size:8pt; font-= style:italic">Esta revista est=C3=A1 protegida bajo una licencia Creative C= ommons en la 4.0 International. Copia de la licencia: </span><a href=3D"htt= p://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:no= ne"></a></p></div><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt; font-size:8pt"><a href=3D"http://creativecommons.org/licenses/by-nc-s= a/4.0/" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font= -size:8pt; text-decoration:underline; color:#0563c1">http://creativecommons= .org/licenses/by-nc-sa/4.0/</span></a></p><p style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-size:8pt"= > </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt"><span style=3D"height:0pt; display:block; position:absolute; z-index:= 345"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAE0AAAAcCAYA= AAAk2zLiAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAEz9JREFUaIHlmHt= 01NW1xz/nN7+ZzCOZPMkTJgmvBCIhgBAS4EICCI1FpXJLReBiEasVWWrrWnZpG2lRV8HHtauWWh= 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span">la</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </spa= n><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-sp= acing:1.2pt"> </span><span class=3D"awspan">o</span><span class=3D"awspan" = style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">los</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"a= wspan">MRC.</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </= span><span class=3D"awspan">Asimismo,</span><span class=3D"awspan" style=3D= "letter-spacing:1.2pt"> </span><span class=3D"awspan">se</span><span class= =3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">d= escartaron</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </s= pan><span class=3D"awspan">publicaciones</span><span class=3D"awspan" style= =3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">con</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan= ">bajo rigor metodol=C3=B3gico, duplicados y estudios enfocados en poblacio= nes con comorbilidades que pudieran influir en los resultados. </span></p><= p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class= =3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"= > </span><span class=3D"awspan">selecci=C3=B3n</span><span class=3D"awspan"= style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">estudios</span><span class=3D"awspan" style=3D"letter-spacing:0.05= pt"> </span><span class=3D"awspan">sigui=C3=B3</span><span class=3D"awspan"= style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">un</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">proceso</span><span class=3D"awspan" style=3D"letter-spacing:0.05p= t"> </span><span class=3D"awspan">riguroso</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">en</span><span = class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"aws= pan">varias</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> <= /span><span class=3D"awspan">etapas.</span><span class=3D"awspan" style=3D"= letter-spacing:0.05pt"> </span><span class=3D"awspan">En</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= primer</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span= ><span class=3D"awspan">lugar,</span><span class=3D"awspan" style=3D"letter= -spacing:0.05pt"> </span><span class=3D"awspan">se eliminaron</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awsp= an">los</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </spa= n><span class=3D"awspan">art=C3=ADculos</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">duplicados</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class= =3D"awspan">utilizando</span><span class=3D"awspan" style=3D"letter-spacing= :-0.1pt"> </span><span class=3D"awspan">software</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">especiali= zado.</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span>= <span class=3D"awspan">Posteriormente,</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">se realiz=C3=B3</= span><span class=3D"awspan" style=3D"letter-spacing:3.05pt"> </span><span c= lass=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spacing:3.= 05pt"> </span><span class=3D"awspan">revisi=C3=B3n</span><span class=3D"aws= pan" style=3D"letter-spacing:3.05pt"> </span><span class=3D"awspan">inicial= </span><span class=3D"awspan" style=3D"letter-spacing:3.05pt"> </span><span= class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:= 3.05pt"> </span><span class=3D"awspan">t=C3=ADtulo</span><span class=3D"aws= pan" style=3D"letter-spacing:3.05pt"> </span><span class=3D"awspan">y</span= ><span class=3D"awspan" style=3D"letter-spacing:3.05pt"> </span><span class= =3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:3.05pt"= > </span><span class=3D"awspan">resumen</span><span class=3D"awspan" style= =3D"letter-spacing:3.05pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.05pt"> </span><span class=3D"awspa= n">cada</span><span class=3D"awspan" style=3D"letter-spacing:3.05pt"> </spa= n><span class=3D"awspan">art=C3=ADculo,</span><span class=3D"awspan" style= =3D"letter-spacing:3.05pt"> </span><span class=3D"awspan">evaluando</span><= span class=3D"awspan" style=3D"letter-spacing:3.05pt"> </span><span class= =3D"awspan">su relevancia</span><span class=3D"awspan" style=3D"letter-spac= ing:0.6pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">funci=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span cl= ass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.6p= t"> </span><span class=3D"awspan">criterios</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">previamente</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span clas= s=3D"awspan">establecidos.</span><span class=3D"awspan" style=3D"letter-spa= cing:0.6pt"> </span><span class=3D"awspan">Los</span><span class=3D"awspan"= style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">estudios</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span clas= s=3D"awspan">seleccionados pasaron</span><span class=3D"awspan" style=3D"le= tter-spacing:2.1pt"> </span><span class=3D"awspan">a</span><span class=3D"a= wspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">una</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span cla= ss=3D"awspan">revisi=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:2.1pt"> </span><span class=3D"awspan">exhaustiva</span><span class=3D= "awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">del<= /span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span c= lass=3D"awspan">texto</span><span class=3D"awspan" style=3D"letter-spacing:= 2.1pt"> </span><span class=3D"awspan">completo,</span><span class=3D"awspan= " style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">durante</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span clas= s=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"= > </span><span class=3D"awspan">cual</span><span class=3D"awspan" style=3D"= letter-spacing:2.1pt"> </span><span class=3D"awspan">se</span><span class= =3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">v= erific=C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> <= /span><span class=3D"awspan">su adecuaci=C3=B3n</span><span class=3D"awspan= " style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">al</span><= span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class= =3D"awspan">marco</span><span class=3D"awspan" style=3D"letter-spacing:0.85= pt"> </span><span class=3D"awspan">metodol=C3=B3gico</span><span class=3D"a= wspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">y</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span cla= ss=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0.85= pt"> </span><span class=3D"awspan">objetivos</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">del</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"= awspan">estudio,</span><span class=3D"awspan" style=3D"letter-spacing:0.85p= t"> </span><span class=3D"awspan">=E2=80=9Ccomo</span><span class=3D"awspan= " style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">se</span><= span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class= =3D"awspan">muestra</span><span class=3D"awspan" style=3D"letter-spacing:0.= 85pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">la figura 1=E2=80= =9D.</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t"><span class=3D"awspan">Los</span><span class=3D"awspan" style=3D"letter-= spacing:0.4pt"> </span><span class=3D"awspan">estudios</span><span class=3D= "awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">rele= vantes</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span>= <span class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spac= ing:0.4pt"> </span><span class=3D"awspan">obtuvieron</span><span class=3D"a= wspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">en</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span clas= s=3D"awspan">texto</span><span class=3D"awspan" style=3D"letter-spacing:0.4= pt"> </span><span class=3D"awspan">completo</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">para</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"aw= span">su</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </spa= n><span class=3D"awspan">revisi=C3=B3n.</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">Los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan= ">hallazgos son</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt= "> </span><span class=3D"awspan">presentados</span><span class=3D"awspan" s= tyle=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">en</span><spa= n class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"a= wspan">forma</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> = </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lett= er-spacing:2.15pt"> </span><span class=3D"awspan">una</span><span class=3D"= awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">revi= si=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </s= pan><span class=3D"awspan">narrativa</span><span class=3D"awspan" style=3D"= letter-spacing:2.15pt"> </span><span class=3D"awspan">que</span><span class= =3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">= cubre</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:2.15pt"> </span><span class=3D"awspan">informaci=C3=B3n</span><span cla= ss=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan= ">actual disponible sobre los efectos de CR en el envejecimiento de la pobl= aci=C3=B3n general.</span></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:10pt"><span class=3D"awspan" style=3D"font-size= :10pt; font-weight:bold">Figura 1.</span><span class=3D"awspan" style=3D"fo= nt-size:10pt; font-style:italic"> Flujograma de selecci=C3=B3n de art=C3=AD= culos</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1= pt"><span class=3D"awspan" style=3D"font-weight:bold; color:#767171">3.Resu= ltados</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:= 1pt"><span class=3D"awspan" style=3D"font-weight:bold">Restricci=C3=B3n Cal= =C3=B3rica</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-l= eft:1pt"><span class=3D"awspan">La</span><span class=3D"awspan" style=3D"le= tter-spacing:1.45pt"> </span><span class=3D"awspan">restricci=C3=B3n</span>= <span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" style=3D"letter-spac= ing:1.45pt"> </span><span class=3D"awspan">es</span><span class=3D"awspan" = style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">una</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D= "awspan">intervenci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spa= cing:1.45pt"> </span><span class=3D"awspan">no</span><span class=3D"awspan"= style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">farmacol=C3= =B3gica</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </spa= n><span class=3D"awspan">ni</span><span class=3D"awspan" style=3D"letter-sp= acing:1.45pt"> </span><span class=3D"awspan">gen=C3=A9tica</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan"= >propuesta</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </= span><span class=3D"awspan">en modelos</span><span class=3D"awspan" style= =3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">experimentales,</= span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span c= lass=3D"awspan">capaz</span><span class=3D"awspan" style=3D"letter-spacing:= 0.75pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">incrementar</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span clas= s=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt= "> </span><span class=3D"awspan">esperanza</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"aws= pan">vida</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </s= pan><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-s= pacing:0.75pt"> </span><span class=3D"awspan">mejorar</span><span class=3D"= awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">la</= span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span c= lass=3D"awspan">salud. Consiste</span><span class=3D"awspan" style=3D"lette= r-spacing:0.8pt"> </span><span class=3D"awspan">en</span><span class=3D"aws= pan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">reducci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spa= cing:0.8pt"> </span><span class=3D"awspan">cr=C3=B3nica</span><span class= =3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">d= e</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span= class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0= .8pt"> </span><span class=3D"awspan">ingesta</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">cal=C3=B3rica<= /span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span c= lass=3D"awspan">total</span><span class=3D"awspan" style=3D"letter-spacing:= 0.8pt"> </span><span class=3D"awspan">sin</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">llegar</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"aw= span">a</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span= ><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spa= cing:0.8pt"> </span><span class=3D"awspan">desnutrici=C3=B3n (8).</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"= awspan">Se</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </= span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter= -spacing:-0.1pt"> </span><span class=3D"awspan">reconoce</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= tambi=C3=A9n</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> = </span><span class=3D"awspan">como</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.1pt"> </span><span class=3D"awspan">una</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= reducci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"= > </span><span class=3D"awspan">sostenida</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">en</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awsp= an">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span= ><span class=3D"awspan">ingesta</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">energ= =C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.1pt"> </span><span class=3D"awspan">los </span></p><p class=3D"awd= iv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span style= =3D"height:0pt; display:block; position:absolute; z-index:347"><img src=3D"= data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUG= BwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQU= FBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh= 4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECBwMGCAUE/= 8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSByExExQXQVFTVmGSlOMIFSJUcYGT0TI3UnWR= syMzNkJydKGy0haCsRg4Q2IkwWNzg//EABsBAQEBAQEBAQEAAAAAAAAAAAABAgMEBQYH/8QANBE= BAQACAgIABAIJAwQDAAAAAAECEQMSBFEFITFBE4EUIjI0YXGRsdGhwfAGMzXhUlPx/9oADAMBAA= IRAxEAPwDqXfGR5+77cnfGR5+77cuIf0nUfi91yzkX/P3fblO+L/n7vty4w1F3XJORf8/d9uU74= yPP3fblhKGobrk74v8An7vtyd8ZHn7vty4w1Flrk74v+fu+3KTkZHn7vtywSV1F3WffOR5+77cn= fOR5+77cuMXUZ3XJ3zkefu+3K98ZHn7vty4hNRZaznJyPP3fbk75yPP3fblxz2hqFtcnfOR5+77= cnfOR5+77cuMNRN1yTkZG39fd9uWPfOR5+57csJRdRd1yd85Hn7ntyd8ZHn7vty4w0S1yd8ZHn7= 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color:#ffffff">      = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11= pt; letter-spacing:3pt; color:#ffffff">P=C3=A1gina</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:11pt; color:#ffffff"> 74 | 88<= /span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:9pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472= c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1= o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D= "color:#ffffff">ISSN: </span><span class=3D"awspan" style=3D"font-weight:bo= ld; color:#ffffff">2697-3391</span><span class=3D"awspan" style=3D"color:#f= fffff">Vol. 8 No. 2, pp. 69 =E2=80=93 88, abril - junio 2025Revista en cien= cias m=C3=A9dicas, salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliog= r=C3=A1fica</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt"><span><svg font-family=3D"Times New Roman" font-size=3D"16" heigh= t=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/200= 0/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Roma= n'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g= ><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d"= fill-rule=3D"evenodd" /></g></g></svg></span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span class=3D"awspa= n" style=3D"font-family:Ebrima; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline">www.anatomiadigital.org</span></a></p><p style=3D"m= argin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" s= tyle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigi= taleditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:11pt; text-decoration:underline">www.c= ienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin= -right:1pt; 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (0059= 3) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size= :11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; = text-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a= ></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><a href=3D"http://www.cienciadigit= aleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" = style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http= ://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn A= mbate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">         </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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yJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDPz+97/niy++YN= y4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jy= ck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSp= U6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+= ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq= 6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XV= kJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4= vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4= tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D"28" alt=3D"= " style=3D"margin-left:441.05pt; position:absolute" /></span><span class=3D= "awspan">requerimientos</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.15pt"> </span><span class=3D"awspan">energ=C3=A9ticos</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan= ">previos</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </= span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-= spacing:-0.15pt"> </span><span class=3D"awspan">la</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">interv= enci=C3=B3n,</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt">= </span><span class=3D"awspan">mientras</span><span class=3D"awspan" style= =3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">se</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aws= pan">mantiene</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"= > </span><span class=3D"awspan">un</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.15pt"> </span><span class=3D"awspan">suministro de nutrient= es suficiente para lograr la estabilidad de peso (9). </span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspa= n">En</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><= span class=3D"awspan">humanos</span><span class=3D"awspan" style=3D"letter-= spacing:1.4pt"> </span><span class=3D"awspan">se</span><span class=3D"awspa= n" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">ha</span><= span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D= "awspan">documentado</span><span class=3D"awspan" style=3D"letter-spacing:1= .4pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style= =3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">la</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan"= >RC</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><sp= an class=3D"awspan">tiene</span><span class=3D"awspan" style=3D"letter-spac= ing:1.4pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">capacidad</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt">= </span><span class=3D"awspan">contrarrestar</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">ciertas altera= ciones</span><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span= ><span class=3D"awspan">relacionadas</span><span class=3D"awspan" style=3D"= letter-spacing:2.75pt"> </span><span class=3D"awspan">con</span><span class= =3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><sp= an class=3D"awspan">edad.</span><span class=3D"awspan" style=3D"letter-spac= ing:2.75pt"> </span><span class=3D"awspan">En</span><span class=3D"awspan" = style=3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">adultos</spa= n><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span clas= s=3D"awspan">sanos</span><span class=3D"awspan" style=3D"letter-spacing:2.7= 5pt"> </span><span class=3D"awspan">sin</span><span class=3D"awspan" style= =3D"letter-spacing:2.75pt"> </span><span class=3D"awspan">patolog=C3=ADas</= span><span class=3D"awspan" style=3D"letter-spacing:2.75pt"> </span><span c= lass=3D"awspan">subyacentes, mejor=C3=B3</span><span class=3D"awspan" style= =3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">la</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aws= pan">calidad</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.15pt"> </span><span class=3D"awspan">vida</span><span class= =3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan"= >al</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><= span class=3D"awspan">ocasionar</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.15pt"> </span><span class=3D"awspan">una</span><span class=3D"= awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">p= =C3=A9rdida</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> = </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.15pt"> </span><span class=3D"awspan">peso</span><span class= =3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan"= >de</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><= span class=3D"awspan">entre</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.15pt"> </span><span class=3D"awspan">el</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">10%</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span cla= ss=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:-0.15p= t"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"= letter-spacing:-0.15pt"> </span><span class=3D"awspan">13%.</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspa= n">Los niveles</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:0.9pt"> </span><span class=3D"awspan">insulina,</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan"= >la</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><sp= an class=3D"awspan">temperatura</span><span class=3D"awspan" style=3D"lette= r-spacing:0.9pt"> </span><span class=3D"awspan">corporal,</span><span class= =3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">e= l</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span= class=3D"awspan">gasto</span><span class=3D"awspan" style=3D"letter-spacin= g:0.9pt"> </span><span class=3D"awspan">energ=C3=A9tico</span><span class= =3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">e= n</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span= class=3D"awspan">reposo,</span><span class=3D"awspan" style=3D"letter-spac= ing:0.9pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">actividad del<= /span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span c= lass=3D"awspan">eje</span><span class=3D"awspan" style=3D"letter-spacing:0.= 3pt"> </span><span class=3D"awspan">tiroideo</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">y</span><span = class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awsp= an">el</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span>= <span class=3D"awspan">estr=C3=A9s</span><span class=3D"awspan" style=3D"le= tter-spacing:0.3pt"> </span><span class=3D"awspan">oxidativo</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan= ">se</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><s= pan class=3D"awspan">redujeron</span><span class=3D"awspan" style=3D"letter= -spacing:0.3pt"> </span><span class=3D"awspan">(8).</span><span class=3D"aw= span" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">La</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class= =3D"awspan">justificaci=C3=B3n</span><span class=3D"awspan" style=3D"letter= -spacing:0.3pt"> </span><span class=3D"awspan">para</span><span class=3D"aw= span" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">iniciar= </span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span = class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0.= 3pt"> </span><span class=3D"awspan">es disminuir</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class= =3D"awspan">tasa</span><span class=3D"awspan" style=3D"letter-spacing:-0.4p= t"> </span><span class=3D"awspan">metab=C3=B3lica,</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">energ= =C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </spa= n><span class=3D"awspan">empleada</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.4pt"> </span><span class=3D"awspan">por</span><span class=3D= "awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">el<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span = class=3D"awspan">organismo</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.4pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan"= style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">reposo</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span clas= s=3D"awspan">para</span><span class=3D"awspan" style=3D"letter-spacing:-0.4= pt"> </span><span class=3D"awspan">mantener las funciones corporales (9).</= span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><sp= an class=3D"awspan">Los</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.7pt"> </span><span class=3D"awspan">programas</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span clas= s=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-= spacing:-0.7pt"> </span><span class=3D"awspan">cal=C3=B3rica</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspa= n">por</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span= ><span class=3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.7pt"> </span><span class=3D"awspan">general</span><span class=3D"aw= span" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">pueden= </span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span= class=3D"awspan">durar</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.7pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">24</span><span= class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"aw= span">horas</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> <= /span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter= -spacing:-0.7pt"> </span><span class=3D"awspan">3</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">semanas = y</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><spa= n class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:= 0.65pt"> </span><span class=3D"awspan">caracterizan</span><span class=3D"aw= span" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">por</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span cl= ass=3D"awspan">proporcionar</span><span class=3D"awspan" style=3D"letter-sp= acing:0.65pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan= " style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">30%</span>= <span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"= > </span><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"l= etter-spacing:0.65pt"> </span><span class=3D"awspan">demandas</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awsp= an">totales</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> <= /span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lette= r-spacing:0.65pt"> </span><span class=3D"awspan">energ=C3=ADa</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awsp= an">(10).</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </s= pan><span class=3D"awspan">Los niveles</span><span class=3D"awspan" style= =3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">t=C3=ADpicos</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span clas= s=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt= "> </span><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D"l= etter-spacing:1.05pt"> </span><span class=3D"awspan">en</span><span class= =3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">= ratones</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </spa= n><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spa= cing:1.05pt"> </span><span class=3D"awspan">ratas</span><span class=3D"awsp= an" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">oscilan<= /span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span = class=3D"awspan">entre</span><span class=3D"awspan" style=3D"letter-spacing= :1.05pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">10</span><span = class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"aws= pan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span= ><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spa= cing:1.05pt"> </span><span class=3D"awspan">50%,</span><span class=3D"awspa= n" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">mientras<= /span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span = class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:1= .05pt"> </span><span class=3D"awspan">en humanos</span><span class=3D"awspa= n" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D= "awspan">mayor=C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:= 0.3pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan= ">estudios</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </s= pan><span class=3D"awspan">apuntan</span><span class=3D"awspan" style=3D"le= tter-spacing:0.3pt"> </span><span class=3D"awspan">a</span><span class=3D"a= wspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">una</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span cla= ss=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt= "> </span><span class=3D"awspan">del</span><span class=3D"awspan" style=3D"= letter-spacing:0.3pt"> </span><span class=3D"awspan">10</span><span class= =3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">a= l</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span= class=3D"awspan">25</span><span class=3D"awspan" style=3D"letter-spacing:0= .3pt"> </span><span class=3D"awspan">%</span><span class=3D"awspan" style= =3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">por</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan= ">d=C3=ADa,</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </= span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter= -spacing:0.3pt"> </span><span class=3D"awspan">RC</span><span class=3D"awsp= an" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">sin alter= aciones</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </spa= n><span class=3D"awspan">temporales</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.4pt"> </span><span class=3D"awspan">significativas</span><= span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"= > </span><span class=3D"awspan">los</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.4pt"> </span><span class=3D"awspan">patrones</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awsp= an">alimentarios</span><span class=3D"awspan" style=3D"letter-spacing:-0.4p= t"> </span><span class=3D"awspan">diarios</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">se</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awsp= an">puede</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </s= pan><span class=3D"awspan">lograr reduciendo</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">el</span><span= class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"aws= pan">tama=C3=B1o</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:0.2pt"> </span><span class=3D"awspan">las</span><span class= =3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">c= omidas</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span>= <span class=3D"awspan">(4).</span><span class=3D"awspan" style=3D"letter-sp= acing:0.2pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan"= style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">RC</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"a= wspan">consiste</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"= > </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"le= tter-spacing:0.2pt"> </span><span class=3D"awspan">reducir</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><spa= n class=3D"awspan">disponibilidad</span><span class=3D"awspan" style=3D"let= ter-spacing:0.2pt"> </span><span class=3D"awspan">de calor=C3=ADas</span><s= pan class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span class=3D"= awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </s= pan><span class=3D"awspan">hasta</span><span class=3D"awspan" style=3D"lett= er-spacing:2.5pt"> </span><span class=3D"awspan">un</span><span class=3D"aw= span" style=3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">50%,</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span cla= ss=3D"awspan">sin</span><span class=3D"awspan" style=3D"letter-spacing:2.5p= t"> </span><span class=3D"awspan">embargo,</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">sus</span><span = class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span class=3D"awsp= an">l=C3=ADmites</span><span class=3D"awspan" style=3D"letter-spacing:2.5pt= "> </span><span class=3D"awspan">deben</span><span class=3D"awspan" style= =3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">entenderse</span><= span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span class=3D= "awspan">bien</span><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> = </span><span class=3D"awspan">antes</span><span class=3D"awspan" style=3D"l= etter-spacing:2.5pt"> </span><span class=3D"awspan">de aplicarla a un human= o (11).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt"><span class=3D"awspan" style=3D"font-weight:bold">Otras intervencione= s diet=C3=A9ticas: </span></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt"><span class=3D"awspan" style=3D"font-weight:bold">Ayuno</= span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><sp= an class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-spacing= :1.55pt"> </span><span class=3D"awspan">t=C3=A9rmino</span><span class=3D"a= wspan" style=3D"letter-spacing:1.55pt"> </span><span class=3D"awspan">ayuno= </span><span class=3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span= class=3D"awspan">intermitente</span><span class=3D"awspan" style=3D"letter= -spacing:1.55pt"> </span><span class=3D"awspan">incluye</span><span class= =3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span class=3D"awspan">= diferentes</span><span class=3D"awspan" style=3D"letter-spacing:1.55pt"> </= span><span class=3D"awspan">programas</span><span class=3D"awspan" style=3D= "letter-spacing:1.55pt"> </span><span class=3D"awspan">diet=C3=A9ticos</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span clas= s=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:1.55pt"= > </span><span class=3D"awspan">corto</span><span class=3D"awspan" style=3D= "letter-spacing:1.55pt"> </span><span class=3D"awspan">y</span><span class= =3D"awspan" style=3D"letter-spacing:1.55pt"> </span><span class=3D"awspan">= largo plazo</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> <= /span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"lett= er-spacing:1.35pt"> </span><span class=3D"awspan">ciclos</span><span class= =3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">= regulares</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </s= pan><span class=3D"awspan">entre</span><span class=3D"awspan" style=3D"lett= er-spacing:1.35pt"> </span><span class=3D"awspan">el</span><span class=3D"a= wspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">momen= to</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><sp= an class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing= :1.35pt"> </span><span class=3D"awspan">comer</span><span class=3D"awspan" = style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">y</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"a= wspan">el</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </s= pan><span class=3D"awspan">ayuno.</span><span class=3D"awspan" style=3D"let= ter-spacing:1.35pt"> </span><span class=3D"awspan">(9).</span><span class= =3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">= Es</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><sp= an class=3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spacing= :1.35pt"> </span><span class=3D"awspan">t=C3=A9rmino vagamente</span><span = class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awsp= an">definido</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> <= /span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"lett= er-spacing:0.9pt"> </span><span class=3D"awspan">se</span><span class=3D"aw= span" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">aplica<= /span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span c= lass=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.9p= t"> </span><span class=3D"awspan">diferentes</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">reg=C3=ADmenes= </span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.= 9pt"> </span><span class=3D"awspan">ayuno</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">arr=C3=ADtmico,</= span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span cl= ass=3D"awspan">r=C3=ADtmico</span><span class=3D"awspan" style=3D"letter-sp= acing:0.9pt"> </span><span class=3D"awspan">o recurrente,</span><span class= =3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">= en</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><sp= an class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacin= g:0.85pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"a= wspan">reducci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:= 0.85pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">calor=C3=ADas</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span cl= ass=3D"awspan">no</span><span class=3D"awspan" style=3D"letter-spacing:0.85= pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D= "letter-spacing:0.85pt"> </span><span class=3D"awspan">logra</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspa= n">reduciendo</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt">= </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"let= ter-spacing:0.85pt"> </span><span class=3D"awspan">tama=C3=B1o</span><span = class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"aws= pan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </spa= n><span class=3D"awspan">las comidas,</span><span class=3D"awspan" style=3D= "letter-spacing:-0.6pt"> </span><span class=3D"awspan">sino</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan= ">salt=C3=A1ndose</span><span class=3D"awspan" style=3D"letter-spacing:-0.6= pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">o</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan= ">varias</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </sp= an><span class=3D"awspan">comidas</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.6pt"> </span><span class=3D"awspan">consecutivas.</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"a= wspan">Se</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </s= pan><span class=3D"awspan">caracteriza</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">por</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awsp= an">un</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span= ><span class=3D"awspan">cambio metab=C3=B3lico</span><span class=3D"awspan"= style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D= "awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> <= /span><span class=3D"awspan">dependencia</span><span class=3D"awspan" style= =3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspa= n">la</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span>= <span class=3D"awspan">glucosa</span><span class=3D"awspan" style=3D"letter= -spacing:0.35pt"> </span><span class=3D"awspan">a</span><span class=3D"awsp= an" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">metabolizaci=C3=B3n</span><span class=3D"awspan" style=3D"lette= r-spacing:0.35pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">los</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span cl= ass=3D"awspan">l=C3=ADpidos,</span><span class=3D"awspan" style=3D"letter-s= pacing:0.35pt"> </span><span class=3D"awspan">el</span><span class=3D"awspa= n" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">uso</span= ><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">de =C3=A1cidos</span><span class=3D"awspan" style=3D"letter-spa= cing:0.7pt"> </span><span class=3D"awspan">grasos</span><span class=3D"awsp= an" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">libres</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span cla= ss=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"= > </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"le= tter-spacing:0.7pt"> </span><span class=3D"awspan">producci=C3=B3n</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </s= pan><span class=3D"awspan">cuerpos</span><span class=3D"awspan" style=3D"le= tter-spacing:0.7pt"> </span><span class=3D"awspan">cet=C3=B3nicos</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"a= wspan">en</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </sp= an><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-s= pacing:0.7pt"> </span><span class=3D"awspan">h=C3=ADgado.</span><span class= =3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">I= nicia</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><= span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.7pt"> </span><span class=3D"awspan">forma gradual</span><span class=3D= "awspan" style=3D"letter-spacing:5.55pt"> </span><span class=3D"awspan">des= pu=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:5.55pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:5.55pt"> </span><span class=3D"awspan">12</span><span class=3D"awsp= an" style=3D"letter-spacing:5.55pt"> </span><span class=3D"awspan">a</span>= <span class=3D"awspan" style=3D"letter-spacing:5.55pt"> </span><span class= =3D"awspan">36</span><span class=3D"awspan" style=3D"letter-spacing:5.55pt"= > </span><span class=3D"awspan">h</span><span class=3D"awspan" style=3D"let= ter-spacing:5.55pt"> </span><span class=3D"awspan">de</span><span class=3D"= awspan" style=3D"letter-spacing:5.55pt"> </span><span class=3D"awspan">abst= inencia</span><span class=3D"awspan" style=3D"letter-spacing:5.55pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:5.55pt"> </span><span class=3D"awspan">alimentos,</span><span class= =3D"awspan" style=3D"letter-spacing:5.55pt"> </span><span class=3D"awspan">= dependiendo</span><span class=3D"awspan" style=3D"letter-spacing:5.55pt"> <= /span><span class=3D"awspan">del almacenamiento</span><span class=3D"awspan= " style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">basal</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span clas= s=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt= "> </span><span class=3D"awspan">gluc=C3=B3geno</span><span class=3D"awspan= " style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">hep=C3=A1t= ico,</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><= span class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spac= ing:1.15pt"> </span><span class=3D"awspan">niveles</span><span class=3D"aws= pan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span clas= s=3D"awspan">actividad</span><span class=3D"awspan" style=3D"letter-spacing= :1.15pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">otros</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"a= wspan">factores (4).</span><span class=3D"awspan" style=3D"letter-spacing:0= .25pt"> </span><span class=3D"awspan">Existen</span><span class=3D"awspan" = style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">varios</span= ><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">tipos</span><span class=3D"awspan" style=3D"letter-spacing:0.25= pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D= "letter-spacing:0.25pt"> </span><span class=3D"awspan">ayuno</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspa= n">intermitente</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt= "> </span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"= letter-spacing:0.25pt"> </span><span class=3D"awspan">duraciones</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"a= wspan">desde</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> = </span><span class=3D"awspan">12</span><span class=3D"awspan" style=3D"lett= er-spacing:0.25pt"> </span><span class=3D"awspan">horas</span><span class= =3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">= comiendo y</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </s= pan><span class=3D"awspan">12</span><span class=3D"awspan" style=3D"letter-= spacing:1.2pt"> </span><span class=3D"awspan">horas</span><span class=3D"aw= span" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class= =3D"awspan">ayuno,</span><span class=3D"awspan" style=3D"letter-spacing:1.2= pt"> </span><span class=3D"awspan">hasta</span><span class=3D"awspan" style= =3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">4</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">= horas</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><= span class=3D"awspan">comiendo</span><span class=3D"awspan" style=3D"letter= -spacing:1.2pt"> </span><span class=3D"awspan">y</span><span class=3D"awspa= n" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">20</span><= span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D= "awspan">horas</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:1.2pt"> </span><span class=3D"awspan">ayuno</span><span class= =3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">o= </span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span = class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:1.= 2pt"> </span><span class=3D"awspan">puede</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">aplicar semanalme= nte con 5 d=C3=ADas de comida y 2 d=C3=ADas de ayuno (12).</span></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt= "><span class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-sp= acing:1.9pt"> </span><span class=3D"awspan">alimentaci=C3=B3n</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspa= n">con</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span>= <span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">de</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan"= >tiempo</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span= ><span class=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spa= cing:1.9pt"> </span><span class=3D"awspan">un</span><span class=3D"awspan" = style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">patr=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span cl= ass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.9p= t"> </span><span class=3D"awspan">alimentaci=C3=B3n</span><span class=3D"aw= span" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">que</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span clas= s=3D"awspan">implica restringir</span><span class=3D"awspan" style=3D"lette= r-spacing:0.25pt"> </span><span class=3D"awspan">la</span><span class=3D"aw= span" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">ingest= a</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= 0.25pt"> </span><span class=3D"awspan">alimentos</span><span class=3D"awspa= n" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">a</span><= span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">per=C3=ADodos</span><span class=3D"awspan" style=3D"letter-spac= ing:0.25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">tiempo</span= ><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">espec=C3=ADficos</span><span class=3D"awspan" style=3D"letter-s= pacing:0.25pt"> </span><span class=3D"awspan">del</span><span class=3D"awsp= an" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">d=C3=ADa= ,</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><spa= n class=3D"awspan">generalmente entre</span><span class=3D"awspan" style=3D= "letter-spacing:-0.3pt"> </span><span class=3D"awspan">8</span><span class= =3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">= y</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><spa= n class=3D"awspan">12</span><span class=3D"awspan" style=3D"letter-spacing:= -0.3pt"> </span><span class=3D"awspan">h</span><span class=3D"awspan" style= =3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">cada</span><span = class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"aws= pan">d=C3=ADa.</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"= > </span><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.3pt"> </span><span class=3D"awspan">ayuno</span><span class= =3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">= en</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><sp= an class=3D"awspan">d=C3=ADas</span><span class=3D"awspan" style=3D"letter-= spacing:-0.3pt"> </span><span class=3D"awspan">alternos</span><span class= =3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">= implica</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </spa= n><span class=3D"awspan">no</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.3pt"> </span><span class=3D"awspan">consumir</span><span class=3D"= awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">calo= r=C3=ADas</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </s= pan><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-= spacing:-0.3pt"> </span><span class=3D"awspan">los</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">d=C3=AD= as de</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span>= <span class=3D"awspan">ayuno</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.6pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan= " style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">alternar</= span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span c= lass=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:-0= .6pt"> </span><span class=3D"awspan">d=C3=ADas</span><span class=3D"awspan"= style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D= "awspan">ayuno</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"= > </span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.6pt"> </span><span class=3D"awspan">un</span><span class= =3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">= d=C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </sp= an><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.6pt"> </span><span class=3D"awspan">ingesta</span><span class=3D"= awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">ilim= itada.</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span= ><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.6pt"> </span><span class=3D"awspan">ayuno</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">modifica= do en</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span>= <span class=3D"awspan">d=C3=ADas</span><span class=3D"awspan" style=3D"lett= er-spacing:1.85pt"> </span><span class=3D"awspan">alternos</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan"= >consiste</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </s= pan><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-= spacing:1.85pt"> </span><span class=3D"awspan">consumir</span><span class= =3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">= menos</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span>= <span class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spa= cing:1.85pt"> </span><span class=3D"awspan">25%</span><span class=3D"awspan= " style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class= =3D"awspan">las</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt= "> </span><span class=3D"awspan">necesidades</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">energ=C3=A9ti= cas </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><span style=3D"height:0pt; display:block; position:absol= ute; z-index:415"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYA= BgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYG= h0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4e= Hh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQA= CAwEBAAAAAAAAAAAAAAECBwMGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSByExEx= QXQVFTVmGSlOMIFSJUcYGT0TI3UnWRsyMzNkJydKGy0haCsRg4Q2IkwWNzg//EABsBAQEBAQEBA= QEAAAAAAAAAAAABAgMEBQYH/8QANBEBAQACAgIABAIJAwQDAAAAAAECEQMSBFEFITFBE4EUIjI0= YXGRsdGhwfAGMzXhUlPx/9oADAMBAAIRAxEAPwDqXfGR5+77cnfGR5+77cuIf0nUfi91yzkX/P3= fblO+L/n7vty4w1F3XJORf8/d9uU74yPP3fblhKGobrk74v8An7vtyd8ZHn7vty4w1Flrk74v+f= u+3KTkZHn7vtywSV1F3WffOR5+77cnfOR5+77cuMXUZ3XJ3zkefu+3K98ZHn7vty4hNRZaznJyP= 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position:absolute" /></spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4= 472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D= "color:#ffffff">ISSN: </span><span class=3D"awspan" style=3D"font-weight:bo= ld; color:#ffffff">2697-3391</span><span class=3D"awspan" style=3D"color:#f= fffff">Vol. 8 No. 2, pp. 69 =E2=80=93 88, abril - junio 2025Revista en cien= cias m=C3=A9dicas, salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliog= r=C3=A1fica</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt"><span><svg font-family=3D"Times New Roman" font-size=3D"16" heigh= t=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/200= 0/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Roma= n'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g= ><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d"= fill-rule=3D"evenodd" /></g></g></svg></span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span class=3D"awspa= n" style=3D"font-family:Ebrima; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline">www.anatomiadigital.org</span></a></p><p style=3D"m= argin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" s= tyle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigi= taleditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:11pt; text-decoration:underline">www.c= ienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin= -right:1pt; 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (0059= 3) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size= :11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; = text-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a= ></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><a href=3D"http://www.cienciadigit= aleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" = style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http= ://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn A= mbate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">         </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"aws= pan">de</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span= ><span class=3D"awspan">=E2=80=9Cayuno=E2=80=9D,</span><span class=3D"awspa= n" style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspan">alternados= </span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span = class=3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:3= .9pt"> </span><span class=3D"awspan">un</span><span class=3D"awspan" style= =3D"letter-spacing:3.9pt"> </span><span class=3D"awspan">d=C3=ADa</span><sp= an class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"a= wspan">de</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </sp= an><span class=3D"awspan">ingesta</span><span class=3D"awspan" style=3D"let= ter-spacing:3.9pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspan">alimen= tos</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><sp= an class=3D"awspan">sin restricciones.</span><span class=3D"awspan" style= =3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">El</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspa= n">ayuno</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </sp= an><span class=3D"awspan">peri=C3=B3dico</span><span class=3D"awspan" style= =3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">hace</span><span = class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"aws= pan">referencia</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt= "> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.2pt"> </span><span class=3D"awspan">ayunar</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan"= >=C3=BAnicamente</span><span class=3D"awspan" style=3D"letter-spacing:-0.2p= t"> </span><span class=3D"awspan">uno</span><span class=3D"awspan" style=3D= "letter-spacing:-0.2pt"> </span><span class=3D"awspan">o</span><span class= =3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">= dos</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><s= pan class=3D"awspan">d=C3=ADas</span><span class=3D"awspan" style=3D"letter= -spacing:-0.2pt"> </span><span class=3D"awspan">a</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">la seman= a</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><spa= n class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0= .55pt"> </span><span class=3D"awspan">consumir</span><span class=3D"awspan"= style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">alimentos</= span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span c= lass=3D"awspan">ad</span><span class=3D"awspan" style=3D"letter-spacing:0.5= 5pt"> </span><span class=3D"awspan">libitum</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">(a</span><span= class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"aw= span">libre</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> <= /span><span class=3D"awspan">demanda)</span><span class=3D"awspan" style=3D= "letter-spacing:0.55pt"> </span><span class=3D"awspan">entre</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspa= n">5</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><= span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacin= g:0.55pt"> </span><span class=3D"awspan">6</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">d=C3=ADas</span= ><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class= =3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:0.55pt"> </span><span class=3D"awspan">semana (5).</span><span = class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awsp= an">La</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span>= <span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">diet=C3=A9tica,</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span cla= ss=3D"awspan">describe</span><span class=3D"awspan" style=3D"letter-spacing= :0.8pt"> </span><span class=3D"awspan">m=C3=A1s</span><span class=3D"awspan= " style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">bien</span>= <span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt">= </span><span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan= " style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"= awspan">macronutrientes</span><span class=3D"awspan" style=3D"letter-spacin= g:0.8pt"> </span><span class=3D"awspan">(p.</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">ej., prote=C3= =ADnas, carbohidratos y amino=C3=A1cidos) en lugar de la ingesta general de= alimentos (4).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt"><span class=3D"awspan" style=3D"font-weight:bold">Envejecimie= nto</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= "><span class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.2pt"> </span><span class=3D"awspan">salud</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">y</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class= =3D"awspan">supervivencia</span><span class=3D"awspan" style=3D"letter-spac= ing:-0.2pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">un</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"= awspan">organismo</span><span class=3D"awspan" style=3D"letter-spacing:-0.2= pt"> </span><span class=3D"awspan">org=C3=A1nico</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">es</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class= =3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"= > </span><span class=3D"awspan">proceso</span><span class=3D"awspan" style= =3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspa= n">equilibrio</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt">= </span><span class=3D"awspan">din=C3=A1mico entre</span><span class=3D"aws= pan" style=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">el</spa= n><span class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span clas= s=3D"awspan">proceso</span><span class=3D"awspan" style=3D"letter-spacing:3= .85pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">da=C3=B1o</span><= span class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span class= =3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:3.85pt">= </span><span class=3D"awspan">reparaci=C3=B3n,</span><span class=3D"awspan= " style=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">ocurrencia= </span><span class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span= class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:3.= 85pt"> </span><span class=3D"awspan">mantenimiento.</span><span class=3D"aw= span" style=3D"letter-spacing:3.85pt"> </span><span class=3D"awspan">El</sp= an><span class=3D"awspan" style=3D"letter-spacing:3.85pt"> </span><span cla= ss=3D"awspan">concepto tradicional</span><span class=3D"awspan" style=3D"le= tter-spacing:6.2pt"> </span><span class=3D"awspan">homeostasis,</span><span= class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"aws= pan">no</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span= ><span class=3D"awspan">contiene</span><span class=3D"awspan" style=3D"lett= er-spacing:6.2pt"> </span><span class=3D"awspan">procesos</span><span class= =3D"awspan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"awspan">d= in=C3=A1micos</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> = </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"lette= r-spacing:6.2pt"> </span><span class=3D"awspan">la</span><span class=3D"aws= pan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"awspan">compleji= dad</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><sp= an class=3D"awspan">de interacciones</span><span class=3D"awspan" style=3D"= letter-spacing:6.2pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"awspan">l= os</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><spa= n class=3D"awspan">sistemas</span><span class=3D"awspan" style=3D"letter-sp= acing:6.2pt"> </span><span class=3D"awspan">biol=C3=B3gicos.</span><span cl= ass=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"awspan= ">Por</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><= span class=3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spaci= ng:6.2pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" s= tyle=3D"letter-spacing:6.2pt"> </span><span class=3D"awspan">se</span><span= class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span><span class=3D"aws= pan">ha</span><span class=3D"awspan" style=3D"letter-spacing:6.2pt"> </span= ><span class=3D"awspan">reemplazado</span><span class=3D"awspan" style=3D"l= etter-spacing:6.2pt"> </span><span class=3D"awspan">por homeodin=C3=A1mica<= /span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span c= lass=3D"awspan">dado</span><span class=3D"awspan" style=3D"letter-spacing:0= .2pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style= =3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan= ">sistemas</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </s= pan><span class=3D"awspan">biol=C3=B3gicos</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">no</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspa= n">son</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span>= <span class=3D"awspan">permanentes</span><span class=3D"awspan" style=3D"le= tter-spacing:0.2pt"> </span><span class=3D"awspan">o</span><span class=3D"a= wspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">inmuta= bles.</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><= span class=3D"awspan">Sus principales</span><span class=3D"awspan" style=3D= "letter-spacing:-0.15pt"> </span><span class=3D"awspan">caracter=C3=ADstica= s</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><sp= an class=3D"awspan">son</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.15pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">control</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span cla= ss=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.15= pt"> </span><span class=3D"awspan">da=C3=B1os,</span><span class=3D"awspan"= style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">respuesta<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span= class=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">y</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span cla= ss=3D"awspan">remodelaci=C3=B3n. </span><span class=3D"awspan"> </span= ><span class=3D"awspan">El envejecimiento</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">se</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan= ">define</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </spa= n><span class=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-= spacing:0.3pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">contracci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span= ><span class=3D"awspan">gradual</span><span class=3D"awspan" style=3D"lette= r-spacing:0.3pt"> </span><span class=3D"awspan">del</span><span class=3D"aw= span" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">espacio= </span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span = class=3D"awspan">homeodin=C3=A1mico.</span><span class=3D"awspan" style=3D"= letter-spacing:0.3pt"> </span><span class=3D"awspan">Esta comprensi=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span c= lass=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:2.= 5pt"> </span><span class=3D"awspan">envejecimiento</span><span class=3D"aws= pan" style=3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">ha</span= ><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span class= =3D"awspan">llevado</span><span class=3D"awspan" style=3D"letter-spacing:2.= 5pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D= "letter-spacing:2.5pt"> </span><span class=3D"awspan">un</span><span class= =3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">c= ambio</span><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><= span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spaci= ng:2.5pt"> </span><span class=3D"awspan">nuestro</span><span class=3D"awspa= n" style=3D"letter-spacing:2.5pt"> </span><span class=3D"awspan">enfoque</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.5pt"> </span><span cla= ss=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:2.5pt= "> </span><span class=3D"awspan">las intervenciones para el envejecimiento = (2).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t"><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-s= pacing:3.25pt"> </span><span class=3D"awspan">envejecimiento</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class=3D"awspa= n">tambi=C3=A9n</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt= "> </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"l= etter-spacing:3.25pt"> </span><span class=3D"awspan">conceptualiza</span><s= pan class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class=3D= "awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt">= </span><span class=3D"awspan">una</span><span class=3D"awspan" style=3D"le= tter-spacing:3.25pt"> </span><span class=3D"awspan">disminuci=C3=B3n</span>= <span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class= =3D"awspan">gradual</span><span class=3D"awspan" style=3D"letter-spacing:3.= 25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">las funciones</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span clas= s=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"= > </span><span class=3D"awspan">los</span><span class=3D"awspan" style=3D"l= etter-spacing:1.7pt"> </span><span class=3D"awspan">=C3=B3rganos</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"aw= span">y</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span= ><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spa= cing:1.7pt"> </span><span class=3D"awspan">cuerpo,</span><span class=3D"aws= pan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">que</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class= =3D"awspan">conduce</span><span class=3D"awspan" style=3D"letter-spacing:1.= 7pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D= "letter-spacing:1.7pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">v= ulnerabilidad</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> = </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"lette= r-spacing:1.7pt"> </span><span class=3D"awspan">los</span><span class=3D"aw= span" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">desaf= =C3=ADos ambientales</span><span class=3D"awspan" style=3D"letter-spacing:0= .8pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">al</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan"= >aumento</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </spa= n><span class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-s= pacing:0.8pt"> </span><span class=3D"awspan">riesgo</span><span class=3D"aw= span" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">enfermedad</span><span class=3D"awspan" style=3D"letter-spacing= :0.8pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">muerte</span><span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"aws= pan">(7).</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </sp= an><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-s= pacing:0.8pt"> </span><span class=3D"awspan">envejecimiento</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan"= >se caracteriza</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt= "> </span><span class=3D"awspan">por</span><span class=3D"awspan" style=3D"= letter-spacing:1.25pt"> </span><span class=3D"awspan">dos</span><span class= =3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">= aspectos</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </sp= an><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-= spacing:1.25pt"> </span><span class=3D"awspan">guardan</span><span class=3D= "awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">rel= aci=C3=B3n:</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> <= /span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"lette= r-spacing:1.25pt"> </span><span class=3D"awspan">mal</span><span class=3D"a= wspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">funci= onamiento</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:1.25pt"> </span><span class=3D"awspan">procesos biol=C3=B3gicos</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span cla= ss=3D"awspan">b=C3=A1sicos</span><span class=3D"awspan" style=3D"letter-spa= cing:1.65pt"> </span><span class=3D"awspan">acompa=C3=B1ado</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan= ">del</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span>= <span class=3D"awspan">paralelo</span><span class=3D"awspan" style=3D"lette= r-spacing:1.65pt"> </span><span class=3D"awspan">deterioro</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan"= >funcional.</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> <= /span><span class=3D"awspan">Recientemente</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">se</span><span = class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"aws= pan">ha planteado</span><span class=3D"awspan" style=3D"letter-spacing:3.75= pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style= =3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span class=3D"awspa= n">envejecimiento</span><span class=3D"awspan" style=3D"letter-spacing:3.75= pt"> </span><span class=3D"awspan">est=C3=A1</span><span class=3D"awspan" s= tyle=3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">determinado</= span><span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span c= lass=3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:3.= 75pt"> </span><span class=3D"awspan">nueve</span><span class=3D"awspan" sty= le=3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">procesos</span>= <span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span class= =3D"awspan">biol=C3=B3gicos: inestabilidad</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">gen=C3=B3mica,<= /span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span = class=3D"awspan">desgaste</span><span class=3D"awspan" style=3D"letter-spac= ing:0.45pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">los</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D= "awspan">tel=C3=B3meros,</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.45pt"> </span><span class=3D"awspan">alteraciones</span><span class=3D= "awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">epi= gen=C3=A9ticas,</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt= "> </span><span class=3D"awspan">p=C3=A9rdida</span><span class=3D"awspan" = style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">de proteosta= sis,</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><= span class=3D"awspan">detecci=C3=B3n</span><span class=3D"awspan" style=3D"= letter-spacing:1.15pt"> </span><span class=3D"awspan">desregulada</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </= span><span class=3D"awspan">nutrientes,</span><span class=3D"awspan" style= =3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">disfunci=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span c= lass=3D"awspan">mitocondrial,</span><span class=3D"awspan" style=3D"letter-= spacing:1.15pt"> </span><span class=3D"awspan">senescencia celular, agotami= ento de las c=C3=A9lulas madre y comunicaci=C3=B3n intercelular alterada (1= ).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><span class=3D"awspan">Envejecimiento</span><span class=3D"awspan" style= =3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">primario,</span><= span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class= =3D"awspan">reconocido</span><span class=3D"awspan" style=3D"letter-spacing= :0.15pt"> </span><span class=3D"awspan">como</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">el</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"a= wspan">proceso</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"= > </span><span class=3D"awspan">inevitable</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">relacionado</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span cla= ss=3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:0.15= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:0.15pt"> </span><span class=3D"awspan">tasa metab=C3=B3lica= </span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span= class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:2.= 45pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">acumulaci=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:2.= 45pt"> </span><span class=3D"awspan">da=C3=B1o</span><span class=3D"awspan"= style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">oxidativo.<= /span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span = class=3D"awspan">Justifica</span><span class=3D"awspan" style=3D"letter-spa= cing:2.45pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan"= style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">reducci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><= span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spaci= ng:2.45pt"> </span><span class=3D"awspan">funciones fisiol=C3=B3gicas</span= ><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">asociadas</span><span class=3D"awspan" style=3D"letter-spacing:= 0.35pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style= =3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspa= n">edad</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </spa= n><span class=3D"awspan">debido</span><span class=3D"awspan" style=3D"lette= r-spacing:0.35pt"> </span><span class=3D"awspan">al</span><span class=3D"aw= span" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">gasto<= /span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span = class=3D"awspan">energ=C3=A9tico</span><span class=3D"awspan" style=3D"lett= er-spacing:0.35pt"> </span><span class=3D"awspan">fundamentado</span><span = class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"aws= pan">en</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </spa= n><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-sp= acing:0.35pt"> </span><span class=3D"awspan">teor=C3=ADa</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">= de la</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><= span class=3D"awspan">tasa</span><span class=3D"awspan" style=3D"letter-spa= cing:1.6pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">vida</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"= awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </sp= an><span class=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-s= pacing:1.6pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">o= xidativo</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </spa= n><span class=3D"awspan">consolidado</span><span class=3D"awspan" style=3D"= letter-spacing:1.6pt"> </span><span class=3D"awspan">por</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">l= a</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span= class=3D"awspan">teor=C3=ADa</span><span class=3D"awspan" style=3D"letter-= spacing:1.6pt"> </span><span class=3D"awspan">del</span><span class=3D"awsp= an" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">envejecim= iento</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><= span class=3D"awspan">por radicales</span><span class=3D"awspan" style=3D"l= etter-spacing:0.55pt"> </span><span class=3D"awspan">libres.</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspa= n">El</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span>= <span class=3D"awspan">envejecimiento</span><span class=3D"awspan" style=3D= "letter-spacing:0.55pt"> </span><span class=3D"awspan">secundario</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"= awspan">abarca</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"= > </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"le= tter-spacing:0.55pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span= class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"aw= span">ambiental</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt= "> </span><span class=3D"awspan">extr=C3=ADnseco</span><span class=3D"awspa= n" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">que acele= ra</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><sp= an class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing= :1.45pt"> </span><span class=3D"awspan">envejecimiento</span><span class=3D= "awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">pri= mario</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span>= <span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.45pt"> </span><span class=3D"awspan">aumenta</span><span class=3D"awsp= an" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">mortalidad</span><span class=3D"awspan" style=3D"letter-spacing= :1.45pt"> </span><span class=3D"awspan">asociada</span><span class=3D"awspa= n" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">a</span><= span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">enfermedades, como estilos de vida poco saludables y enfermedad= es (13).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt"><span class=3D"awspan" style=3D"font-weight:bold">Restricci=C3=B3n</= span><span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4p= t"> </span><span class=3D"awspan" style=3D"font-weight:bold">cal=C3=B3rica<= /span><span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4= pt"> </span><span class=3D"awspan" style=3D"font-weight:bold">como</span><s= pan class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4pt"> </s= pan><span class=3D"awspan" style=3D"font-weight:bold">intervenci=C3=B3n</sp= an><span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4pt"= > </span><span class=3D"awspan" style=3D"font-weight:bold">nutricional</spa= n><span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4pt">= </span><span class=3D"awspan" style=3D"font-weight:bold">para</span><span = class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.4pt"> </span>= <span class=3D"awspan" style=3D"font-weight:bold">el</span><span class=3D"a= wspan" style=3D"font-weight:bold; letter-spacing:-0.4pt"> </span><span clas= s=3D"awspan" style=3D"font-weight:bold">envejecimiento</span><span class=3D= "awspan" style=3D"font-weight:bold; letter-spacing:-0.4pt"> </span><span cl= ass=3D"awspan" style=3D"font-weight:bold">saludable</span></p><p class=3D"a= wdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan" st= yle=3D"font-weight:bold">Autofagia </span></p><p class=3D"awdiv" style=3D"m= argin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span class=3D"awspan= ">Mecanismos celulares relacionados con la autoalimentaci=C3=B3n que favore= ce que las c=C3=A9lulas puedan</span><span class=3D"awspan" style=3D"letter= -spacing:1.85pt"> </span><span class=3D"awspan">eliminar</span><span class= =3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">= prote=C3=ADnas</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"= > </span><span class=3D"awspan">agregadas</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">y</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspa= n">mal</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span= ><span class=3D"awspan">plegadas,</span><span class=3D"awspan" style=3D"let= ter-spacing:1.85pt"> </span><span class=3D"awspan">as=C3=AD</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan= ">como</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span= ><span class=3D"awspan">org=C3=A1nulos</span><span class=3D"awspan" style= =3D"letter-spacing:1.85pt"> </span><span class=3D"awspan">lesionados. Inves= tigaciones</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </= span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-= spacing:0.35pt"> </span><span class=3D"awspan">nivel</span><span class=3D"a= wspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">molec= ular</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><= span class=3D"awspan">revelan</span><span class=3D"awspan" style=3D"letter-= spacing:0.35pt"> </span><span class=3D"awspan">que</span><span class=3D"aws= pan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">niveles= </span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span= class=3D"awspan">bajos</span><span class=3D"awspan" style=3D"letter-spacin= g:0.35pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">energ=C3=ADa</= span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span c= lass=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0.35= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:0.35pt"> </span><span class=3D"awspan">privaci=C3=B3n</span= ><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">de </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:11pt"><span style=3D"height:0pt; display:block; pos= ition:absolute; z-index:483"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZ= JRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXEx= QaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eH= h4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB= /8QAHAABAQACAwEBAAAAAAAAAAAAAAECBwMGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQ= FEQYSByExExQXQVFTVmGSlOMIFSJUcYGT0TI3UnWRsyMzNkJydKGy0haCsRg4Q2IkwWNzg//EAB= 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font-size:11pt; color:#f= fffff"> 76 | 88</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:9pt"><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=AD= a</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">  </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">D= igital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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position:absolute"= /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9p= t; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn A= mbate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">         </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:= absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weig= ht:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; colo= r:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4= 472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Tels. 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Directo (00593) 0998-235-4= 85</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><a href=3D"http:/= /www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decora= tion:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.cienciadigitaleditorial= .com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"ma= rgin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = ;        </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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positi= on:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (J= ard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">= Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#447= 2c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80= =93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Tels. 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cNoeC2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDP= z+97/niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz= 8qVK9m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdEC= AXp6nDRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m= 7di0Oh4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7= /88sawSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1s= njxYkpKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcH= C2BlZSU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY= 2nnvuOXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D= "28" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></span><s= pan class=3D"awspan">nutrientes</span><span class=3D"awspan" style=3D"lette= r-spacing:1.35pt"> </span><span class=3D"awspan">esenciales</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan= ">como</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span= ><span class=3D"awspan">glucosa</span><span class=3D"awspan" style=3D"lette= r-spacing:1.35pt"> </span><span class=3D"awspan">y</span><span class=3D"aws= pan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">amino= =C3=A1cidos</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> <= /span><span class=3D"awspan">pueden</span><span class=3D"awspan" style=3D"l= etter-spacing:1.35pt"> </span><span class=3D"awspan">conducir</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awsp= an">al</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span= ><span class=3D"awspan">agotamiento</span><span class=3D"awspan" style=3D"l= etter-spacing:1.35pt"> </span><span class=3D"awspan">de ATP e inducci=C3=B3= n de la autofagia (10)</span></p><p class=3D"awdiv" style=3D"margin-right:1= pt; margin-left:1pt"><span class=3D"awspan">La</span><span class=3D"awspan"= style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">autofagia</s= pan><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span cla= ss=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt= "> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"l= etter-spacing:3.2pt"> </span><span class=3D"awspan">mecanismo</span><span c= lass=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspa= n">de</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><= span class=3D"awspan">remodelaci=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">de</span><span cla= ss=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan"= >c=C3=A9lulas</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> = </span><span class=3D"awspan">eucariotas</span><span class=3D"awspan" style= =3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">mediada</span><spa= n class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"aw= span">por lisosoma</span><span class=3D"awspan" style=3D"letter-spacing:0.5= 5pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D= "letter-spacing:0.55pt"> </span><span class=3D"awspan">trav=C3=A9s</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D= "awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> = </span><span class=3D"awspan">cual</span><span class=3D"awspan" style=3D"le= tter-spacing:0.55pt"> </span><span class=3D"awspan">se</span><span class=3D= "awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">rec= iclan</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span>= <span class=3D"awspan">sus</span><span class=3D"awspan" style=3D"letter-spa= cing:0.55pt"> </span><span class=3D"awspan">componentes</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= da=C3=B1ados</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> = </span><span class=3D"awspan">o</span><span class=3D"awspan" style=3D"lette= r-spacing:0.55pt"> </span><span class=3D"awspan">disfuncionales.</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"a= wspan">Se</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </s= pan><span class=3D"awspan">ha demostrado</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">que</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacin= g:0.4pt"> </span><span class=3D"awspan">promueve</span><span class=3D"awspa= n" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D= "awspan">autofagia</span><span class=3D"awspan" style=3D"letter-spacing:0.4= pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"= letter-spacing:0.4pt"> </span><span class=3D"awspan">se</span><span class= =3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">c= ree</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><sp= an class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacin= g:0.4pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">mecanismo</span>= <span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"= > </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"le= tter-spacing:0.4pt"> </span><span class=3D"awspan">cual</span><span class= =3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">s= e relaciona</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> <= /span><span class=3D"awspan">este</span><span class=3D"awspan" style=3D"let= ter-spacing:0.95pt"> </span><span class=3D"awspan">proceso</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan"= >y</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><sp= an class=3D"awspan">las</span><span class=3D"awspan" style=3D"letter-spacin= g:0.95pt"> </span><span class=3D"awspan">v=C3=ADas</span><span class=3D"aws= pan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span clas= s=3D"awspan">detecci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:0.95pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan= " style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">nutrientes= </span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span= class=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spacing:0= .95pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">v=C3=ADa</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D= "awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> = </span><span class=3D"awspan">objetivo</span><span class=3D"awspan" style= =3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspa= n">la rapamicina</span><span class=3D"awspan" style=3D"letter-spacing:2.6pt= "> </span><span class=3D"awspan">mTOR,</span><span class=3D"awspan" style= =3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">una</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan= ">serina/treonina</span><span class=3D"awspan" style=3D"letter-spacing:2.6p= t"> </span><span class=3D"awspan">quinasa.</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">La</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspa= n">deficiencia</span><span class=3D"awspan" style=3D"letter-spacing:2.6pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:2.6pt"> </span><span class=3D"awspan">nutrientes</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan= ">que</span><span class=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><= span class=3D"awspan">se produce</span><span class=3D"awspan" style=3D"lett= er-spacing:0.2pt"> </span><span class=3D"awspan">durante</span><span class= =3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">l= a</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span= class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0= .2pt"> </span><span class=3D"awspan">inhibe</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">la</span><span = class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awsp= an">v=C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> <= /span><span class=3D"awspan">mTOR</span><span class=3D"awspan" style=3D"let= ter-spacing:0.2pt"> </span><span class=3D"awspan">y</span><span class=3D"aw= span" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">regula<= /span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span c= lass=3D"awspan">negativamente</span><span class=3D"awspan" style=3D"letter-= spacing:0.2pt"> </span><span class=3D"awspan">mTOR1,</span><span class=3D"a= wspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">esta</= span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span cl= ass=3D"awspan">=C3=BAltima se</span><span class=3D"awspan" style=3D"letter-= spacing:-0.1pt"> </span><span class=3D"awspan">encarga</span><span class=3D= "awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span = class=3D"awspan">inhibir</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.1pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">autofagia</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span cla= ss=3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= pt"> </span><span class=3D"awspan">medio</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspa= n">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span>= <span class=3D"awspan">fosforilaci=C3=B3n</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">e</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspa= n">inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 1pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">complejo ULK (12)= . </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"= ><span class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spa= cing:0.55pt"> </span><span class=3D"awspan">autofagia</span><span class=3D"= awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">est= =C3=A1</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span= ><span class=3D"awspan">regulada</span><span class=3D"awspan" style=3D"lett= er-spacing:0.55pt"> </span><span class=3D"awspan">por</span><span class=3D"= awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">se= =C3=B1ales</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.55pt"> </span><span class=3D"awspan">detecci=C3=B3n</span><span = class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"aws= pan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </spa= n><span class=3D"awspan">nutrientes.</span><span class=3D"awspan" style=3D"= letter-spacing:0.55pt"> </span><span class=3D"awspan">La</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= se=C3=B1alizaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing= :0.55pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">la autofagia</s= pan><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </span><span cla= ss=3D"awspan">est=C3=A1</span><span class=3D"awspan" style=3D"letter-spacin= g:3.8pt"> </span><span class=3D"awspan">modulada</span><span class=3D"awspa= n" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan">principalm= ente</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </span><s= pan class=3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spaci= ng:3.8pt"> </span><span class=3D"awspan">v=C3=ADas</span><span class=3D"aws= pan" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan">de</span= ><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </span><span class= =3D"awspan">se=C3=B1alizaci=C3=B3n</span><span class=3D"awspan" style=3D"le= tter-spacing:3.8pt"> </span><span class=3D"awspan">de</span><span class=3D"= awspan" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan">detec= ci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </sp= an><span class=3D"awspan">de nutrientes.</span><span class=3D"awspan" style= =3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">La</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan"= >insulina</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </sp= an><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-sp= acing:0.9pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan"= style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">IGF</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"= awspan">(factor</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:0.9pt"> </span><span class=3D"awspan">crecimiento</span><span = class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awsp= an">similar</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </= span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-= spacing:0.9pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">insulina)<= /span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span c= lass=3D"awspan">inducen</span><span class=3D"awspan" style=3D"letter-spacin= g:0.9pt"> </span><span class=3D"awspan">la activaci=C3=B3n</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan"= >de</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><s= pan class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacin= g:0.55pt"> </span><span class=3D"awspan">se=C3=B1alizaci=C3=B3n</span><span= class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"aw= span">del</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </s= pan><span class=3D"awspan">objetivo</span><span class=3D"awspan" style=3D"l= etter-spacing:0.55pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><sp= an class=3D"awspan">rapamicina</span><span class=3D"awspan" style=3D"letter= -spacing:0.55pt"> </span><span class=3D"awspan">(mTOR)</span><span class=3D= "awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">en<= /span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span = class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0= .55pt"> </span><span class=3D"awspan">mam=C3=ADferos</span><span class=3D"a= wspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">e inh= iben</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><= span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.25pt"> </span><span class=3D"awspan">inicio</span><span class=3D"awspa= n" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">de</span>= <span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"= > </span><span class=3D"awspan">autofagia.</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">La</span><span = class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"aws= pan">activaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0= .25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspa= n">prote=C3=ADna</span><span class=3D"awspan" style=3D"letter-spacing:0.25p= t"> </span><span class=3D"awspan">quinasa</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">activada</span><= span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt= "> </span><span class=3D"awspan">AMP (AMPK)</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">mediante</span= ><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class= =3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"= > </span><span class=3D"awspan">aumento</span><span class=3D"awspan" style= =3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspa= n">la</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span>= <span class=3D"awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"= letter-spacing:1.05pt"> </span><span class=3D"awspan">AMP/ATP</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awsp= an">durante</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> <= /span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lette= r-spacing:1.05pt"> </span><span class=3D"awspan">inanici=C3=B3n</span><span= class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"aw= span">aumenta directamente la autofagia e inhibe el complejo mTOR (14).</sp= an></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span= class=3D"awspan" style=3D"font-weight:bold">Efectos sobre v=C3=ADas de det= ecci=C3=B3n de nutrientes</span></p><p class=3D"awdiv" style=3D"margin-righ= t:1pt; margin-left:1pt"><span class=3D"awspan">En</span><span class=3D"awsp= an" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">los</span= ><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">=C3=BAltimos</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.8pt"> </span><span class=3D"awspan">a=C3=B1os</span><span class=3D"aws= pan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">las</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">v=C3=ADas</span><span class=3D"awspan" style=3D"letter-spacing:= 0.8pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">c=C3=A9lulas</span= ><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">sensibles</span><span class=3D"awspan" style=3D"letter-spacing:= 0.8pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan= ">nutrientes</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> <= /span><span class=3D"awspan">han</span><span class=3D"awspan" style=3D"lett= er-spacing:0.8pt"> </span><span class=3D"awspan">captado</span><span class= =3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">e= l</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span= class=3D"awspan">inter=C3=A9s dado</span><span class=3D"awspan" style=3D"l= etter-spacing:5.15pt"> </span><span class=3D"awspan">su</span><span class= =3D"awspan" style=3D"letter-spacing:5.15pt"> </span><span class=3D"awspan">= potencial</span><span class=3D"awspan" style=3D"letter-spacing:5.15pt"> </s= pan><span class=3D"awspan">como</span><span class=3D"awspan" style=3D"lette= r-spacing:5.15pt"> </span><span class=3D"awspan">dianas</span><span class= =3D"awspan" style=3D"letter-spacing:5.15pt"> </span><span class=3D"awspan">= terap=C3=A9uticas</span><span class=3D"awspan" style=3D"letter-spacing:5.15= pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D= "letter-spacing:5.15pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:5.15pt"> </span><span class=3D"awspan">= prevenci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:5.15pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:5.15pt"> </span><span class=3D"awspan">enfermedades relaciona= das</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><s= pan class=3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spaci= ng:3.25pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">edad.</span><= span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class= =3D"awspan">Se</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt"= > </span><span class=3D"awspan">reagrupan</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">principalmente</= span><span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span c= lass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:3.2= 5pt"> </span><span class=3D"awspan">las</span><span class=3D"awspan" style= =3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">v=C3=ADas</span><= span class=3D"awspan" style=3D"letter-spacing:3.25pt"> </span><span class= =3D"awspan">IGF</span><span class=3D"awspan" style=3D"letter-spacing:3.25pt= "> </span><span class=3D"awspan">(factor</span><span class=3D"awspan" style= =3D"letter-spacing:3.25pt"> </span><span class=3D"awspan">de crecimiento</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span cl= ass=3D"awspan">similar</span><span class=3D"awspan" style=3D"letter-spacing= :1.15pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">la</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awsp= an">insulina)</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt">= </span><span class=3D"awspan">/insulina,</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">TOR</span><span = class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"aws= pan">(objetivo</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:1.15pt"> </span><span class=3D"awspan">la</span><span class=3D= "awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">rap= amicina)</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </sp= an><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-sp= acing:1.15pt"> </span><span class=3D"awspan">AMPK (prote=C3=ADna quinasa ac= tivada por AMP) (1).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt= ; margin-left:1pt"><span class=3D"awspan">La</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">RC</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"a= wspan">tiene</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> = </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lett= er-spacing:0.95pt"> </span><span class=3D"awspan">capacidad</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan= ">de</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><= span class=3D"awspan">activar</span><span class=3D"awspan" style=3D"letter-= spacing:0.95pt"> </span><span class=3D"awspan">a</span><span class=3D"awspa= n" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class= =3D"awspan">prote=C3=ADna</span><span class=3D"awspan" style=3D"letter-spac= ing:0.95pt"> </span><span class=3D"awspan">quinasa</span><span class=3D"aws= pan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">activad= a</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><spa= n class=3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacing= :0.95pt"> </span><span class=3D"awspan">AMP</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">(AMPK), misma<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span = class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.1pt"> </span><span class=3D"awspan">inhibe</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"a= wspan">actividad</span><span class=3D"awspan" style=3D"letter-spacing:-0.1p= t"> </span><span class=3D"awspan">quinada</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awsp= an">(mTOR)</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </= span><span class=3D"awspan">un</span><span class=3D"awspan" style=3D"letter= -spacing:-0.1pt"> </span><span class=3D"awspan">represor</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= de</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><sp= an class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing= :-0.1pt"> </span><span class=3D"awspan">autofagia</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">(8).</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span cla= ss=3D"awspan">Todas las</span><span class=3D"awspan" style=3D"letter-spacin= g:0.55pt"> </span><span class=3D"awspan">c=C3=A9lulas</span><span class=3D"= awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">dete= ctan</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><= span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.55pt"> </span><span class=3D"awspan">disponibilidad</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= de</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><sp= an class=3D"awspan">micronutrientes</span><span class=3D"awspan" style=3D"l= etter-spacing:0.55pt"> </span><span class=3D"awspan">y</span><span class=3D= "awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">rea= ccionan</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </spa= n><span class=3D"awspan">ante</span><span class=3D"awspan" style=3D"letter-= spacing:0.55pt"> </span><span class=3D"awspan">una</span><span class=3D"aws= pan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">mayor</= span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span c= lass=3D"awspan">o menor</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.6pt"> </span><span class=3D"awspan">disponibilidad</span><span class= =3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">= a</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><spa= n class=3D"awspan">trav=C3=A9s</span><span class=3D"awspan" style=3D"letter= -spacing:-0.6pt"> </span><span class=3D"awspan">de</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">varias<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span = class=3D"awspan">v=C3=ADas</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.6pt"> </span><span class=3D"awspan">interconectadas,</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspa= n">incluidas</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> = </span><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.6pt"> </span><span class=3D"awspan">controlados</span><span = class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"aws= pan">por el</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">objetivo</span><span class=3D"awspan" style=3D"= letter-spacing:0.4pt"> </span><span class=3D"awspan">mec=C3=A1nico</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </s= pan><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-= spacing:0.4pt"> </span><span class=3D"awspan">rapamicina</span><span class= =3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">(= mTOR)</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><= span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacin= g:0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">prote=C3=ADna</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span cla= ss=3D"awspan">quinasa</span><span class=3D"awspan" style=3D"letter-spacing:= 0.4pt"> </span><span class=3D"awspan">activada</span><span class=3D"awspan"= style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">por</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">AMP (AMPK).</span><span class=3D"awspan" style=3D"letter-spacing:0.= 7pt"> </span><span class=3D"awspan">Mtor</span><span class=3D"awspan" style= =3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">respuesta</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"= awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </sp= an><span class=3D"awspan">amino=C3=A1cidos</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">y</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan= ">factores</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:0.7pt"> </span><span class=3D"awspan">crecimiento.</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">= La</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><spa= n class=3D"awspan">AMPK,</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.7pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">otro lado,</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span cla= ss=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:0.35p= t"> </span><span class=3D"awspan">activa</span><span class=3D"awspan" style= =3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">en</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspa= n">condiciones</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:0.35pt"> </span><span class=3D"awspan">baja</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">= energ=C3=ADa</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> = </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"lette= r-spacing:0.35pt"> </span><span class=3D"awspan">estimula</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><sp= an class=3D"awspan">cetog=C3=A9nesis,</span><span class=3D"awspan" style=3D= "letter-spacing:0.35pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">= oxidaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"= > </span><span class=3D"awspan">de =C3=A1cidos</span><span class=3D"awspan"= style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">grasos,</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span cla= ss=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.05p= t"> </span><span class=3D"awspan">captaci=C3=B3n</span><span class=3D"awspa= n" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">de</span>= <span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class= =3D"awspan">glucosa</span><span class=3D"awspan" style=3D"letter-spacing:0.= 05pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.0= 5pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">lipog=C3=A9nesis</span><span class=3D"awspan" style=3D"letter-spacing:0.= 05pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">varios</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"a= wspan">tipos</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> = </span><span class=3D"awspan">de c=C3=A9lulas (4).</span></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span = class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spacing:-0= .1pt"> </span><span class=3D"awspan">acetilaci=C3=B3n</span><span class=3D"= awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</= span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span c= lass=3D"awspan">prote=C3=ADnas</span><span class=3D"awspan" style=3D"letter= -spacing:-0.1pt"> </span><span class=3D"awspan">es</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">un</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span clas= s=3D"awspan">importante</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.1pt"> </span><span class=3D"awspan">regulador</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span clas= s=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt= "> </span><span class=3D"awspan">autofagia.</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">El</span><span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"aw= span">mantenimiento de</span><span class=3D"awspan" style=3D"letter-spacing= :0.9pt"> </span><span class=3D"awspan">des</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">acetilaci=C3=B3n= </span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span = class=3D"awspan">r=C3=ADtmica</span><span class=3D"awspan" style=3D"letter-= spacing:0.9pt"> </span><span class=3D"awspan">por</span><span class=3D"awsp= an" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">CR</span>= <span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class= =3D"awspan">est=C3=A1</span><span class=3D"awspan" style=3D"letter-spacing:= 0.9pt"> </span><span class=3D"awspan">hipot=C3=A9ticamente</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">= relacionado</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </= span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"lette= r-spacing:0.9pt"> </span><span class=3D"awspan">un</span><span class=3D"aws= pan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">aumento<= /span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span c= lass=3D"awspan">de los</span><span class=3D"awspan" style=3D"letter-spacing= :0.35pt"> </span><span class=3D"awspan">niveles</span><span class=3D"awspan= " style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">NAD+.</span><span class=3D"awspan" style=3D"letter-spacing:0.35= pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan" style=3D= "letter-spacing:0.35pt"> </span><span class=3D"awspan">restricci=C3=B3n</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span cla= ss=3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" style=3D"letter-sp= acing:0.35pt"> </span><span class=3D"awspan">des</span><span class=3D"awspa= n" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">acetila</= span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span c= lass=3D"awspan">histonas</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.35pt"> </span><span class=3D"awspan">H3</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">y</span><span= class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"aw= span">H4.</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </s= pan><span class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-= spacing:0.35pt"> </span><span class=3D"awspan">inanici=C3=B3n aguda</span><= span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D= "awspan">induce</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"= > </span><span class=3D"awspan">una</span><span class=3D"awspan" style=3D"l= etter-spacing:1.9pt"> </span><span class=3D"awspan">reducci=C3=B3n</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </s= pan><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-= spacing:1.9pt"> </span><span class=3D"awspan">acetilaci=C3=B3n</span><span = class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awsp= an">de</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span>= <span class=3D"awspan">prote=C3=ADnas</span><span class=3D"awspan" style=3D= "letter-spacing:1.9pt"> </span><span class=3D"awspan">citoplasm=C3=A1ticas<= /span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span c= lass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:1.9= pt"> </span><span class=3D"awspan">c=C3=A9lulas </span></p><p class=3D"awdi= v" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span style= =3D"height:0pt; display:block; position:absolute; z-index:551"><img src=3D"= data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUG= BwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQU= FBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh= 4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECBwMGCAUE/= 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letter-spacing:3p= t; color:#ffffff">P=C3=A1gina</span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:11pt; color:#ffffff"> 77 | 88</span></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">         <= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">A= mbato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> =         </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-235-48= 5</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><a href=3D"http://= www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoratio= n:underline">www.anatomiadigital.org</span></a></p><p style=3D"margin-right= :1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; ma= rgin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigitaleditoria= l.com" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; text-decoration:underline">www.cienciadigit= aleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anat= om=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Tel. 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"= text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org= " style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:11pt; text-decoration:underline">www.anatomiadigital.o= rg</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8= pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><a href=3D"http://www.= cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p clas= s=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a = href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:no= ne"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; te= xt-decoration:underline">www.cienciadigitaleditorial.com</span></a></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.or= g</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8p= t"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">Tel. 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.anatomiadigital.org" st= yle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigi= tal.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1"= >www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4= 472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-we= ight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">       =   </span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. 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0dXVSWN9A3pVT1RUFHPm30bTxYsUP1OMwWCgqKgIq9V6+eCvZaj6q+kf/vAHDhw4wK1TbmVK7mT= a7XY8bjeKgAGSR4R4qjC9gbBIQ8iOo6MTR0f7zWjMQTYEqtARGW7tjyOc3d04u7sJ0VzX4WTlIA= gBIiyWECoet4umC67LZKtEDGJ8Oto7Q+CpWkBScbSChvoG9Ho902bMYOKkSSxYeCf/2P53nlm7l= qamJubPn8/w4cNDESeEIBAIYLfbOXbsGG+//Taf7t/HLdm3cNePFtLb66KsrIy271oHAXa97V/J= kF6PnP6/071S62b6nZ1d3LN4MQCqpgWJweZLzQB0dHQSFRPD9Jn/QVRUJP/4cAcvvvgCZWVl5OT= kkJGRQVxcHB6Ph4sXL3Ly5Mlgg9rZTt70fG6bN4+ICCsfbt1G+f6D9Hl9VyyuqiqpqakAoaoppa= Szs5Po6GgCgQBdXV03dN5oNBIREYHD4QgRmC6Xi+TkZBRF4dKlS6H8eyMJDw8nLS2Nzs5Ompub0= ev1IZqpr6/vJpoCKbiy5YBgY/nBu++x6sFV5ORMYEhsHIcOHOJ4xXFOnvwavd6AXq9H07TgAkKQ= mmpjyQ+Xckv2OExGI9u3lXLwOoABxMXF8corr1BfX09vby9VVVVMmjQp9Hh/8803OXHixA3dHjN= mDKtWreKtt94iOzubnp4ePB4Pd999N36/n927d7Nr165Qz3g9KS4uxu/3o6oqW7ZswWQysXr1al= 566SVOnDhx3R5ysFwDmuYPUHP2LP/98susWLGCsWPH8pMlP2HOvDk0NjTSdOkidrsdnaLDZrMxL= NVGSnIK4eZwXK5e/ra5hH2f7MPnvf6JBWlyK8ePHycrK4uamhqKiop49dVXkVJSXV19U4fNZjNj= xoxh+fLlOJ1OWlpamDBhAps2baKtrY2IiAh0Ot1NbUyfPp2dO3dy+vRpuru7mTlzJhaLhby8PKq= rq783Uq8BrR+4pvoLvLjhJebcNoeC2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tve= JhfrVIKVFVlaioKBITEzEYDPz+97/niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2tr= XR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdH= Pv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iX= q6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAo= waNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi= 4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0= Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhO= K/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D= " width=3D"77" height=3D"28" alt=3D"" style=3D"margin-left:441.05pt; positi= on:absolute" /></span><span class=3D"awspan">mononucleares</span><span clas= s=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan"= >de</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><s= pan class=3D"awspan">sangre</span><span class=3D"awspan" style=3D"letter-sp= acing:4.15pt"> </span><span class=3D"awspan">perif=C3=A9rica,</span><span c= lass=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awsp= an">dado</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </sp= an><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-= spacing:4.15pt"> </span><span class=3D"awspan">se</span><span class=3D"awsp= an" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">acopla</= span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span c= lass=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:4.15= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:4.15pt"> </span><span class=3D"awspan">disminuci=C3=B3n</sp= an><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span cla= ss=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:4.15p= t"> </span><span class=3D"awspan">la acetiltransferasa</span><span class=3D= "awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">EP30= 0,</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><spa= n class=3D"awspan">as=C3=AD</span><span class=3D"awspan" style=3D"letter-sp= acing:1.6pt"> </span><span class=3D"awspan">como</span><span class=3D"awspa= n" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">a</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"= awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </s= pan><span class=3D"awspan">activaci=C3=B3n</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">de</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspa= n">la</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><= span class=3D"awspan">desacetilasa</span><span class=3D"awspan" style=3D"le= tter-spacing:1.6pt"> </span><span class=3D"awspan">SIRT</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">1= .</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span= class=3D"awspan">Tanto</span><span class=3D"awspan" style=3D"letter-spacin= g:1.6pt"> </span><span class=3D"awspan">la desacetilaci=C3=B3n</span><span = class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"aws= pan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </spa= n><span class=3D"awspan">histonas</span><span class=3D"awspan" style=3D"let= ter-spacing:0.05pt"> </span><span class=3D"awspan">como</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><sp= an class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing= :0.05pt"> </span><span class=3D"awspan">prote=C3=ADnas</span><span class=3D= "awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">cit= os=C3=B3licas</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt">= </span><span class=3D"awspan">pueden</span><span class=3D"awspan" style=3D= "letter-spacing:0.05pt"> </span><span class=3D"awspan">afectar</span><span = class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"aws= pan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </spa= n><span class=3D"awspan">expresi=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">y actividad,</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span clas= s=3D"awspan">respectivamente,</span><span class=3D"awspan" style=3D"letter-= spacing:0.75pt"> </span><span class=3D"awspan">de</span><span class=3D"awsp= an" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">prote=C3= =ADnas</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span= ><span class=3D"awspan">fundamentales</span><span class=3D"awspan" style=3D= "letter-spacing:0.75pt"> </span><span class=3D"awspan">para</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><= span class=3D"awspan">autofagia.</span><span class=3D"awspan" style=3D"lett= er-spacing:0.75pt"> </span><span class=3D"awspan">La</span><span class=3D"a= wspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">inhib= ici=C3=B3n de</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt">= </span><span class=3D"awspan">EP300</span><span class=3D"awspan" style=3D"= letter-spacing:-0.6pt"> </span><span class=3D"awspan">generalmente</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D= "awspan">resulta</span><span class=3D"awspan" style=3D"letter-spacing:-0.6p= t"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"= letter-spacing:-0.6pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">= inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.6pt"> </span><span class=3D"awspan">mTORC1</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan= ">y</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><s= pan class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.6pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">activaci=C3=B3= n</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= -0.6pt"> </span><span class=3D"awspan">AMPK. Sugiriendo</span><span class= =3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">q= ue</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><spa= n class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:= 1.4pt"> </span><span class=3D"awspan">desacetilaci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">d= e</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span= class=3D"awspan">prote=C3=ADnas</span><span class=3D"awspan" style=3D"lett= er-spacing:1.4pt"> </span><span class=3D"awspan">puede</span><span class=3D= "awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">prov= ocar</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><s= pan class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spaci= ng:1.4pt"> </span><span class=3D"awspan">reacci=C3=B3n</span><span class=3D= "awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">auto= f=C3=A1gica dominante independiente de otros sistemas reguladores (8).</spa= n></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span = class=3D"awspan">Se</span><span class=3D"awspan" style=3D"letter-spacing:1.= 45pt"> </span><span class=3D"awspan">ha</span><span class=3D"awspan" style= =3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">demostrado</span>= <span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">que,</span><span class=3D"awspan" style=3D"letter-spacing:1.45p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:1.45pt"> </span><span class=3D"awspan">presencia</span><span= class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"aw= span">de</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </sp= an><span class=3D"awspan">nutrientes</span><span class=3D"awspan" style=3D"= letter-spacing:1.45pt"> </span><span class=3D"awspan">celulares</span><span= class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"aw= span">induce</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> = </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lett= er-spacing:1.45pt"> </span><span class=3D"awspan">estimulaci=C3=B3n</span><= span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">del receptor</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.65pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">insulina</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span c= lass=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:-0.6= 5pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">IGF-1R</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D= "awspan">generando</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 65pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">cascada</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt= "> </span><span class=3D"awspan">fosforilaci=C3=B3n</span><span class=3D"aw= span" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">que</= span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span = class=3D"awspan">activa</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.65pt"> </span><span class=3D"awspan">AKT que</span><span class=3D"awsp= an" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">induce</= span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span c= lass=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.2= 5pt"> </span><span class=3D"awspan">metabolismo</span><span class=3D"awspan= " style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"= > </span><span class=3D"awspan">glucosa</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">a</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan= ">trav=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:0.25pt"> </span><span class=3D"awspan">GSK-3=CE=B2,</span><span= class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"aw= span">suprime</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt">= </span><span class=3D"awspan">una</span><span class=3D"awspan" style=3D"le= tter-spacing:0.25pt"> </span><span class=3D"awspan">amplia</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan"= >gama de</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </sp= an><span class=3D"awspan">respuestas</span><span class=3D"awspan" style=3D"= letter-spacing:1.85pt"> </span><span class=3D"awspan">celulares.</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"a= wspan">a</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </sp= an><span class=3D"awspan">trav=C3=A9s</span><span class=3D"awspan" style=3D= "letter-spacing:1.85pt"> </span><span class=3D"awspan">del</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan"= >factor</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:1.85pt"> </span><span class=3D"awspan">transcripci=C3=B3n</span><span= class=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"aw= span">FOXO</span><span class=3D"awspan" style=3D"letter-spacing:1.85pt"> </= span><span class=3D"awspan">(Forkhead</span><span class=3D"awspan" style=3D= "letter-spacing:1.85pt"> </span><span class=3D"awspan">box)</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.85pt"> </span><span class=3D"awspan= ">y estimula</span><span class=3D"awspan" style=3D"letter-spacing:2.4pt"> <= /span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lette= r-spacing:2.4pt"> </span><span class=3D"awspan">s=C3=ADntesis</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.4pt"> </span><span class=3D"awspa= n">de</span><span class=3D"awspan" style=3D"letter-spacing:2.4pt"> </span><= span class=3D"awspan">prote=C3=ADnas</span><span class=3D"awspan" style=3D"= letter-spacing:2.4pt"> </span><span class=3D"awspan">activando</span><span = class=3D"awspan" style=3D"letter-spacing:2.4pt"> </span><span class=3D"awsp= an">TORC1,</span><span class=3D"awspan" style=3D"letter-spacing:2.4pt"> </s= pan><span class=3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-= spacing:2.4pt"> </span><span class=3D"awspan">que</span><span class=3D"awsp= an" style=3D"letter-spacing:2.4pt"> </span><span class=3D"awspan">conduce</= span><span class=3D"awspan" style=3D"letter-spacing:2.4pt"> </span><span cl= ass=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:2.4pt= "> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"l= etter-spacing:2.4pt"> </span><span class=3D"awspan">s=C3=ADntesis</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.4pt"> </span><span class=3D"a= wspan">de prote=C3=ADnas</span><span class=3D"awspan" style=3D"letter-spaci= ng:2.95pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">al</span><span= class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"aw= span">crecimiento</span><span class=3D"awspan" style=3D"letter-spacing:2.95= pt"> </span><span class=3D"awspan">celular.</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">En</span><span= class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"aw= span">contraste</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt= "> </span><span class=3D"awspan">cuando</span><span class=3D"awspan" style= =3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awspa= n">c=C3=A9lula</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"= > </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"le= tter-spacing:2.95pt"> </span><span class=3D"awspan">ve</span><span class=3D= "awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">pri= vada</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><= span class=3D"awspan">de nutrientes</span><span class=3D"awspan" style=3D"l= etter-spacing:0.05pt"> </span><span class=3D"awspan">o</span><span class=3D= "awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">en<= /span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span = class=3D"awspan">condiciones</span><span class=3D"awspan" style=3D"letter-s= pacing:0.05pt"> </span><span class=3D"awspan">de</span><span class=3D"awspa= n" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">baja</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span clas= s=3D"awspan">energ=C3=ADa,</span><span class=3D"awspan" style=3D"letter-spa= cing:0.05pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan= " style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">niveles</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span cl= ass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.05= pt"> </span><span class=3D"awspan">AMPK</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">aumentan</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">e</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </= span><span class=3D"awspan">inhiben</span><span class=3D"awspan" style=3D"l= etter-spacing:0.05pt"> </span><span class=3D"awspan">la s=C3=ADntesis</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"= > </span><span class=3D"awspan">prote=C3=ADnas</span><span class=3D"awspan"= style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">a</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"= awspan">trav=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:-0= .6pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">TORC1,</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"a= wspan">reduciendo</span><span class=3D"awspan" style=3D"letter-spacing:-0.6= pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">procesos</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D= "awspan">anab=C3=B3licos</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.6pt"> </span><span class=3D"awspan">e</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">induciendo la = respiraci=C3=B3n mitocondrial (1).</span></p><p class=3D"awdiv" style=3D"ma= rgin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weigh= t:bold">Estr=C3=A9s oxidativo</span></p><p class=3D"awdiv" style=3D"margin-= right:1pt; margin-left:1pt"><span class=3D"awspan">Del</span><span class=3D= "awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">ox= =C3=ADgeno</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </= span><span class=3D"awspan">empleado</span><span class=3D"awspan" style=3D"= letter-spacing:-0.1pt"> </span><span class=3D"awspan">por</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= las</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><s= pan class=3D"awspan">mitocondrias</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.1pt"> </span><span class=3D"awspan">para</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><sp= an class=3D"awspan">producci=C3=B3n</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= ATP</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><s= pan class=3D"awspan">entre</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.1pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan"= style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">1%</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D= "awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </= span><span class=3D"awspan">3% genera</span><span class=3D"awspan" style=3D= "letter-spacing:1.65pt"> </span><span class=3D"awspan">especies</span><span= class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"aw= span">reactivas</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:1.65pt"> </span><span class=3D"awspan">ox=C3=ADgeno.</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D= "awspan">Al</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> <= /span><span class=3D"awspan">inducir</span><span class=3D"awspan" style=3D"= letter-spacing:1.65pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">= RC</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><sp= an class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spacin= g:1.65pt"> </span><span class=3D"awspan">desaceleraci=C3=B3n</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspa= n">de</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:1.65pt"> </span><span class=3D"awspan">tasa metab=C3=B3lica</span><span= class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"aw= span">se</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </sp= an><span class=3D"awspan">prolonga</span><span class=3D"awspan" style=3D"le= tter-spacing:0.55pt"> </span><span class=3D"awspan">en</span><span class=3D= "awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">con= secuencia</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </s= pan><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-= spacing:0.55pt"> </span><span class=3D"awspan">vida</span><span class=3D"aw= span" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">=C3=BA= til</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><s= pan class=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-spacin= g:0.55pt"> </span><span class=3D"awspan">reducir</span><span class=3D"awspa= n" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">el</span>= <span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class= =3D"awspan">da=C3=B1o</span><span class=3D"awspan" style=3D"letter-spacing:= 0.55pt"> </span><span class=3D"awspan">oxidativo</span><span class=3D"awspa= n" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">a</span><= span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class= =3D"awspan">nivel celular</span><span class=3D"awspan" style=3D"letter-spac= ing:3.2pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" st= yle=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">tisular</span><= span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D= "awspan">(9)</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> <= /span><span class=3D"awspan">Los</span><span class=3D"awspan" style=3D"lett= er-spacing:3.2pt"> </span><span class=3D"awspan">elementos</span><span clas= s=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">= reactivos</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </sp= an><span class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-= spacing:3.2pt"> </span><span class=3D"awspan">ox=C3=ADgeno</span><span clas= s=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">= ROS</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><sp= an class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing= :3.2pt"> </span><span class=3D"awspan">producen</span><span class=3D"awspan= " style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">como subpro= ductos</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </span>= <span class=3D"awspan">cuya</span><span class=3D"awspan" style=3D"letter-sp= acing:3.8pt"> </span><span class=3D"awspan">acumulaci=C3=B3n</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan= ">t=C3=B3xica</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> = </span><span class=3D"awspan">aumenta</span><span class=3D"awspan" style=3D= "letter-spacing:3.8pt"> </span><span class=3D"awspan">el</span><span class= =3D"awspan" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan">e= str=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </s= pan><span class=3D"awspan">oxidativo</span><span class=3D"awspan" style=3D"= letter-spacing:3.8pt"> </span><span class=3D"awspan">en</span><span class= =3D"awspan" style=3D"letter-spacing:3.8pt"> </span><span class=3D"awspan">l= as</span><span class=3D"awspan" style=3D"letter-spacing:3.8pt"> </span><spa= n class=3D"awspan">c=C3=A9lulas conforme</span><span class=3D"awspan" style= =3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">avanza</span><span= class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"aws= pan">la</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span= ><span class=3D"awspan">edad,</span><span class=3D"awspan" style=3D"letter-= spacing:1.8pt"> </span><span class=3D"awspan">se</span><span class=3D"awspa= n" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">relaciona<= /span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span c= lass=3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:1.= 8pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span class=3D"awspan= " style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">del</span><= span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D= "awspan">ret=C3=ADculo</span><span class=3D"awspan" style=3D"letter-spacing= :1.8pt"> </span><span class=3D"awspan">endoplasm=C3=A1tico,</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan"= >estado generado por la acumulaci=C3=B3n de prote=C3=ADnas mal plegadas (12= ). </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= "><span class=3D"awspan">Los</span><span class=3D"awspan" style=3D"letter-s= pacing:0.4pt"> </span><span class=3D"awspan">niveles</span><span class=3D"a= wspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">elevad= os</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= 0.4pt"> </span><span class=3D"awspan">ROS</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan"= >los</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">productos</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">del</span><span class=3D"aws= pan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">estr=C3= =A9s</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">oxidativo</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">se</span><span class=3D"awsp= an" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">relaciona= n</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span= class=3D"awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:= 0.4pt"> </span><span class=3D"awspan">una disfunci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= progresiva</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.05pt"> </span><span class=3D"awspan">las</span><span class=3D"aw= span" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">mitoco= ndrias.</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </spa= n><span class=3D"awspan">Puede</span><span class=3D"awspan" style=3D"letter= -spacing:0.05pt"> </span><span class=3D"awspan">deberse</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= al</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><sp= an class=3D"awspan">da=C3=B1o</span><span class=3D"awspan" style=3D"letter-= spacing:0.05pt"> </span><span class=3D"awspan">del</span><span class=3D"aws= pan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">ADN</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span cla= ss=3D"awspan">mitocondrial o</span><span class=3D"awspan" style=3D"letter-s= pacing:0.7pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan"= style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">la</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"a= wspan">oxidaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:= 0.7pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">da=C3=B1o</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </s= pan><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"letter= -spacing:0.7pt"> </span><span class=3D"awspan">prote=C3=ADnas</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspa= n">mitocondriales.</span><span class=3D"awspan" style=3D"letter-spacing:0.7= pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan" style=3D= "letter-spacing:0.7pt"> </span><span class=3D"awspan">falla</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan"= >en</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><sp= an class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacin= g:0.7pt"> </span><span class=3D"awspan">mecanismos</span><span class=3D"aws= pan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">de regul= aci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:1.1pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">producci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span= ><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spa= cing:1.1pt"> </span><span class=3D"awspan">ROS</span><span class=3D"awspan"= style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">en</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"a= wspan">las</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </s= pan><span class=3D"awspan">mitocondrias</span><span class=3D"awspan" style= =3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">puede</span><span = class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awsp= an">conducir</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> <= /span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter= -spacing:1.1pt"> </span><span class=3D"awspan">sus</span><span class=3D"aws= pan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">efectos = perjudiciales</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt">= </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.6pt"> </span><span class=3D"awspan">el</span><span class=3D"= awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">enve= jecimiento</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </= span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-= spacing:-0.6pt"> </span><span class=3D"awspan">el</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">c=C3=A1n= cer</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><s= pan class=3D"awspan">(3). </span><span class=3D"awspan"> </span><span = class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spacing:-0= .6pt"> </span><span class=3D"awspan">eficiencia</span><span class=3D"awspan= " style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">mitocondri= al</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><sp= an class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing= :-0.6pt"> </span><span class=3D"awspan">considera beneficiosa</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awsp= an">porque</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </= span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter= -spacing:0.15pt"> </span><span class=3D"awspan">consumo</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= de</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><sp= an class=3D"awspan">ox=C3=ADgeno</span><span class=3D"awspan" style=3D"lett= er-spacing:0.15pt"> </span><span class=3D"awspan">mitocondrial</span><span = class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"aws= pan">es</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </spa= n><span class=3D"awspan">proporcional</span><span class=3D"awspan" style=3D= "letter-spacing:0.15pt"> </span><span class=3D"awspan">a</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><sp= an class=3D"awspan">producci=C3=B3n de</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">especies</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">reactivas</span><span class=3D"awspan" style=3D"letter-spacing:0.0= 5pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">ox=C3=ADgeno,</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span cla= ss=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spacing:0.05p= t"> </span><span class=3D"awspan">decir,</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">da=C3=B1o</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> = </span><span class=3D"awspan">oxidativo,</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">por</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awsp= an">lo</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span= ><span class=3D"awspan">cual</span><span class=3D"awspan" style=3D"letter-s= pacing:0.05pt"> </span><span class=3D"awspan">es</span><span class=3D"awspa= n" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">trascende= ntal la din=C3=A1mica mitocondrial (9).</span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font= -weight:bold">Din=C3=A1mica mitocondrial</span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span class=3D"a= wspan">La</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </sp= an><span class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">cal=C3=B3rica</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span cla= ss=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt= "> </span><span class=3D"awspan">disminuir</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">la</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspa= n">cantidad</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:1.7pt"> </span><span class=3D"awspan">sustratos</span><span class= =3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">r= icos</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><s= pan class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacin= g:1.7pt"> </span><span class=3D"awspan">energ=C3=ADa</span><span class=3D"a= wspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">alivia= </span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span = class=3D"awspan">la fuerza</span><span class=3D"awspan" style=3D"letter-spa= cing:1.6pt"> </span><span class=3D"awspan">motriz</span><span class=3D"awsp= an" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">de</span>= <span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class= =3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"= > </span><span class=3D"awspan">protones</span><span class=3D"awspan" style= =3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">disminuyendo</span= ><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class= =3D"awspan">su</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt">= </span><span class=3D"awspan">fuga</span><span class=3D"awspan" style=3D"l= etter-spacing:1.6pt"> </span><span class=3D"awspan">al</span><span class=3D= "awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">espa= cio</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><sp= an class=3D"awspan">intermembrana</span><span class=3D"awspan" style=3D"let= ter-spacing:1.6pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">las mi= tocondrias,</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </= span><span class=3D"awspan">adem=C3=A1s</span><span class=3D"awspan" style= =3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">la</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan"= >reducci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:0.2pt"> </span><span class=3D"awspan">prote=C3=ADnas</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"a= wspan">desacopladoras</span><span class=3D"awspan" style=3D"letter-spacing:= 0.2pt"> </span><span class=3D"awspan">puede</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">reducir</span><= span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D= "awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </= span><span class=3D"awspan">fuga</span><span class=3D"awspan" style=3D"lett= er-spacing:0.2pt"> </span><span class=3D"awspan">de </span></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span st= yle=3D"height:0pt; display:block; position:absolute; z-index:619"><img src= =3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQF= BQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wB= DAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh= 4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECBwMGC= AUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSByExExQXQVFTVmGSlOMIFSJUcYGT0TI3= UnWRsyMzNkJydKGy0haCsRg4Q2IkwWNzg//EABsBAQEBAQEBAQEAAAAAAAAAAAABAgMEBQYH/8Q= ANBEBAQACAgIABAIJAwQDAAAAAAECEQMSBFEFITFBE4EUIjI0YXGRsdGhwfAGMzXhUlPx/9oADA= MBAAIRAxEAPwDqXfGR5+77cnfGR5+77cuIf0nUfi91yzkX/P3fblO+L/n7vty4w1F3XJORf8/d9= uU74yPP3fblhKGobrk74v8An7vtyd8ZHn7vty4w1Flrk74v+fu+3KTkZHn7vtywSV1F3WffOR5+= 77cnfOR5+77cuMXUZ3XJ3zkefu+3K98ZHn7vty4hNRZaznJyPP3fbk75yPP3fblxz2hqFtcnfOR= 5+77cnfOR5+77cuMNRN1yTkZG39fd9uWPfOR5+57csJRdRd1yd85Hn7ntyd8ZHn7vty4w0S1yd8= 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a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:11pt; letter-spacing:3pt; color:#ffffff">Procedimien= tos M=C3=A9dicos</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:11pt; letter-spacing:3pt; color:#ffffff">  </span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing:= 3pt; color:#ffffff">       </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing:3p= t; color:#ffffff">P=C3=A1gina</span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:11pt; color:#ffffff"> 78 | 88</span></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">         <= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">A= mbato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> =         </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-235-48= 5</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><a href=3D"http://= www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoratio= n:underline">www.anatomiadigital.org</span></a></p><p style=3D"margin-right= :1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; ma= rgin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigitaleditoria= l.com" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; text-decoration:underline">www.cienciadigit= aleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anat= om=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Tel. 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digita= l</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador = (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"= text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org= " style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:11pt; text-decoration:underline">www.anatomiadigital.o= rg</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8= pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><a href=3D"http://www.= cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p clas= s=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a = href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:no= ne"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; te= xt-decoration:underline">www.cienciadigitaleditorial.com</span></a></p><p c= lass=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amb= ate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) = 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Di= recto (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt= ; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-= decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.or= g</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8p= t"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">Tel. 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">  </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4= 472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-we= ight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">       =   </span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. 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0dXVSWN9A3pVT1RUFHPm30bTxYsUP1OMwWCgqKgIq9V6+eCvZaj6q+kf/vAHDhw4wK1TbmVK7mT= a7XY8bjeKgAGSR4R4qjC9gbBIQ8iOo6MTR0f7zWjMQTYEqtARGW7tjyOc3d04u7sJ0VzX4WTlIA= gBIiyWECoet4umC67LZKtEDGJ8Oto7Q+CpWkBScbSChvoG9Ho902bMYOKkSSxYeCf/2P53nlm7l= qamJubPn8/w4cNDESeEIBAIYLfbOXbsGG+//Taf7t/HLdm3cNePFtLb66KsrIy271oHAXa97V/J= kF6PnP6/071S62b6nZ1d3LN4MQCqpgWJweZLzQB0dHQSFRPD9Jn/QVRUJP/4cAcvvvgCZWVl5OT= kkJGRQVxcHB6Ph4sXL3Ly5Mlgg9rZTt70fG6bN4+ICCsfbt1G+f6D9Hl9VyyuqiqpqakAoaoppa= Szs5Po6GgCgQBdXV03dN5oNBIREYHD4QgRmC6Xi+TkZBRF4dKlS6H8eyMJDw8nLS2Nzs5Ompub0= ev1IZqpr6/vJpoCKbiy5YBgY/nBu++x6sFV5ORMYEhsHIcOHOJ4xXFOnvwavd6AXq9H07TgAkKQ= mmpjyQ+Xckv2OExGI9u3lXLwOoABxMXF8corr1BfX09vby9VVVVMmjQp9Hh/8803OXHixA3dHjN= mDKtWreKtt94iOzubnp4ePB4Pd999N36/n927d7Nr165Qz3g9KS4uxu/3o6oqW7ZswWQysXr1al= 566SVOnDhx3R5ysFwDmuYPUHP2LP/98susWLGCsWPH8pMlP2HOvDk0NjTSdOkidrsdnaLDZrMxL= NVGSnIK4eZwXK5e/ra5hH2f7MPnvf6JBWlyK8ePHycrK4uamhqKiop49dVXkVJSXV19U4fNZjNj= xoxh+fLlOJ1OWlpamDBhAps2baKtrY2IiAh0Ot1NbUyfPp2dO3dy+vRpuru7mTlzJhaLhby8PKq= rq783Uq8BrR+4pvoLvLjhJebcNoeC2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tve= JhfrVIKVFVlaioKBITEzEYDPz+97/niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2tr= XR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdH= Pv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iX= q6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAo= waNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi= 4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0= Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhO= K/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D= " width=3D"77" height=3D"28" alt=3D"" style=3D"margin-left:441.05pt; positi= on:absolute" /></span><span class=3D"awspan">protones,</span><span class=3D= "awspan" style=3D"letter-spacing:3.65pt"> </span><span class=3D"awspan">a</= span><span class=3D"awspan" style=3D"letter-spacing:3.65pt"> </span><span c= lass=3D"awspan">trav=C3=A9s</span><span class=3D"awspan" style=3D"letter-sp= acing:3.65pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan= " style=3D"letter-spacing:3.65pt"> </span><span class=3D"awspan">estos</spa= n><span class=3D"awspan" style=3D"letter-spacing:3.65pt"> </span><span clas= s=3D"awspan">procesos</span><span class=3D"awspan" style=3D"letter-spacing:= 3.65pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.65pt"> </span><span class=3D"awspan">disipa</span><sp= an class=3D"awspan" style=3D"letter-spacing:3.65pt"> </span><span class=3D"= awspan">menor</span><span class=3D"awspan" style=3D"letter-spacing:3.65pt">= </span><span class=3D"awspan">energ=C3=ADa</span><span class=3D"awspan" st= yle=3D"letter-spacing:3.65pt"> </span><span class=3D"awspan">en</span><span= class=3D"awspan" style=3D"letter-spacing:3.65pt"> </span><span class=3D"aw= span">forma</span><span class=3D"awspan" style=3D"letter-spacing:3.65pt"> <= /span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lette= r-spacing:3.65pt"> </span><span class=3D"awspan">calor, requiriendo menor c= antidad de sustratos ricos en energ=C3=ADa (9). </span></p><p class=3D"awdi= v" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan" style= =3D"font-weight:bold">Efecto sobre metabolismo energ=C3=A9tico</span></p><p= class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D= "awspan">En</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </= span><span class=3D"awspan">base</span><span class=3D"awspan" style=3D"lett= er-spacing:0.8pt"> </span><span class=3D"awspan">a</span><span class=3D"aws= pan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">teor=C3=ADa</span><span class=3D"awspan" style=3D"letter-spacin= g:0.8pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">la</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspa= n">=E2=80=9Ctasa</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:0.8pt"> </span><span class=3D"awspan">vida=E2=80=9D,</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"= awspan">aquellos</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt= "> </span><span class=3D"awspan">individuos</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">con</span><span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"aws= pan">tasas</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </s= pan><span class=3D"awspan">metab=C3=B3licas</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">m=C3=A1s elevad= as</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><sp= an class=3D"awspan">tienen</span><span class=3D"awspan" style=3D"letter-spa= cing:1.45pt"> </span><span class=3D"awspan">menor</span><span class=3D"awsp= an" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">esperanz= a</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= 1.45pt"> </span><span class=3D"awspan">vida</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">y</span><span = class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"aws= pan">viceversa.</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt= "> </span><span class=3D"awspan">Teniendo</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">en</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awsp= an">cuenta</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </= span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"lette= r-spacing:1.45pt"> </span><span class=3D"awspan">es</span><span class=3D"aw= span" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">una ca= racter=C3=ADstica</span><span class=3D"awspan" style=3D"letter-spacing:1.65= pt"> </span><span class=3D"awspan">espec=C3=ADfica</span><span class=3D"aws= pan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span clas= s=3D"awspan">cada</span><span class=3D"awspan" style=3D"letter-spacing:1.65= pt"> </span><span class=3D"awspan">especie,</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">no</span><span= class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"aw= span">extrapolable.</span><span class=3D"awspan" style=3D"letter-spacing:1.= 65pt"> </span><span class=3D"awspan">Con</span><span class=3D"awspan" style= =3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspa= n">RC</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:1.65pt"> </span><span class=3D"awspan">reducci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">= de ingesta</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> <= /span><span class=3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">se</span><span= class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"a= wspan">produce</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt= "> </span><span class=3D"awspan">m=C3=A1s</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">r=C3=A1pido</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span cl= ass=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 65pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">reducci=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span = class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.65pt"> </span><span class=3D"awspan">gasto</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">energ=C3=A9t= ico,</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span>= <span class=3D"awspan">gener=C3=A1ndose un</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">d=C3=A9ficit</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span clas= s=3D"awspan">energ=C3=A9tico</span><span class=3D"awspan" style=3D"letter-s= pacing:2.2pt"> </span><span class=3D"awspan">agudo,</span><span class=3D"aw= span" style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">sin</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span clas= s=3D"awspan">embargo,</span><span class=3D"awspan" style=3D"letter-spacing:= 2.2pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">masa</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspa= n">corporal</span><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </= span><span class=3D"awspan">es</span><span class=3D"awspan" style=3D"letter= -spacing:2.2pt"> </span><span class=3D"awspan">proporcional</span><span cla= ss=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan"= >al</span><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><sp= an class=3D"awspan">gasto energ=C3=A9tico por lo que con el tiempo se aprox= iman hasta el equilibrio. Dicha reducci=C3=B3n de la</span><span class=3D"a= wspan" style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">tasa<= /span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span = class=3D"awspan">metab=C3=B3lica</span><span class=3D"awspan" style=3D"lett= er-spacing:2.45pt"> </span><span class=3D"awspan">puede</span><span class= =3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">= relacionase</span><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> <= /span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"lett= er-spacing:2.45pt"> </span><span class=3D"awspan">respuestas</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspa= n">hormonales</span><span class=3D"awspan" style=3D"letter-spacing:2.45pt">= </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"lett= er-spacing:2.45pt"> </span><span class=3D"awspan">RC</span><span class=3D"a= wspan" style=3D"letter-spacing:2.45pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.45pt"> </span><span cl= ass=3D"awspan">hormonas tiroideas,</span><span class=3D"awspan" style=3D"le= tter-spacing:0.25pt"> </span><span class=3D"awspan">leptina</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan= ">e</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><s= pan class=3D"awspan">insulina.</span><span class=3D"awspan" style=3D"letter= -spacing:0.25pt"> </span><span class=3D"awspan">Dado</span><span class=3D"a= wspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">que</= span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span c= lass=3D"awspan">las</span><span class=3D"awspan" style=3D"letter-spacing:0.= 25pt"> </span><span class=3D"awspan">concentraciones</span><span class=3D"a= wspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">de</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span cl= ass=3D"awspan">leptina</span><span class=3D"awspan" style=3D"letter-spacing= :0.25pt"> </span><span class=3D"awspan">son</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">proporcionales= a</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><spa= n class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:= 1.7pt"> </span><span class=3D"awspan">masa</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">grasa</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"aw= span">con</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </sp= an><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-s= pacing:1.7pt"> </span><span class=3D"awspan">intervenci=C3=B3n</span><span = class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awsp= an">se</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span>= <span class=3D"awspan">redujo</span><span class=3D"awspan" style=3D"letter-= spacing:1.7pt"> </span><span class=3D"awspan">las</span><span class=3D"awsp= an" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">concentra= ciones</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span>= <span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spac= ing:1.7pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">hormona.</span= ><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class= =3D"awspan">La adaptaci=C3=B3n</span><span class=3D"awspan" style=3D"letter= -spacing:0.7pt"> </span><span class=3D"awspan">metab=C3=B3lica</span><span = class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awsp= an">producto</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> <= /span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lette= r-spacing:0.7pt"> </span><span class=3D"awspan">la</span><span class=3D"aws= pan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">RC</span= ><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class= =3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt">= </span><span class=3D"awspan">relacion=C3=B3</span><span class=3D"awspan" = style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">con</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"a= wspan">concentraciones</span><span class=3D"awspan" style=3D"letter-spacing= :0.7pt"> </span><span class=3D"awspan">menores</span><span class=3D"awspan"= style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">de insulina = y menor resistencia a la misma (9).</span></p><p class=3D"awdiv" style=3D"m= argin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weig= ht:bold">RC y senescencia celular</span></p><p class=3D"awdiv" style=3D"mar= gin-right:1pt; margin-left:1pt"><span class=3D"awspan">La</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= RC</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><sp= an class=3D"awspan">influye</span><span class=3D"awspan" style=3D"letter-sp= acing:0.55pt"> </span><span class=3D"awspan">sobre</span><span class=3D"aws= pan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">el</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span clas= s=3D"awspan">ciclo</span><span class=3D"awspan" style=3D"letter-spacing:0.5= 5pt"> </span><span class=3D"awspan">celular,</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">su</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"a= wspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0= .55pt"> </span><span class=3D"awspan">subyace</span><span class=3D"awspan" = style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">en</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"= awspan">que,</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> = </span><span class=3D"awspan">debido</span><span class=3D"awspan" style=3D"= letter-spacing:0.55pt"> </span><span class=3D"awspan">a</span><span class= =3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><sp= an class=3D"awspan">naturaleza energ=C3=A9ticamente</span><span class=3D"aw= span" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">costosa= </span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.= 5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">proliferaci=C3=B3n= </span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span = class=3D"awspan">celular,</span><span class=3D"awspan" style=3D"letter-spac= ing:0.5pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" = style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">lo</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"aw= span">cual</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </s= pan><span class=3D"awspan">guardan</span><span class=3D"awspan" style=3D"le= tter-spacing:0.5pt"> </span><span class=3D"awspan">una</span><span class=3D= "awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">corr= elaci=C3=B3n negativa.</span><span class=3D"awspan" style=3D"letter-spacing= :0.75pt"> </span><span class=3D"awspan">Se</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">ha</span><span = class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"aws= pan">planteado</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"= > </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"le= tter-spacing:0.75pt"> </span><span class=3D"awspan">hip=C3=B3tesis</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D= "awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> <= /span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"lett= er-spacing:0.75pt"> </span><span class=3D"awspan">la</span><span class=3D"a= wspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">dismi= nuci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> <= /span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lette= r-spacing:0.75pt"> </span><span class=3D"awspan">la</span><span class=3D"aw= span" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">prolif= eraci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> = </span><span class=3D"awspan">celular con</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">CR</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan= ">aumentar=C3=A1</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt= "> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"l= etter-spacing:1.2pt"> </span><span class=3D"awspan">tiempo</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">= que</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><sp= an class=3D"awspan">las</span><span class=3D"awspan" style=3D"letter-spacin= g:1.2pt"> </span><span class=3D"awspan">c=C3=A9lulas</span><span class=3D"a= wspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">pasan<= /span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span c= lass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:1.2= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:1.2pt"> </span><span class=3D"awspan">fase</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">= G0/G1</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><= span class=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spac= ing:1.2pt"> </span><span class=3D"awspan">ciclo</span><span class=3D"awspan= " style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">celular, do= nde</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><s= pan class=3D"awspan">las</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.25pt"> </span><span class=3D"awspan">c=C3=A9lulas</span><span class=3D= "awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">da= =C3=B1adas</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </= span><span class=3D"awspan">tendr=C3=A1n</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">m=C3=A1s</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D= "awspan">tiempo</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt= "> </span><span class=3D"awspan">para</span><span class=3D"awspan" style=3D= "letter-spacing:0.25pt"> </span><span class=3D"awspan">reparar</span><span = class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"aws= pan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </spa= n><span class=3D"awspan">ADN</span><span class=3D"awspan" style=3D"letter-s= pacing:0.25pt"> </span><span class=3D"awspan">antes</span><span class=3D"aw= span" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">de</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span cla= ss=3D"awspan">entrar</span><span class=3D"awspan" style=3D"letter-spacing:0= .25pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">la fase</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"a= wspan">S.</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </sp= an><span class=3D"awspan">Por</span><span class=3D"awspan" style=3D"letter-= spacing:0.8pt"> </span><span class=3D"awspan">otro</span><span class=3D"aws= pan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">lado,</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span cla= ss=3D"awspan">aumento</span><span class=3D"awspan" style=3D"letter-spacing:= 0.8pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">la</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan"= >proliferaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.= 8pt"> </span><span class=3D"awspan">celular</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">se</span><span = class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awsp= an">ha</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span>= <span class=3D"awspan">asociado</span><span class=3D"awspan" style=3D"lette= r-spacing:0.8pt"> </span><span class=3D"awspan">con</span><span class=3D"aw= span" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">un</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class= =3D"awspan">menor tiempo</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.05pt"> </span><span class=3D"awspan">para</span><span class=3D"awspan"= style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">la</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">reparaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.05pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan" = style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">ADN,</span><= span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class= =3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"= > </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"l= etter-spacing:0.05pt"> </span><span class=3D"awspan">aumenta</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">el</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span>= <span class=3D"awspan">riesgo</span><span class=3D"awspan" style=3D"letter-= spacing:0.05pt"> </span><span class=3D"awspan">de</span><span class=3D"awsp= an" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">una</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span clas= s=3D"awspan">s=C3=ADntesis</span><span class=3D"awspan" style=3D"letter-spa= cing:0.05pt"> </span><span class=3D"awspan">no</span><span class=3D"awspan"= style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">reparada de= l ADN, lo que eventualmente aumenta el da=C3=B1o al ADN (12).</span></p><p = class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"= awspan" style=3D"font-weight:bold">Mim=C3=A9ticos de restricci=C3=B3n cal= =C3=B3rica</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-l= eft:1pt"><span class=3D"awspan">Se</span><span class=3D"awspan" style=3D"le= tter-spacing:3.95pt"> </span><span class=3D"awspan">ha</span><span class=3D= "awspan" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">ded= icado</span><span class=3D"awspan" style=3D"letter-spacing:3.95pt"> </span>= <span class=3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spac= ing:3.95pt"> </span><span class=3D"awspan">inter=C3=A9s</span><span class= =3D"awspan" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">= considerable</span><span class=3D"awspan" style=3D"letter-spacing:3.95pt"> = </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"lette= r-spacing:3.95pt"> </span><span class=3D"awspan">identificar</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspa= n">compuestos</span><span class=3D"awspan" style=3D"letter-spacing:3.95pt">= </span><span class=3D"awspan">farmac=C3=A9uticos</span><span class=3D"awsp= an" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">o suplem= entos</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span>= <span class=3D"awspan">diet=C3=A9ticos</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">que</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awsp= an">produzcan</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt">= </span><span class=3D"awspan">efectos</span><span class=3D"awspan" style= =3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">similares</span><= span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class= =3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt">= </span><span class=3D"awspan">los</span><span class=3D"awspan" style=3D"le= tter-spacing:0.05pt"> </span><span class=3D"awspan">de</span><span class=3D= "awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">la<= /span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span = class=3D"awspan">RC,</span><span class=3D"awspan" style=3D"letter-spacing:0= .05pt"> </span><span class=3D"awspan">esto</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">dado</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"a= wspan">que</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </= span><span class=3D"awspan">las intervenciones</span><span class=3D"awspan"= style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">antienvejeci= miento</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span>= <span class=3D"awspan">requieren</span><span class=3D"awspan" style=3D"lett= er-spacing:2.3pt"> </span><span class=3D"awspan">disciplina</span><span cla= ss=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan"= >y</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><spa= n class=3D"awspan">esfuerzos</span><span class=3D"awspan" style=3D"letter-s= pacing:2.3pt"> </span><span class=3D"awspan">sostenidos.</span><span class= =3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">E= s</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span= class=3D"awspan">as=C3=AD como,</span><span class=3D"awspan" style=3D"lett= er-spacing:6.35pt"> </span><span class=3D"awspan">se</span><span class=3D"a= wspan" style=3D"letter-spacing:6.35pt"> </span><span class=3D"awspan">ha</s= pan><span class=3D"awspan" style=3D"letter-spacing:6.35pt"> </span><span cl= ass=3D"awspan">demostrado</span><span class=3D"awspan" style=3D"letter-spac= ing:6.35pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan"= style=3D"letter-spacing:6.35pt"> </span><span class=3D"awspan">varios</spa= n><span class=3D"awspan" style=3D"letter-spacing:6.35pt"> </span><span clas= s=3D"awspan">compuestos</span><span class=3D"awspan" style=3D"letter-spacin= g:6.35pt"> </span><span class=3D"awspan">org=C3=A1nicos</span><span class= =3D"awspan" style=3D"letter-spacing:6.35pt"> </span><span class=3D"awspan">= modulan</span><span class=3D"awspan" style=3D"letter-spacing:6.35pt"> </spa= n><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"letter-s= pacing:6.35pt"> </span><span class=3D"awspan">v=C3=ADas antienvejecimiento<= /span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.= 15pt"> </span><span class=3D"awspan">manera</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">similar</span>= <span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class= =3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:1.15pt"> </span><span class=3D"awspan">RC</span><span class=3D"= awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">y</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span cl= ass=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:1.15= pt"> </span><span class=3D"awspan">ayuno</span><span class=3D"awspan" style= =3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">intermitente</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span clas= s=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"= > </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"le= tter-spacing:1.15pt"> </span><span class=3D"awspan">los</span><span class= =3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">= conoce como mim=C3=A9ticos de RC (7).</span></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span class=3D"awsp= an">Los</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span= ><span class=3D"awspan">mim=C3=A9ticos</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">de</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan"= >la</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><sp= an class=3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" style=3D"= letter-spacing:0.4pt"> </span><span class=3D"awspan">cal=C3=B3rica</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">MRC</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">definen</span><span class=3D= "awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">como= </span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span = class=3D"awspan">compuestos</span><span class=3D"awspan" style=3D"letter-sp= acing:0.4pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan= " style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">activan la<= /span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span c= lass=3D"awspan">autofagia</span><span class=3D"awspan" style=3D"letter-spac= ing:1.2pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">promover</span= ><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt">= </span><span class=3D"awspan">desacetilaci=C3=B3n</span><span class=3D"aws= pan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">de</span= ><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class= =3D"awspan">prote=C3=ADnas</span><span class=3D"awspan" style=3D"letter-spa= cing:1.2pt"> </span><span class=3D"awspan">celulares.</span><span class=3D"= awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">Por</= span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span cl= ass=3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spacing:1.2p= t"> </span><span class=3D"awspan">que,</span><span class=3D"awspan" style= =3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">entre</span><span = class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awsp= an">los criterios</span><span class=3D"awspan" style=3D"letter-spacing:4.9p= t"> </span><span class=3D"awspan">para</span><span class=3D"awspan" style= =3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">considerarse</span= ><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><span class= =3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:4.9pt= "> </span><span class=3D"awspan">MRC</span><span class=3D"awspan" style=3D"= letter-spacing:4.9pt"> </span><span class=3D"awspan">est=C3=A1n:</span><spa= n class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><span class=3D"aw= span">1.</span><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </spa= n><span class=3D"awspan">Agotar</span><span class=3D"awspan" style=3D"lette= r-spacing:4.9pt"> </span><span class=3D"awspan">AcCoA,</span><span class=3D= "awspan" style=3D"letter-spacing:4.9pt"> </span><span class=3D"awspan">2.</= span><span class=3D"awspan" style=3D"letter-spacing:4.9pt"> </span><span cl= ass=3D"awspan">Inhibir</span><span class=3D"awspan" style=3D"letter-spacing= :4.9pt"> </span><span class=3D"awspan">las acetiltransferasas</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspa= n">y</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><s= pan class=3D"awspan">3.</span><span class=3D"awspan" style=3D"letter-spacin= g:0.2pt"> </span><span class=3D"awspan">Estimular</span><span class=3D"awsp= an" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">desacetil= asas.</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><= span class=3D"awspan">(8).</span><span class=3D"awspan" style=3D"letter-spa= cing:0.2pt"> </span><span class=3D"awspan">Son</span><span class=3D"awspan"= style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">compuestos</= span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span cl= ass=3D"awspan">farmacol=C3=B3gicamente activos</span><span class=3D"awspan"= style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">que</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"= awspan">imitan</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt">= </span><span class=3D"awspan">algunos</span><span class=3D"awspan" style= =3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">efectos</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"aw= span">similares</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"= > </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"let= ter-spacing:1.2pt"> </span><span class=3D"awspan">los</span><span class=3D"= awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">de</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span cla= ss=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt= "> </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"l= etter-spacing:1.2pt"> </span><span class=3D"awspan">c=C3=A9lulas</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"aw= span">y</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span= ><span class=3D"awspan">organismos</span><span class=3D"awspan" style=3D"le= tter-spacing:1.2pt"> </span><span class=3D"awspan">(4). </span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><spa= n style=3D"height:0pt; display:block; position:absolute; z-index:687"><img = src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEB= AQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/= 2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4= eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECBw= MGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSByExExQXQVFTVmGSlOMIFSJUcYGT0= TI3UnWRsyMzNkJydKGy0haCsRg4Q2IkwWNzg//EABsBAQEBAQEBAQEAAAAAAAAAAAABAgMEBQYH= /8QANBEBAQACAgIABAIJAwQDAAAAAAECEQMSBFEFITFBE4EUIjI0YXGRsdGhwfAGMzXhUlPx/9o= 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AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAH/2Q=3D=3D= " width=3D"794" height=3D"1123" alt=3D"" style=3D"margin-left:-1.75pt; posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:11pt; color:#ffffff">       =             &#x= a0;            =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; letter-spacing:3pt; color:#ffffff">Procedim= ientos M=C3=A9dicos</span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; letter-spacing:3pt; color:#ffffff">  </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spaci= ng:3pt; color:#ffffff">       </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing= :3pt; color:#ffffff">P=C3=A1gina</span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:11pt; color:#ffffff"> 79 | 88</span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Tels. 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pos= ition:absolute" /></span><span class=3D"awspan" style=3D"color:#ffffff">ISS= N: </span><span class=3D"awspan" style=3D"font-weight:bold; color:#ffffff">= 2697-3391</span><span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2= , pp. 69 =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3=A9dicas, = salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span><sv= g font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" version= =3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"wid= th:209.31px; height:41.33px; font-family:'Times New Roman'; font-size:16px"= xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0= L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"eveno= dd" /></g></g></svg></span></p><p class=3D"awdiv" style=3D"margin-right:1pt= ; margin-left:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font-fam= ily:Ebrima; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=AD= a Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 = Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><a href=3D"http://www.anatomiadigital.org" s= tyle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadig= ital.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:11pt; text-decoration:underline">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline">www.cienciadigitaleditorial.com</span></a>= </p><p class=3D"awdiv" style=3D"margin-right:1pt; 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position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">Tel. 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.anatomiadigital.org" st= yle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigi= tal.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1"= >www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0= 998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#44= 72c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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.05pt"> </span><span class=3D"awspan">proporcionar</span><span class=3D"aws= pan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">condici= ones</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><= span class=3D"awspan">similares</span><span class=3D"awspan" style=3D"lette= r-spacing:1.05pt"> </span><span class=3D"awspan">a</span><span class=3D"aws= pan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">las</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span cla= ss=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.05p= t"> </span><span class=3D"awspan">restricci=C3=B3n</span><span class=3D"aws= pan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">cal=C3= =B3rica</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </spa= n><span class=3D"awspan">sin</span><span class=3D"awspan" style=3D"letter-s= pacing:1.05pt"> </span><span class=3D"awspan">la necesidad de dietas estric= tas (10).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-le= ft:1pt"><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"let= ter-spacing:0.8pt"> </span><span class=3D"awspan">concepto</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">= de</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><spa= n class=3D"awspan">mim=C3=A9ticos</span><span class=3D"awspan" style=3D"let= ter-spacing:0.8pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">RC</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span clas= s=3D"awspan">(MRC)</span><span class=3D"awspan" style=3D"letter-spacing:0.8= pt"> </span><span class=3D"awspan">fue</span><span class=3D"awspan" style= =3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">propuesto</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"= awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </= span><span class=3D"awspan">primera</span><span class=3D"awspan" style=3D"l= etter-spacing:0.8pt"> </span><span class=3D"awspan">vez</span><span class= =3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">e= n</span><span class=3D"awspan" style=3D"letter-spacing:0.8pt"> </span><span= class=3D"awspan">1998</span><span class=3D"awspan" style=3D"letter-spacing= :0.8pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.8pt"> </span><span class=3D"awspan">un estudio</span>= <span class=3D"awspan" style=3D"letter-spacing:3.1pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:3.1pt">= </span><span class=3D"awspan">2-desoxi-D-glucosa.</span><span class=3D"aws= pan" style=3D"letter-spacing:3.1pt"> </span><span class=3D"awspan">Convenci= onalmente</span><span class=3D"awspan" style=3D"letter-spacing:3.1pt"> </sp= an><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-s= pacing:3.1pt"> </span><span class=3D"awspan">clasifican</span><span class= =3D"awspan" style=3D"letter-spacing:3.1pt"> </span><span class=3D"awspan">c= omo</span><span class=3D"awspan" style=3D"letter-spacing:3.1pt"> </span><sp= an class=3D"awspan">ascendentes, aquellos</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">que</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspa= n">suprimen</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </= span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter= -spacing:1.2pt"> </span><span class=3D"awspan">producci=C3=B3n</span><span = class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awsp= an">de</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span>= <span class=3D"awspan">energ=C3=ADa,</span><span class=3D"awspan" style=3D"= letter-spacing:1.2pt"> </span><span class=3D"awspan">y</span><span class=3D= "awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">de</= span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span cl= ass=3D"awspan">tipo</span><span class=3D"awspan" style=3D"letter-spacing:1.= 2pt"> </span><span class=3D"awspan">posterior</span><span class=3D"awspan" = style=3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">los</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"a= wspan">que</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </s= pan><span class=3D"awspan">regulan</span><span class=3D"awspan" style=3D"le= tter-spacing:1.2pt"> </span><span class=3D"awspan">o modulan</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">gen=C3=A9ticamente</span><span class=3D"awspan" style=3D"letter-spacing:= 0.05pt"> </span><span class=3D"awspan">las</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">prote=C3=ADnas<= /span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.= 05pt"> </span><span class=3D"awspan">se=C3=B1alizaci=C3=B3n</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan= ">intracelular</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"= > </span><span class=3D"awspan">(15).</span><span class=3D"awspan" style=3D= "letter-spacing:0.05pt"> </span><span class=3D"awspan">Los</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan"= >criterios</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </= span><span class=3D"awspan">para definir</span><span class=3D"awspan" style= =3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">los</span><span = class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aw= span">mim=C3=A9ticos</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">la</span><span = class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aw= span">restricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing= :-0.15pt"> </span><span class=3D"awspan">cal=C3=B3rica</span><span class=3D= "awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">in= icialmente</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> <= /span><span class=3D"awspan">son</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.15pt"> </span><span class=3D"awspan">los</span><span class=3D= "awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">si= guientes:</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </= span><span class=3D"awspan">capacidad de</span><span class=3D"awspan" style= =3D"letter-spacing:1.2pt"> </span><span class=3D"awspan">imitar</span><span= class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"aws= pan">los</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </spa= n><span class=3D"awspan">efectos</span><span class=3D"awspan" style=3D"lett= er-spacing:1.2pt"> </span><span class=3D"awspan">metab=C3=B3licos,</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"= awspan">hormonales</span><span class=3D"awspan" style=3D"letter-spacing:1.2= pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"= letter-spacing:1.2pt"> </span><span class=3D"awspan">fisiol=C3=B3gicos</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.2pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:1.2pt"> </span><span class=3D"awspan">restricci=C3=B3n</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.2pt"> </span><span class=3D"= awspan">cal=C3=B3rica; activar</span><span class=3D"awspan" style=3D"letter= -spacing:0.5pt"> </span><span class=3D"awspan">las</span><span class=3D"aws= pan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">v=C3=ADa= s</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span= class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0= .5pt"> </span><span class=3D"awspan">respuesta</span><span class=3D"awspan"= style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">al</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"a= wspan">estr=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:0.5= pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">se</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan"= >presentan</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </s= pan><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-= spacing:0.5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">RC</span><= span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D= "awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </s= pan><span class=3D"awspan">mejorar</span><span class=3D"awspan" style=3D"le= tter-spacing:0.5pt"> </span><span class=3D"awspan">la</span><span class=3D"= awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">prote= cci=C3=B3n frente</span><span class=3D"awspan" style=3D"letter-spacing:4.4p= t"> </span><span class=3D"awspan">al</span><span class=3D"awspan" style=3D"= letter-spacing:4.4pt"> </span><span class=3D"awspan">estr=C3=A9s.</span><sp= an class=3D"awspan" style=3D"letter-spacing:4.4pt"> </span><span class=3D"a= wspan">En</span><span class=3D"awspan" style=3D"letter-spacing:4.4pt"> </sp= an><span class=3D"awspan">este</span><span class=3D"awspan" style=3D"letter= -spacing:4.4pt"> </span><span class=3D"awspan">contexto</span><span class= =3D"awspan" style=3D"letter-spacing:4.4pt"> </span><span class=3D"awspan">l= os</span><span class=3D"awspan" style=3D"letter-spacing:4.4pt"> </span><spa= n class=3D"awspan">principales</span><span class=3D"awspan" style=3D"letter= -spacing:4.4pt"> </span><span class=3D"awspan">candidatos</span><span class= =3D"awspan" style=3D"letter-spacing:4.4pt"> </span><span class=3D"awspan">s= on</span><span class=3D"awspan" style=3D"letter-spacing:4.4pt"> </span><spa= n class=3D"awspan">inhibidores</span><span class=3D"awspan" style=3D"letter= -spacing:4.4pt"> </span><span class=3D"awspan">del metabolismo</span><span = class=3D"awspan" style=3D"letter-spacing:1.95pt"> </span><span class=3D"aws= pan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.95pt"> </spa= n><span class=3D"awspan">grasas</span><span class=3D"awspan" style=3D"lette= r-spacing:1.95pt"> </span><span class=3D"awspan">y</span><span class=3D"aws= pan" style=3D"letter-spacing:1.95pt"> </span><span class=3D"awspan">carbohi= dratos</span><span class=3D"awspan" style=3D"letter-spacing:1.95pt"> </span= ><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spac= ing:1.95pt"> </span><span class=3D"awspan">nivel</span><span class=3D"awspa= n" style=3D"letter-spacing:1.95pt"> </span><span class=3D"awspan">intestina= l,</span><span class=3D"awspan" style=3D"letter-spacing:1.95pt"> </span><sp= an class=3D"awspan">inhibidores</span><span class=3D"awspan" style=3D"lette= r-spacing:1.95pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:1.95pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.95pt"> </span><span cla= ss=3D"awspan">gluc=C3=B3lisis intracelular,</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">estimuladores<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0= .1pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">v=C3=ADa</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D= "awspan">AMPK,</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"= > </span><span class=3D"awspan">activadores</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"aw= span">sirtuina,</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt= "> </span><span class=3D"awspan">inhibidores</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"a= wspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </s= pan><span class=3D"awspan">v=C3=ADa mTOR y poliaminas (16).</span></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"aw= span">Metformina,</span><span class=3D"awspan" style=3D"letter-spacing:-0.6= pt"> </span><span class=3D"awspan">biguanida</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">sint=C3=A9tic= a,</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><sp= an class=3D"awspan">f=C3=A1rmaco</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.6pt"> </span><span class=3D"awspan">antidiab=C3=A9tico</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class= =3D"awspan">eficaz</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 6pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">v=C3=ADa</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D= "awspan">oral</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt">= </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.6pt"> </span><span class=3D"awspan">sensibilizante a</span><s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> </span><span class=3D"aw= span">la</span><span class=3D"awspan" style=3D"letter-spacing:2pt"> </span>= <span class=3D"awspan">insulina</span><span class=3D"awspan" style=3D"lette= r-spacing:2pt"> </span><span class=3D"awspan">primera</span><span class=3D"= awspan" style=3D"letter-spacing:2pt"> </span><span class=3D"awspan">l=C3=AD= nea</span><span class=3D"awspan" style=3D"letter-spacing:2pt"> </span><span= class=3D"awspan">para</span><span class=3D"awspan" style=3D"letter-spacing= :2pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style= =3D"letter-spacing:2pt"> </span><span class=3D"awspan">tratamiento</span><s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> </span><span class=3D"aw= span">de</span><span class=3D"awspan" style=3D"letter-spacing:2pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:2pt"> </span><span class=3D"awspan">diabetes</span><span class=3D"awspa= n" style=3D"letter-spacing:2pt"> </span><span class=3D"awspan">mellitus</sp= an><span class=3D"awspan" style=3D"letter-spacing:2pt"> </span><span class= =3D"awspan">tipo</span><span class=3D"awspan" style=3D"letter-spacing:2pt">= </span><span class=3D"awspan">2</span><span class=3D"awspan" style=3D"lett= er-spacing:2pt"> </span><span class=3D"awspan">(DM2). Compuesto</span><span= class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"aws= pan">que</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </spa= n><span class=3D"awspan">atrae</span><span class=3D"awspan" style=3D"letter= -spacing:1.7pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">atenci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><s= pan class=3D"awspan">dados</span><span class=3D"awspan" style=3D"letter-spa= cing:1.7pt"> </span><span class=3D"awspan">sus</span><span class=3D"awspan"= style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">efectos</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class= =3D"awspan">mediados</span><span class=3D"awspan" style=3D"letter-spacing:1= .7pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" style= =3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">la</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan"= >prote=C3=ADna</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt">= </span><span class=3D"awspan">quinasa activada</span><span class=3D"awspan= " style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">por</span><= span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D= "awspan">AMP</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> <= /span><span class=3D"awspan">(AMPK).</span><span class=3D"awspan" style=3D"= letter-spacing:0.1pt"> </span><span class=3D"awspan">Inhibe</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan"= >transitoriamente</span><span class=3D"awspan" style=3D"letter-spacing:0.1p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:0.1pt"> </span><span class=3D"awspan">cadena</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan"= >respiratoria</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> = </span><span class=3D"awspan">mitocondrial, aumenta</span><span class=3D"aw= span" style=3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span cla= ss=3D"awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:3.75pt"> </span><span class=3D"awspan">AMP/ATP</span><span class=3D"a= wspan" style=3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">intra= celular</span><span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </spa= n><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spa= cing:3.75pt"> </span><span class=3D"awspan">activa</span><span class=3D"aws= pan" style=3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">la</spa= n><span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span clas= s=3D"awspan">AMPK,</span><span class=3D"awspan" style=3D"letter-spacing:3.7= 5pt"> </span><span class=3D"awspan">lo</span><span class=3D"awspan" style= =3D"letter-spacing:3.75pt"> </span><span class=3D"awspan">que</span><span c= lass=3D"awspan" style=3D"letter-spacing:3.75pt"> </span><span class=3D"awsp= an">mejora</span><span class=3D"awspan" style=3D"letter-spacing:3.75pt"> </= span><span class=3D"awspan">el metabolismo</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"aws= pan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </spa= n><span class=3D"awspan">glucosa</span><span class=3D"awspan" style=3D"lett= er-spacing:0.15pt"> </span><span class=3D"awspan">(13). </span><span class= =3D"awspan"> </span><span class=3D"awspan">Esto</span><span class=3D"a= wspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">por</= span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span c= lass=3D"awspan">medio</span><span class=3D"awspan" style=3D"letter-spacing:= 0.15pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">3</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspa= n">mecanismos:</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"= > </span><span class=3D"awspan">activaci=C3=B3n</span><span class=3D"awspan= " style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">alost=C3= =A9rica mediante</span><span class=3D"awspan" style=3D"letter-spacing:-0.1p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:-0.1pt"> </span><span class=3D"awspan">uni=C3=B3n</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"a= wspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </s= pan><span class=3D"awspan">AMP</span><span class=3D"awspan" style=3D"letter= -spacing:-0.1pt"> </span><span class=3D"awspan">a</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class= =3D"awspan">subunidad</span><span class=3D"awspan" style=3D"letter-spacing:= -0.1pt"> </span><span class=3D"awspan">=CE=A5,</span><span class=3D"awspan"= style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">promoci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><= span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.1pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">fosforilaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.1pt"> </span><span class=3D"awspan">Thr-172</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">e inh= ibici=C3=B3n de la desfosforilaci=C3=B3n de Thr-172 (17). </span></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"aws= pan">La</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span= ><span class=3D"awspan">evidencia</span><span class=3D"awspan" style=3D"let= ter-spacing:1.9pt"> </span><span class=3D"awspan">respalda</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">= que</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><sp= an class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing= :1.9pt"> </span><span class=3D"awspan">metformina</span><span class=3D"awsp= an" style=3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">puede</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span clas= s=3D"awspan">aumentar</span><span class=3D"awspan" style=3D"letter-spacing:= 1.9pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:1.9pt"> </span><span class=3D"awspan">activaci=C3=B3n</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.9pt"> </span><span cla= ss=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.9pt= "> </span><span class=3D"awspan">AMPK</span><span class=3D"awspan" style=3D= "letter-spacing:1.9pt"> </span><span class=3D"awspan">al modular</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"a= wspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </s= pan><span class=3D"awspan">producci=C3=B3n</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"aws= pan">ATP</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </sp= an><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-s= pacing:0.05pt"> </span><span class=3D"awspan">las</span><span class=3D"awsp= an" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">mitocond= rias</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><= span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacin= g:0.05pt"> </span><span class=3D"awspan">dado</span><span class=3D"awspan" = style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">que</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D= "awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> <= /span><span class=3D"awspan">AMPK</span><span class=3D"awspan" style=3D"let= ter-spacing:0.05pt"> </span><span class=3D"awspan">est=C3=A1</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspa= n">regulada</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> <= /span><span class=3D"awspan">a la</span><span class=3D"awspan" style=3D"let= ter-spacing:0.9pt"> </span><span class=3D"awspan">baja</span><span class=3D= "awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">en</= span><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span cl= ass=3D"awspan">muchos</span><span class=3D"awspan" style=3D"letter-spacing:= 0.9pt"> </span><span class=3D"awspan">tipos</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awsp= an">enfermedades</span><span class=3D"awspan" style=3D"letter-spacing:0.9pt= "> </span><span class=3D"awspan">metab=C3=B3licas,</span><span class=3D"aws= pan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class= =3D"awspan">metformina</span><span class=3D"awspan" style=3D"letter-spacing= :0.9pt"> </span><span class=3D"awspan">mostr=C3=B3</span><span class=3D"aws= pan" style=3D"letter-spacing:0.9pt"> </span><span class=3D"awspan">un</span= ><span class=3D"awspan" style=3D"letter-spacing:0.9pt"> </span><span class= =3D"awspan">efecto beneficioso</span><span class=3D"awspan" style=3D"letter= -spacing:-0.15pt"> </span><span class=3D"awspan">particular</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspa= n">en</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span= ><span class=3D"awspan">varias</span><span class=3D"awspan" style=3D"letter= -spacing:-0.15pt"> </span><span class=3D"awspan">enfermedades</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"aws= pan">metab=C3=B3licas</span><span class=3D"awspan" style=3D"letter-spacing:= -0.15pt"> </span><span class=3D"awspan">relacionadas</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">con<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span= class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">edad</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">(14).</span><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span cla= ss=3D"awspan">Inhibidores</span><span class=3D"awspan" style=3D"letter-spac= ing:6.3pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan" = style=3D"letter-spacing:6.3pt"> </span><span class=3D"awspan">cotrasportado= r</span><span class=3D"awspan" style=3D"letter-spacing:6.3pt"> </span><span= class=3D"awspan">sodio</span><span class=3D"awspan" style=3D"letter-spacin= g:6.3pt"> </span><span class=3D"awspan">glucosa2</span><span class=3D"awspa= n" style=3D"letter-spacing:6.3pt"> </span><span class=3D"awspan">(SGLT2)</s= pan><span class=3D"awspan" style=3D"letter-spacing:6.3pt"> </span><span cla= ss=3D"awspan">incluyen</span><span class=3D"awspan" style=3D"letter-spacing= :6.3pt"> </span><span class=3D"awspan">canaglifozina, dapaglifozina</span><= span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D= "awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt"> </s= pan><span class=3D"awspan">empaglifozina.</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan">El</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"awspan= ">cotransportador</span><span class=3D"awspan" style=3D"letter-spacing:1.8p= t"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"= letter-spacing:1.8pt"> </span><span class=3D"awspan">sodio-glucosa</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.8pt"> </span><span class=3D"= awspan">(SGLT)-2</span><span class=3D"awspan" style=3D"letter-spacing:1.8pt= "> </span><span class=3D"awspan">es</span><span class=3D"awspan" style=3D"l= etter-spacing:1.8pt"> </span><span class=3D"awspan">una prote=C3=ADna</span= ><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class= =3D"awspan">integral</span><span class=3D"awspan" style=3D"letter-spacing:0= .25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">membrana</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D= "awspan">codificada</span><span class=3D"awspan" style=3D"letter-spacing:0.= 25pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" style= =3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspa= n">gen</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span= ><span class=3D"awspan">SLC7A2,</span><span class=3D"awspan" style=3D"lette= r-spacing:0.25pt"> </span><span class=3D"awspan">que</span><span class=3D"a= wspan" style=3D"letter-spacing:0.25pt"> </span><span class=3D"awspan">trans= porta</span><span class=3D"awspan" style=3D"letter-spacing:0.25pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:0.25pt"> </span><span class=3D"awspan">glucosa a</span><span class=3D"a= wspan" style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">trav= =C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:2.6pt"> </span= ><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spa= cing:2.6pt"> </span><span class=3D"awspan">las</span><span class=3D"awspan"= style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">membranas</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span cla= ss=3D"awspan">celulares</span><span class=3D"awspan" style=3D"letter-spacin= g:2.6pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">ri=C3=B1=C3=B3n= ,</span><span class=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span= class=3D"awspan">su</span><span class=3D"awspan" style=3D"letter-spacing:2= .6pt"> </span><span class=3D"awspan">mecanismo</span><span class=3D"awspan"= style=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">de</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.6pt"> </span><span class=3D"a= wspan">acci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:2.6= pt"> </span><span class=3D"awspan">implica</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.6pt"> </span><span class=3D"awspan">la inhibici=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacin= g:0.4pt"> </span><span class=3D"awspan">SGLT-2</span><span class=3D"awspan"= style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">en</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"a= wspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </s= pan><span class=3D"awspan">t=C3=BAbulos</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">renales</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"aw= span">proximales</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt= "> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"le= tter-spacing:0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"= awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">promo= ci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </sp= an><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-s= pacing:0.4pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan= " style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">excreci=C3= =B3n urinaria</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> = </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lett= er-spacing:1.1pt"> </span><span class=3D"awspan">glucosa</span><span class= =3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">m= ediante</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span= ><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spa= cing:1.1pt"> </span><span class=3D"awspan">inhibici=C3=B3n</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">= de</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><spa= n class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:= 1.1pt"> </span><span class=3D"awspan">reabsorci=C3=B3n</span><span class=3D= "awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">de</= span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span cl= ass=3D"awspan">glucosa.</span><span class=3D"awspan" style=3D"letter-spacin= g:1.1pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">glucosuria induc= ida</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><sp= an class=3D"awspan">produce</span><span class=3D"awspan" style=3D"letter-sp= acing:1.1pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan= " style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">p=C3=A9rdid= a</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span= class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1= .1pt"> </span><span class=3D"awspan">aproximadamente</span><span class=3D"a= wspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">200</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span cla= ss=3D"awspan">kcal/d=C3=ADa,</span><span class=3D"awspan" style=3D"letter-s= pacing:1.1pt"> </span><span class=3D"awspan">promoviendo</span><span class= =3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">a= s=C3=AD</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span= ><span class=3D"awspan">una p=C3=A9rdida</span><span class=3D"awspan" style= =3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">de</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"aws= pan">peso</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </= span><span class=3D"awspan">constante</span><span class=3D"awspan" style=3D= "letter-spacing:-0.25pt"> </span><span class=3D"awspan">y</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >genera</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </sp= an><span class=3D"awspan">un</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.25pt"> </span><span class=3D"awspan">cambio</span><span class=3D"= awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">pro= gresivo</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </sp= an><span class=3D"awspan">hacia</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.25pt"> </span><span class=3D"awspan">la</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">util= izaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.25pt"> </span><span class=3D"awspan">sustratos grasos dando = lugar a una marcada cetog=C3=A9nesis (13)(18).</span></p><p class=3D"awdiv"= style=3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span clas= s=3D"awspan">Los</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt= "> </span><span class=3D"awspan">inhibidores</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">de</span><span= class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"aws= pan">SGLT2</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </s= pan><span class=3D"awspan">activan</span><span class=3D"awspan" style=3D"le= tter-spacing:0.6pt"> </span><span class=3D"awspan">un</span><span class=3D"= awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">estad= o</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span= class=3D"awspan">catab=C3=B3lico</span><span class=3D"awspan" style=3D"let= ter-spacing:0.6pt"> </span><span class=3D"awspan">similar</span><span class= =3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">a= l</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span= class=3D"awspan">ayuno,</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.6pt"> </span><span class=3D"awspan">reduciendo</span><span class=3D"aw= span" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">la se= =C3=B1alizaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1= pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D= "letter-spacing:1pt"> </span><span class=3D"awspan">insulina</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">= al</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span = class=3D"awspan">disminuir</span><span class=3D"awspan" style=3D"letter-spa= cing:1pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" st= yle=3D"letter-spacing:1pt"> </span><span class=3D"awspan">glucemia.</span><= span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"a= wspan">El</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span= ><span class=3D"awspan">bajo</span><span class=3D"awspan" style=3D"letter-s= pacing:1pt"> </span><span class=3D"awspan">nivel</span><span class=3D"awspa= n" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">de</span><sp= an class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"aws= pan">insulina</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </= span><span class=3D"awspan">aumenta</span><span class=3D"awspan" style=3D"l= etter-spacing:1pt"> </span><span class=3D"awspan">la lip=C3=B3lisis,</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">donde</span><span class=3D"awspan" style=3D"letter-spacing:-0.4= 5pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" style= =3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">=C3=A1cidos</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span cla= ss=3D"awspan">grasos</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.45pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">someten</span><= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"= > 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| 88</span></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9= pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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color:#ffff= ff">2697-3391</span><span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 N= o. 2, pp. 69 =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3=A9dic= as, salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</sp= an></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span= ><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" ver= sion=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D= "width:209.31px; height:41.33px; font-family:'Times New Roman'; font-size:1= 6px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"= M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"e= venodd" /></g></g></svg></span></p><p class=3D"awdiv" style=3D"margin-right= :1pt; margin-left:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font= -family:Ebrima; font-size:11pt; color:#ffffff">www.anatomiadigital.org</spa= n></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; 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position:absolute" /></span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold= ; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:= absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (J= ard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">= Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">       =   </span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"te= xt-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; m= argin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" = style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anat= omiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt= ; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= </a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font= -size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline; 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.anatomiadigital.org" st= yle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigi= tal.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1"= >www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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Directo (00593) 0998-235-485</= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><a href=3D"http://www= .anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.anatomiadigital.org" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; color:#0563c1">www.anatomiadigital.org</span></a></p><p style=3D"= margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" = style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-r= ight:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadig= italeditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0= 998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#44= 72c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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wcQ+JigxALiTKYfB1cPTWp0dXVSWN9A3pVT1RUFHPm30bTxYsUP1OMwWCgqKgIq9V6+eCvZaj6q= +kf/vAHDhw4wK1TbmVK7mTa7XY8bjeKgAGSR4R4qjC9gbBIQ8iOo6MTR0f7zWjMQTYEqtARGW7t= jyOc3d04u7sJ0VzX4WTlIAgBIiyWECoet4umC67LZKtEDGJ8Oto7Q+CpWkBScbSChvoG9Ho902b= MYOKkSSxYeCf/2P53nlm7lqamJubPn8/w4cNDESeEIBAIYLfbOXbsGG+//Taf7t/HLdm3cNePFt= Lb66KsrIy271oHAXa97V/JkF6PnP6/071S62b6nZ1d3LN4MQCqpgWJweZLzQB0dHQSFRPD9Jn/Q= VRUJP/4cAcvvvgCZWVl5OTkkJGRQVxcHB6Ph4sXL3Ly5Mlgg9rZTt70fG6bN4+ICCsfbt1G+f6D= 9Hl9VyyuqiqpqakAoaoppaSzs5Po6GgCgQBdXV03dN5oNBIREYHD4QgRmC6Xi+TkZBRF4dKlS6H= 8eyMJDw8nLS2Nzs5Ompub0ev1IZqpr6/vJpoCKbiy5YBgY/nBu++x6sFV5ORMYEhsHIcOHOJ4xX= FOnvwavd6AXq9H07TgAkKQmmpjyQ+Xckv2OExGI9u3lXLwOoABxMXF8corr1BfX09vby9VVVVMm= jQp9Hh/8803OXHixA3dHjNmDKtWreKtt94iOzubnp4ePB4Pd999N36/n927d7Nr165Qz3g9KS4u= xu/3o6oqW7ZswWQysXr1al566SVOnDhx3R5ysFwDmuYPUHP2LP/98susWLGCsWPH8pMlP2HOvDk= 0NjTSdOkidrsdnaLDZrMxLNVGSnIK4eZwXK5e/ra5hH2f7MPnvf6JBWlyK8ePHycrK4uamhqKio= p49dVXkVJSXV19U4fNZjNjxoxh+fLlOJ1OWlpamDBhAps2baKtrY2IiAh0Ot1NbUyfPp2dO3dy+= vRpuru7mTlzJhaLhby8PKqrq783Uq8BrR+4pvoLvLjhJebcNoeC2QXExccyJCmByUou/VSJpmlo= gQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDPz+97/niy++YNy4cVewHdcTIQRHjhw= hIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jyck0NTVRVFRESUnJDU= EL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSpU6c4V1t30yvRL5qm0= d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+ybNky/H4/TU1NvPvu= uzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq6WWVlZ37tZIQSKomA= wGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XVkJCAikpKdTW1pKbm0= tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4vV6qqqquq1dWVsa8e= fMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4tf//fy/8AgnKjIiDL= f+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D"28" alt=3D"" style=3D"margin= -left:441.05pt; position:absolute" /></span><span class=3D"awspan">que</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span clas= s=3D"awspan">pueden</span><span class=3D"awspan" style=3D"letter-spacing:1.= 45pt"> </span><span class=3D"awspan">ser</span><span class=3D"awspan" style= =3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">usadas</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"a= wspan">por</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </= span><span class=3D"awspan">c=C3=A9lulas</span><span class=3D"awspan" style= =3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspa= n">alta</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </spa= n><span class=3D"awspan">actividad</span><span class=3D"awspan" style=3D"le= tter-spacing:1.45pt"> </span><span class=3D"awspan">metab=C3=B3lica</span><= span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">para</span><span class=3D"awspan" style=3D"letter-spacing:1.45p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:1.45pt"> </span><span class=3D"awspan">producci=C3=B3n</span= ><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span class= =3D"awspan">de energ=C3=ADa (19). </span></p><p class=3D"awdiv" style=3D"ma= rgin-right:1pt; margin-left:1pt"><span class=3D"awspan">Las</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan= ">v=C3=ADas</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> <= /span><span class=3D"awspan">mTOR,</span><span class=3D"awspan" style=3D"le= tter-spacing:1.05pt"> </span><span class=3D"awspan">AMPK</span><span class= =3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">= y</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><spa= n class=3D"awspan">sirtuina-1</span><span class=3D"awspan" style=3D"letter-= spacing:1.05pt"> </span><span class=3D"awspan">(SIRT1)</span><span class=3D= "awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">son= </span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span= class=3D"awspan">moduladores</span><span class=3D"awspan" style=3D"letter-= spacing:1.05pt"> </span><span class=3D"awspan">clave</span><span class=3D"a= wspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span cl= ass=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:1.05= pt"> </span><span class=3D"awspan">proceso</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">de envejecimien= to.</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><= span class=3D"awspan">La</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.25pt"> </span><span class=3D"awspan">prote=C3=ADna</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >quinasa</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </s= pan><span class=3D"awspan">mTOR</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.25pt"> </span><span class=3D"awspan">es</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">un</= span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span = class=3D"awspan">regulador</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.25pt"> </span><span class=3D"awspan">fundamental</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >del</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span>= <span class=3D"awspan">crecimiento y</span><span class=3D"awspan" style=3D"= letter-spacing:-0.3pt"> </span><span class=3D"awspan">el</span><span class= =3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">= metabolismo</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> <= /span><span class=3D"awspan">celular,</span><span class=3D"awspan" style=3D= "letter-spacing:-0.3pt"> </span><span class=3D"awspan">se</span><span class= =3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">= trata</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span>= <span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spac= ing:-0.3pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan"= style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">serina-treo= nina</span><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><= span class=3D"awspan">quinasa</span><span class=3D"awspan" style=3D"letter-= spacing:-0.3pt"> </span><span class=3D"awspan">de</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.3pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.3pt"> </span><span class= =3D"awspan">familia</span><span class=3D"awspan" style=3D"letter-spacing:-0= .3pt"> </span><span class=3D"awspan">relacionada con</span><span class=3D"a= wspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span clas= s=3D"awspan">fosfatidilinositol-3-OH</span><span class=3D"awspan" style=3D"= letter-spacing:0.5pt"> </span><span class=3D"awspan">quinasa,</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspa= n">est=C3=A1</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> <= /span><span class=3D"awspan">controlada</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">por</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan= ">nutrientes</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> <= /span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter= -spacing:0.5pt"> </span><span class=3D"awspan">hormonas</span><span class= =3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">y= </span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span = class=3D"awspan">est=C3=A1 mediada</span><span class=3D"awspan" style=3D"le= tter-spacing:1.1pt"> </span><span class=3D"awspan">por</span><span class=3D= "awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">la</= span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span cl= ass=3D"awspan">formaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-= spacing:1.1pt"> </span><span class=3D"awspan">de</span><span class=3D"awspa= n" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">dos</span>= <span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class= =3D"awspan">complejos:</span><span class=3D"awspan" style=3D"letter-spacing= :1.1pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">complejo</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class=3D"= awspan">mTOR</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> <= /span><span class=3D"awspan">1</span><span class=3D"awspan" style=3D"letter= -spacing:1.1pt"> </span><span class=3D"awspan">y</span><span class=3D"awspa= n" style=3D"letter-spacing:1.1pt"> </span><span class=3D"awspan">mTOR</span= ><span class=3D"awspan" style=3D"letter-spacing:1.1pt"> </span><span class= =3D"awspan">2,</span><span class=3D"awspan" style=3D"letter-spacing:1.1pt">= </span><span class=3D"awspan">ambos relacionados</span><span class=3D"awsp= an" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">con</span= ><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class= =3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt">= </span><span class=3D"awspan">envejecimiento,</span><span class=3D"awspan"= style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">se</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"a= wspan">estimula</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"= > </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"le= tter-spacing:0.2pt"> </span><span class=3D"awspan">respuesta</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan= ">al</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><s= pan class=3D"awspan">incremento</span><span class=3D"awspan" style=3D"lette= r-spacing:0.2pt"> </span><span class=3D"awspan">de</span><span class=3D"aws= pan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">insulina= </span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span = class=3D"awspan">e IGF1.</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.25pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan" = style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">prote=C3=AD= na</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><s= pan class=3D"awspan">quinasa</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.25pt"> </span><span class=3D"awspan">activada</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >por</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span>= <span class=3D"awspan">AMP</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.25pt"> </span><span class=3D"awspan">(AMPK)</span><span class=3D"aw= span" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">es</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span c= lass=3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 25pt"> </span><span class=3D"awspan">sensor</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">del</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D= "awspan">estado</span><span class=3D"awspan" style=3D"letter-spacing:-0.25p= t"> </span><span class=3D"awspan">energ=C3=A9tico de la c=C3=A9lula, se act= iva en respuesta al aumento de la relaci=C3=B3n AMP/ATP (18).</span></p><p = class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"= awspan">Los</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </= span><span class=3D"awspan">SGLT2i</span><span class=3D"awspan" style=3D"le= tter-spacing:2.3pt"> </span><span class=3D"awspan">activan</span><span clas= s=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><spa= n class=3D"awspan">AMPK,</span><span class=3D"awspan" style=3D"letter-spaci= ng:2.3pt"> </span><span class=3D"awspan">mediante</span><span class=3D"awsp= an" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class= =3D"awspan">inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:2.3pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan= " style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">complejo</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span cla= ss=3D"awspan">I</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"= > </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"le= tter-spacing:2.3pt"> </span><span class=3D"awspan">la</span><span class=3D"= awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">caden= a respiratoria</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"= > </span><span class=3D"awspan">mitocondrial,</span><span class=3D"awspan" = style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">incrementand= o</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><spa= n class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing= :4.15pt"> </span><span class=3D"awspan">niveles</span><span class=3D"awspan= " style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span class= =3D"awspan">AMP</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt= "> </span><span class=3D"awspan">celular</span><span class=3D"awspan" style= =3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan= ">activando alost=C3=A9ricamente</span><span class=3D"awspan" style=3D"lett= er-spacing:0.3pt"> </span><span class=3D"awspan">la</span><span class=3D"aw= span" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">AMPK</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span cla= ss=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"= > </span><span class=3D"awspan">trav=C3=A9s</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">de</span><span = class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awsp= an">lafosforilaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.3pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">Thr-172</span><= span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D= "awspan">por</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> <= /span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lette= r-spacing:0.3pt"> </span><span class=3D"awspan">quinasa</span><span class= =3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">h= ep=C3=A1tica B1</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt= "> </span><span class=3D"awspan">(LKB1).</span><span class=3D"awspan" style= =3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">Se</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspa= n">ha</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span>= <span class=3D"awspan">planteado</span><span class=3D"awspan" style=3D"lett= er-spacing:0.75pt"> </span><span class=3D"awspan">que</span><span class=3D"= awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">la</= span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span c= lass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.7= 5pt"> </span><span class=3D"awspan">AMPK</span><span class=3D"awspan" style= =3D"letter-spacing:0.75pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><= span class=3D"awspan">regulaci=C3=B3n</span><span class=3D"awspan" style=3D= "letter-spacing:0.75pt"> </span><span class=3D"awspan">positiva</span><span= class=3D"awspan" style=3D"letter-spacing:0.75pt"> </span><span class=3D"aw= span">de</span><span class=3D"awspan" style=3D"letter-spacing:0.75pt"> </sp= an><span class=3D"awspan">adiponectina suprimen</span><span class=3D"awspan= " style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">la</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">inflamaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.25pt"> </span><span class=3D"awspan">cr=C3=B3nica.</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awsp= an">La</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </spa= n><span class=3D"awspan">regulaci=C3=B3n</span><span class=3D"awspan" style= =3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">negativa</span><= span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt= "> </span><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"= letter-spacing:-0.25pt"> </span><span class=3D"awspan">v=C3=ADas</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> <= /span><span class=3D"awspan">insulina/IGF1</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">y</span><span = class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"aw= span">la se=C3=B1alizaci=C3=B3n</span><span class=3D"awspan" style=3D"lette= r-spacing:2.9pt"> </span><span class=3D"awspan">de</span><span class=3D"aws= pan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">mTOR</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span clas= s=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:2.9pt">= </span><span class=3D"awspan">partir</span><span class=3D"awspan" style=3D= "letter-spacing:2.9pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">u= na</span><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><spa= n class=3D"awspan">reducci=C3=B3n</span><span class=3D"awspan" style=3D"let= ter-spacing:2.9pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span clas= s=3D"awspan">glucosa</span><span class=3D"awspan" style=3D"letter-spacing:2= .9pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan= ">amino=C3=A1cidos circulantes</span><span class=3D"awspan" style=3D"letter= -spacing:0.5pt"> </span><span class=3D"awspan">promueven</span><span class= =3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">m= ecanismos</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </sp= an><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-s= pacing:0.5pt"> </span><span class=3D"awspan">reparaci=C3=B3n</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan= ">celular</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </sp= an><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-= spacing:0.5pt"> </span><span class=3D"awspan">incluyen</span><span class=3D= "awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">la</= span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span cl= ass=3D"awspan">autofagia</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.5pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">la proteostasis,= </span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span= class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:= 0.85pt"> </span><span class=3D"awspan">confieren</span><span class=3D"awspa= n" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">resistenc= ia</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><sp= an class=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-spacing= :0.85pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span class=3D"aw= span" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">celula= r</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><spa= n class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0= .85pt"> </span><span class=3D"awspan">aten=C3=BAan</span><span class=3D"aws= pan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">la</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span clas= s=3D"awspan">senescencia</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">celular (19). </span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspa= n">Rapamicina,</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"= > </span><span class=3D"awspan">inicialmente</span><span class=3D"awspan" s= tyle=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">descrita</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span clas= s=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:1.45= pt"> </span><span class=3D"awspan">f=C3=A1rmaco</span><span class=3D"awspan= " style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">inmunosupr= esor,</span><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span>= <span class=3D"awspan">hoy</span><span class=3D"awspan" style=3D"letter-spa= cing:1.45pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan"= style=3D"letter-spacing:1.45pt"> </span><span class=3D"awspan">d=C3=ADa</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.45pt"> </span><span cl= ass=3D"awspan">referido como</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.45pt"> </span><span class=3D"awspan">un</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">compues= to</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><s= pan class=3D"awspan">MRC.</span><span class=3D"awspan" style=3D"letter-spac= ing:-0.45pt"> </span><span class=3D"awspan">Se</span><span class=3D"awspan"= style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">ha</span><= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class= =3D"awspan">demostrado</span><span class=3D"awspan" style=3D"letter-spacing= :-0.45pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">la</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D= "awspan">rapamicina</span><span class=3D"awspan" style=3D"letter-spacing:-0= .45pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" style= =3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">une</span><span = class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"aw= span">directamente</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 45pt"> </span><span class=3D"awspan">entre FKBP12</span><span class=3D"awsp= an" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">y</span><sp= an class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"aws= pan">las</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span>= <span class=3D"awspan">subunidades</span><span class=3D"awspan" style=3D"le= tter-spacing:1pt"> </span><span class=3D"awspan">de</span><span class=3D"aw= span" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">mTOR</spa= n><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class= =3D"awspan">quinasa</span><span class=3D"awspan" style=3D"letter-spacing:1p= t"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"= letter-spacing:1pt"> </span><span class=3D"awspan">mTORC1,</span><span clas= s=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">ca= usando</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><s= pan class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacin= g:1pt"> </span><span class=3D"awspan">inhibici=C3=B3n</span><span class=3D"= awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">de mTOR= </span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><spa= n class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.55pt"> </span><span class=3D"awspan">su</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">v=C3=ADa</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt= "> </span><span class=3D"awspan">se=C3=B1alizaci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan"= >posterior,</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> = </span><span class=3D"awspan">llamando</span><span class=3D"awspan" style= =3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">considerablement= e</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><sp= an class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing= :-0.55pt"> </span><span class=3D"awspan">atenci=C3=B3n</span><span class=3D= "awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">po= rque la</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span= ><span class=3D"awspan">actividad</span><span class=3D"awspan" style=3D"let= ter-spacing:0.7pt"> </span><span class=3D"awspan">y</span><span class=3D"aw= span" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">expresi= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span= ><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spa= cing:0.7pt"> </span><span class=3D"awspan">mTOR</span><span class=3D"awspan= " style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">aumentan</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span cla= ss=3D"awspan">significativamente</span><span class=3D"awspan" style=3D"lett= er-spacing:0.7pt"> </span><span class=3D"awspan">en</span><span class=3D"aw= span" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">el</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class= =3D"awspan">envejecimiento</span><span class=3D"awspan" style=3D"letter-spa= cing:0.7pt"> </span><span class=3D"awspan">y en</span><span class=3D"awspan= " style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">las</span>= <span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class= =3D"awspan">enfermedades</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.95pt"> </span><span class=3D"awspan">relacionadas</span><span class=3D= "awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">con= </span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span= class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0= .95pt"> </span><span class=3D"awspan">edad</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">(14).</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"= awspan">La</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </= span><span class=3D"awspan">rapamicina,</span><span class=3D"awspan" style= =3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">en</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspa= n">complejo</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> <= /span><span class=3D"awspan">con</span><span class=3D"awspan" style=3D"lett= er-spacing:0.95pt"> </span><span class=3D"awspan">la prote=C3=ADna</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt= "> </span><span class=3D"awspan">uni=C3=B3n</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">a</span><span= class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"a= wspan">FK506</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt">= </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.35pt"> </span><span class=3D"awspan">12</span><span class=3D= "awspan" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">kD= a</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><sp= an class=3D"awspan">(FKBP12),</span><span class=3D"awspan" style=3D"letter-= spacing:-0.35pt"> </span><span class=3D"awspan">act=C3=BAa</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan= ">inhibiendo</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.35pt"> </span><span class=3D"awspan">se=C3=B1alizaci=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span= class=3D"awspan">mTOR y,</span><span class=3D"awspan" style=3D"letter-spac= ing:2.25pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan"= style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">lo</span><s= pan class=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D= "awspan">tanto,</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt= "> </span><span class=3D"awspan">protege</span><span class=3D"awspan" style= =3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspa= n">m=C3=BAsculo</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt= "> </span><span class=3D"awspan">envejecido</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">de</span><span= class=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D"aw= span">la</span><span class=3D"awspan" style=3D"letter-spacing:2.25pt"> </sp= an><span class=3D"awspan">atrofia</span><span class=3D"awspan" style=3D"let= ter-spacing:2.25pt"> </span><span class=3D"awspan">y</span><span class=3D"a= wspan" style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">la</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.25pt"> </span><span cl= ass=3D"awspan">p=C3=A9rdida</span><span class=3D"awspan" style=3D"letter-sp= acing:2.25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan= " style=3D"letter-spacing:2.25pt"> </span><span class=3D"awspan">calidad mu= scular</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span= ><span class=3D"awspan">al</span><span class=3D"awspan" style=3D"letter-spa= cing:0.35pt"> </span><span class=3D"awspan">reducir</span><span class=3D"aw= span" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">el</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span cla= ss=3D"awspan">estr=C3=A9s</span><span class=3D"awspan" style=3D"letter-spac= ing:0.35pt"> </span><span class=3D"awspan">oxidativo</span><span class=3D"a= wspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">mitoc= ondrial</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </spa= n><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spa= cing:0.35pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan"= style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">da=C3=B1o</= span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span c= lass=3D"awspan">celular</span><span class=3D"awspan" style=3D"letter-spacin= g:0.35pt"> </span><span class=3D"awspan">relacionado</span><span class=3D"a= wspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">con</= span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span c= lass=3D"awspan">la edad</span><span class=3D"awspan" style=3D"letter-spacin= g:1.5pt"> </span><span class=3D"awspan">avanzada</span><span class=3D"awspa= n" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">(20).</spa= n><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class= =3D"awspan">Estos</span><span class=3D"awspan" style=3D"letter-spacing:1.5p= t"> </span><span class=3D"awspan">efectos</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">de</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><s= pan class=3D"awspan">rapamicina</span><span class=3D"awspan" style=3D"lette= r-spacing:1.5pt"> </span><span class=3D"awspan">sobre</span><span class=3D"= awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">la</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span cla= ss=3D"awspan">longevidad,</span><span class=3D"awspan" style=3D"letter-spac= ing:1.5pt"> </span><span class=3D"awspan">explicados</span><span class=3D"a= wspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">a trav= =C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:0.55pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan= " style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">activaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:0.55pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan= " style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">autofagia<= /span><span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span = class=3D"awspan">mediada</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.55pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" = style=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">la</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class=3D"= awspan">inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacin= g:0.55pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.55pt"> </span><span class=3D"awspan">mTORC1,</span>= <span class=3D"awspan" style=3D"letter-spacing:0.55pt"> </span><span class= =3D"awspan">sugieren que</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.95pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">rapamicina</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span cl= ass=3D"awspan">podr=C3=ADa</span><span class=3D"awspan" style=3D"letter-spa= cing:0.95pt"> </span><span class=3D"awspan">usarse</span><span class=3D"aws= pan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">como</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span cl= ass=3D"awspan">un</span><span class=3D"awspan" style=3D"letter-spacing:0.95= pt"> </span><span class=3D"awspan">f=C3=A1rmaco</span><span class=3D"awspan= " style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">antienveje= cimiento.</span><span class=3D"awspan" style=3D"letter-spacing:0.95pt"> </s= pan><span class=3D"awspan">Sin</span><span class=3D"awspan" style=3D"letter= -spacing:0.95pt"> </span><span class=3D"awspan">embargo,</span><span class= =3D"awspan" style=3D"letter-spacing:0.95pt"> </span><span class=3D"awspan">= la rapamicina</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt">= </span><span class=3D"awspan">tambi=C3=A9n</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">presenta</span= ><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span class= =3D"awspan">importantes</span><span class=3D"awspan" style=3D"letter-spacin= g:1.05pt"> </span><span class=3D"awspan">efectos</span><span class=3D"awspa= n" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">inmunosup= resores</span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </spa= n><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-s= pacing:1.05pt"> </span><span class=3D"awspan">limitan</span><span class=3D"= awspan" style=3D"letter-spacing:1.05pt"> </span><span class=3D"awspan">su</= span><span class=3D"awspan" style=3D"letter-spacing:1.05pt"> </span><span c= lass=3D"awspan">uso</span><span class=3D"awspan">  </span><span class= =3D"awspan">(21). </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; = margin-left:1pt; margin-bottom:10pt"><span class=3D"awspan">La</span><span = class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"aw= span">rapamicina</span><span class=3D"awspan" style=3D"letter-spacing:-0.55= pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D= "letter-spacing:-0.55pt"> </span><span class=3D"awspan">descubri=C3=B3</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span cla= ss=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 55pt"> </span><span class=3D"awspan">un</span><span class=3D"awspan" style= =3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">agente</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D= "awspan">antif=C3=BAngico,</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.55pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan"= style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">luego</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span cla= ss=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:-0.55= pt"> </span><span class=3D"awspan">identific=C3=B3</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">su</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span cl= ass=3D"awspan">actividad inmunosupresora</span><span class=3D"awspan" style= =3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan= ">anticancer=C3=ADgena</span><span class=3D"awspan" style=3D"letter-spacing= :1.25pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" sty= le=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">inhibir</span><= span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class= =3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"= > </span><span class=3D"awspan">objetivo</span><span class=3D"awspan" style= =3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">mecanicista</span= ><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"= > </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"le= tter-spacing:1.25pt"> </span><span class=3D"awspan">rapamicina (mTOR),</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span clas= s=3D"awspan">prote=C3=ADna</span><span class=3D"awspan" style=3D"letter-spa= cing:0.45pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan= " style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">pertenece<= /span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span = class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.4= 5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">familia</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"= awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </= span><span class=3D"awspan">fosfatidil</span><span class=3D"awspan" style= =3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">3</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan= ">quinasa</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </s= pan><span class=3D"awspan">PI3K</span><span class=3D"awspan" style=3D"lette= r-spacing:0.45pt"> </span><span class=3D"awspan">que</span><span class=3D"a= wspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">regul= a</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><spa= n class=3D"awspan">no solo</span><span class=3D"awspan" style=3D"letter-spa= cing:0.6pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" = style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">crecimiento</= span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span cl= ass=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt= "> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"l= etter-spacing:0.6pt"> </span><span class=3D"awspan">proliferaci=C3=B3n</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class= =3D"awspan">sino</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt= "> </span><span class=3D"awspan">tambi=C3=A9n</span><span class=3D"awspan" = style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">el</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"aw= span">metabolismo</span><span class=3D"awspan" style=3D"letter-spacing:0.6p= t"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"l= etter-spacing:0.6pt"> </span><span class=3D"awspan">el</span><span class=3D= "awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">enve= jecimiento. mTOR</span><span class=3D"awspan" style=3D"letter-spacing:-0.7p= t"> </span><span class=3D"awspan">forma</span><span class=3D"awspan" style= =3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">dos</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awsp= an">complejos</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt">= </span><span class=3D"awspan">proteicos</span><span class=3D"awspan" style= =3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">distintos,</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class= =3D"awspan">mTORC1</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 7pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D= "letter-spacing:-0.7pt"> </span><span class=3D"awspan">mTORC2;</span><span = class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"aws= pan">el</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </spa= n><span class=3D"awspan">primero</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.7pt"> </span><span class=3D"awspan">es</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">muy <= /span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><span style=3D"height:0pt; display:block; position:absolute; = z-index:823"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD= /2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx= 8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eH= h4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAABAQACAwEB= AAAAAAAAAAAAAAECBwMGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSByExExQXQVF= 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color:#ffffff">P=C3=A1gina</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:11pt; color:#ffffff"> 81 | 88<= /span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:9pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bol= d; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline">www.anatomiadigital.org</spa= n></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><a href=3D"http://www.ciencia= digitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline">www.cienciadigitaleditorial.com</span></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472= c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1= o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D= "color:#ffffff">ISSN: </span><span class=3D"awspan" style=3D"font-weight:bo= ld; color:#ffffff">2697-3391</span><span class=3D"awspan" style=3D"color:#f= fffff">Vol. 8 No. 2, pp. 69 =E2=80=93 88, abril - junio 2025Revista en cien= cias m=C3=A9dicas, salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliog= r=C3=A1fica</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt"><span><svg font-family=3D"Times New Roman" font-size=3D"16" heigh= t=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/200= 0/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Roma= n'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g= ><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d"= fill-rule=3D"evenodd" /></g></g></svg></span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><span class=3D"awspa= n" style=3D"font-family:Ebrima; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline">www.anatomiadigital.org</span></a></p><p style=3D"m= argin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" s= tyle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigi= taleditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:11pt; text-decoration:underline">www.c= ienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin= -right:1pt; 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-= 235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><a href=3D"h= ttp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cl= ass=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><= a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-dec= oration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine; 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098= 4058533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (0059= 3) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size= :11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; = text-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a= ></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#x= a0;      </span><a href=3D"http://www.cienciadigit= aleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" = style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http= ://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /= ></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn A= mbate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">         </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:abso= lute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:b= old; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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color:#0563c1">www.cienciadigitaleditorial= .com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:883"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhE= UgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwA= AA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFA= UBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ= 0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicVi= CCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQq= CgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrK= ysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDc= rkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHM= DLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeV= uYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuL= jA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJ= DCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSS= RCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nM= XbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3= Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmB= jdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHny= hFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1u= jVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAA= AAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-1= pt; 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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yJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDPz+97/niy++YN= y4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz8qVK9m3bx/Jy= ck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdECAXp6nDRfvMSp= U6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m7di0Oh4ODBw+= ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7/88sawSImorq= 6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1snjxYkpKSr7XV= kJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcHC2BlZSU5OTl4= vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY2nnvuOXJycv4= tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D"28" alt=3D"= " style=3D"margin-left:441.05pt; position:absolute" /></span><span class=3D= "awspan">sensible</span><span class=3D"awspan" style=3D"letter-spacing:1.75= pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style=3D"= letter-spacing:1.75pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:1.75pt"> </span><span class=3D"awspan">= rapamicina,</span><span class=3D"awspan" style=3D"letter-spacing:1.75pt"> <= /span><span class=3D"awspan">mientras</span><span class=3D"awspan" style=3D= "letter-spacing:1.75pt"> </span><span class=3D"awspan">que</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.75pt"> </span><span class=3D"awspan"= >el</span><span class=3D"awspan" style=3D"letter-spacing:1.75pt"> </span><s= pan class=3D"awspan">segundo</span><span class=3D"awspan" style=3D"letter-s= pacing:1.75pt"> </span><span class=3D"awspan">s=C3=B3lo</span><span class= =3D"awspan" style=3D"letter-spacing:1.75pt"> </span><span class=3D"awspan">= es</span><span class=3D"awspan" style=3D"letter-spacing:1.75pt"> </span><sp= an class=3D"awspan">cr=C3=B3nicamente</span><span class=3D"awspan" style=3D= "letter-spacing:1.75pt"> </span><span class=3D"awspan">sensible</span><span= class=3D"awspan" style=3D"letter-spacing:1.75pt"> </span><span class=3D"aw= span">a</span><span class=3D"awspan" style=3D"letter-spacing:1.75pt"> </spa= n><span class=3D"awspan">la rapamicina (2).</span></p><p class=3D"awdiv" st= yle=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"f= ont-weight:bold; color:#767171">4.Discusi=C3=B3n</span></p><p class=3D"awdi= v" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">Como<= /span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span c= lass=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:0.1= pt"> </span><span class=3D"awspan">propone</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">en</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspa= n">el</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><= span class=3D"awspan">estudio</span><span class=3D"awspan" style=3D"letter-= spacing:0.1pt"> </span><span class=3D"awspan">actual</span><span class=3D"a= wspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span clas= s=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"= > </span><span class=3D"awspan">es</span><span class=3D"awspan" style=3D"le= tter-spacing:0.1pt"> </span><span class=3D"awspan">una</span><span class=3D= "awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">inte= rvenci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> = </span><span class=3D"awspan">capaz</span><span class=3D"awspan" style=3D"l= etter-spacing:0.1pt"> </span><span class=3D"awspan">de</span><span class=3D= "awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">incr= ementar</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span= ><span class=3D"awspan">la esperanza</span><span class=3D"awspan" style=3D"= letter-spacing:0.3pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">v= ida</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><sp= an class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:= 0.3pt"> </span><span class=3D"awspan">mejorar</span><span class=3D"awspan" = style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"aw= span">salud</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </= span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter= -spacing:0.3pt"> </span><span class=3D"awspan">modelos</span><span class=3D= "awspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">expe= rimentales</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </s= pan><span class=3D"awspan">(7). </span><span class=3D"awspan"> </span>= <span class=3D"awspan">Una</span><span class=3D"awspan" style=3D"letter-spa= cing:0.3pt"> </span><span class=3D"awspan">investigaci=C3=B3n realizada</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span cla= ss=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.15p= t"> </span><span class=3D"awspan">C.</span><span class=3D"awspan" style=3D"= letter-spacing:2.15pt"> </span><span class=3D"awspan">elegans</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awsp= an">como</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </sp= an><span class=3D"awspan">modelo</span><span class=3D"awspan" style=3D"lett= er-spacing:2.15pt"> </span><span class=3D"awspan">experimental</span><span = class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"aws= pan">demostr=C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:2.1= 5pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style= =3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">una</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awsp= an">mezcla</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:2.15pt"> </span><span class=3D"awspan">15 compuestos</span><span c= lass=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspa= n">identificados</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt= "> </span><span class=3D"awspan">como</span><span class=3D"awspan" style=3D= "letter-spacing:3.6pt"> </span><span class=3D"awspan">MRC</span><span class= =3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">p= or</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><spa= n class=3D"awspan">marcadores</span><span class=3D"awspan" style=3D"letter-= spacing:3.6pt"> </span><span class=3D"awspan">transcripcionales,</span><spa= n class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"aw= span">gener=C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:3.6p= t"> </span><span class=3D"awspan">un aumento</span><span class=3D"awspan" s= tyle=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">porcentual</sp= an><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span clas= s=3D"awspan">significativo</span><span class=3D"awspan" style=3D"letter-spa= cing:2.2pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" = style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span class=3D"aw= span">longevidad</span><span class=3D"awspan" style=3D"letter-spacing:2.2pt= "> </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"l= etter-spacing:2.2pt"> </span><span class=3D"awspan">hasta</span><span class= =3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">u= n</span><span class=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span= class=3D"awspan">15%</span><span class=3D"awspan" style=3D"letter-spacing:= 2.2pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:2.2pt"> </span><span class=3D"awspan">la</span><span cla= ss=3D"awspan" style=3D"letter-spacing:2.2pt"> </span><span class=3D"awspan"= >poblaci=C3=B3n estudiada.</span><span class=3D"awspan" style=3D"letter-spa= cing:3.2pt"> </span><span class=3D"awspan">Adem=C3=A1s,</span><span class= =3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">m= uestra</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span>= <span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spac= ing:3.2pt"> </span><span class=3D"awspan">seguridad</span><span class=3D"aw= span" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt">= </span><span class=3D"awspan">intervenci=C3=B3n</span><span class=3D"awspa= n" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">ya</span><= span class=3D"awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D= "awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:3.2pt"> <= /span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lette= r-spacing:3.2pt"> </span><span class=3D"awspan">mezcla</span><span class=3D= "awspan" style=3D"letter-spacing:3.2pt"> </span><span class=3D"awspan">fue = empleada</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </spa= n><span class=3D"awspan">durante</span><span class=3D"awspan" style=3D"lett= er-spacing:1.7pt"> </span><span class=3D"awspan">18</span><span class=3D"aw= span" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">meses</= span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span cl= ass=3D"awspan">sin</span><span class=3D"awspan" style=3D"letter-spacing:1.7= pt"> </span><span class=3D"awspan">crear</span><span class=3D"awspan" style= =3D"letter-spacing:1.7pt"> </span><span class=3D"awspan">diferencias</span>= <span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class= =3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:1.7pt"> </span><span class=3D"awspan">mortalidad</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><span class=3D"awspan= ">o</span><span class=3D"awspan" style=3D"letter-spacing:1.7pt"> </span><sp= an class=3D"awspan">morbilidad</span><span class=3D"awspan" style=3D"letter= -spacing:1.7pt"> </span><span class=3D"awspan">entre ninguno de los grupos = (22).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1= pt"><span class=3D"awspan">En</span><span class=3D"awspan" style=3D"letter-= spacing:-0.2pt"> </span><span class=3D"awspan">base</span><span class=3D"aw= span" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">al</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span cla= ss=3D"awspan">presente</span><span class=3D"awspan" style=3D"letter-spacing= :-0.2pt"> </span><span class=3D"awspan">estudio</span><span class=3D"awspan= " style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">que</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class= =3D"awspan">expone</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 2pt"> </span><span class=3D"awspan">como</span><span class=3D"awspan" style= =3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">la</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspa= n">RC</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span>= <span class=3D"awspan">tiene</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.2pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">capacidad= </span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span= class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.2pt"> </span><span class=3D"awspan">activar</span><span class=3D"awspan" = style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">AMPK, misma<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span = class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.2pt"> </span><span class=3D"awspan">inhibe</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"a= wspan">actividad</span><span class=3D"awspan" style=3D"letter-spacing:-0.2p= t"> </span><span class=3D"awspan">mTOR,</span><span class=3D"awspan" style= =3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">represor</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D= "awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> <= /span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.2pt"> </span><span class=3D"awspan">autofagia</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan"= >(7).</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span>= <span class=3D"awspan">Se</span><span class=3D"awspan" style=3D"letter-spac= ing:-0.2pt"> </span><span class=3D"awspan">ha</span><span class=3D"awspan" = style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">demostrado</= span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span c= lass=3D"awspan">que la</span><span class=3D"awspan" style=3D"letter-spacing= :0.4pt"> </span><span class=3D"awspan">RC</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">promueve</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </s= pan><span class=3D"awspan">autofagia</span><span class=3D"awspan" style=3D"= letter-spacing:0.4pt"> </span><span class=3D"awspan">y</span><span class=3D= "awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">como= </span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span = class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:0.= 4pt"> </span><span class=3D"awspan">cree</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">el</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan"= >mecanismo</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </s= pan><span class=3D"awspan">por</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">el</span><span class=3D"awsp= an" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">cual</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">guardan</span><span class=3D"awspan" style=3D"letter-spacing:0.= 4pt"> </span><span class=3D"awspan">relaci=C3=B3n con</span><span class=3D"= awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">la</= span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span c= lass=3D"awspan">detecci=C3=B3n</span><span class=3D"awspan" style=3D"letter= -spacing:0.65pt"> </span><span class=3D"awspan">de</span><span class=3D"aws= pan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">nutrien= tes</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><s= pan class=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spacin= g:0.65pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">medio</span><= span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"= > </span><span class=3D"awspan">mTOR.</span><span class=3D"awspan" style=3D= "letter-spacing:0.65pt"> </span><span class=3D"awspan">Sin</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan"= >embargo,</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </s= pan><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-= spacing:0.65pt"> </span><span class=3D"awspan">acuerdo</span><span class=3D= "awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">con= </span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span= class=3D"awspan">el estudio</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.35pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">RC</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span cla= ss=3D"awspan">mejora</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.35pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">funci=C3=B3n</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span c= lass=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:-0.3= 5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">calidad</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class= =3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:-0.35p= t"> </span><span class=3D"awspan">m=C3=BAsculo</span><span class=3D"awspan"= style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">esquel=C3= =A9tico</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </sp= an><span class=3D"awspan">independientemente de</span><span class=3D"awspan= " style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">la</span><s= pan class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"= awspan">supresi=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing= :3.6pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">mTOR,</span><span= class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"aws= pan">dado</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </sp= an><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-= spacing:3.6pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">inducci=C3= =B3n</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><s= pan class=3D"awspan">mediada</span><span class=3D"awspan" style=3D"letter-s= pacing:3.6pt"> </span><span class=3D"awspan">por</span><span class=3D"awspa= n" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">RC</span><= span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D= "awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </= span><span class=3D"awspan">genes</span><span class=3D"awspan" style=3D"let= ter-spacing:3.6pt"> </span><span class=3D"awspan">de mantenimiento</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D= "awspan">som=C3=A1tico</span><span class=3D"awspan" style=3D"letter-spacing= :-0.1pt"> </span><span class=3D"awspan">Xbp1</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">se</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"a= wspan">asoci=C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 1pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">acumulaci=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0= .1pt"> </span><span class=3D"awspan">p62</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan= ">mayor</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </spa= n><span class=3D"awspan">integridad</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.1pt"> </span><span class=3D"awspan">del m=C3=BAsculo</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span clas= s=3D"awspan">esquel=C3=A9tico.</span><span class=3D"awspan" style=3D"letter= -spacing:-0.15pt"> </span><span class=3D"awspan">Lo</span><span class=3D"aw= span" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">que</= span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span = class=3D"awspan">destaca</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.15pt"> </span><span class=3D"awspan">que</span><span class=3D"awspan"= style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class= =3D"awspan">supresi=C3=B3n</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.15pt"> </span><span class=3D"awspan">mTOR1</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">no</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span cl= ass=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= 5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">=C3=BAnica</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span clas= s=3D"awspan">responsable de los efectos beneficiosos de la RC en la homeost= asis muscular (23).</span></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt"><span class=3D"awspan">Como</span><span class=3D"awspan" = style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">se</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"= awspan">expresa</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt= "> </span><span class=3D"awspan">durante</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspa= n">estudio</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </= span><span class=3D"awspan">algunos</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.1pt"> </span><span class=3D"awspan">MRC</span><span class= =3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">= como</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><= span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.1pt"> </span><span class=3D"awspan">rapamicina</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">act= =C3=BAan</span><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </sp= an><span class=3D"awspan">inhibiendo la</span><span class=3D"awspan" style= =3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">se=C3=B1alizaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </sp= an><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.25pt"> </span><span class=3D"awspan">mTOR,</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">lo</= span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span = class=3D"awspan">cual</span><span class=3D"awspan" style=3D"letter-spacing:= -0.25pt"> </span><span class=3D"awspan">protege</span><span class=3D"awspan= " style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">el</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">m=C3=BAsculo</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.25pt"> </span><span class=3D"awspan">envejecido</span><span class=3D"= awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">de<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span= class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.25pt"> </span><span class=3D"awspan">atrofia</span><span class=3D"awspan"= style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">y</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt= "> </span><span class=3D"awspan">p=C3=A9rdida de</span><span class=3D"awspa= n" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">calidad</s= pan><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span cla= ss=3D"awspan">muscular</span><span class=3D"awspan" style=3D"letter-spacing= :3.6pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">reducir</span><sp= an class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"a= wspan">el</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </sp= an><span class=3D"awspan">estr=C3=A9s</span><span class=3D"awspan" style=3D= "letter-spacing:3.6pt"> </span><span class=3D"awspan">oxidativo</span><span= class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"aws= pan">mitocondrial</span><span class=3D"awspan" style=3D"letter-spacing:3.6p= t"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"l= etter-spacing:3.6pt"> </span><span class=3D"awspan">el</span><span class=3D= "awspan" style=3D"letter-spacing:3.6pt"> </span><span class=3D"awspan">da= =C3=B1o</span><span class=3D"awspan" style=3D"letter-spacing:3.6pt"> </span= ><span class=3D"awspan">celular relacionado</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">con</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"a= wspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </s= pan><span class=3D"awspan">edad</span><span class=3D"awspan" style=3D"lette= r-spacing:0.05pt"> </span><span class=3D"awspan">avanzada</span><span class= =3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">= (20).</span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span>= <span class=3D"awspan">Sin</span><span class=3D"awspan" style=3D"letter-spa= cing:0.05pt"> </span><span class=3D"awspan">embargo,</span><span class=3D"a= wspan" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">un</s= pan><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span cl= ass=3D"awspan">estudio</span><span class=3D"awspan" style=3D"letter-spacing= :0.05pt"> </span><span class=3D"awspan">comparativo</span><span class=3D"aw= span" style=3D"letter-spacing:0.05pt"> </span><span class=3D"awspan">entre<= /span><span class=3D"awspan" style=3D"letter-spacing:0.05pt"> </span><span = class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0.= 05pt"> </span><span class=3D"awspan">y rapamicina</span><span class=3D"awsp= an" style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">demuestr= a</span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><spa= n class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing= :1.35pt"> </span><span class=3D"awspan">ejercen</span><span class=3D"awspan= " style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">efectos</s= pan><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span cl= ass=3D"awspan">distintos,</span><span class=3D"awspan" style=3D"letter-spac= ing:1.35pt"> </span><span class=3D"awspan">no</span><span class=3D"awspan" = style=3D"letter-spacing:1.35pt"> </span><span class=3D"awspan">superpuestos= </span><span class=3D"awspan" style=3D"letter-spacing:1.35pt"> </span><span= class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1.= 35pt"> </span><span class=3D"awspan">frecuentemente aditivos</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan= ">en</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><s= pan class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacin= g:0.6pt"> </span><span class=3D"awspan">envejecimiento</span><span class=3D= "awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">del<= /span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span c= lass=3D"awspan">m=C3=BAsculo</span><span class=3D"awspan" style=3D"letter-s= pacing:0.6pt"> </span><span class=3D"awspan">esquel=C3=A9tico</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspa= n">(23).</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </spa= n><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter-sp= acing:0.6pt"> </span><span class=3D"awspan">fracaso</span><span class=3D"aw= span" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt">= </span><span class=3D"awspan">rapamicina para</span><span class=3D"awspan"= style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">recapitular= </span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span= class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:= -0.7pt"> </span><span class=3D"awspan">efectos</span><span class=3D"awspan"= style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D= "awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> <= /span><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.7pt"> </span><span class=3D"awspan">y</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">vicever= sa</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><sp= an class=3D"awspan">plantea</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.7pt"> </span><span class=3D"awspan">una</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">perspecti= va</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><sp= an class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing= :-0.7pt"> </span><span class=3D"awspan">intervenciones m=C3=BAltiples</span= ><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class= =3D"awspan">aditivas.</span><span class=3D"awspan" style=3D"letter-spacing:= 1.65pt"> </span><span class=3D"awspan">El</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">estudio</span><s= pan class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D= "awspan">citado</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt= "> </span><span class=3D"awspan">tambi=C3=A9n</span><span class=3D"awspan" = style=3D"letter-spacing:1.65pt"> </span><span class=3D"awspan">menciona</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span cla= ss=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:1.65= pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D= "letter-spacing:1.65pt"> </span><span class=3D"awspan">fenotipo</span><span= class=3D"awspan" style=3D"letter-spacing:1.65pt"> </span><span class=3D"aw= span">muscular</span><span class=3D"awspan" style=3D"letter-spacing:1.65pt"= > </span><span class=3D"awspan">m=C3=A1s consistente</span><span class=3D"a= wspan" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">ident= ificado</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </spa= n><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-sp= acing:4.15pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan= " style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">investigac= i=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </sp= an><span class=3D"awspan">es</span><span class=3D"awspan" style=3D"letter-s= pacing:4.15pt"> </span><span class=3D"awspan">el</span><span class=3D"awspa= n" style=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">cambio</s= pan><span class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span cl= ass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:4.15= pt"> </span><span class=3D"awspan">propiedad</span><span class=3D"awspan" s= tyle=3D"letter-spacing:4.15pt"> </span><span class=3D"awspan">de</span><spa= n class=3D"awspan" style=3D"letter-spacing:4.15pt"> </span><span class=3D"a= wspan">fibras musculares</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.4pt"> </span><span class=3D"awspan">r=C3=A1pidas</span><span class=3D= "awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">a</= span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span c= lass=3D"awspan">lentas</span><span class=3D"awspan" style=3D"letter-spacing= :-0.4pt"> </span><span class=3D"awspan">resistentes</span><span class=3D"aw= span" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">a</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span clas= s=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt= "> </span><span class=3D"awspan">fatiga</span><span class=3D"awspan" style= =3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan= ">m=C3=A1s</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </= span><span class=3D"awspan">resistentes</span><span class=3D"awspan" style= =3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">a</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><= span class=3D"awspan">atrofia</span><span class=3D"awspan" style=3D"letter-= spacing:-0.4pt"> </span><span class=3D"awspan">relacionada con</span><span = class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awsp= an">la</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span>= <span class=3D"awspan">edad,</span><span class=3D"awspan" style=3D"letter-s= pacing:1.6pt"> </span><span class=3D"awspan">dicha</span><span class=3D"aws= pan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">modifica= ci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </sp= an><span class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-s= pacing:1.6pt"> </span><span class=3D"awspan">aprecia</span><span class=3D"a= wspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">tanto<= /span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span c= lass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:1.6= pt"> </span><span class=3D"awspan">RC</span><span class=3D"awspan" style=3D= "letter-spacing:1.6pt"> </span><span class=3D"awspan">como</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">= en</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><spa= n class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:= 1.6pt"> </span><span class=3D"awspan">intervenci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">c= on rapamicina, aunque en esta =C3=BAltima de forma menos marcada (23).</spa= n></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; margin= -bottom:10pt"><span class=3D"awspan">En</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">este</span><span= class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"a= wspan">mismo</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt">= </span><span class=3D"awspan">contexto</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">un</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"aws= pan">estudio</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt">= </span><span class=3D"awspan">realizado</span><span class=3D"awspan" style= =3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">en</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"aws= pan">ratones</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt">= </span><span class=3D"awspan">macho</span><span class=3D"awspan" style=3D"= letter-spacing:-0.65pt"> </span><span class=3D"awspan">encontr=C3=B3</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.65p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:-0.65pt"> </span><span class=3D"awspan">CR</span><span class= =3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan"= >mejor=C3=B3 la</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> = </span><span class=3D"awspan">composici=C3=B3n</span><span class=3D"awspan"= style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">corporal</span= ><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D= "awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </spa= n><span class=3D"awspan">proporcion=C3=B3</span><span class=3D"awspan" styl= e=3D"letter-spacing:1pt"> </span><span class=3D"awspan">protecci=C3=B3n</sp= an><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><span class= =3D"awspan">parcial</span><span class=3D"awspan" style=3D"letter-spacing:1p= t"> </span><span class=3D"awspan">contra</span><span class=3D"awspan" style= =3D"letter-spacing:1pt"> </span><span class=3D"awspan">el</span><span class= =3D"awspan" style=3D"letter-spacing:1pt"> </span><span class=3D"awspan">det= erioro</span><span class=3D"awspan" style=3D"letter-spacing:1pt"> </span><s= pan class=3D"awspan">funcional relacionado</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">con</span><span= class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"aw= span">la</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </sp= an><span class=3D"awspan">edad.</span><span class=3D"awspan" style=3D"lette= r-spacing:2.15pt"> </span><span class=3D"awspan">Las</span><span class=3D"a= wspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">v=C3= =ADas</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span>= <span class=3D"awspan">enriquecidas</span><span class=3D"awspan" style=3D"l= etter-spacing:2.15pt"> </span><span class=3D"awspan">por</span><span class= =3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">= CR</span><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><sp= an class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing= :2.15pt"> </span><span class=3D"awspan">ratones</span><span class=3D"awspan= " style=3D"letter-spacing:2.15pt"> </span><span class=3D"awspan">macho</spa= n><span class=3D"awspan" style=3D"letter-spacing:2.15pt"> </span><span clas= s=3D"awspan">apoyan</span><span class=3D"awspan" style=3D"letter-spacing:2.= 15pt"> </span><span class=3D"awspan">el mantenimiento</span><span class=3D"= awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">y</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span cl= ass=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= pt"> </span><span class=3D"awspan">reparaci=C3=B3n</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">de</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span clas= s=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:-0.1p= t"> </span><span class=3D"awspan">m=C3=BAsculos</span><span class=3D"awspan= " style=3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">y</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D= "awspan">suprimen</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">procesos</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> </span><span class=3D= "awspan">asociados</span><span class=3D"awspan" style=3D"letter-spacing:-0.= 1pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan" style= =3D"letter-spacing:-0.1pt"> </span><span class=3D"awspan">el envejecimiento= </span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span= class=3D"awspan">muscular.</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.2pt"> </span><span class=3D"awspan">La</span><span class=3D"awspan= " style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">regulaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </spa= n><span class=3D"awspan">negativa</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.2pt"> </span><span class=3D"awspan">de</span><span class=3D"= awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">las<= 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pos= ition:absolute" /></span><span class=3D"awspan" style=3D"color:#ffffff">ISS= N: </span><span class=3D"awspan" style=3D"font-weight:bold; color:#ffffff">= 2697-3391</span><span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2= , pp. 69 =E2=80=93 88, abril - junio 2025Revista en ciencias m=C3=A9dicas, = salud p=C3=BAblicaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span><sv= g font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" version= =3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"wid= th:209.31px; height:41.33px; font-family:'Times New Roman'; font-size:16px"= xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0= L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"eveno= dd" /></g></g></svg></span></p><p class=3D"awdiv" style=3D"margin-right:1pt= ; margin-left:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font-fam= ily:Ebrima; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=AD= a Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 = Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><a href=3D"http://www.anatomiadigital.org" s= tyle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadig= ital.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:11pt; text-decoration:underline">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline">www.cienciadigitaleditorial.com</span></a>= </p><p class=3D"awdiv" style=3D"margin-right:1pt; 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position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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position= :absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"t= ext-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; = margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org"= style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:11pt; text-decoration:underline; color:#0563c1">www.ana= tomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1p= t; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= </a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font= -size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline; 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.anatomiadigital.org" st= yle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigi= tal.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1"= >www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista= Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amba= to =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fo= nt-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bo= ld; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0= 998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-w= eight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#44= 72c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; fo= nt-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">    = 0;     </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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0.85pt"> </span><span class=3D"awspan">mTORC1,</span><span class=3D"awspan"= style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">dio</span><= span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class= =3D"awspan">como</span><span class=3D"awspan" style=3D"letter-spacing:0.85p= t"> </span><span class=3D"awspan">resultado</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">un</span><span= class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"aw= span">mayor</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> <= /span><span class=3D"awspan">equilibrio</span><span class=3D"awspan" style= =3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">y</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan= ">coordinaci=C3=B3n, sin</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.4pt"> </span><span class=3D"awspan">tener</span><span class=3D"awspan"= style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">ning=C3=BAn<= /span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span c= lass=3D"awspan">impacto</span><span class=3D"awspan" style=3D"letter-spacin= g:0.4pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">la</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspa= n">cantidad</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">m=C3=BAsculo.</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan= ">Estos</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span= ><span class=3D"awspan">resultados</span><span class=3D"awspan" style=3D"le= tter-spacing:0.4pt"> </span><span class=3D"awspan">respaldan</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan= ">el</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><s= pan class=3D"awspan">papel de</span><span class=3D"awspan" style=3D"letter-= spacing:0.15pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">rapamici= na</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><sp= an class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing= :0.15pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">mantenimiento</= span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span c= lass=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.1= 5pt"> </span><span class=3D"awspan">las</span><span class=3D"awspan" style= =3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">caracter=C3=ADsti= cas</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><s= pan class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacin= g:0.15pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">funci=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span c= lass=3D"awspan">muscular</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.15pt"> </span><span class=3D"awspan">sin</span><span class=3D"awspan" = style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">la consiguie= nte p=C3=A9rdida de masa muscular (24).</span></p><p class=3D"awdiv" style= =3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">En</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"aw= span">concordancia</span><span class=3D"awspan" style=3D"letter-spacing:0.6= pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan" style= =3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">los</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan= ">resultados</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> <= /span><span class=3D"awspan">del</span><span class=3D"awspan" style=3D"lett= er-spacing:0.6pt"> </span><span class=3D"awspan">estudio</span><span class= =3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">a= ctual</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><= span class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spac= ing:0.6pt"> </span><span class=3D"awspan">proponen</span><span class=3D"aws= pan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">que</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt">= </span><span class=3D"awspan">autofagia</span><span class=3D"awspan" style= =3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">se estimula</span>= <span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class= =3D"awspan">mediante</span><span class=3D"awspan" style=3D"letter-spacing:0= .65pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style= =3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">inhibici=C3=B3n</= span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span c= lass=3D"awspan">del</span><span class=3D"awspan" style=3D"letter-spacing:0.= 65pt"> </span><span class=3D"awspan">receptor</span><span class=3D"awspan" = style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">de</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"= awspan">rapamicina</span><span class=3D"awspan" style=3D"letter-spacing:0.6= 5pt"> </span><span class=3D"awspan">mTOR.</span><span class=3D"awspan" styl= e=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">Un</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awsp= an">estudio</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> <= /span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lette= r-spacing:0.65pt"> </span><span class=3D"awspan">2021 propone</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"aws= pan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </s= pan><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-= spacing:-0.25pt"> </span><span class=3D"awspan">RC</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">junto<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span= class=3D"awspan">conNPY</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.25pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">grelina</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span cla= ss=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.2= 5pt"> </span><span class=3D"awspan">son</span><span class=3D"awspan" style= =3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">MRC,</span><span= class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"a= wspan">estimulan</span><span class=3D"awspan" style=3D"letter-spacing:-0.25= pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D= "letter-spacing:-0.25pt"> </span><span class=3D"awspan">autofagia</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D= "awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> <= /span><span class=3D"awspan">trav=C3=A9s de</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">la</span><span = class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awsp= an">inhibici=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.= 7pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">PI3K/AKT/</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"= awspan">MTOR</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> <= /span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter= -spacing:0.7pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">activaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span= ><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spa= cing:0.7pt"> </span><span class=3D"awspan">ERK1/2-MAPK</span><span class=3D= "awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">auto= fagia</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><= span class=3D"awspan">en cultivos primarios de neuronas corticales de rata = (25). </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:= 1pt"><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"letter= -spacing:4.6pt"> </span><span class=3D"awspan">estudio</span><span class=3D= "awspan" style=3D"letter-spacing:4.6pt"> </span><span class=3D"awspan">actu= al</span><span class=3D"awspan" style=3D"letter-spacing:4.6pt"> </span><spa= n class=3D"awspan">identifica</span><span class=3D"awspan" style=3D"letter-= spacing:4.6pt"> </span><span class=3D"awspan">las</span><span class=3D"awsp= an" style=3D"letter-spacing:4.6pt"> </span><span class=3D"awspan">v=C3=ADas= </span><span class=3D"awspan" style=3D"letter-spacing:4.6pt"> </span><span = class=3D"awspan">mTOR,</span><span class=3D"awspan" style=3D"letter-spacing= :4.6pt"> </span><span class=3D"awspan">AMPK</span><span class=3D"awspan" st= yle=3D"letter-spacing:4.6pt"> </span><span class=3D"awspan">y</span><span c= lass=3D"awspan" style=3D"letter-spacing:4.6pt"> </span><span class=3D"awspa= n">sirtuina-1</span><span class=3D"awspan" style=3D"letter-spacing:4.6pt"> = </span><span class=3D"awspan">(SIRT1)</span><span class=3D"awspan" style=3D= "letter-spacing:4.6pt"> </span><span class=3D"awspan">como moduladores</spa= n><span class=3D"awspan" style=3D"letter-spacing:4.85pt"> </span><span clas= s=3D"awspan">clave</span><span class=3D"awspan" style=3D"letter-spacing:4.8= 5pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" style= =3D"letter-spacing:4.85pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:4.85pt"> </span><span class=3D"awspa= n">proceso</span><span class=3D"awspan" style=3D"letter-spacing:4.85pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:4.85pt"> </span><span class=3D"awspan">envejecimiento.</span><span= class=3D"awspan" style=3D"letter-spacing:4.85pt"> </span><span class=3D"aw= span">Un</span><span class=3D"awspan" style=3D"letter-spacing:4.85pt"> </sp= an><span class=3D"awspan">estudio</span><span class=3D"awspan" style=3D"let= ter-spacing:4.85pt"> </span><span class=3D"awspan">por</span><span class=3D= "awspan" style=3D"letter-spacing:4.85pt"> </span><span class=3D"awspan">med= io</span><span class=3D"awspan" style=3D"letter-spacing:4.85pt"> </span><sp= an class=3D"awspan">de transferencia</span><span class=3D"awspan" style=3D"= letter-spacing:0.5pt"> </span><span class=3D"awspan">Western</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan= ">mostr=C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> = </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"let= ter-spacing:0.5pt"> </span><span class=3D"awspan">los</span><span class=3D"= awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">nivel= es</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><spa= n class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:= 0.5pt"> </span><span class=3D"awspan">prote=C3=ADna</span><span class=3D"aw= span" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">CK2=CE= =B1</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><sp= an class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacing:= 0.5pt"> </span><span class=3D"awspan">CK2=CE=B2</span><span class=3D"awspan= " style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">aumentaron<= /span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span c= lass=3D"awspan">en la</span><span class=3D"awspan" style=3D"letter-spacing:= 2.65pt"> </span><span class=3D"awspan">condici=C3=B3n</span><span class=3D"= awspan" style=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">CR. = </span><span class=3D"awspan"> </span><span class=3D"awspan">El</span>= <span class=3D"awspan" style=3D"letter-spacing:2.65pt"> </span><span class= =3D"awspan">estudio</span><span class=3D"awspan" style=3D"letter-spacing:2.= 65pt"> </span><span class=3D"awspan">tambi=C3=A9n</span><span class=3D"awsp= an" style=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">indic=C3= =B3</span><span class=3D"awspan" style=3D"letter-spacing:2.65pt"> </span><s= pan class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacin= g:2.65pt"> </span><span class=3D"awspan">manera</span><span class=3D"awspan= " style=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">importante= </span><span class=3D"awspan" style=3D"letter-spacing:2.65pt"> </span><span= class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:= 2.65pt"> </span><span class=3D"awspan">CR</span><span class=3D"awspan" styl= e=3D"letter-spacing:2.65pt"> </span><span class=3D"awspan">regul=C3=B3 posi= tivamente</span><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </s= pan><span class=3D"awspan">CK2</span><span class=3D"awspan" style=3D"letter= -spacing:2.35pt"> </span><span class=3D"awspan">y</span><span class=3D"awsp= an" style=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">SIRT1</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span cl= ass=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.35= pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D= "letter-spacing:2.35pt"> </span><span class=3D"awspan">nivel</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class=3D"awspa= n">de</span><span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span>= <span class=3D"awspan">transcripci=C3=B3n,</span><span class=3D"awspan" sty= le=3D"letter-spacing:2.35pt"> </span><span class=3D"awspan">mientras</span>= <span class=3D"awspan" style=3D"letter-spacing:2.35pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:2.35pt= "> </span><span class=3D"awspan">CK2</span><span class=3D"awspan" style=3D"= letter-spacing:2.35pt"> </span><span class=3D"awspan">regul=C3=B3 positivam= ente</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><s= pan class=3D"awspan">SIRT1</span><span class=3D"awspan" style=3D"letter-spa= cing:1.4pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" = style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">el</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"aw= span">nivel</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </= span><span class=3D"awspan">postranscripci=C3=B3n.</span><span class=3D"aws= pan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">CK2,</sp= an><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span clas= s=3D"awspan">inducida</span><span class=3D"awspan" style=3D"letter-spacing:= 1.4pt"> </span><span class=3D"awspan">por</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.4pt"> </span><span class=3D"awspan">CR,</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.4pt"> </span><span class=3D"awspa= n">estimula</span><span class=3D"awspan" style=3D"letter-spacing:1.4pt"> </= span><span class=3D"awspan">el inicio</span><span class=3D"awspan" style=3D= "letter-spacing:1.6pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">l= a</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span= class=3D"awspan">autofagia</span><span class=3D"awspan" style=3D"letter-sp= acing:1.6pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" = style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">la</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"aw= span">nucleaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:= 1.6pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" style= =3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">inhibir</span><spa= n class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"aw= span">la</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </spa= n><span class=3D"awspan">v=C3=ADa</span><span class=3D"awspan" style=3D"let= ter-spacing:1.6pt"> </span><span class=3D"awspan">AKT-mTOR</span><span clas= s=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">= y</span><span class=3D"awspan" style=3D"letter-spacing:1.6pt"> </span><span= class=3D"awspan">activar</span><span class=3D"awspan" style=3D"letter-spac= ing:1.6pt"> </span><span class=3D"awspan">las</span><span class=3D"awspan" = style=3D"letter-spacing:1.6pt"> </span><span class=3D"awspan">v=C3=ADas SIR= T1-FoxO3a y SIRT1-LKB1-AMPK (26).</span></p><p class=3D"awdiv" style=3D"mar= gin-right:1pt; margin-left:1pt"><span class=3D"awspan">En</span><span class= =3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">= un</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><sp= an class=3D"awspan">estudio</span><span class=3D"awspan" style=3D"letter-sp= acing:1.25pt"> </span><span class=3D"awspan">que</span><span class=3D"awspa= n" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">agrup=C3= =B3</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><s= pan class=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing= :1.25pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" st= yle=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">participantes<= /span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span = class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:1.= 25pt"> </span><span class=3D"awspan">base</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">a</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspa= n">su</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </span>= <span class=3D"awspan">capacidad</span><span class=3D"awspan" style=3D"lett= er-spacing:1.25pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:1.25pt"> </span><span class=3D"awspan">repar= aci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:1.25pt"> </= span><span class=3D"awspan">de ADN,</span><span class=3D"awspan" style=3D"l= etter-spacing:0.85pt"> </span><span class=3D"awspan">ya</span><span class= =3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">= sea</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><s= pan class=3D"awspan">baja</span><span class=3D"awspan" style=3D"letter-spac= ing:0.85pt"> </span><span class=3D"awspan">o</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">alta</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D= "awspan">previo</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt= "> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"l= etter-spacing:0.85pt"> </span><span class=3D"awspan">RC,</span><span class= =3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">= se</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><sp= an class=3D"awspan">hizo</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">evidente</span><span class=3D"aws= pan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">que</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span cla= ss=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-spacing:0.85= pt"> </span><span class=3D"awspan">participantes</span><span class=3D"awspa= n" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">del</span= ><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class= =3D"awspan">grupo bajo</span><span class=3D"awspan" style=3D"letter-spacing= :0.2pt"> </span><span class=3D"awspan">ten=C3=ADan</span><span class=3D"aws= pan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">un</span= ><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class= =3D"awspan">aumento</span><span class=3D"awspan" style=3D"letter-spacing:0.= 2pt"> </span><span class=3D"awspan">significativo</span><span class=3D"awsp= an" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">en</span>= <span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class= =3D"awspan">SIRT1,</span><span class=3D"awspan" style=3D"letter-spacing:0.2= pt"> </span><span class=3D"awspan">mismo</span><span class=3D"awspan" style= =3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">que</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan= ">participa</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </= span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter= -spacing:0.2pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:0.2pt"> </span><span class=3D"awspan">regulaci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.2pt"> </span= ><span class=3D"awspan">de la</span><span class=3D"awspan" style=3D"letter-= spacing:0.4pt"> </span><span class=3D"awspan">reparaci=C3=B3n</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspa= n">del</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span>= <span class=3D"awspan">ADN</span><span class=3D"awspan" style=3D"letter-spa= cing:0.4pt"> </span><span class=3D"awspan">mediante</span><span class=3D"aw= span" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">la</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">modulaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:0.4pt"> </span><span class=3D"awspan">del</span><span class=3D"awspan= " style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">estado</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt">= </span><span class=3D"awspan">acetilaci=C3=B3n</span><span class=3D"awspan= " style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"= awspan">XPA</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">factor esencial</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">para</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt= "> </span><span class=3D"awspan">reparaci=C3=B3n</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">por</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span cla= ss=3D"awspan">escisi=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.25pt"> </span><span class=3D"awspan">de</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">nucle=C3= =B3tidos.</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </= span><span class=3D"awspan">Es</span><span class=3D"awspan" style=3D"letter= -spacing:-0.25pt"> </span><span class=3D"awspan">as=C3=AD</span><span class= =3D"awspan" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan"= >como</span><span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> </span= ><span class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.25pt"> </span><span class=3D"awspan">mayor</span><span class=3D"aw= span" style=3D"letter-spacing:-0.25pt"> </span><span class=3D"awspan">expre= si=C3=B3n de</span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt">= </span><span class=3D"awspan">ARNm</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.05pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan"= >SIRT1</span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> </spa= n><span class=3D"awspan">puede</span><span class=3D"awspan" style=3D"letter= -spacing:-0.05pt"> </span><span class=3D"awspan">conducir</span><span class= =3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan"= >a</span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><s= pan class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.05pt"> </span><span class=3D"awspan">mayor</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan">desaceti= laci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> = </span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.05pt"> </span><span class=3D"awspan">XPA</span><span class=3D= "awspan" style=3D"letter-spacing:-0.05pt"> </span><span class=3D"awspan">y<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> </span><span= class=3D"awspan">posiblemente a una mayor tasa de reparaci=C3=B3n del ADN = (27). </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:= 1pt"><span class=3D"awspan">Como</span><span class=3D"awspan" style=3D"lett= er-spacing:2.1pt"> </span><span class=3D"awspan">se</span><span class=3D"aw= span" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">plantea= </span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span = class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2.= 1pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style= =3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">apartado</span><sp= an class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"a= wspan">de</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </sp= an><span class=3D"awspan">estr=C3=A9s</span><span class=3D"awspan" style=3D= "letter-spacing:2.1pt"> </span><span class=3D"awspan">oxidativo</span><span= class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"aws= pan">los</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </spa= n><span class=3D"awspan">niveles</span><span class=3D"awspan" style=3D"lett= er-spacing:2.1pt"> </span><span class=3D"awspan">elevados</span><span class= =3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">d= e</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span= class=3D"awspan">ROS</span><span class=3D"awspan" style=3D"letter-spacing:= 2.1pt"> </span><span class=3D"awspan">se correlacionan</span><span class=3D= "awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">con= </span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span= class=3D"awspan">disfunci=C3=B3n</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.2pt"> </span><span class=3D"awspan">mitocondrial</span><span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"aw= span">progresiva,</span><span class=3D"awspan" style=3D"letter-spacing:-0.2= pt"> </span><span class=3D"awspan">es</span><span class=3D"awspan" style=3D= "letter-spacing:-0.2pt"> </span><span class=3D"awspan">as=C3=AD</span><span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"aw= span">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </s= pan><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-= spacing:-0.2pt"> </span><span class=3D"awspan">falla</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span cl= ass=3D"awspan">su</span><span class=3D"awspan" style=3D"letter-spacing:-0.2= pt"> </span><span class=3D"awspan">regulaci=C3=B3n se</span><span class=3D"= awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">ha</= span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span c= lass=3D"awspan">relacionado</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.2pt"> </span><span class=3D"awspan">con</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">efectos</= span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span c= lass=3D"awspan">perjudiciales</span><span class=3D"awspan" style=3D"letter-= spacing:-0.2pt"> </span><span class=3D"awspan">en</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">el</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class= =3D"awspan">envejecimiento</span><span class=3D"awspan" style=3D"letter-spa= cing:-0.2pt"> </span><span class=3D"awspan">(14).</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">La</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class= =3D"awspan">acumulaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.2pt"> </span><span class=3D"awspan">de ROS</span><span class=3D"a= wspan" style=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">produ= cidos</span><span class=3D"awspan" style=3D"letter-spacing:3.55pt"> </span>= <span class=3D"awspan">como</span><span class=3D"awspan" style=3D"letter-sp= acing:3.55pt"> </span><span class=3D"awspan">subproductos</span><span class= =3D"awspan" style=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">= incrementa</span><span class=3D"awspan" style=3D"letter-spacing:3.55pt"> </= span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter= -spacing:3.55pt"> </span><span class=3D"awspan">estr=C3=A9s</span><span cla= ss=3D"awspan" style=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan= ">oxidativo</span><span class=3D"awspan" style=3D"letter-spacing:3.55pt"> <= /span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"lette= r-spacing:3.55pt"> </span><span class=3D"awspan">las</span><span class=3D"a= wspan" style=3D"letter-spacing:3.55pt"> </span><span class=3D"awspan">c=C3= =A9lulas conforme</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= 5pt"> </span><span class=3D"awspan">avanza</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">la</span><span= class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"a= wspan">edad</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> = </span><span class=3D"awspan">(11). </span><span class=3D"awspan"> </s= pan><span class=3D"awspan">Un</span><span class=3D"awspan" style=3D"letter-= spacing:-0.15pt"> </span><span class=3D"awspan">estudio</span><span class= =3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan"= >que</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span>= <span class=3D"awspan">abordaba</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.15pt"> </span><span class=3D"awspan">la</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">infl= uencia</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.15pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">expresi= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </sp= an><span class=3D"awspan">del ARNm</span><span class=3D"awspan" style=3D"le= tter-spacing:2.9pt"> </span><span class=3D"awspan">de</span><span class=3D"= awspan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">genes= </span><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span = class=3D"awspan">asociados</span><span class=3D"awspan" style=3D"letter-spa= cing:2.9pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" = style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">envejecimient= o</span><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span= class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:2= .9pt"> </span><span class=3D"awspan">PBMC</span><span class=3D"awspan" styl= e=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">determin=C3=B3</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span cla= ss=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:2.9p= t"> </span><span class=3D"awspan">una</span><span class=3D"awspan" style=3D= "letter-spacing:2.9pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:2.9pt"> </span><span class=3D"awspan">l= as funciones</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt">= </span><span class=3D"awspan">m=C3=A1s</span><span class=3D"awspan" style= =3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">relevantes</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span clas= s=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.35p= t"> </span><span class=3D"awspan">SIRT3</span><span class=3D"awspan" style= =3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">es</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"aws= pan">controlar</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt= "> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.35pt"> </span><span class=3D"awspan">cantidad</span><span = class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"aw= span">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </s= pan><span class=3D"awspan">ROS</span><span class=3D"awspan" style=3D"letter= -spacing:-0.35pt"> </span><span class=3D"awspan">en</span><span class=3D"aw= span" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">la</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span c= lass=3D"awspan">c=C3=A9lula</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.35pt"> </span><span class=3D"awspan">mediante la</span><span class= =3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan"= >desacetilaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style= =3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">activaci=C3=B3n<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span= class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.15pt"> </span><span class=3D"awspan">SOD2,</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">proceso</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span cla= ss=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.1= 5pt"> </span><span class=3D"awspan">conduce</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">a</span><span= class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class=3D"a= wspan">una</span><span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> <= /span><span class=3D"awspan">eliminaci=C3=B3n</span><span class=3D"awspan" = style=3D"letter-spacing:-0.15pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.15pt"> </span><span class= =3D"awspan">ROS, donde</span><span class=3D"awspan" style=3D"letter-spacing= :0.15pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" sty= le=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">estr=C3=A9s</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span cla= ss=3D"awspan">oxidativo</span><span class=3D"awspan" style=3D"letter-spacin= g:0.15pt"> </span><span class=3D"awspan">estimula</span><span class=3D"awsp= an" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">a</span>= <span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class= =3D"awspan">SIRT3</span><span class=3D"awspan" style=3D"letter-spacing:0.15= pt"> </span><span class=3D"awspan">para</span><span class=3D"awspan" style= =3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">que</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awsp= an">desacetile</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"= > </span><span class=3D"awspan">FOXO3,</span><span class=3D"awspan" style= =3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">afectando</span><= span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class= =3D"awspan">as=C3=AD</span><span class=3D"awspan" style=3D"letter-spacing:0= .15pt"> </span><span class=3D"awspan">la biog=C3=A9nesis</span><span class= =3D"awspan" style=3D"letter-spacing:3pt"> </span><span class=3D"awspan">mit= ocondrial</span><span class=3D"awspan" style=3D"letter-spacing:3pt"> </span= ><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spac= ing:3pt"> </span><span class=3D"awspan">dando</span><span class=3D"awspan" = style=3D"letter-spacing:3pt"> </span><span class=3D"awspan">como</span><spa= n class=3D"awspan" style=3D"letter-spacing:3pt"> </span><span class=3D"awsp= an">resultado</span><span class=3D"awspan" style=3D"letter-spacing:3pt"> </= span><span class=3D"awspan">mayor</span><span class=3D"awspan" style=3D"let= ter-spacing:3pt"> </span><span class=3D"awspan">protecci=C3=B3n</span><span= class=3D"awspan" style=3D"letter-spacing:3pt"> </span><span class=3D"awspa= n">contra</span><span class=3D"awspan" style=3D"letter-spacing:3pt"> </span= ><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spa= cing:3pt"> </span><span class=3D"awspan">estr=C3=A9s oxidativo (27).</span>= </p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; margin-b= ottom:10pt"><span class=3D"awspan">El</span><span class=3D"awspan" style=3D= "letter-spacing:2.95pt"> </span><span class=3D"awspan">estudio</span><span = class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"aws= pan">actual</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> <= /span><span class=3D"awspan">determina</span><span class=3D"awspan" style= =3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">que</span><span c= lass=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awsp= an">el</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span= ><span class=3D"awspan">da=C3=B1o</span><span class=3D"awspan" style=3D"let= ter-spacing:2.95pt"> </span><span class=3D"awspan">oxidativo</span><span cl= ass=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awspa= n">es</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span>= <span class=3D"awspan">trascendental</span><span class=3D"awspan" style=3D"= letter-spacing:2.95pt"> </span><span class=3D"awspan">en</span><span class= =3D"awspan" style=3D"letter-spacing:2.95pt"> </span><span class=3D"awspan">= la</span><span class=3D"awspan" style=3D"letter-spacing:2.95pt"> </span><sp= an class=3D"awspan">din=C3=A1mica mitocondrial</span><span class=3D"awspan"= style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">y</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:-0.35p= t"> </span><span class=3D"awspan">intervenciones</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">en</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span clas= s=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:-0.35p= t"> 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position:absolute" /></span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold= ; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">R= evista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-235-485</= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><a href=3D"http://www= .anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.anatomiadigital.org" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline">www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1p= t; margin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">        = ; </span><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-d= ecoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margi= n-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.c= om" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:11pt; text-decoration:underline">www.cienciadigitale= ditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">Tel. 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position:= absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (J= ard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">         = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">= Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">       =   </span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><a href=3D"http://www.anatomiadigital.org" style=3D"te= xt-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; m= argin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" = style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anat= omiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt= ; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= </a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font= -size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline; color:#0563c1">www.cienciadigitaled= itorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; mar= gin-left:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; posi= tion:absolute; z-index:998"><img src=3D"data:image/png;base64,iVBORw0KGgoAA= AANSUhEUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQB= lSsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0= huWAqFAUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDd= rtNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFR= kdHicViCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBS= ChEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYv= GbDabrKysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32t= vbIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9P= nHD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaY= Tdt1yeVuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt918= 5OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQP= poQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNj= T9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL= 0zSj5nMXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJf= LSE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaT= Qa3PjmBjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpK= RQKPHnyhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9T= rVZZW1ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycX= cKidnAAAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-= left:-1pt; 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p= osition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa = Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">     &#x= a0;   </span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><a href=3D"http://www.anatomiadigital.org" st= yle=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-rig= ht:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigi= tal.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:11pt; text-decoration:underline; color:#0563c1"= >www.anatomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin= -left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">         </span>= <a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t; font-size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anato= m=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-2= 35-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><a href=3D"ht= tp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a= href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p s= tyle=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><a href=3D"http://www.cienciadigitaleditori= al.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"= margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.ci= enciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underli= ne; color:#0563c1">www.cienciadigitaleditorial.com</span></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span= style=3D"height:0pt; display:block; position:absolute; z-index:1010"><img = src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABMAAAATCAYAAAByUDbMAA= AABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJREFUOI1tlM1PG0cYxn8zu= /baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICjUKglBgndWq0/ljbCNbr= 3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5imiZSSj4vIQRCCKFfNCu= lCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGEYKgDP89jf32dpaYmDgw= MGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3vD8+XMqlQpKKSzLwh4bw= 8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgzkSemZmH5G7fRkqJ7/sk= jAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz+H6AEJK9vb/Z3t7hzPP= w+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A8j1QqxbWhIbLXr2MYBl= JKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiYQRrYZBZiTD4T8HZCyLO= xN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFKkcV1tfXeLrwlH8/vOdb= 20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhbn4l8MBhEsGQyeXnYdTs= MpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZnJZEin0wA4jsNxvc7du3= dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD2qIFD0el06nQ7/1et43= hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRBw8ekkql0HWNP5bLvH27= C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kghaDQdPtY+0mw2CcMQTdO= YmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5QyMrqKCqUU7XabcrnM+v= r6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR5KKeLxOLZtUyqVKBQKx= OPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFTkSuQmCC" width=3D"1= 9" height=3D"19" alt=3D"" style=3D"margin-left:-1pt; 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position:absolute" /></span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weigh= t:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold;= color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolut= e" /></span><span style=3D"height:0pt; display:block; position:absolute; z-= index:1014"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAA= AASCAYAAABWzo5XAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFU= OI1VlM1PIkkYxn/VTdMNDUIM4jIxozsBD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1E= PyMrAyofY2tBde2C6d3yTSiVV9T71vE89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJy= cxDAMhxI9DBPgeUkosy6JarVIul7m6usKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnp= yeOjo4olUo0m01c10UIAQIEAo81QCKRYH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCq= KtMz0wTUALe3t9i2DUCz2WRnZwcpJfl8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVk= A9Ho9Dg4OmJqaGgENh0NOT0+p1+s+SCgUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+f= kI6PX1lbOzM1+DeDzOysoKoXAYx3GIRCI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azC= UA4HGZ1dRVN04hEIqiKyvbv2xT2C1jPFo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z2= 6RO9bpd/W00K+3/w3H+i+e0bX76UkVIihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHF= xQTab5f7+/n//CDFiFIvFUFXVX/Q2pJTEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOp= qm8dTv02630TSNYDCIUEYm9SIej49KMwyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4f= X3xmWmaxvT09AgoEAiQy+WoVCrUajUcx6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4= cjAYcHx8zPb2Nt1uF0VRfA28XvNKd10XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRV= P2B+FNk2Tzc1NFhcX0TRtdMb7jKSU2LbN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQo= g3QN7c7Xa5vr6mWq3SaDQQQpBKpchkMqTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC"= width=3D"18" height=3D"18" alt=3D"" style=3D"margin-left:-1pt; position:ab= solute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight= :bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> =         </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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pos= ition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digit= al</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador= (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Tels. 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1OMwWCgqKgIq9V6+eCvZaj6q+kf/vAHDhw4wK1TbmVK7mTa7XY8bjeKgAGSR4R4qjC9gbBIQ8iO= o6MTR0f7zWjMQTYEqtARGW7tjyOc3d04u7sJ0VzX4WTlIAgBIiyWECoet4umC67LZKtEDGJ8Oto= 7Q+CpWkBScbSChvoG9Ho902bMYOKkSSxYeCf/2P53nlm7lqamJubPn8/w4cNDESeEIBAIYLfbOX= bsGG+//Taf7t/HLdm3cNePFtLb66KsrIy271oHAXa97V/JkF6PnP6/071S62b6nZ1d3LN4MQCqp= gWJweZLzQB0dHQSFRPD9Jn/QVRUJP/4cAcvvvgCZWVl5OTkkJGRQVxcHB6Ph4sXL3Ly5Mlgg9rZ= Tt70fG6bN4+ICCsfbt1G+f6D9Hl9VyyuqiqpqakAoaoppaSzs5Po6GgCgQBdXV03dN5oNBIREYH= D4QgRmC6Xi+TkZBRF4dKlS6H8eyMJDw8nLS2Nzs5Ompub0ev1IZqpr6/vJpoCKbiy5YBgY/nBu+= +x6sFV5ORMYEhsHIcOHOJ4xXFOnvwavd6AXq9H07TgAkKQmmpjyQ+Xckv2OExGI9u3lXLwOoABx= MXF8corr1BfX09vby9VVVVMmjQp9Hh/8803OXHixA3dHjNmDKtWreKtt94iOzubnp4ePB4Pd999= N36/n927d7Nr165Qz3g9KS4uxu/3o6oqW7ZswWQysXr1al566SVOnDhx3R5ysFwDmuYPUHP2LP/= 98susWLGCsWPH8pMlP2HOvDk0NjTSdOkidrsdnaLDZrMxLNVGSnIK4eZwXK5e/ra5hH2f7MPnvf= 6JBWlyK8ePHycrK4uamhqKiop49dVXkVJSXV19U4fNZjNjxoxh+fLlOJ1OWlpamDBhAps2baKtr= Y2IiAh0Ot1NbUyfPp2dO3dy+vRpuru7mTlzJhaLhby8PKqrq783Uq8BrR+4pvoLvLjhJebcNoeC= 2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDPz+97/= niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz8qVK9= m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdECAXp6n= DRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m7di0O= h4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7/88sa= wSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1snjxYk= pKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcHC2BlZ= SU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY2nnvu= OXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D"28" = alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></span><span c= lass=3D"awspan">debido</span><span class=3D"awspan" style=3D"letter-spacing= :-0.4pt"> </span><span class=3D"awspan">al</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">estr=C3=A9s</sp= an><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span cla= ss=3D"awspan">oxidativo.</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.4pt"> </span><span class=3D"awspan">En</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.4pt"> </span><span class=3D"awspan">este</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D= "awspan">contexto</span><span class=3D"awspan" style=3D"letter-spacing:-0.4= pt"> </span><span class=3D"awspan">un</span><span class=3D"awspan" style=3D= "letter-spacing:-0.4pt"> </span><span class=3D"awspan">ensayo</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class=3D"awsp= an">cl=C3=ADnico</span><span class=3D"awspan" style=3D"letter-spacing:-0.4p= t"> </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D= "letter-spacing:-0.4pt"> </span><span class=3D"awspan">inclu=C3=ADa</span><= span class=3D"awspan" style=3D"letter-spacing:-0.4pt"> </span><span class= =3D"awspan">63</span><span class=3D"awspan" style=3D"letter-spacing:-0.4pt"= > </span><span class=3D"awspan">participantes encontr=C3=B3</span><span cla= ss=3D"awspan" style=3D"letter-spacing:4.1pt"> </span><span class=3D"awspan"= >que</span><span class=3D"awspan" style=3D"letter-spacing:4.1pt"> </span><s= pan class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacin= g:4.1pt"> </span><span class=3D"awspan">intervenci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:4.1pt"> </span><span class=3D"awspan">c= on</span><span class=3D"awspan" style=3D"letter-spacing:4.1pt"> </span><spa= n class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spacing= :4.1pt"> </span><span class=3D"awspan">mezcla</span><span class=3D"awspan" = style=3D"letter-spacing:4.1pt"> </span><span class=3D"awspan">de</span><spa= n class=3D"awspan" style=3D"letter-spacing:4.1pt"> </span><span class=3D"aw= span">mim=C3=A9ticos</span><span class=3D"awspan" style=3D"letter-spacing:4= .1pt"> </span><span class=3D"awspan">MRC</span><span class=3D"awspan" style= =3D"letter-spacing:4.1pt"> </span><span class=3D"awspan">increment=C3=B3</s= pan><span class=3D"awspan" style=3D"letter-spacing:4.1pt"> </span><span cla= ss=3D"awspan">el antioxidante</span><span class=3D"awspan" style=3D"letter-= spacing:0.85pt"> </span><span class=3D"awspan">y</span><span class=3D"awspa= n" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">marcador<= /span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span = class=3D"awspan">celular</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.85pt"> </span><span class=3D"awspan">GSH</span><span class=3D"awspan" = style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">al</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"= awspan">igual</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt">= </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"le= tter-spacing:0.85pt"> </span><span class=3D"awspan">de</span><span class=3D= "awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">la<= /span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span = class=3D"awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter= -spacing:0.85pt"> </span><span class=3D"awspan">Glu/Gln,</span><span class= =3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">= marcador</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </sp= an><span class=3D"awspan">de neurotransmisi=C3=B3n</span><span class=3D"aws= pan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">excitat= oria</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><= span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spacin= g:1.15pt"> </span><span class=3D"awspan">bioenerg=C3=A9tica.</span><span cl= ass=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspa= n">El</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span>= <span class=3D"awspan">estudio</span><span class=3D"awspan" style=3D"letter= -spacing:1.15pt"> </span><span class=3D"awspan">plantea</span><span class= =3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">= que</span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><s= pan class=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacin= g:1.15pt"> </span><span class=3D"awspan">d=C3=A9ficit</span><span class=3D"= awspan" style=3D"letter-spacing:1.15pt"> </span><span class=3D"awspan">de</= span><span class=3D"awspan" style=3D"letter-spacing:1.15pt"> </span><span c= lass=3D"awspan">GSH mitocondrial</span><span class=3D"awspan" style=3D"lett= er-spacing:0.1pt"> </span><span class=3D"awspan">del</span><span class=3D"a= wspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">cerebr= o</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span= class=3D"awspan">se</span><span class=3D"awspan" style=3D"letter-spacing:0= .1pt"> </span><span class=3D"awspan">corresponde</span><span class=3D"awspa= n" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">con</span>= <span class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class= =3D"awspan">alteraciones</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.1pt"> </span><span class=3D"awspan">en</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">la</span><span = class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"awsp= an">funci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt= "> </span><span class=3D"awspan">mitocondrial</span><span class=3D"awspan" = style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">y</span><span= class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"aws= pan">la producci=C3=B3n de energ=C3=ADa (28).</span><span class=3D"awspan">=   </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt"><span class=3D"awspan">El</span><span class=3D"awspan" style=3D"lette= r-spacing:4.65pt"> </span><span class=3D"awspan">presente</span><span class= =3D"awspan" style=3D"letter-spacing:4.65pt"> </span><span class=3D"awspan">= estudio</span><span class=3D"awspan" style=3D"letter-spacing:4.65pt"> </spa= n><span class=3D"awspan">sostiene</span><span class=3D"awspan" style=3D"let= ter-spacing:4.65pt"> </span><span class=3D"awspan">que</span><span class=3D= "awspan" style=3D"letter-spacing:4.65pt"> </span><span class=3D"awspan">var= ios</span><span class=3D"awspan" style=3D"letter-spacing:4.65pt"> </span><s= pan class=3D"awspan">compuestos</span><span class=3D"awspan" style=3D"lette= r-spacing:4.65pt"> </span><span class=3D"awspan">org=C3=A1nicos</span><span= class=3D"awspan" style=3D"letter-spacing:4.65pt"> </span><span class=3D"aw= span">modulan</span><span class=3D"awspan" style=3D"letter-spacing:4.65pt">= </span><span class=3D"awspan">las</span><span class=3D"awspan" style=3D"le= tter-spacing:4.65pt"> </span><span class=3D"awspan">v=C3=ADas antienvejecim= iento</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><= span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.3pt"> </span><span class=3D"awspan">manera</span><span class=3D"awspan= " style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">similar</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span clas= s=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:0.3pt"> </span><span class=3D"awspan">RC</span><span class=3D"a= wspan" style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">(6).</= span><span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span cl= ass=3D"awspan">Reconocidos</span><span class=3D"awspan" style=3D"letter-spa= cing:0.3pt"> </span><span class=3D"awspan">como</span><span class=3D"awspan= " style=3D"letter-spacing:0.3pt"> </span><span class=3D"awspan">MRC.</span>= <span class=3D"awspan" style=3D"letter-spacing:0.3pt"> </span><span class= =3D"awspan">Un</span><span class=3D"awspan" style=3D"letter-spacing:0.3pt">= </span><span class=3D"awspan">estudio de</span><span class=3D"awspan" styl= e=3D"letter-spacing:3.45pt"> </span><span class=3D"awspan">2020</span><span= class=3D"awspan" style=3D"letter-spacing:3.45pt"> </span><span class=3D"aw= span">centrado</span><span class=3D"awspan" style=3D"letter-spacing:3.45pt"= > </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"le= tter-spacing:3.45pt"> </span><span class=3D"awspan">identificar</span><span= class=3D"awspan" style=3D"letter-spacing:3.45pt"> </span><span class=3D"aw= span">supuestos</span><span class=3D"awspan" style=3D"letter-spacing:3.45pt= "> </span><span class=3D"awspan">mim=C3=A9ticos</span><span class=3D"awspan= " style=3D"letter-spacing:3.45pt"> </span><span class=3D"awspan">de</span><= span class=3D"awspan" style=3D"letter-spacing:3.45pt"> </span><span class= =3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:3.45pt"= > </span><span class=3D"awspan">mediante</span><span class=3D"awspan" style= =3D"letter-spacing:3.45pt"> </span><span class=3D"awspan">marcadores transc= riptacionales</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt">= </span><span class=3D"awspan">seleccionaron</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">15</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"a= wspan">compuestos</span><span class=3D"awspan" style=3D"letter-spacing:0.35= pt"> </span><span class=3D"awspan">integrados</span><span class=3D"awspan" = style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">en</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"= awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </= span><span class=3D"awspan">estudio</span><span class=3D"awspan" style=3D"l= etter-spacing:0.35pt"> </span><span class=3D"awspan">en</span><span class= =3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">= una</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><s= pan class=3D"awspan">mezcla y</span><span class=3D"awspan" style=3D"letter-= spacing:-0.6pt"> </span><span class=3D"awspan">se</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">estudi= =C3=B3</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span= ><span class=3D"awspan">sus</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.6pt"> </span><span class=3D"awspan">efectos</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span cl= ass=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.6= pt"> </span><span class=3D"awspan">firma</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">transcript=C3=B3m= ica</span><span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><s= pan class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.6pt"> </span><span class=3D"awspan">ratones</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">y</span><= span class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class= =3D"awspan">gusanos.</span><span class=3D"awspan" style=3D"letter-spacing:-= 0.6pt"> </span><span class=3D"awspan">El</span><span class=3D"awspan" style= =3D"letter-spacing:-0.6pt"> </span><span class=3D"awspan">estudio</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.6pt"> </span><span class=3D"= awspan">extrae que</span><span class=3D"awspan" style=3D"letter-spacing:0.4= pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D= "letter-spacing:0.4pt"> </span><span class=3D"awspan">transcriptoma</span><= span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D= "awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">corteza</span><span class=3D"awspan" style=3D"l= etter-spacing:0.4pt"> </span><span class=3D"awspan">cerebral,</span><span c= lass=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspa= n">coraz=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"= > </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"let= ter-spacing:0.4pt"> </span><span class=3D"awspan">m=C3=BAsculo</span><span = class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awsp= an">esquel=C3=A9tico</span><span class=3D"awspan" style=3D"letter-spacing:0= .4pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">ratones,</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"a= wspan">tres tejidos</span><span class=3D"awspan" style=3D"letter-spacing:-0= .5pt"> </span><span class=3D"awspan">reconocidos</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">por</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span class= =3D"awspan">estar</span><span class=3D"awspan" style=3D"letter-spacing:-0.5= pt"> </span><span class=3D"awspan">fuertemente</span><span class=3D"awspan"= style=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">influenciad= os</span><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><sp= an class=3D"awspan">por</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.5pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" st= yle=3D"letter-spacing:-0.5pt"> </span><span class=3D"awspan">proceso</span>= <span class=3D"awspan" style=3D"letter-spacing:-0.5pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.5pt"= > </span><span class=3D"awspan">envejecimiento, cambia</span><span class=3D= "awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">pr= oducto</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.45pt"> </span><span class=3D"awspan">la</span><span class=3D"awspa= n" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">mezcla</= span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span = class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:-0= .45pt"> </span><span class=3D"awspan">micronutrientes,</span><span class=3D= "awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">de= </span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><spa= n class=3D"awspan">forma</span><span class=3D"awspan" style=3D"letter-spaci= ng:-0.45pt"> </span><span class=3D"awspan">similar</span><span class=3D"aws= pan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">a</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span cla= ss=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.45= pt"> </span><span class=3D"awspan">causada</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan">por</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"= awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> <= /span><span class=3D"awspan">RC en</span><span class=3D"awspan" style=3D"le= tter-spacing:0.65pt"> </span><span class=3D"awspan">relaci=C3=B3n</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"= awspan">con</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> <= /span><span class=3D"awspan">el</span><span class=3D"awspan" style=3D"lette= r-spacing:0.65pt"> </span><span class=3D"awspan">perfil</span><span class= =3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">= transcript=C3=B3mico</span><span class=3D"awspan" style=3D"letter-spacing:0= .65pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.65pt"> </span><span class=3D"awspan">ratones</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"= awspan">viejos</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"= > </span><span class=3D"awspan">no</span><span class=3D"awspan" style=3D"le= tter-spacing:0.65pt"> </span><span class=3D"awspan">tratados</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><span class=3D"awspa= n">(22). </span><span class=3D"awspan"> </span><span class=3D"awspan">= Un</span><span class=3D"awspan" style=3D"letter-spacing:0.65pt"> </span><sp= an class=3D"awspan">estudio doble</span><span class=3D"awspan" style=3D"let= ter-spacing:0.15pt"> </span><span class=3D"awspan">ciego,</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= aleatorizado</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> = </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"lette= r-spacing:0.15pt"> </span><span class=3D"awspan">controlado</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan= ">con</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span>= <span class=3D"awspan">placebo</span><span class=3D"awspan" style=3D"letter= -spacing:0.15pt"> </span><span class=3D"awspan">demuestra</span><span class= =3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan">= que</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><s= pan class=3D"awspan">una</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.15pt"> </span><span class=3D"awspan">intervenci=C3=B3n</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><span class=3D"awspan= ">de</span><span class=3D"awspan" style=3D"letter-spacing:0.15pt"> </span><= span class=3D"awspan">6 semanas</span><span class=3D"awspan" style=3D"lette= r-spacing:-0.7pt"> </span><span class=3D"awspan">con</span><span class=3D"a= wspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">una</= span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span c= lass=3D"awspan">mezcla</span><span class=3D"awspan" style=3D"letter-spacing= :-0.7pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">micronutrientes= </span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span= class=3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:= -0.7pt"> </span><span class=3D"awspan">imitan</span><span class=3D"awspan" = style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">los</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class=3D= "awspan">efectos</span><span class=3D"awspan" style=3D"letter-spacing:-0.7p= t"> </span><span class=3D"awspan">biol=C3=B3gicos</span><span class=3D"awsp= an" style=3D"letter-spacing:-0.7pt"> </span><span class=3D"awspan">de</span= ><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"> </span><span class= =3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:-0.7pt"= > </span><span class=3D"awspan">sobre la</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">qu=C3=ADmica</span= ><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">cerebral</span><span class=3D"awspan" style=3D"letter-spacing:0= .4pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" style= =3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">adultos</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"aw= span">sanos</span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.4pt"> </span><span class=3D"awspan">mediana</span><span class=3D= "awspan" style=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">edad= </span><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span = class=3D"awspan">muestra</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.4pt"> </span><span class=3D"awspan">una</span><span class=3D"awspan" s= tyle=3D"letter-spacing:0.4pt"> </span><span class=3D"awspan">tendencia</spa= n><span class=3D"awspan" style=3D"letter-spacing:0.4pt"> </span><span class= =3D"awspan">estad=C3=ADstica hacia</span><span class=3D"awspan" style=3D"le= tter-spacing:2.7pt"> </span><span class=3D"awspan">un</span><span class=3D"= awspan" style=3D"letter-spacing:2.7pt"> </span><span class=3D"awspan">aumen= to</span><span class=3D"awspan" style=3D"letter-spacing:2.7pt"> </span><spa= n class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-spacing:= 2.7pt"> </span><span class=3D"awspan">NAA/H2O</span><span class=3D"awspan" = style=3D"letter-spacing:2.7pt"> </span><span class=3D"awspan">en</span><spa= n class=3D"awspan" style=3D"letter-spacing:2.7pt"> </span><span class=3D"aw= span">mujeres</span><span class=3D"awspan" style=3D"letter-spacing:2.7pt"> = </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"let= ter-spacing:2.7pt"> </span><span class=3D"awspan">toman</span><span class= =3D"awspan" style=3D"letter-spacing:2.7pt"> </span><span class=3D"awspan">e= l</span><span class=3D"awspan" style=3D"letter-spacing:2.7pt"> </span><span= class=3D"awspan">suplemento,</span><span class=3D"awspan" style=3D"letter-= spacing:2.7pt"> </span><span class=3D"awspan">pero</span><span class=3D"aws= pan" style=3D"letter-spacing:2.7pt"> </span><span class=3D"awspan">no</span= ><span class=3D"awspan" style=3D"letter-spacing:2.7pt"> </span><span class= =3D"awspan">en hombres.</span><span class=3D"awspan" style=3D"letter-spacin= g:-0.2pt"> </span><span class=3D"awspan">NAA</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">es</span><spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"a= wspan">un</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </s= pan><span class=3D"awspan">supuesto</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.2pt"> </span><span class=3D"awspan">marcador</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awsp= an">de</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span= ><span class=3D"awspan">integridad</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.2pt"> </span><span class=3D"awspan">y</span><span class=3D"= awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">func= i=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </sp= an><span class=3D"awspan">neuronal,</span><span class=3D"awspan" style=3D"l= etter-spacing:-0.2pt"> </span><span class=3D"awspan">lo</span><span class= =3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><span class=3D"awspan">= que</span><span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> </span><s= pan class=3D"awspan">sugiere que</span><span class=3D"awspan" style=3D"lett= er-spacing:0.85pt"> </span><span class=3D"awspan">la</span><span class=3D"a= wspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">suple= mentaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"= > </span><span class=3D"awspan">puede</span><span class=3D"awspan" style=3D= "letter-spacing:0.85pt"> </span><span class=3D"awspan">tener</span><span cl= ass=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspa= n">el</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span>= <span class=3D"awspan">potencial</span><span class=3D"awspan" style=3D"lett= er-spacing:0.85pt"> </span><span class=3D"awspan">de</span><span class=3D"a= wspan" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">promo= ver</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><s= pan class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacin= g:0.85pt"> </span><span class=3D"awspan">vialidad</span><span class=3D"awsp= an" style=3D"letter-spacing:0.85pt"> </span><span class=3D"awspan">y</span>= <span class=3D"awspan" style=3D"letter-spacing:0.85pt"> </span><span class= =3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing:0.85pt"= > </span><span class=3D"awspan">integridad neuronal, al menos en mujeres (2= 8). </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t"><span class=3D"awspan" style=3D"font-weight:bold; color:#767171">5.Concl= usiones</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt; margin-bottom:10pt"><span class=3D"awspan" style=3D"font-family:'Wing= dings 3'">=EF=82=B7</span><span class=3D"awspan">El</span><span class=3D"aw= span" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">estudi= o</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><spa= n class=3D"awspan">subraya</span><span class=3D"awspan" style=3D"letter-spa= cing:0.35pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan"= style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">potencial</= span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span c= lass=3D"awspan">significativo</span><span class=3D"awspan" style=3D"letter-= spacing:0.35pt"> </span><span class=3D"awspan">de</span><span class=3D"awsp= an" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan">la</span= ><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class= =3D"awspan">restricci=C3=B3n</span><span class=3D"awspan" style=3D"letter-s= pacing:0.35pt"> </span><span class=3D"awspan">cal=C3=B3rica</span><span cla= ss=3D"awspan" style=3D"letter-spacing:0.35pt"> </span><span class=3D"awspan= ">(RC)</span><span class=3D"awspan" style=3D"letter-spacing:0.35pt"> </span= ><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-spac= ing:0.35pt"> </span><span class=3D"awspan">sus mim=C3=A9ticos</span><span c= lass=3D"awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"awsp= an">como</span><span class=3D"awspan" style=3D"letter-spacing:5.05pt"> </sp= an><span class=3D"awspan">intervenciones</span><span class=3D"awspan" style= =3D"letter-spacing:5.05pt"> </span><span class=3D"awspan">viables</span><sp= an class=3D"awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"= awspan">para</span><span class=3D"awspan" style=3D"letter-spacing:5.05pt"> = </span><span class=3D"awspan">retrasar</span><span class=3D"awspan" style= =3D"letter-spacing:5.05pt"> </span><span class=3D"awspan">el</span><span cl= ass=3D"awspan" style=3D"letter-spacing:5.05pt"> </span><span class=3D"awspa= n">envejecimiento</span><span class=3D"awspan" style=3D"letter-spacing:5.05= pt"> </span><span class=3D"awspan">y promover</span><span class=3D"awspan" = style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">una</span><sp= an class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"a= wspan">mayor</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> <= /span><span class=3D"awspan">longevidad.</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">A</span><span clas= s=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">= trav=C3=A9s</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </= span><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter= -spacing:0.5pt"> </span><span class=3D"awspan">la</span><span class=3D"awsp= an" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">reducci= =C3=B3n</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span= ><span class=3D"awspan">cal=C3=B3rica</span><span class=3D"awspan" style=3D= "letter-spacing:0.5pt"> </span><span class=3D"awspan">sostenida,</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"aw= span">se ha</span><span class=3D"awspan" style=3D"letter-spacing:3.5pt"> </= span><span class=3D"awspan">demostrado</span><span class=3D"awspan" style= =3D"letter-spacing:3.5pt"> </span><span class=3D"awspan">que</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.5pt"> </span><span class=3D"awspan= ">la</span><span class=3D"awspan" style=3D"letter-spacing:3.5pt"> </span><s= pan class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacin= g:3.5pt"> </span><span class=3D"awspan">mejora</span><span class=3D"awspan"= style=3D"letter-spacing:3.5pt"> </span><span class=3D"awspan">la</span><sp= an class=3D"awspan" style=3D"letter-spacing:3.5pt"> </span><span class=3D"a= wspan">salud</span><span class=3D"awspan" style=3D"letter-spacing:3.5pt"> <= /span><span class=3D"awspan">metab=C3=B3lica,</span><span class=3D"awspan" = style=3D"letter-spacing:3.5pt"> </span><span class=3D"awspan">disminuye</sp= an><span class=3D"awspan" style=3D"letter-spacing:3.5pt"> </span><span clas= s=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:3.5pt"= > </span><span class=3D"awspan">estr=C3=A9s oxidativo,</span><span class=3D= "awspan" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">y</= span><span class=3D"awspan" style=3D"letter-spacing:3.95pt"> </span><span c= lass=3D"awspan">activa</span><span class=3D"awspan" style=3D"letter-spacing= :3.95pt"> </span><span class=3D"awspan">mecanismos</span><span class=3D"aws= pan" style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">celular= es</span><span class=3D"awspan" style=3D"letter-spacing:3.95pt"> </span><sp= an class=3D"awspan">clave</span><span class=3D"awspan" style=3D"letter-spac= ing:3.95pt"> </span><span class=3D"awspan">como</span><span class=3D"awspan= " style=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">la</span><= span class=3D"awspan" style=3D"letter-spacing:3.95pt"> </span><span class= =3D"awspan">autofagia,</span><span class=3D"awspan" style=3D"letter-spacing= :3.95pt"> </span><span class=3D"awspan">lo</span><span class=3D"awspan" sty= le=3D"letter-spacing:3.95pt"> </span><span class=3D"awspan">que contribuye<= /span><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span c= lass=3D"awspan">a</span><span class=3D"awspan" style=3D"letter-spacing:2.3p= t"> </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"= letter-spacing:2.3pt"> </span><span class=3D"awspan">preservaci=C3=B3n</spa= n><span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:2.3pt">= </span><span class=3D"awspan">la</span><span class=3D"awspan" style=3D"let= ter-spacing:2.3pt"> </span><span class=3D"awspan">homeodin=C3=A1mica</span>= <span class=3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class= =3D"awspan">celular</span><span class=3D"awspan" style=3D"letter-spacing:2.= 3pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan" style=3D= "letter-spacing:2.3pt"> </span><span class=3D"awspan">la</span><span class= =3D"awspan" style=3D"letter-spacing:2.3pt"> </span><span class=3D"awspan">f= uncionalidad mitocondrial.</span><span class=3D"awspan" style=3D"letter-spa= cing:0.6pt"> </span><span class=3D"awspan">Adem=C3=A1s,</span><span class= =3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">l= a</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span= class=3D"awspan">RC</span><span class=3D"awspan" style=3D"letter-spacing:0= .6pt"> </span><span class=3D"awspan">modula</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">v=C3=ADas</span= ><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </span><span class= =3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt">= </span><span class=3D"awspan">se=C3=B1alizaci=C3=B3n</span><span class=3D"= awspan" style=3D"letter-spacing:0.6pt"> </span><span class=3D"awspan">funda= mentales,</span><span class=3D"awspan" style=3D"letter-spacing:0.6pt"> </sp= an><span class=3D"awspan">como las</span><span class=3D"awspan" style=3D"le= tter-spacing:3.9pt"> </span><span class=3D"awspan">v=C3=ADas</span><span cl= ass=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspan= ">mTOR,</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span= ><span class=3D"awspan">AMPK</span><span class=3D"awspan" style=3D"letter-s= pacing:3.9pt"> </span><span class=3D"awspan">y</span><span class=3D"awspan"= style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspan">SIRT1,</span= ><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"= > </span><span class=3D"awspan">son</span><span class=3D"awspan" style=3D"l= etter-spacing:3.9pt"> </span><span class=3D"awspan">cruciales</span><span c= lass=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspa= n">en</span><span class=3D"awspan" style=3D"letter-spacing:3.9pt"> </span><= span class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spaci= ng:3.9pt"> </span><span class=3D"awspan">regulaci=C3=B3n</span><span class= =3D"awspan" style=3D"letter-spacing:3.9pt"> </span><span class=3D"awspan">d= el envejecimiento.</span><span class=3D"awspan" style=3D"letter-spacing:1.5= pt"> </span><span class=3D"awspan">Por</span><span class=3D"awspan" style= =3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">otro</span><span c= lass=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspa= n">lado,</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </spa= n><span class=3D"awspan">los</span><span class=3D"awspan" style=3D"letter-s= pacing:1.5pt"> </span><span class=3D"awspan">mim=C3=A9ticos</span><span cla= ss=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan"= >de</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><sp= an class=3D"awspan">la</span><span class=3D"awspan" style=3D"letter-spacing= :1.5pt"> </span><span class=3D"awspan">RC</span><span class=3D"awspan" styl= e=3D"letter-spacing:1.5pt"> </span><span class=3D"awspan">ofrecen</span><sp= an class=3D"awspan" style=3D"letter-spacing:1.5pt"> </span><span class=3D"a= wspan">una</span><span class=3D"awspan" style=3D"letter-spacing:1.5pt"> </s= pan><span class=3D"awspan">alternativa prometedora</span><span class=3D"aws= pan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">al</span= ><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class= =3D"awspan">replicar</span><span class=3D"awspan" style=3D"letter-spacing:0= .5pt"> </span><span class=3D"awspan">los</span><span class=3D"awspan" style= =3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">efectos</span><spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"aw= span">antienvejecimiento</span><span class=3D"awspan" style=3D"letter-spaci= ng:0.5pt"> </span><span class=3D"awspan">de</span><span class=3D"awspan" st= yle=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">la</span><span = class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span><span class=3D"awsp= an">RC</span><span class=3D"awspan" style=3D"letter-spacing:0.5pt"> </span>= <span class=3D"awspan">sin</span><span class=3D"awspan" style=3D"letter-spa= cing:0.5pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan" = style=3D"letter-spacing:0.5pt"> </span><span class=3D"awspan">necesidad de<= /span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span= class=3D"awspan">adherirse</span><span class=3D"awspan" style=3D"letter-sp= acing:-0.35pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan= " style=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">estrictas= </span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><spa= n class=3D"awspan">restricciones</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.35pt"> </span><span class=3D"awspan">diet=C3=A9ticas,</span><= span class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class= =3D"awspan">lo</span><span class=3D"awspan" style=3D"letter-spacing:-0.35pt= "> </span><span class=3D"awspan">que</span><span class=3D"awspan" style=3D"= letter-spacing:-0.35pt"> </span><span class=3D"awspan">podr=C3=ADa</span><s= pan class=3D"awspan" style=3D"letter-spacing:-0.35pt"> </span><span class= =3D"awspan">hacer</span><span class=3D"awspan" style=3D"letter-spacing:-0.3= 5pt"> </span><span class=3D"awspan">m=C3=A1s</span><span class=3D"awspan" s= tyle=3D"letter-spacing:-0.35pt"> </span><span class=3D"awspan">accesibles e= stas</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span>= <span class=3D"awspan">intervenciones</span><span class=3D"awspan" style=3D= "letter-spacing:-0.45pt"> </span><span class=3D"awspan">a</span><span class= =3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"awspan"= >un</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><= span class=3D"awspan">p=C3=BAblico</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.45pt"> </span><span class=3D"awspan">m=C3=A1s</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"aws= pan">amplio.</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt">= </span><span class=3D"awspan">Sin</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.45pt"> </span><span class=3D"awspan">embargo,</span><span c= lass=3D"awspan" style=3D"letter-spacing:-0.45pt"> </span><span class=3D"aws= pan">aunque</span><span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> = </span><span class=3D"awspan">los</span><span class=3D"awspan" style=3D"let= ter-spacing:-0.45pt"> </span><span class=3D"awspan">beneficios son</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"= awspan">evidentes,</span><span class=3D"awspan" style=3D"letter-spacing:0.1= pt"> </span><span class=3D"awspan">se</span><span class=3D"awspan" style=3D= "letter-spacing:0.1pt"> </span><span class=3D"awspan">requieren</span><span= class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"aws= pan">m=C3=A1s</span><span class=3D"awspan" style=3D"letter-spacing:0.1pt"> = </span><span class=3D"awspan">investigaciones</span><span class=3D"awspan" = style=3D"letter-spacing:0.1pt"> </span><span class=3D"awspan">para</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.1pt"> </span><span class=3D"= awspan">comprender</span><span class=3D"awspan" style=3D"letter-spacing:0.1= pt"> </span><span class=3D"awspan">completamente los</span><span class=3D"a= wspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">mecani= smos</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><s= pan class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-spacin= g:0.7pt"> </span><span class=3D"awspan">acci=C3=B3n,</span><span class=3D"a= wspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">la</sp= an><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span clas= s=3D"awspan">seguridad</span><span class=3D"awspan" style=3D"letter-spacing= :0.7pt"> </span><span class=3D"awspan">a</span><span class=3D"awspan" style= =3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">largo</span><span = class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span class=3D"awsp= an">plazo</span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </sp= an><span class=3D"awspan">y</span><span class=3D"awspan" style=3D"letter-sp= acing:0.7pt"> </span><span class=3D"awspan">la</span><span class=3D"awspan"= style=3D"letter-spacing:0.7pt"> </span><span class=3D"awspan">efectividad<= /span><span class=3D"awspan" style=3D"letter-spacing:0.7pt"> </span><span c= lass=3D"awspan">cl=C3=ADnica</span><span class=3D"awspan" style=3D"letter-s= pacing:0.7pt"> </span><span class=3D"awspan">de estas</span><span class=3D"= awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">int= ervenciones</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> = </span><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"lett= er-spacing:-0.55pt"> </span><span class=3D"awspan">humanos.</span><span cla= ss=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspa= n">Este</span><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </sp= an><span class=3D"awspan">conocimiento</span><span class=3D"awspan" style= =3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">podr=C3=ADa</spa= n><span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span cla= ss=3D"awspan">allanar</span><span class=3D"awspan" style=3D"letter-spacing:= -0.55pt"> </span><span class=3D"awspan">el</span><span class=3D"awspan" sty= le=3D"letter-spacing:-0.55pt"> </span><span class=3D"awspan">camino</span><= span class=3D"awspan" style=3D"letter-spacing:-0.55pt"> </span><span class= =3D"awspan">para </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; m= argin-left:1pt; font-size:11pt"><span style=3D"height:0pt; display:block; p= osition:absolute; z-index:1027"><img src=3D"data:image/jpeg;base64,/9j/4AAQ= SkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhw= XExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh= 4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBA= xEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECBwMGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAEC= AwQFEQYSByExExQXQVFTVmGSlOMIFSJUcYGT0TI3UnWRsyMzNkJydKGy0haCsRg4Q2IkwWNzg//= EABsBAQEBAQEBAQEAAAAAAAAAAAABAgMEBQYH/8QANBEBAQACAgIABAIJAwQDAAAAAAECEQMSBF= 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/VYuXaqrVjHtxaomeqneN52j1y12CwAFAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA= AAAAAAAAAAAAAAAAAAAAAAAAAAAH/2Q=3D=3D" width=3D"794" height=3D"1123" alt=3D= "" style=3D"margin-left:-1.75pt; position:absolute" /></span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ffffff"> = ;            &#= xa0;            = ;            </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter= -spacing:3pt; color:#ffffff">Procedimientos M=C3=A9dicos</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spacing:3p= t; color:#ffffff">  </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:11pt; letter-spacing:3pt; color:#ffffff">  &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:11pt; letter-spacing:3pt; color:#ffffff">P=C3=A1gina</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; colo= r:#ffffff"> 84 | 88</span></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:9pt"><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:9pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#447= 2c4">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:8pt">         </span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80= =93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:8pt">Tel. Directo (00593) 0998-235-485</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><a href=3D"http://www.anatomiadigital.or= g" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margi= n-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomi= adigital.org" style=3D"text-decoration:none"><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:11pt; text-decoration:underline">www.ana= tomiadigital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1p= t; font-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= </a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font= -size:11pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"tex= t-decoration:none"><span class=3D"awspan" style=3D"font-family:Calibri; fon= t-size:11pt; text-decoration:underline">www.cienciadigitaleditorial.com</sp= an></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:9pt"><span style=3D"height:0pt; display:block; position:absolute; = z-index:1030"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABM= AAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJRE= FUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICj= UKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5i= miZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGE= YKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3v= D8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgz= kSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz= +H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A= 8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiY= QRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFK= kcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhb= n4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZn= JZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD= 2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRB= w8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kgh= aDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5Q= yMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR= 5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFT= kSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:3.84pt; 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positio= n:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-we= ight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Ja= rd=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:8pt">         <= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">T= els. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:8pt">       &= #xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">Tel. 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position:absolute" = /></span><span class=3D"awspan" style=3D"color:#ffffff">ISSN: </span><span = class=3D"awspan" style=3D"font-weight:bold; color:#ffffff">2697-3391</span>= <span class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2, pp. 69 =E2=80= =93 88, abril - junio 2025Revista en ciencias m=C3=A9dicas, salud p=C3=BAbl= icaArt=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica</span></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span><svg font-family= =3D"Times New Roman" font-size=3D"16" height=3D"41.33" version=3D"1.1" widt= h=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D"width:209.31px; = height:41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:xlink= =3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0 L209= ,0 L209,41 L209,41 L0,41 Z" fill=3D"#7d7d7d" fill-rule=3D"evenodd" /></g></= g></svg></span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:11pt"><span class=3D"awspan" style=3D"font-family:Ebrima; = font-size:11pt; color:#ffffff">www.anatomiadigital.org</span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9pt"><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:= bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">=   </span><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) <= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Tels. 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Directo (0059= 3) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a><= /p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size= :11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:= none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; = text-decoration:underline">www.anatomiadigital.org</span></a></p><p style= =3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><a href=3D"http://www.cienciadigitaleditorial.c= om" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"marg= in-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienci= adigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:11pt; text-decoration:underline">= www.cienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" style=3D"m= argin-right:1pt; 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position:absolute" /></span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color= :#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font= -weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = ;        </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-235-4= 85</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><a href=3D"http:/= /www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a h= ref=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decora= tion:underline">www.anatomiadigital.org</span></a></p><p style=3D"margin-ri= ght:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"= text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt;= margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadigitaledito= rial.com" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:11pt; text-decoration:underline">www.cienciadi= gitaleditorial.com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1= pt; 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position:absolute" /></span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revist= a Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Amb= ato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">    &= #xa0;    </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">Tels. 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= position:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa= Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 E= cuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Tels. 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position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; 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posit= ion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digi= tal</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuado= r (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><span c= lass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &#= xa0;      </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-2= 35-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><a href=3D"ht= tp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a= href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p s= tyle=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><a href=3D"http://www.cienciadigitaleditori= al.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"= margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.ci= enciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underli= ne; 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position:absolute" /></span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weigh= t:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold;= color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:ab= solute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight= :bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> =         </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard= =C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel= s. 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pos= ition:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digit= al</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador= (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Tels. 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position:absolute" /></span><span> = </span></p><p class=3D"awdiv" style=3D"font-size:8pt; background-color:#fff= fff"><span class=3D"awspan" style=3D"font-size:8pt; font-style:italic">Esta= revista est=C3=A1 protegida bajo una licencia Creative Commons en la 4.0 I= nternational. 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2QXExccyJCmByUou/VSJpmlogQDuXhdHv/qKXWW7qK2tveJhfrVIKVFVlaioKBITEzEYDPz+97/= niy++YNy4cVewHdcTIQRHjhwhIyODsLAw9u7dS2RkJK2trXR1deH3+2+6vqIoFBcXk5+fz8qVK9= m3bx/Jyck0NTVRVFRESUnJDUEL0vc3AC04A9zOXnb9fSdHPv+SMWPHMmLkCGJiYggzGdECAXp6n= DRfvMSpU6c4V1t30yvRL5qm0d3dTWtr6+UHPdTW1nLp0iXq6+tDdNGNxOfz0dnZycaNG1m7di0O= h4ODBw+ybNky/H4/TU1NvPvuuzf0RVVVli1bxq5duwgEAowaNYq+vj5qa2tJTU0lMzOTL7/88sa= wSImorq6WWVlZ37tZIQSKomAwGEKNrMfjwe/3f28OGCwWi4WFCxei0+k4d+4cJ06cwOv1snjxYk= pKSr7XVkJCAikpKdTW1pKbm0tjYyPt7e0UFBQghODw4cM0Nzff1E5WVhbTp0/n4sWLNDcHC2BlZ= SU5OTl4vV6qqqquq1dWVsa8efMQDQ0N8v777/+XNz1YBhOK/67+/0b36rX/FXvXmzN47GY2nnvu= OXJycv4tf//fy/8AgnKjIiDLf+gAAAAASUVORK5CYII=3D" width=3D"77" height=3D"28" = alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></span><span c= lass=3D"awspan">el</span><span class=3D"awspan" style=3D"letter-spacing:0.4= 5pt"> </span><span class=3D"awspan">desarrollo</span><span class=3D"awspan"= style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">de</span><s= pan class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D= "awspan">terapias</span><span class=3D"awspan" style=3D"letter-spacing:0.45= pt"> </span><span class=3D"awspan">antienvejecimiento</span><span class=3D"= awspan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">m=C3= =A1s</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </span><= span class=3D"awspan">efectivas</span><span class=3D"awspan" style=3D"lette= r-spacing:0.45pt"> </span><span class=3D"awspan">y</span><span class=3D"aws= pan" style=3D"letter-spacing:0.45pt"> </span><span class=3D"awspan">persona= lizadas</span><span class=3D"awspan" style=3D"letter-spacing:0.45pt"> </spa= n><span class=3D"awspan">en</span><span class=3D"awspan" style=3D"letter-sp= acing:0.45pt"> </span><span class=3D"awspan">el futuro.</span></p><p class= =3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspa= n" style=3D"font-weight:bold; color:#767171">6.Conflicto de intereses</span= ></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span c= lass=3D"awspan">Los</span><span class=3D"awspan" style=3D"letter-spacing:2.= 1pt"> </span><span class=3D"awspan">autores</span><span class=3D"awspan" st= yle=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">declaran</span>= <span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class= =3D"awspan">que</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"= > </span><span class=3D"awspan">no</span><span class=3D"awspan" style=3D"le= tter-spacing:2.1pt"> </span><span class=3D"awspan">existe</span><span class= =3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">c= onflicto</span><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </spa= n><span class=3D"awspan">de</span><span class=3D"awspan" style=3D"letter-sp= acing:2.1pt"> </span><span class=3D"awspan">intereses</span><span class=3D"= awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">en</s= pan><span class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span cla= ss=3D"awspan">relaci=C3=B3n</span><span class=3D"awspan" style=3D"letter-sp= acing:2.1pt"> </span><span class=3D"awspan">con</span><span class=3D"awspan= " style=3D"letter-spacing:2.1pt"> </span><span class=3D"awspan">el</span><s= pan class=3D"awspan" style=3D"letter-spacing:2.1pt"> </span><span class=3D"= awspan">art=C3=ADculo presentado.</span></p><p class=3D"awdiv" style=3D"mar= gin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weight= :bold; color:#767171">7.Declaraci=C3=B3n de contribuci=C3=B3n de los autore= s</span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt">= <span class=3D"awspan">Todos autores contribuyeron significativamente en la= elaboraci=C3=B3n del art=C3=ADculo.</span></p><p class=3D"awdiv" style=3D"= margin-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-wei= ght:bold; color:#767171">8.Costos de financiamiento </span></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">L= a</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><sp= an class=3D"awspan">presente</span><span class=3D"awspan" style=3D"letter-s= pacing:-0.65pt"> </span><span class=3D"awspan">investigaci=C3=B3n</span><sp= an class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D= "awspan">fue</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt">= </span><span class=3D"awspan">financiada</span><span class=3D"awspan" styl= e=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan">en</span><span = class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"aw= span">su</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </s= pan><span class=3D"awspan">totalidad</span><span class=3D"awspan" style=3D"= letter-spacing:-0.65pt"> </span><span class=3D"awspan">con</span><span clas= s=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan= ">fondos</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </s= pan><span class=3D"awspan">propios</span><span class=3D"awspan" style=3D"le= tter-spacing:-0.65pt"> </span><span class=3D"awspan">de</span><span class= =3D"awspan" style=3D"letter-spacing:-0.65pt"> </span><span class=3D"awspan"= >los</span><span class=3D"awspan" style=3D"letter-spacing:-0.65pt"> </span>= <span class=3D"awspan">autores.</span></p><p class=3D"awdiv" style=3D"margi= n-right:1pt; margin-left:1pt"><span class=3D"awspan" style=3D"font-weight:b= old; color:#767171">9.Referencias Bibliogr=C3=A1ficas</span></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">= 1.Giacomello E, Toniolo L. The Potential of Calorie Restriction and Calorie= Restriction Mimetics in Delaying Aging: Focus on Experimental Models. Nutr= ients [Internet]. 2021 [cited 2024 September 15]; 13(7): 2346.</span><span = class=3D"awspan">  </span><span class=3D"awspan">Available from: </spa= n><a href=3D"https://pubmed.ncbi.nlm.nih.gov/34371855/" style=3D"text-decor= ation:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-le= ft:1pt"><a href=3D"https://pubmed.ncbi.nlm.nih.gov/34371855/" style=3D"text= -decoration:none"><span class=3D"awspan" style=3D"text-decoration:underline= ">https://pubmed.ncbi.nlm.nih.gov/34371855/</span></a></p><p class=3D"awdiv= " style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">2.Liu = J. Antiaging agents: safe interventions to slow aging and healthy life span= extension. Natural products and bioprospecting [Internet]. 2022 [cited 202= 4 September 15]; 12(1):18. Available from: </span><a href=3D"https://pubmed= .ncbi.nlm.nih.gov/35534591/" style=3D"text-decoration:none"></a></p><p clas= s=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><a href=3D"https://= pubmed.ncbi.nlm.nih.gov/35534591/" style=3D"text-decoration:none"><span cla= ss=3D"awspan" style=3D"text-decoration:underline">https://pubmed.ncbi.nlm.n= ih.gov/35534591/</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt= ; margin-left:1pt"><span class=3D"awspan">3.Mehdi M, Solanki P, Singh P. Ox= idative stress, antioxidants, hormesis and calorie restriction: The current= perspective in the biology of aging. Archives of gerontology and geriatric= s [Internet]. 2021 [cited 2024 September 15]; 95:104413. Available from: </= span><a href=3D"https://pubmed.ncbi.nlm.nih.gov/33845417/" style=3D"text-de= coration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin= -left:1pt"><a href=3D"https://pubmed.ncbi.nlm.nih.gov/33845417/" style=3D"t= ext-decoration:none"><span class=3D"awspan" style=3D"text-decoration:underl= ine">https://pubmed.ncbi.nlm.nih.gov/33845417/</span></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt"><span class=3D"awspan">4.H= ofer S, Carmona-Gutierrez D, Mueller M, Madeo F. The ups and downs of calor= ic restriction and fasting from molecular effects to clinical application. = EMBO molecular medicine [Internet]. 2022 [cited 2024 September 15]; 14(1): = e14418. 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Available from: </span><a = href=3D"https://pubmed.ncbi.nlm.nih.gov/33920973/" style=3D"text-decoration= :none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1p= t"><a href=3D"https://pubmed.ncbi.nlm.nih.gov/33920973/" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"text-decoration:underline">htt= ps://pubmed.ncbi.nlm.nih.gov/33920973/</span></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span class=3D= "awspan">6.Kraus W, Bhapkar M, Huffman K, Pieper C, Krupa D, Redman L, et a= l. 2 years of calorie restriction and cardiometabolic risk (CALERIE): explo= ratory </span></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt; font-size:11pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:1095"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQ= EAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERG= 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position:absolute" />= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; = font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   = 0;      </span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amba= te=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Dig= ital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuad= or (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><a href=3D"http://www.anatomiadigital.org" styl= e=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right= :1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigita= l.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; text-decoration:underline">www.anatomiadigi= tal.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-s= ize:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><a href=3D"http:/= /www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p= class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt= "><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decorati= on:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11p= t; text-decoration:underline">www.cienciadigitaleditorial.com</span></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></s= pan><span style=3D"height:0pt; display:block; position:absolute; z-index:11= 26"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAAAASCAYAA= ABWzo5XAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFUOI1VlM1P= IkkYxn/VTdMNDUIM4jIxozsBD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1EPyMrAyof= Y2tBde2C6d3yTSiVV9T71vE89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJycxDAMhxI= 9DBPgeUkosy6JarVIul7m6usKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnpyeOjo4ol= Uo0m01c10UIAQIEAo81QCKRYH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCqKtMz0wTU= ALe3t9i2DUCz2WRnZwcpJfl8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVkA9Ho9Dg4= OmJqaGgENh0NOT0+p1+s+SCgUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+fkI6PX1lb= OzM1+DeDzOysoKoXAYx3GIRCI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azCUA4HGZ1d= RVN04hEIqiKyvbv2xT2C1jPFo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z26RO9bpd/= W00K+3/w3H+i+e0bX76UkVIihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHFxQTab5f7= +/n//CDFiFIvFUFXVX/Q2pJTEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOpqm8dTv02= 630TSNYDCIUEYm9SIej49KMwyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4fX3xmWmax= vT09AgoEAiQy+WoVCrUajUcx6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4cjAYcHx8= zPb2Nt1uF0VRfA28XvNKd10XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRVP2B+FNk2= Tzc1NFhcX0TRtdMb7jKSU2LbN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQog3QN7c7X= a5vr6mWq3SaDQQQpBKpchkMqTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC" width= =3D"18" height=3D"18" alt=3D"" style=3D"margin-left:5.66pt; position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline">www.anatomiadigital.org</spa= n></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><a href=3D"http://www.ciencia= digitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline">www.cienciadigitaleditorial.com</span></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-d= ecoration:underline; color:#0563c1">www.cienciadigitaleditorial.com</span><= /a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-= size:9pt"><span style=3D"height:0pt; display:block; position:absolute; z-in= dex:1134"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABMAAAA= TCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAA7BJREFUOI= 1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqFAUBReICjUKgl= BgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBDQ0OMjo5imiZS= Sj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicViCCGuoGEYKgD= P89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQqCgDdv3vD8+X= MqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabrKysnIPgzkSem= ZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxDcrkcc7Nz+H6A= EJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OHMDLdyt/A8j1Q= qxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1yeVuYZomiYQRrY= ZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185OemyuLjA4rMFKkcV1= tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBMJDCTqUhbn4l8= MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJSSRCIRjZnJZEi= n0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5nMXbGxsUD2qIF= D0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix3Qmf/iRBw8ek= kql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3PjmBjdv2kghaDQd= PtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHnyhFwuh5QyMrq= KCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1ujVqvheR5KKe= LxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnAAAAAElFTkSuQ= mCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-1pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; color:#0563c1">www.cienciadigitaleditorial= .com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:1137"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUh= EUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGw= AAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqF= AUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBD= Q0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicV= iCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQ= qCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabr= KysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxD= crkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OH= MDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1ye= VuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185Oemyu= LjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBM= JDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJS= SRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5n= MXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix= 3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3Pjm= Bjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHn= yhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1= ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnA= AAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-= 1pt; 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posit= ion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digi= tal</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuado= r (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-2= 35-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><a href=3D"ht= tp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a= href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p s= tyle=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><a href=3D"http://www.cienciadigitaleditori= al.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"= margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.ci= enciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underli= ne; 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position:absolute" /></span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weigh= t:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4= ">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o)= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font= -weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#= 4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold;= color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:ab= solute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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5pt; position:absolute" /></span><span class=3D"awspan" style=3D"font-famil= y:Calibri; font-size:11pt; color:#ffffff">     &#x= a0;            =             &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:11pt; letter-spacing:3pt; color:#ffffff"= >Procedimientos M=C3=A9dicos</span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:11pt; letter-spacing:3pt; color:#ffffff">  </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; let= ter-spacing:3pt; color:#ffffff">       </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; lette= r-spacing:3pt; color:#ffffff">P=C3=A1gina</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:11pt; color:#ffffff"> 86 | 88</span></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:9= pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; fon= t-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight= :bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">    &#x= a0;    </span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tels. 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= position:absolute" /></span><span class=3D"awspan" style=3D"font-family:Cal= ibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; = font-weight:bold; color:#4472c4">  </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Di= gital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecua= dor (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font= -family:Calibri; font-size:8pt">       &= #xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">Tels. 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position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline">www.anatomiadigital.org</spa= n></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><a href=3D"http://www.ciencia= digitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline">www.cienciadigitaleditorial.com</span></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline">www.anatomiadigital.org</span></a></p><p = style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">    = ;     </span><a href=3D"http://www.cienciadigitaleditor= ial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D= "margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.c= ienciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underl= ine">www.cienciadigitaleditorial.com</span></a></p><p class=3D"awdiv" style= =3D"margin-right:1pt; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. 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posit= ion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digi= tal</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuado= r (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">  </spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:8pt">       = 0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span = class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  &= #xa0;      </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">Tels. 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Directo (00593) 0998-235-48= 5</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><a href=3D"http://= www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoratio= n:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p style= =3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><a href=3D"http://www.cienciadigitaleditorial.c= om" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"marg= in-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienci= adigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:11pt; text-decoration:underline; 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position:absolute" /></span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold= ; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">&#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">     =     </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 098405= 8533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0= 998-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4= 472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. 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Availa= ble from: </span><a href=3D"https://pubmed.ncbi.nlm.nih.gov/32075050/" styl= e=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right= :1pt; margin-left:1pt; margin-bottom:10pt"><a href=3D"https://pubmed.ncbi.n= lm.nih.gov/32075050/" style=3D"text-decoration:none"><span class=3D"awspan"= style=3D"text-decoration:underline">https://pubmed.ncbi.nlm.nih.gov/320750= 50/</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left= :1pt; font-size:11pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:1231"><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQ= EAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERG= CEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4e= Hh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARjAxoDASIAAhEBAxEB/8QAHAA= BAQACAwEBAAAAAAAAAAAAAAECBwMGCAUE/8QATRABAAEDAgIDCwgGCQMEAgMAAAECAwQFEQYSBy= 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position:absolute" />= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; = font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; col= or:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span cla= ss=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   = 0;      </span><span class=3D"awspan" style=3D"fon= t-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Amba= te=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font= -size:8pt">         </span><span cl= ass=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Dig= ital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuad= or (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">Tels. 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Directo (00593) 0998-235-485</span><span class=3D"awspan= " style=3D"font-family:Calibri; font-size:8pt">     = 0;    </span><a href=3D"http://www.anatomiadigital.org" styl= e=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-right= :1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigita= l.org" style=3D"text-decoration:none"><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:11pt; text-decoration:underline">www.anatomiadigi= tal.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-s= ize:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt= ">         </span><a href=3D"http:/= /www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p= class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt= "><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decorati= on:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11p= t; text-decoration:underline">www.cienciadigitaleditorial.com</span></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; 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position:absolute" /></s= pan><span style=3D"height:0pt; display:block; position:absolute; z-index:12= 62"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABIAAAASCAYAA= ABWzo5XAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGwAAAztJREFUOI1VlM1P= IkkYxn/VTdMNDUIM4jIxozsBD9zEg5rg6kkTM3sy/pGzyXrwpCshMtFl1sSPhFmVg1EPyMrAyof= Y2tBde2C6d3yTSiVV9T71vE89bwk5CgCklLiui2VZ1Ot1Hh4e6HQ6CCGIx+OkUikmJycxDAMhxI= 9DBPgeUkosy6JarVIul7m6usKyLFzXBUBVVUzTJJvNsry8zMzMDIZheOkI13WllJKnpyeOjo4ol= Uo0m01c10UIAQIEAo81QCKRYH19nYWFBcLhMIqiiICUkpeXF05OTigUCrTb7dENQqCqKtMz0wTU= ALe3t9i2DUCz2WRnZwcpJfl8HoCAlJJarUaxWPRBvFJy8zkys7MM7AFjsRh/f/2KZVkA9Ho9Dg4= OmJqaGgENh0NOT0+p1+s+SCgUIp/P89O7FLZtE9R1MrMZTDPM8V/HWJaFlJJGo8H5+fkI6PX1lb= OzM1+DeDzOysoKoXAYx3GIRCI8P1uoaoD372cIh00+l0r0+32GwyF3d3cAKK1Wi2azCUA4HGZ1d= RVN04hEIqiKyvbv2xT2C1jPFo7jMDExwcePv/ov7cmhdDodn41t2xweHqLrOv/U6/z26RO9bpd/= W00K+3/w3H+i+e0bX76UkVIihPAfwPcRwHA45PHxEV3X2dvbIxqNsrGxQa/Xo1KpcHFxQTab5f7= +/n//CDFiFIvFUFXVX/Q2pJTEYjGSySSKopBMJt94yTsXDAZHQOPj4yQSCT/Zo6zrOpqm8dTv02= 630TSNYDCIUEYm9SIej49KMwyDubk5dnd3/c3BYMjy8i9Eo1HGxmL8/OEDruvyzrJ4fX3xmWmax= vT09AgoEAiQy+WoVCrUajUcx6Vc/pNIJEqj8cDN7c33RImU0Gq1cIaO3yq5XG5UquM4cjAYcHx8= zPb2Nt1uF0VRfA28XvNKd10XKSWhUIitrS2WlpbQdV0EhBAEg0Hm5+fp9/vs7++/aRVP2B+FNk2= Tzc1NFhcX0TRtdMb7jKSU2LbN5eUlxWKRm5sbbNv2vxFFUTAMg3Q6zdraGplMxl8XQog3QN7c7X= a5vr6mWq3SaDQQQpBKpchkMqTTaUzTfGMVIYT4D2/Tm3grhukFAAAAAElFTkSuQmCC" width= =3D"18" height=3D"18" alt=3D"" style=3D"margin-left:5.66pt; position:absolu= te" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline">www.anatomiadigital.org</spa= n></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = 0;       </span><a href=3D"http://www.ciencia= digitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline">www.cienciadigitaleditorial.com</span></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; 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position:absolute" /></span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-wei= ght:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3= =B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 5112= 62 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direct= o (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:Ca= libri; font-size:8pt">         </sp= an><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none= "></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; fo= nt-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-deco= ration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</s= pan></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><a href=3D"http://www.cienc= iadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"= awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; color:#0563c1">www.cienciadigitaleditorial= .com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:1273"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUh= EUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGw= AAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqF= AUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBD= Q0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicV= iCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQ= qCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabr= KysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxD= crkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OH= MDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1ye= VuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185Oemyu= LjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBM= JDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJS= SRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5n= MXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix= 3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3Pjm= Bjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHn= yhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1= ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnA= AAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-= 1pt; 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posit= ion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digi= tal</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuado= r (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom= =C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2= =80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Re= vista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D= "awspan" style=3D"font-family:Calibri; font-size:8pt">   &#x= a0;     </span><span class=3D"awspan" style=3D"font-fam= ily:Calibri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:= #4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">      = ;   </span><span class=3D"awspan" style=3D"font-family:Calibri; f= ont-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><= span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#= xa0;       </span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533<= /span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&= #xa0;        </span><span class=3D"awspa= n" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 0998-2= 35-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size= :8pt">         </span><a href=3D"ht= tp://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p><p cla= ss=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a= href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-deco= ration:underline; color:#0563c1">www.anatomiadigital.org</span></a></p><p s= tyle=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:8pt">    =      </span><a href=3D"http://www.cienciadigitaleditori= al.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"= margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.ci= enciadigitaleditorial.com" style=3D"text-decoration:none"><span class=3D"aw= span" style=3D"font-family:Calibri; font-size:11pt; text-decoration:underli= ne; 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position:absolute" /></span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weigh= t:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4= ">  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:9pt; font-weight:bold; color:#4472c4">Digital</span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">    &#= xa0;    </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o)= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >         </span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:absolute" /></sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font= -weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"aws= pan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#= 4472c4">  </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold;= color:#4472c4">  </span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital</span><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  =        </span><span class=3D"awspan" style=3D= "font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn = Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">         </span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. 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position:ab= solute" /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</s= pan><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#x= a0;        </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jar= d=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:= Calibri; font-size:8pt">         </= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Te= ls. 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Available from: </span><a href=3D"h= ttps://pubmed.ncbi.nlm.nih.gov/32335159/" style=3D"text-decoration:none"></= a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt"><a hre= f=3D"https://pubmed.ncbi.nlm.nih.gov/32335159/" style=3D"text-decoration:no= ne"><span class=3D"awspan" style=3D"text-decoration:underline">https://pubm= ed.ncbi.nlm.nih.gov/32335159/</span></a></p><p class=3D"awdiv" style=3D"mar= gin-right:1pt; margin-left:1pt; margin-bottom:10pt"><span style=3D"height:0= pt; display:block; position:absolute; z-index:1299"><img src=3D"data:image/= jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAEBAQEBAQEBAQEBAQEBAQEBAQEBAQE= BAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQH/2wBDAQEBAQEBAQEBAQ= EBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQEBAQH/w= AARCABAAHoDASIAAhEBAxEB/8QAHgAAAgICAwEBAAAAAAAAAAAACQoHCAEGBAULAgP/xABOEAAA= BgECAwQDCgkGDwAAAAABAgMEBQYHCBEACSESExQxFSJBChYjOVFxd4GhthgZMjM3OGFysRcaUnS= 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position:absolute" /></span><span class=3D"awspan" style=3D"font-family= :Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3= =ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4= ">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 = Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Tels. 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa</span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"> = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt;= font-weight:bold; color:#4472c4">Digital</span><span class=3D"awspan" styl= e=3D"font-family:Calibri; font-size:8pt">      = 0;   </span><span class=3D"awspan" style=3D"font-family:Calibri; = font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span>= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" sty= le=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">= Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-fa= mily:Calibri; font-size:8pt">        = 0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058533</span><spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">  = ;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anat= om=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. 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posi= tion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Dig= ital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">         </span><span class=3D"= awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuad= or (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">       &#= xa0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anat= om=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-family:Calibri= ; font-size:8pt">         </span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato = =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan"= style=3D"font-family:Calibri; font-size:8pt">     = ;    </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">Tels. 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position:absolute" /></span><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4"= >Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" style=3D"font-f= amily:Calibri; font-size:8pt">       &#x= a0; </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8= pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Tels. 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Directo (00593) 0998-235-485</= span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">&#= xa0;        </span><a href=3D"http://www= .anatomiadigital.org" style=3D"text-decoration:none"></a></p><p class=3D"aw= div" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D= "http://www.anatomiadigital.org" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; color:#0563c1">www.anatomiadigital.org</span></a></p><p style=3D"= margin-right:1pt; margin-left:1pt; font-size:8pt"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:8pt">     &#= xa0;   </span><a href=3D"http://www.cienciadigitaleditorial.com" = style=3D"text-decoration:none"></a></p><p class=3D"awdiv" style=3D"margin-r= ight:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://www.cienciadig= italeditorial.com" style=3D"text-decoration:none"><span class=3D"awspan" st= yle=3D"font-family:Calibri; font-size:11pt; 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position:absolute" /></span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-weight:bold; = color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:8pt">     &= #xa0;   </span><span class=3D"awspan" style=3D"font-family:Calibr= i; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate=C3=B1o) </sp= an><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> = 0;        </span><span class=3D"awspan" = style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511262 y 0984058= 533</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8p= t">         </span><span class=3D"a= wspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Directo (00593) 09= 98-235-485</span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">         </span><a href= =3D"http://www.anatomiadigital.org" style=3D"text-decoration:none"></a></p>= <p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11= pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; tex= t-decoration:underline; color:#0563c1">www.anatomiadigital.org</span></a></= p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><a href=3D"http://www.cienciadigitale= ditorial.com" style=3D"text-decoration:none"></a></p><p class=3D"awdiv" sty= le=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href=3D"http://= www.cienciadigitaleditorial.com" style=3D"text-decoration:none"><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:11pt; text-decoration:u= nderline; 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position:absolute" /></spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><span class= =3D"awspan" style=3D"font-family:Calibri; font-size:8pt">   =       </span><span class=3D"awspan" style=3D"font-= family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3=ADn Ambate= =C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. (00593) 511= 262 y 0984058533</span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:8pt">         </span><sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tel. Direc= to (00593) 0998-235-485</span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:8pt">         </s= pan><a href=3D"http://www.anatomiadigital.org" style=3D"text-decoration:non= e"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; f= ont-size:11pt"><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-siz= e:11pt; text-decoration:underline; color:#0563c1">www.anatomiadigital.org</= span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; font-size:8pt">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &= #xa0;       </span><a href=3D"http://www.cien= ciadigitaleditorial.com" style=3D"text-decoration:none"></a></p><p class=3D= "awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:11pt"><a href= =3D"http://www.cienciadigitaleditorial.com" style=3D"text-decoration:none">= <span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; 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position:absolute= " /></span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa Digital</span><s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"> &#x= a0;       </span><span class=3D"awspan" style= =3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (Jard=C3= =ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-family:Cali= bri; font-size:8pt">         </span= ><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Tels. = (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tel. Directo (00593) 0998-235-485</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><a href=3D"http://www.anatomiadigital.org" style=3D"text-dec= oration:none"></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-= left:1pt; font-size:11pt"><a href=3D"http://www.anatomiadigital.org" style= =3D"text-decoration:none"><span class=3D"awspan" style=3D"font-family:Calib= ri; font-size:11pt; text-decoration:underline; color:#0563c1">www.anatomiad= igital.org</span></a></p><p style=3D"margin-right:1pt; margin-left:1pt; fon= t-size:8pt"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 8pt">         </span><a href=3D"htt= p://www.cienciadigitaleditorial.com" style=3D"text-decoration:none"></a></p= ><p class=3D"awdiv" style=3D"margin-right:1pt; margin-left:1pt; font-size:1= 1pt"><a href=3D"http://www.cienciadigitaleditorial.com" style=3D"text-decor= ation:none"><span class=3D"awspan" style=3D"font-family:Calibri; font-size:= 11pt; text-decoration:underline; color:#0563c1">www.cienciadigitaleditorial= .com</span></a></p><p class=3D"awdiv" style=3D"margin-right:1pt; margin-lef= t:1pt; font-size:9pt"><span style=3D"height:0pt; display:block; position:ab= solute; z-index:1354"><img src=3D"data:image/png;base64,iVBORw0KGgoAAAANSUh= EUgAAABMAAAATCAYAAAByUDbMAAAABHNCSVQICAgIfAhkiAAAAAlwSFlzAAAOxAAADsQBlSsOGw= AAA7BJREFUOI1tlM1PG0cYxn8zu/baXhzWBKfpEpNg1aVNkJAi2VLCsYLSQ3LM3xfCue0huWAqF= AUBReICjUKglBgndWq0/ljbCNbr3clh+UjUvJcZafT+NO/M8zxCKaUAzhcu9qenpzQaDdrtNgBD= Q0OMjo5imiZSSj4vIQRCCKFfNCulCIIAx3HY2dlhdXWVbrfL2dkZAIZhkE6nKRaLFItFRkdHicV= iCCGuoGEYKgDP89jf32dpaYmDgwMGgwFCCDRNAyAMQ8IwRAjB+Pg4s7OzTE9Pk0wmAZBSChEEgQ= qCgDdv3vD8+XMqlQpKKSzLwh4bw8pkkELQ7Xap1Wo4joMKQ7LZLI8fP+b+/fvE43E0TYvGbDabr= KysnIPgzkSemZmH5G7fRkqJ7/skjAQf3r9na2uL16//wnEcXr58ycjICIVCIbpdEEa32tvbIwxD= crkcc7Nz+H6AEJK9vb/Z3t7hzPPw+z5zcz/z/eQkSimOjo7Y3t7m9Ow0gvl9n83NTfr9PnHD4OH= MDLdyt/A8j1QqxbWhIbLXr2MYBlJKLMtibn4e0zQZDAbs7u7SarUimOu6VCoVALLZLPaYTdt1ye= VuYZomiYQRrYZBZiTD4T8HZCyLOxN3ADg+PsZtuxGs1Wrh+z5CCKzhYdrtFovPFvjt9185Oemyu= LjA4rMFKkcV1tfXeLrwlH8/vOdb20Yphed5nJycAKAHQRAJFQhRCAS6pqFLHSkECSPBQPpoQpBM= JDCTqUhbn4l8MBhEsGQyeXnYdTsMpdP8NDuH3++TTKSYn/+FIAiw7TFieox8/jtse4zNjT9BgJS= SRCIRjZnJZEin0wA4jsNxvc7du3dBCHq9HulraRAwCALaboeJ/ARu2+Xdu3cIBKZpXvZL0zSj5n= MXbGxsUD2qIFD0el06nQ7/1et43hlCguu6LC+X6fV6AIyPj2NZVgTTdZ1SqXRJr1arLJfLSE2ix= 3Qmf/iRBw8ekkql0HWNP5bLvH27C4Bpmty7d4/h4eHozaSU5PN5SqUSr169wvd9Dg8PaTQa3Pjm= Bjdv2kghaDQdPtY+0mw2CcMQTdOYmppienqaWCx2ZXSlFPV6nRcvXrC1tXX5O18z+rmpKRQKPHn= yhFwuh5QyMrqKCqUU7XabcrnM+vr6pXY+zyylFLquUywWefToEdls9iLLEEJcwS6q3+9TrVZZW1= ujVqvheR5KKeLxOLZtUyqVKBQKxOPx/4Wj+ILEl0HZ6XTo9XoopS4lcAH5StqKT0/sycXcKidnA= AAAAElFTkSuQmCC" width=3D"19" height=3D"19" alt=3D"" style=3D"margin-left:-= 1pt; 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posit= ion:absolute" /></span><span class=3D"awspan" style=3D"font-family:Calibri;= font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3=ADa</spa= n><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9pt; font-= weight:bold; color:#4472c4">  </span><span class=3D"awspan" style=3D"f= ont-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4">Digital= </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">=          </span><span class=3D"awsp= an" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 Ecuador (= Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"font-fami= ly:Calibri; font-size:8pt">        = </span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:8pt"= >Tels. (00593) 511262 y 0984058533</span><span class=3D"awspan" style=3D"fo= nt-family:Calibri; font-size:8pt">       = ;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-si= ze:8pt">Tel. 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position:absolute" /></span><span class=3D"awspan" style=3D"font-family:C= alibri; font-size:9pt; font-weight:bold; color:#4472c4">Revista Anatom=C3= =ADa</span><span class=3D"awspan" style=3D"font-family:Calibri; font-size:9= pt; font-weight:bold; color:#4472c4">  </span><span class=3D"awspan" s= tyle=3D"font-family:Calibri; font-size:9pt; font-weight:bold; color:#4472c4= ">Digital</span><span class=3D"awspan" style=3D"font-family:Calibri; font-s= ize:8pt">         </span><span clas= s=3D"awspan" style=3D"font-family:Calibri; font-size:8pt">Ambato =E2=80=93 = Ecuador (Jard=C3=ADn Ambate=C3=B1o) </span><span class=3D"awspan" style=3D"= font-family:Calibri; font-size:8pt">      &#x= a0;  </span><span class=3D"awspan" style=3D"font-family:Calibri; font-= size:8pt">Tels. 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