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> </= span>Ambato, <sp= an class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.1pt">Ecuador= .<a href=3D"mailto:asari4346@uta.edu.ec" style=3D"text-decoration:no= ne"></a><a href=3D"mailto:a= sari4346@uta.edu.ec" style=3D"text-decoration:none">asari4346@uta.edu.ec</a>3V=C3=ADcto= r Pe=C3=B1afiel</= span> Gaiborhttps://orci= d.org/0000-0003-3286-4797Docente<span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.4pt"> <= span class=3D"awspan" style=3D"font-size:10pt">Investigador <span= class=3D"awspan" style=3D"font-size:10pt">Universidad T=C3=A9cnica de Ambato, Ambato, Ecuador.<a href=3D"mailto:vi.penafiel= @uta.edu.ec" style=3D"text-decoration:none"></a><a href=3D"mailto:vi.penafiel@uta.edu.ec" style=3D"tex= t-decoration:none">vi.penafiel@uta.ed= u.ec</a>4Ver=C3=B3nica Gabriela L=C3=B3pez Ullaurihttps://orcid.org/0000-0001-6505-5166</= p>Escuela Superior Polit=C3=A9cnica de Chimborazo<a href=3D"mailto:veronicag.lopez@espoch.edu= .ec" 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E= spermatozoides (ICSI)Efficac= y of Assisted Reproduction Techniques: = I= n Vitro Fertilization<sp= an class=3D"awspan" style=3D"font-size:14pt; font-style:italic; letter-spac= ing:-0.25pt"> (IVF) and Intracytoplasmic Sperm Injection (ICSI)<p= class=3D"awdiv" style=3D"font-size:10pt">Art=C3=ADculo </span= >de</span= > Investigaci=C3=B3n Cient=C3=ADfica</spa= n> y Tecnol=C3=B3gi= caEnviado: 17/02/2025 Revisado: 15/03/2025 Aceptado: 08/04/2025 Publicado:08/05/2025= DOI: <a href=3D"https://doi.org/10.33262/anatomi= adigital.v8i2.3373" style=3D"text-decoration:none"></a><a href=3D"https://doi.org/10.33262/anatomiadig= ital.v8i2.3373" style=3D"text-decoration:none">https://doi.org/ 1= 0.33262/anatomiadigital.v8i2.1.3388</a>C=C3=ADtese:Solano <= span class=3D"awspan" style=3D"font-size:10pt">Benalc=C3=A1zar,<span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.45pt"> = E. J., Sari Y=C3=A1nez, A. N.,<= /span> Pe=C3=B1afiel</s= pan>= Gaibor,<span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.45pt"> = V., & L=C3=B3pez Ullauri, V.G.</spa= n> </= span>(2025). <span= class=3D"awspan" style=3D"font-size:10pt">Eficacia de las t=C3=A9cnicas de reproducci=C3= =B3n asistida:</sp= an> <= /span>fecundaci=C3=B3n</spa= n> </= span>in vitro (FIV) e inyecci=C3=B3n intracitoplasm=C3=A1tica de espermatozoides (ICSI). Anatom=C3=ADa Digital, 8(2.1), 6-18. <a href=3D"https://doi.org/%2010.33262/anato= miadigital.v8i2.1.3388" style=3D"text-decoration:none"></a><a href=3D"https://doi.org/%2010.33262/anat= omiadigital.v8i2.1.3388" style=3D"text-decoration:none">https://doi.org/ 10.33262/anatomiadigital.v8i2.1.3388<= /a>ANATOM=C3=8DA DIGITAL, es una</sp= an> <= /span>Revista <span= class=3D"awspan" style=3D"font-size:8pt">Electr=C3=B3nica, Trimestral, que se publicar=C3=A1 en soporte= </sp= an>electr=C3=B3nico<s= pan class=3D"awspan" style=3D"font-size:8pt; letter-spacing:2pt"> <s= pan class=3D"awspan" style=3D"font-size:8pt">tiene como misi=C3=B3n contribuir a la= </spa= n>formaci=C3=B3n<span= class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.35pt"> <= span class=3D"awspan" style=3D"font-size:8pt">de profesionales competentes con visi=C3=B3n human=C3=ADstica y cr=C3=ADtica</= span> </= span>que sean capaces de exp= oner sus<spa= n class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.55pt"> <= span class=3D"awspan" style=3D"font-size:8pt">resultados investigativos y cient=C3=ADficos en la misma<= span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.55pt"> </spa= n>medida que se promueva mediante su intervenci=C3=B3n cambios positivos en la socieda= d. <a href=3D"https://anatomiadigital.org/" style=3D"text-decoration= :none"></a><a href=3D"https:= //anatomiadigital.org/" style=3D"text-decoration:none">https:= //anatomiadigital.org</a>La revista es editada por</= span> = la Editorial Ciencia Digital (Editorial de</s= pan> <= /span>prestigio <spa= n class=3D"awspan" style=3D"font-size:8pt">registrada en la C=C3=A1mara Ecuato= riana de Libro con No de Afiliaci=C3=B3n 663) <a href=3D"http://www.= celibro.org.ec/" style=3D"text-decoration:none"></a><a href=3D"http://www.celibro.org.ec/" style=3D"tex= t-decoration:none">www.celibro.org.ec</a>Esta revista= est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.45pt"> </spa= n>protegida bajo una licencia Creative Comm= ons Atribuci=C3=B3n= -NoComercial-CompartirIgual4.0 International. 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ns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L20= 9,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"evenodd" = /></g></g></svg><a href=3D"http://www.anatomi= adigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>ISSN:<spa= n class=3D"awspan" style=3D"letter-spacing:-0.15pt; color:#ffffff"> = 2697-</spa= n>3391Vol. 8 No.= </sp= an>2.1, pp. 6 =E2=80=93 18,<= /span> abril <spa= n class=3D"awspan" style=3D"color:#ffffff">- mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblica Art= =C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.Palabras claves: </span= >infertilidad, </spa= n>fertilizaci=C3=B3n in<spa= n class=3D"awspan" style=3D"letter-spacing:-0.75pt"> vitro, inyecci=C3=B3n intracitoplasm=C3=A1tica de<= /span> <span= class=3D"awspan">espermatozoides, inseminaci=C3=B3n, fac= tor masculino= .ResumenIntroducci=C3=B3n. = La infertilidad es una condici=C3=B3n relativ= amente com=C3=BAn en la poblaci=C3=B3n general que<sp= an class=3D"awspan" style=3D"letter-spacing:-0.6pt"> llega= a afectar hasta </span= >al 15% de las= parejas = a nivel mundial,<= /span> y = en la actualidad,= los procedimientos e intervencio= nes <span= class=3D"awspan">utilizadas para asistir</span= > la </sp= an>reproducci=C3=B3n no = son <span= class=3D"awspan">totalmente capaces de<= span class=3D"awspan" style=3D"letter-spacing:4pt"> cubrir </= span>por completo la<= /span> <span= class=3D"awspan">tasa de =C3=A9xito,</sp= an> generando alta controversia= <span= class=3D"awspan">en el uso de<spa= n class=3D"awspan" style=3D"letter-spacing:2pt"> FIV <= span class=3D"awspan">y/o ICSI. Objetivo. Evaluar la <span= class=3D"awspan">efectividad de la<span= class=3D"awspan" style=3D"letter-spacing:4pt"> fertilizaci=C3=B3n in vitro (FIV) y la inyecci=C3=B3n intracitoplasm=C3= =A1tica de</s= pan>espermatozoides(= ICSI)como</sp= an>tratamientos</spa= n>parala infertilidad, considerando la<s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> causa <= /span>probable, analizando<sp= an class=3D"awspan" style=3D"letter-spacing:2pt"> los mecanismos fundamentales de<spa= n class=3D"awspan" style=3D"letter-spacing:2pt"> cada = t=C3=A9cnica, sus ventaj= as, desventajas y las opciones terap=C3=A9uticas m=C3=A1s adecuadas seg=C3= =BAn las </s= pan>caracter=C3=ADsticas de= cada pareja. Metodolog=C3=ADa. Se</span= > realiz=C3=B3 una b=C3=BAsqueda en </sp= an>bases de dato= s <sp= an class=3D"awspan">cient=C3=ADficas seleccionando= art=C3=ADculos basados en confiabil= idad, <sp= an class=3D"awspan">validez y relevancia= cl=C3=ADnica, prio= rizando </spa= n>publicaciones en ingl=C3=A9s y espa=C3=B1ol<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> de </sp= an>los =C3=BAltimos 5 a=C3=B1os, se eligieron 15 art=C3=ADculos de alto nivel de evidencia qu= e cumplieron </s= pan>con los criterios</s= pan> establecidos. Resultad= os. La fecundaci=C3=B3n = in <s= pan class=3D"awspan">vitro mostr=C3=B3 cierto </sp= an>grado de supe= rioridad </sp= an>frente a la ICSI con relaci=C3=B3n a la tasa de f= ertilizaci=C3=B3n, sin embargo, esta =C3=BAltima tuvo <s= pan class=3D"awspan">una mayor tasa<span= class=3D"awspan" style=3D"letter-spacing:2pt"> de <sp= an class=3D"awspan">embriones de buena<s= pan class=3D"awspan" style=3D"letter-spacing:4pt"> calidad, aunque el resultado no fue significativamente mayor. Finalme= nte, = se pudo establecer= <span= class=3D"awspan">que la tasa<span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> de </sp= an>nacidos vivos = es indirectam= enteproporcionala = laedadmaterna, independientemente del </sp= an>procedimiento realizado.</span= > Conclusi=C3=B3n. La <= /span>fecundaci=C3=B3n in vitro <= span class=3D"awspan">se ha convertido<s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> en = la t=C3=A9cnica de repro= ducci=C3=B3n </s= pan>asistida de elecci= =C3=B3n <= span class=3D"awspan">en diversas condiciones c= omo la infertilidad inexplicada, endometriosis, y problemas ov=C3=A1ricos y= masculinos, no as=C3=AD la ICSI, misma que se reserva para casos espec=C3= =ADficos de infertilidad masculina a pesar de su mayor interv= encionismo. </sp= an>Cada enfoque tiene</s= pan> sus = propias indicaciones y consider= aciones, destacando la importancia de una selecci=C3=B3n cuidadosa basada e= n el diagn=C3=B3stico individual. =C3=81rea de estudio general: Medicina=C3=81rea de estudio esp= ec=C3=ADfica: Ginecolog=C3=ADa<sp= an class=3D"awspan" style=3D"letter-spacing:-0.1pt"> y </= span>Obstetricia.</s= pan>Tipo de estudio:<= span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:2.85pt; col= or:#333333"> Revisi= =C3=B3n Bibliogr=C3=A1fica.Keywords:</sp= an>AbstractEsta revista </spa= n>est=C3= =A1 protegida bajo una licencia Creative<span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spacing= :-0.2pt"> Commons en la 4.0 International. 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dth=3D"77" height=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:a= bsolute" /><svg font-family=3D"Times New Roman" font-size=3D"1= 6" height=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3= .org/2000/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times = New Roman'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><d= efs /><g><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"= #7c7c7c" fill-rule=3D"evenodd" /></g></g></svg><a href=3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none= ">www.anatomiadig= ital.org</a>ISSN: 2697-3391Vol. 8 No. 2.1, pp.</sp= an> <= /span>6 =E2=80=93 18, abril -= mayo <spa= n class=3D"awspan" style=3D"color:#ffffff">2025 Revista en ciencias m=C3=A9= dicas, salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica= .Infertility, in vitro= fertilizatio= n, intracytoplasmic sperm injection, insemina= tion, </span= >male factor.Introduction. Infertility= is a relat= ively = common condition = in the </span= >general population, affecting = up to 15%</= span> of couples worldwide. Cur= rently, </sp= an>the procedures = and <= span class=3D"awspan">interventions used to assist </= span>reproduction are not </spa= n>fully capable = of <sp= an class=3D"awspan">achieving a complete = success </spa= n>rate, generating significant = controversy regarding the</s= pan> use of IVF and/or </= span>ICSI. Objective. To evalua= te the </span= >effectiveness of = in <sp= an class=3D"awspan">vitro fertilization = (IVF) = and intracytoplasmic sperm<s= pan class=3D"awspan" style=3D"letter-spacing:4.45pt"> injection (ICSI) as treatments for infertility, consideri= ng <spa= n class=3D"awspan">the probable cause.</spa= n> This includes analyzing the</= span> fundamental mechanisms of <= span class=3D"awspan">each technique, their advantages, disadvantages, and</sp= an> the most suitable<s= pan class=3D"awspan" style=3D"letter-spacing:1.65pt"> therapeutic options according = to <sp= an class=3D"awspan">the characteristics = of <sp= an class=3D"awspan">each couple. Methodology. A </sp= an>search was conducted<span= class=3D"awspan" style=3D"letter-spacing:-0.05pt"> in </s= pan>scientific databases, selecting= articles based on = reliability, </s= pan>validity, and clinic= al relevance, = prioritizing publications</sp= an> in English and Spanish from the last five </span= >years. Fifteen = high-evidence= articles that met the= established criteria= were selected. Results. In vitro fertilization showed some<sp= an class=3D"awspan" style=3D"letter-spacing:3.4pt"> degree = of superiority over = ICSI regarding fertilization= rates; however, ICSI<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> resulted in a = higher rate </= span>of high-quality embryos, </sp= an>although the diff= erence = was not statistically significant.= Ultimately, it was = determined that the = live <s= pan class=3D"awspan">birth rate is<s= pan class=3D"awspan" style=3D"letter-spacing:4.2pt"> indirectly proportional to<s= pan class=3D"awspan" style=3D"letter-spacing:4.2pt"> maternal age, regardless of= the procedure performed.</spa= n> Conclusion. In vitro fertilization has</sp= an> become the preferred<s= pan class=3D"awspan" style=3D"letter-spacing:2.8pt"> assisted reproductive technique = for <s= pan class=3D"awspan">various conditions = such <= span class=3D"awspan">as unexplained infertility,<s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> endometriosis, and ovarian</span= > and male factors.<span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> On </sp= an>the other hand, ICSI = is reserved for</s= pan> specific cases of<s= pan class=3D"awspan" style=3D"letter-spacing:-0.7pt"> male= infertility despite its</spa= n> higher level of intervention.= Each approach has <= span class=3D"awspan">its own indications and <= span class=3D"awspan">considerations, emphasizing<s= pan class=3D"awspan" style=3D"letter-spacing:9.45pt"> the importance of careful<s= pan class=3D"awspan" style=3D"letter-spacing:0.5pt"> selection based on individual </= span>diagnosis. General Area of Study: = MedicineSpecific area of study:<= /span> Gynecology and<= span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> Obstetrician.Type of study: </sp= an>Bibliography Review.</s= pan><a id=3D"_._Introducci=C3=B3n"></a>1.Introducci=C3=B3nLa<= /span> infertilidad, seg=C3=BAn la = Sociedad Europea = para <= span class=3D"awspan">la Reproducci=C3=B3n Humana </s= pan>y Embriolog=C3=ADa se<s= pan class=3D"awspan" style=3D"letter-spacing:1pt"> define = como una c= ondici=C3=B3n= en la que<= /span> existe imposibilidad para= <span= class=3D"awspan">lograr un embarazoEst= a revista est=C3=A1 protegida bajo una licencia Creative Commons<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> en la 4.0 International. Copia de la licencia: <a href=3D"h= ttp://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:= none"></a><a href=3D"http://= creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:none">= http://creativecommons.org/licenses/by= -nc-sa/4.0/</a><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ffff= ff">D i a g <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-sp= acing:0.5pt; color:#ffffff">n </spa= n>=C3=B3 s<= /span> t i c o M<= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-= spacing:0.45pt; color:#ffffff"> =C3=A9 d = i c oP =C3=A1<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-s= pacing:0.5pt; color:#ffffff"> g i </span= >n <= /span>a 8 = | 18<img src=3D"data:image/jpeg;base64,/9j/= 4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERE= TFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh= 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LP36yfoiknp8aSmiX+vu9nvzttkyR3ovDIRi5gpqr5r+sf/Z" width=3D"77" height=3D"27= " alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /><span= ><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" ver= sion=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D= "width:209.31px; height:41.33px; font-family:'Times New Roman'; font-size:1= 6px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"= M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"e= venodd" /></g></g></svg><a href=3D"http://www= .anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>= ISSN:</sp= an> = 269= 7-3391Vol. 8 No.= 2.1, <spa= n class=3D"awspan" style=3D"color:#ffffff">pp. 6 =E2=80=93 18, abril<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </spa= n>- mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblic= a Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.despu=C3=A9s de<span= class=3D"awspan" style=3D"letter-spacing:-0.25pt"> haber= mantenido relaciones</span= > sexuales regulares sin</sp= an> protecci=C3=B3n por al</= span> menos 12 meses, en</span= > donde intervienen factores</s= pan> que producen alteraciones<= /span> de la reproducci=C3=B3n= <span= class=3D"awspan">en uno o ambos<spa= n class=3D"awspan" style=3D"letter-spacing:1.8pt"> integrantes de la p= areja, = estim=C3=A1ndose que aproximadamente un 15% d= e parejas </s= pan>a escala mundi= al <spa= n class=3D"awspan">padecen infertilidad, = siendo </span= >esta afecci=C3=B3n m=C3=A1s </= span>prevalente en las mujeres. (1,2).= Desde = la d=C3=A9cada de<= /span> los 80 se han </span= >planteado y perfe= ccionado </sp= an>t=C3=A9cnicas de reproducci=C3=B3n asistida (TRA) que<= /span> han permitido lograr</s= pan> la concepci=C3=B3n, actua= lmente </span= >el tratamiento = que <= span class=3D"awspan">ha presentado altas tasas </span= >de =C3=A9xito es<= /span> la fertilizaci=C3=B3n = in <sp= an class=3D"awspan">vitro (FIV), raz=C3= =B3n <= span class=3D"awspan">por la cual<= span class=3D"awspan" style=3D"letter-spacing:0.35pt"> Robert Edwards fue galardonad= o <spa= n class=3D"awspan">con el Premio<s= pan class=3D"awspan" style=3D"letter-spacing:2.15pt"> Nobel de Medicina en = el 2010 al<= span class=3D"awspan" style=3D"letter-spacing:2.15pt"> lograr el nacimiento de la primera beb=C3=A9 p= robeta en el a=C3=B1o 1978. (2,3).Actualmente existen diversas</s= pan> t=C3=A9cnicas de reproducci= =C3=B3n </span= >asistida e incluso<= /span> se considera el surgimiento= de la NPT (Natural </s= pan>Procreative Technology),</span= > la= misma que s= e <span= class=3D"awspan">basa en identificar la</= span> causa de la infertilidad y buscar solucionarla mediante tratamientos</sp= an> m=C3=A9dicos convencionales para<spa= n class=3D"awspan" style=3D"letter-spacing:-0.55pt"> evitar recurrir a t=C3=A9cnicas de concepci=C3=B3n<= /span> <span= class=3D"awspan">artificiales, por su<= /span> <span= class=3D"awspan">parte entre las TRA</s= pan> se mencionan las<sp= an class=3D"awspan" style=3D"letter-spacing:0.85pt"> siguientes: inseminaci=C3=B3n art= ificial </spa= n>(IA), fecundaci=C3=B3n<spa= n class=3D"awspan" style=3D"letter-spacing:0.85pt"> in </s= pan>vitro convencional (FIV),= inyecci=C3=B3n intracitoplasm=C3=A1tica<= span class=3D"awspan" style=3D"letter-spacing:8.4pt"> de </= span>espermatozoides (ICSI), transfe= rencia </span= >de embriones y</s= pan> diagn=C3=B3stico gen=C3=A9tico preimplantacional (DGP), en particul= ar, <= span class=3D"awspan">en este texto</sp= an> se pretende evaluar</spa= n> la eficacia de<span= class=3D"awspan" style=3D"letter-spacing:-0.35pt"> dos </= span>de las t=C3= =A9cnicas </= span>com=C3=BAnmente utilizadas busc= ando <s= pan class=3D"awspan">identificar bajo qu=C3= =A9 <sp= an class=3D"awspan">par=C3=A1metros se pref= iere <s= pan class=3D"awspan">la utilizaci=C3=B3n d= e <span= class=3D"awspan">una t=C3=A9cnica en com= paraci=C3=B3n= a la otra<= /span> para el manejo<sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> de </= span>la infertilidad, identificando riesgos prenatales y</sp= an> perinatales entre las<s= pan class=3D"awspan" style=3D"letter-spacing:0.5pt"> parejas que optaron por <s= pan class=3D"awspan">un tratamiento de</spa= n> FIV o ICSI. (4=E2=80=936).La fertilizaci=C3= =B3n = in vitro es</spa= n> una t=C3=A9cnica basada</sp= an> en la fecundaci=C3=B3n</spa= n> extracorp=C3=B3rea, en prim= era instancia= es necesario ejercer </= span>acciones que = permitan </sp= an>conseguir la = estimulaci=C3=B3n ov=C3=A1rica controlada mediante </s= pan>el uso de</spa= n> medicamentos como la<= span class=3D"awspan" style=3D"letter-spacing:0.45pt"> gonadotropina cori=C3=B3nica = humana, administrados por v=C3=ADa= subcut=C3=A1nea o intramuscul= ar, <s= pan class=3D"awspan">para de esta<= span class=3D"awspan" style=3D"letter-spacing:1.35pt"> manera obtener varios fol=C3= =ADculos </sp= an>a partir de los cuales se extraer=C3=A1n ovocitos, mis= mos <s= pan class=3D"awspan">que ser=C3=A1n fertilizados y<= span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> una vez que =C3=A9stos= progresen sean transferidos</= span> a la cavidad uterina = en un tiemp= o <spa= n class=3D"awspan">aproximado de tres a<= span class=3D"awspan" style=3D"letter-spacing:3pt"> cinco </s= pan>d=C3=ADas, optando p= or realizar dicha transferencia</= span> cuando el cultivo se= encuentre en= etapa de blastocisto.</span= > Finalmente, se menciona que= el <= span class=3D"awspan">ciclo completo de= <span= class=3D"awspan">FIV dura alrededor de dos semanas. (3,7).En un inicio </s= pan>se planteaba = que <s= pan class=3D"awspan">la FIV fue<sp= an class=3D"awspan" style=3D"letter-spacing:0.35pt"> ideada con el = objetivo </sp= an>de brindar trat= amiento </spa= n>a mujeres con = diagn=C3=B3stico de infertilidad<s= pan class=3D"awspan" style=3D"letter-spacing:0.35pt"> tub=C3=A1rica, sin embargo,</spa= n> al d=C3=ADa de hoy </spa= n>se reconoce como = una <sp= an class=3D"awspan">TRA de elecci=C3=B3n</s= pan> en casos de infertilidad = inexplicada, endometriosis, d= isfunci=C3=B3n ov=C3=A1rica resistente</s= pan> a la inducci=C3=B3n= farmacol=C3=B3gica de la</spa= n> ovulaci=C3=B3n, crio preservaci=C3=B3n= de= ovocitos en pacientes </s= pan>oncol=C3=B3gicos, preservaci=C3= =B3n <s= pan class=3D"awspan">de la fertilidad</span= > e infertilidad por factores</sp= an> masculinos por ejemplo,</span= > recuento de espermatozoides</s= pan> m=C3=B3viles<3 millones,<= span class=3D"awspan" style=3D"letter-spacing:0.35pt"> cabe mencionar que<span= class=3D"awspan" style=3D"letter-spacing:0.4pt"> en </spa= n>un ciclo com=C3=BA= n <span= class=3D"awspan">de FIV se fertilizan <= /span>alrededor de 8Esta revista est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spac= ing:-0.2pt"> protegida bajo <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">una<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> licencia Creative </spa= n>Commons= en la <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">4.0<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:2pt"> International. Copia de la licencia: <a h= ref=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-dec= oration:none"></a><a href=3D= "http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoratio= n:none">http://creativecommons.org/lic= enses/by-nc-sa/4.0/</a>D i</spa= n> a g </= span>n =C3=B3 <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">s t<spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:0.4pt; color:#ffffff"> i c <= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#= ffffff">o M<= /span> =C3=A9 d<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#f= fffff"> i c<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-s= pacing:0.5pt; color:#ffffff"> o</spa= n>P =C3=A1<= /span> g i n a <= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#= ffffff">9 | 18<img src=3D"data:image/jpeg;b= 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3Wo3LIDUkNWar41drKrYXUySVwr/v7c4109uMemfXFvacXZ3SNbjLaMTexB7A44kg9nLbGsA0gN= NvhYwG+IDU3kmUwOVfCw4tq+0ZfAi8+g2WcpKuEtVfzZ5/FUraF1lyF0YLhAbIRiR6Ry/eIYJFi= XzO8VjBm+FflLP36yfoiknp8aSmiX+vu9nvzttkyR3ovDIRi5gpqr5r+sf/Z" width=3D"77" = height=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" />= <svg font-family=3D"Times New Roman" font-size=3D"16" height= =3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000= /svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Roman= '; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g>= <g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" = fill-rule=3D"evenodd" /></g></g></svg><a href= =3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org<= /span></a>ISSN: 2697-3391<span= class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2.1,= pp. <span= class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <= span class=3D"awspan" style=3D"color:#ffffff">mayo 2025 Revista en ciencias m=C3=A9dicas, salu= d p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</p= >ovocitos y</spa= n> se transfieren de<spa= n class=3D"awspan" style=3D"letter-spacing:0.45pt"> 3 </sp= an>a 5 por<= span class=3D"awspan" style=3D"letter-spacing:0.45pt"> lo que, la = tasa <= span class=3D"awspan">de embarazos m=C3= =BAltiples </= span>incrementa considerablemente en pacientes que s= e han sometido a esta t=C3=A9cnica. (8,9).<sp= an class=3D"awspan">En contraste, la= inyecci=C3=B3n intracitoplasm=C3=A1tica<= span class=3D"awspan" style=3D"letter-spacing:0.6pt"> de </= span>espermatozoides (ICSI)<s= pan class=3D"awspan" style=3D"letter-spacing:0.6pt"> es </s= pan>una t=C3=A9cnica en la </spa= n>cual se selecci= ona <s= pan class=3D"awspan">un solo espermatozoi= de <sp= an class=3D"awspan">y se inserta<= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> directamente en el<sp= an class=3D"awspan" style=3D"letter-spacing:-0.35pt"> citoplasma de un ovocito<sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> maduro,= pese a que</= span> este procedimiento forma</sp= an> parte de un c= iclo <s= pan class=3D"awspan">de FIV se considera</s= pan> que debe ser reservado </= span>en casos de</sp= an> infertilidad masculina en</spa= n> los que se haya= detectado </= span>alteraciones en las </span= >caracter=C3=ADsticas del<sp= an class=3D"awspan" style=3D"letter-spacing:6.35pt"> semen= como oligozoospermia, asten= ozoospermia, = teratozoospermia, ausencia</= span> de conductos deferentes,<= /span> anticuerpos anti espermatozoides<s= pan class=3D"awspan" style=3D"letter-spacing:2.25pt"> o </= span>que han exper= imentado </sp= an>tasas de =C3=A9= xito <= span class=3D"awspan">nulas o bajas</span= > en ciclos de fertilizaci=C3= =B3n <= span class=3D"awspan">in vitro previas,</= span> asociada a mayor<s= pan class=3D"awspan" style=3D"letter-spacing:1.85pt"> tasa= de =C3=A9xito en </span= >comparaci=C3=B3n con las t=C3=A9cnicas tradicionales de</s= pan> fertilizaci=C3=B3n. Esta = t=C3=A9cnica = supone mayor intervencionismo debido a que<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> el ovocito se somete = a manipulaci=C3=B3n<s= pan class=3D"awspan" style=3D"letter-spacing:-0.15pt"> enzim=C3=A1tica que promueva= <spa= n class=3D"awspan">un estado de madurez,= <span= class=3D"awspan">luego se inyecta= un espermatozoide inmovilizad= o <spa= n class=3D"awspan">con ayuda de<sp= an class=3D"awspan" style=3D"letter-spacing:1.75pt"> una <= /span>pipeta. (9,10).Las <= /span>t=C3=A9cnicas de reproducci=C3=B3n asistida han<sp= an class=3D"awspan" style=3D"letter-spacing:1.6pt"> sido </= span>objeto de contr= oversia </span= >en los aspectos =C3= =A9ticos </sp= an>y morales, sin<= /span> embargo, dichos conflict= os <sp= an class=3D"awspan">no han impedido</span= > el avance, mejora<spa= n class=3D"awspan" style=3D"letter-spacing:1.15pt"> y perfeccionamiento de las<sp= an class=3D"awspan" style=3D"letter-spacing:2.2pt"> mismas,= es por =C3= =A9ste = motivo que la= fertilizaci=C3=B3n in vitro</sp= an> se considera la t=C3=A9cnica= <span= class=3D"awspan">artificial de elecci=C3= =B3n <= span class=3D"awspan">para el manejo</spa= n> de la infertilidad,<s= pan class=3D"awspan" style=3D"letter-spacing:4.95pt"> el procedimiento por la<spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> cual </s= pan>se opte depender= =C3=A1 = de las condiciones</= span> de la pareja inf=C3=A9rtil, por tal raz=C3=B3n,</spa= n> se analizaran distintas</= span> variables con relaci= =C3=B3n </sp= an>a la tasa</sp= an> de fertilizaci=C3=B3n, embriones de = buena calidad, nacidos </sp= an>vivos y el= porcentaje de abortos<sp= an class=3D"awspan" style=3D"letter-spacing:0.6pt"> espont=C3=A1neos, con el<span= class=3D"awspan" style=3D"letter-spacing:0.6pt"> objetivo de identificar cual deber=C3=A1 ser la t=C3=A9cnica de elecci= =C3=B3n rutinaria en estos casos. (11,12).<sp= an class=3D"awspan">Objetivo generalEvaluar la<= /span> efectividad de la fertil= izaci=C3=B3n = in vitro = (FIV) = y la inyecci=C3=B3= n <sp= an class=3D"awspan">intracitoplasm=C3=A1tica de espermatoz= oides = (ICSI) como tratam= ientos </span= >para la infertili= dad, <= span class=3D"awspan">analizando los mecanismos<spa= n class=3D"awspan" style=3D"letter-spacing:2.1pt"> fundamentales de cada t=C3=A9cnica, sus ventajas, desventajas y las opcio= nes terap=C3=A9uticas para establecer un m=C3=A9todo de fertilizaci=C3=B3n = seguro.Objetivos</span= > espec=C3=ADficos= =EF=82=B7Analizar los= pilares b=C3=A1sicos de</span= > cada procedimiento a<s= pan class=3D"awspan" style=3D"letter-spacing:1.05pt"> realizar con relaci=C3=B3n</sp= an> a las parejas sometidas al estudio para demo= strar la efectividad de cada intervenci=C3=B3n.=EF=82=B7</spa= n>Realizar una compa= raci=C3=B3n </= span>entre las varia= bles <s= pan class=3D"awspan">de ambos procedimiento= s, <spa= n class=3D"awspan">para identificar cu=C3=A1l es <= span class=3D"awspan">la t=C3=A9cnica que</= span> representa menor riesgo</spa= n> y = mayor tasa d= e efectividad= .=EF=82=B7Evalu= ar <s= pan class=3D"awspan">los resultados y</= span> caracter=C3=ADsticas de parejas </= span>sometidas a estas </spa= n>intervenciones con el<span= class=3D"awspan" style=3D"letter-spacing:0.35pt"> prop=C3=B3sito de identificar</span= > la incidencia de nacidos = vivos sin = complicaciones a corto y largo plazoEsta revista est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spac= ing:-0.2pt"> protegida bajo <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">una<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> licencia Creative </spa= n>Commons= en la <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">4.0<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:2pt"> International. 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bibliogr=C3=A1fica.<a id=3D"_._Metodolog=C3=ADa"></a>2.Metodolog=C3=AD= aSe e= jecut=C3=B3 </= span>una b=C3=BAsqueda de <= span class=3D"awspan">art=C3=ADculos en v= arias <= span class=3D"awspan">bases de datos= reconocidas en el campo cient=C3=ADfico y m=C3=A9dico</s= pan> como: Science Direct,</spa= n> Web of Science, Elsevier, PubMed y Scielo. La = elecci=C3=B3n de<span= class=3D"awspan" style=3D"letter-spacing:2.55pt"> los </s= pan>art=C3=ADculos se bas=C3=B3= en criterios de = elegibilidad, que = incluyeron: <= /span>la confiabilidad de<sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> las <= /span>fuentes, validez metodol=C3=B3gica, pertinencia tem= =C3=A1tica </= span>y relevancia = en el <= span class=3D"awspan">=C3=A1mbito cl=C3=ADnico.<span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> El </span= >proceso de selecci= =C3=B3n </span= >se realiz=C3=B3 e= n <span= class=3D"awspan">dos fases: la<span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> primera, = mediante una revisi=C3=B3n = de t=C3=ADtulos y res=C3=BAmenes y, en<= /span> <span= class=3D"awspan">la segunda, se efectu=C3=B3<span= class=3D"awspan" style=3D"letter-spacing:-0.05pt"> una evaluaci=C3=B3n completa de los = art=C3=ADculos preseleccionados.</= span> Se dio prioridad</span= > a las publicaciones= en ingl=C3=A9s y<spa= n class=3D"awspan" style=3D"letter-spacing:-0.25pt"> espa=C3=B1ol de los =C3=BAltimos</s= pan> 5 a=C3=B1os (entre<spa= n class=3D"awspan" style=3D"letter-spacing:1.4pt"> 2020 </s= pan>y 2025). En</spa= n> el= proceso investigativo,</sp= an> se incluyeron metaan=C3=A1lisis, art=C3=ADculos de revisi=C3=B3n<s= pan class=3D"awspan" style=3D"letter-spacing:1.3pt"> y </sp= an>art=C3=ADculos originales<= span class=3D"awspan" style=3D"letter-spacing:1.3pt"> que <= /span>se encuentren = en <spa= n class=3D"awspan">ingl=C3=A9s y espa=C3=B1ol, adem=C3=A1s estos deb=C3=ADan</span= > ser publicados dentro<= span class=3D"awspan" style=3D"letter-spacing:3.75pt"> de los =C3=BAltimos<sp= an class=3D"awspan" style=3D"letter-spacing:3.75pt"> 5 </s= pan>a=C3=B1os, estos documentos,</s= pan> deb=C3=ADan contener informaci=C3= =B3n <spa= n class=3D"awspan">sobre la Fertilizaci=C3=B3n<= /span> in= vitro y la</span= > inyecci=C3=B3n intracitoplasm=C3=A1tica de= espermatozoides, as=C3=AD como sus </span= >ventajas, desventajas, indicaciones y tasa </= span>de =C3=A9xito. Por </sp= an>otro lado, lo= s <sp= an class=3D"awspan">criterios de exclusi= =C3=B3n </sp= an>tuvieron varios puntos, </= span>entre ellos: que los </spa= n>documentos tengan una = fecha de publicaci= =C3=B3n </spa= n>superior a 5</sp= an> a=C3=B1os y que<span= class=3D"awspan" style=3D"letter-spacing:0.45pt"> contengan t=C3=A9cnicas diferentes a la FIV o ICSI.<a id=3D"_._Resultados"></a>3.Resultados<p= class=3D"awdiv">En un<span= class=3D"awspan" style=3D"letter-spacing:-0.15pt"> metaan=C3=A1lisis realizado por<= /span> <span= class=3D"awspan">Huang et al.<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> (5) = es posible comparar <= /span>la efectividad de </sp= an>la inyecci=C3=B3n intracitoplasm= =C3=A1tica </= span>de espermatozoides<span= class=3D"awspan" style=3D"letter-spacing:0.65pt"> y </spa= n>de la fertilizac= i=C3=B3n </sp= an>in vitro median= te el <= span class=3D"awspan">estudio de cuatro</sp= an> variables: tasa de<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> fertilizaci=C3=B3n, tasa total<= span class=3D"awspan" style=3D"letter-spacing:0.5pt"> de </= span>fracaso de fert= ilizaci=C3=B3n, tasa de embriones<= span class=3D"awspan" style=3D"letter-spacing:0.75pt"> de buena calidad y </span= >tasa de implantac= i=C3=B3n, </s= pan>en donde se</s= pan> obtuvieron los siguientes resultados:</span= >Tabla = 1.= Efectividad de </= span>la<= /span> inyecci=C3=B3n intracitoplasm= =C3=A1tica de espermatozoides</s= pan> y de = la</span= > fertilizaci=C3=B3n in vitro ICSIFIVVARIABLE= EVENTOSTOTAL%EVENTOS<= /p>TOTAL%Tasa de fertilizaci=C3=B3n</spa= n>1696361846,882659</= p>431161,68Tasa <spa= n class=3D"awspan" style=3D"font-size:10pt">total de fracaso de fertilizaci=C3=B3n166<spa= n class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.2pt">3618</sp= an>4,5916343113,78</= p>Tasa de embr= iones de<= span class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.1pt"> </sp= an>buena calidad</s= pan>1846361851,022118= 431149,13Tasa <s= pan class=3D"awspan" style=3D"font-size:10pt">de implantaci=C3=B3n</= span>817361822,581021</span= >431123,68Fuente: Elaboraci=C3=B3n Propia.<span= class=3D"awspan">Del total de<spa= n class=3D"awspan" style=3D"letter-spacing:0.55pt"> la </s= pan>muestra, 3618 = mujeres </spa= n>optaron por la</= span> ICSI y 4311 por </sp= an>la FIV; la</spa= n> tasa de fertilizaci=C3=B3n = es <sp= an class=3D"awspan">de 46,88% (ICSI)</spa= n> y de 61,68% (FIV); </spa= n>la tasa total</s= pan> de fracaso de fertilizaci= =C3=B3n </spa= n>tiene un porcentaje de 4,59% (IC= SI) <= span class=3D"awspan">y 3,78% (FIV); la tasa de embriones= <span= class=3D"awspan">de buena calidad es</span= > de= 51,02% (ICSI) y <sp= an class=3D"awspan">49,13% (FIV); finalment= e, <spa= n class=3D"awspan">la tasa de implantaci=C3=B3n es de 22,58%</span= > (ICSI) y 23,68%<sp= an class=3D"awspan" style=3D"letter-spacing:-0.15pt"> (FIV). As=C3=AD tambi=C3=A9n,<= /span> <span= class=3D"awspan">en un estudio<= span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> realizado por Yovich= et al. (13) a = una <sp= an class=3D"awspan">poblaci=C3=B3n de 2343<= /span> mujeres, en donde,<s= pan class=3D"awspan" style=3D"letter-spacing:1.4pt"> una </= span>muestra de 125<= /span> opt=C3=B3 por un tratamient= o <spa= n class=3D"awspan">con fertilizaci=C3=B3n in <s= pan class=3D"awspan">vitro, una muestra</= span> de 1981 por inyecci=C3=B3n intracitoplasm=C3=A1tica y las <= span class=3D"awspan">237 mujeres restant= es <sp= an class=3D"awspan">siguieron otros tipos= <span= class=3D"awspan">de trata= mientos,Esta revista est=C3=A1 protegida</span= > bajo una <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">licencia</span= > Creative Commons </sp= an>en</sp= an> la 4.0 International. 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9+m8OHD7NkyRJmzZpVqW2pX78+aWlpXLx4kfj4eN566y1tnaenJ+Hh4ZX6+uL2kpHHPa5Tp04cO= HDghjHu7u44OjpWeltKb9O5ZMmSKnOvWKGfjDzuce3ataOwsJCxY8dq9zVt3rw5ZrOZ06dPAyV3= ox8+fHilt8XGxoYhQ4YwZswYwsLCKv31ROWSn2qFELrIYYsQQhdJHkIIXSR5CCF0keQhhNBFkoc= QQhdJHkIIXSR5CCF0keQhhNBFkocQQhdJHkIIXSR5CCGEEOLO+X/HTqOAf/1oYQAAAABJRU5Erk= Jggg=3D=3D" width=3D"271" height=3D"190" alt=3D"" style=3D"margin-left:195.= 4pt; position:absolute" />ISSN: 2697-3391<span= class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2.1,= pp. <span= class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <= span class=3D"awspan" style=3D"color:#ffffff">mayo 2025 Revista en ciencias m=C3=A9dicas, salu= d p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</p= >muestra un</span= > an=C3=A1lisis en el<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> cual </sp= an>es posible determ= inar <s= pan class=3D"awspan">la tasa de<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> nacidos <= /span>vivos de acuer= do con </span= >el grupo etario</= span> de la madre<span= class=3D"awspan" style=3D"letter-spacing:4.55pt"> y </spa= n>al m=C3=A9todo = seleccionado,= es decir = inyecci=C3=B3n intracitoplasm=C3=A1tica o fertilizaci=C3=B3n in vitro. (5,1= 3).Figura 1. Tasa de Nacidos Vivos<= p class=3D"awdiv">El gr=C3=A1fico</= span> muestra la tasa de = nacidos vivos regis= trados = en los estudios</spa= n> de Yovich et al.(13) & Dang et al. (14= ) <sp= an class=3D"awspan">se aprecia que en el grupo<spa= n class=3D"awspan" style=3D"letter-spacing:-0.05pt"> <35 a=C3=B1os corresponde al= 85,2% </spa= n>(ICSI) y al 77%<= /span> (FIV); en el<span= class=3D"awspan" style=3D"letter-spacing:0.65pt"> grupo <= /span>de 35-39 a= =C3=B1os </sp= an>es de 55,4%</sp= an> (ICSI) y al 42,3% </sp= an>(FIV); en el gr= upo <= span class=3D"awspan">de 40-44 a=C3=B1o= s, <s= pan class=3D"awspan">19% (ICSI) y= al 14% (FIV); y, </sp= an>en el grupo</= span> >45 a=C3=B1os corres= ponde = al 13,3% (ICSI) y al 5,5% (FIV). (13,14).= Iwamoto et= al. (15) presentaron<spa= n class=3D"awspan" style=3D"letter-spacing:0.1pt"> un </spa= n>an=C3=A1lisis retrospectivo</spa= n> en= donde particip=C3=B3<= span class=3D"awspan" style=3D"letter-spacing:0.1pt"> una <= /span>muestra de 46967<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> pacientes, al igual que<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> en </sp= an>el estudio de Yovich<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> et </sp= an>al. (13) es</sp= an> posible determinar la tasa<= /span> de nacidos vivos<= span class=3D"awspan" style=3D"letter-spacing:3.15pt"> y, adem=C3=A1s, tambi=C3=A9n<= /span> es posible divisar</span= > la tasa de = abortos espont=C3=A1neos que se<sp= an class=3D"awspan" style=3D"letter-spacing:2.95pt"> presentaron tras la aplicaci=C3=B3n de cada una </sp= an>de las t=C3=A9c= nicas, </span= >los resultados se presentan en el siguiente cuadro:= Tabla </= span>2.</= span> Tasa de </sp= an>Nacid= os Vivos y Abortos Espont=C3=A1neosVARIABLEICSIFIVNACIDOS VIVOS</sp= an>60,9%64,3%ABORTOS ESPONT=C3=81NEOS</sp= an>11,3%11,8%Fuente: Elaboraci=C3=B3n Propia<sp= an class=3D"awspan">El porcentaje de= nacidos vivos para la = ICSI es de<sp= an class=3D"awspan" style=3D"letter-spacing:0.9pt"> 69,9%, = por su parte,= la FIV tiene un porcentaje de 64,3%, adem=C3=A1s se evidencia que </sp= an>la tasa de</spa= n> abortos espont=C3=A1neos en<= /span> la ICSI es de 11,3%, mientras que, para l= a FIV es de 11,8%. (13=E2=80=9315).<a id=3D"_= ._Discusi=C3=B3n"></a>4.Discusi=C3=B3nLa imposibilidad para </span= >lograr un embara= zo <sp= an class=3D"awspan">despu=C3=A9s de mante= ner <= span class=3D"awspan">una vida sexual</sp= an> activa sin el uso<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> de </sp= an>ning=C3=BAn m=C3=A9todo<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> de </sp= an>planificaci=C3=B3n familiar</span= > durante al menos<span= class=3D"awspan" style=3D"letter-spacing:0.1pt"> 12 </span= >meses se traduceE= sta revista est=C3=A1 protegida bajo una licencia Creative <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">Commons= en la 4.0 International. Copia de la licencia: <a href= =3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decora= tion:none"></a><a href=3D"ht= tp://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:n= one">http://creativecommons.org/licens= es/by-nc-sa/4.0/</a>= D i<= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-= spacing:0.45pt; color:#ffffff"> a g </spa= n>n = =C3=B3 s t i c <spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#fff= fff">o M</span= > =C3=A9 d i c o<sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">P =C3=A1= g i </sp= an>n= a 1= 2 | 18<img src=3D"data:image/jpeg;base64,/9= j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPE= RETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4e= Hh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARhAxkDASI= 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=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></span= ><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.3= 3" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" st= yle=3D"width:209.31px; height:41.33px; font-family:'Times New Roman'; font-= size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path= d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rul= e=3D"evenodd" /></g></g></svg><a href=3D"http= ://www.anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</= a>ISS= N: 2697-3391Vol. 8 No. 2.1,</span= > </s= pan>pp. 6 =E2=80=93 18, abril= - mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3= =BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.en un diagn=C3=B3stico de infertilidad,</sp= an> problema que afecta<= span class=3D"awspan" style=3D"letter-spacing:2.05pt"> hasta el 15% de <s= pan class=3D"awspan">la poblaci=C3=B3n mundial,<spa= n class=3D"awspan" style=3D"letter-spacing:1pt"> y <sp= an class=3D"awspan">cuya prevalencia var=C3=ADa= entre los diferentes<sp= an class=3D"awspan" style=3D"letter-spacing:1pt"> grupos </sp= an>etarios de las= parejas.= Se debe recalcar<s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> que = existen diferentes<sp= an class=3D"awspan" style=3D"letter-spacing:0.25pt"> etiolog=C3=ADas que se<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> asocian a este = problema, </s= pan>dentro de las = cuales </span= >pueden estar rela= cionadas </sp= an>con diferentes = factores </sp= an>que involucran = alteraciones tanto en el sexo </s= pan>masculino como en </span= >el sexo femenin= o, <s= pan class=3D"awspan">raz=C3=B3n por la<= /span> cual es imprescindible = realizar </spa= n>una evaluaci=C3=B3n completa </s= pan>de la pareja</sp= an> inf=C3=A9rtil, tomando en</spa= n> cuenta todos aquellos anteceden= tes <sp= an class=3D"awspan">de inter=C3=A9s que</sp= an> pueda orientar al uso </span= >de una u<spa= n class=3D"awspan" style=3D"letter-spacing:0.6pt"> otra </s= pan>t=C3=A9cnica de reproducci=C3=B3n asistida disponibles en la actualidad. (2,15).</p= >Las terapias</span= > de </sp= an>reproducci=C3=B3n asistida<s= pan class=3D"awspan" style=3D"letter-spacing:3pt"> han </span= >ido mejorando con</span= > el </sp= an>paso de los<sp= an class=3D"awspan" style=3D"letter-spacing:3pt"> a=C3=B1os. Inicialmente, la fecundaci= =C3=B3n </span= >in vitro era= un= procedimiento limitado</span= > al= manejo de l= a infertilidad de origen femenino,= sin embargo, actualmente es la t= =C3=A9cnica <= /span>m=C3=A1s utilizada<sp= an class=3D"awspan" style=3D"letter-spacing:-0.45pt"> para la concepci=C3=B3n extracor= p=C3=B3rea. <= /span>En contraste a <sp= an class=3D"awspan">ello, la inyecci=C3= =B3n <= span class=3D"awspan">intracitoplasm=C3=A1tica de espermat= ozoides </spa= n>se orienta princ= ipalmente </s= pan>a la posibilid= ad <sp= an class=3D"awspan">de lograr la<s= pan class=3D"awspan" style=3D"letter-spacing:2.95pt"> concepci=C3=B3n cuando el afectado= es el factor<span= class=3D"awspan" style=3D"letter-spacing:0.4pt"> masculino= en dependencia de <= span class=3D"awspan">diferentes alteraciones que interfieren en la producci=C3=B3n adecuada de gametos masculinos. (6= ) (16)Actualmente,</sp= an> debido a los diferentes conflictos =C3=A9ticos</sp= an> y morales, algunos<s= pan class=3D"awspan" style=3D"letter-spacing:3.15pt"> expertos consideran una alternativa</s= pan> viable el uso de</spa= n> la <= /span>=E2=80=9Cnaprotecnolog=C3=ADa=E2=80=9D,= como </s= pan>m=C3=A9todo de reproducci=C3=B3n= <span= class=3D"awspan">basado en identificar= <spa= n class=3D"awspan">la probable causa</s= pan> de infertilidad y<= span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> buscar solucionarla a trav=C3= =A9s <= span class=3D"awspan">de tratamientos m= =C3=A9dicos <= /span>convencionales para<sp= an class=3D"awspan" style=3D"letter-spacing:3.15pt"> evitar recurrir a t=C3=A9cnicas de concepci=C3=B3n artificiales. (6,7,12).= En l= os <spa= n class=3D"awspan">estudios previos se</spa= n> analizaron los resultados</span= > obtenidos, en donde<span= class=3D"awspan" style=3D"letter-spacing:3.4pt"> se </span= >pudo identificar varias<sp= an class=3D"awspan" style=3D"letter-spacing:-0.4pt"> controversias entre las<sp= an class=3D"awspan" style=3D"letter-spacing:-0.4pt"> variables sujetas a estudio.= Por un lado, </span= >en lo que corre= sponde </span= >a la tasa<= span class=3D"awspan" style=3D"letter-spacing:0.25pt"> de fertilizaci=C3=B3n, la</sp= an> FIV muestra cierto<s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> grado de superioridad<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> frente a la ICSI, c= oloc=C3=A1ndola como una t= =C3=A9cnica </= span>factible en c= uanto <= span class=3D"awspan">al objetivo de= las TRA, sin embargo,<sp= an class=3D"awspan" style=3D"letter-spacing:1.9pt"> debido = a que en</spa= n> la= ICSI es posi= ble <sp= an class=3D"awspan">seleccionar un solo</sp= an> espermatozoide, se identific=C3=B3<span= class=3D"awspan" style=3D"letter-spacing:1.45pt"> que </s= pan>la tasa de</sp= an> embriones de buena<s= pan class=3D"awspan" style=3D"letter-spacing:1.45pt"> calidad fue ligeramente<s= pan class=3D"awspan" style=3D"letter-spacing:1.45pt"> superior en este grupo<sp= an class=3D"awspan" style=3D"letter-spacing:0.7pt"> de </sp= an>pacientes aunque = el <spa= n class=3D"awspan">porcentaje de superiorid= ad <spa= n class=3D"awspan">no fue significativo</sp= an> frente a la FIV, por = lo que esta<s= pan class=3D"awspan" style=3D"letter-spacing:1.3pt"> variable no deber=C3=ADa<spa= n class=3D"awspan" style=3D"letter-spacing:1.3pt"> considerarse como indicativo<= span class=3D"awspan" style=3D"letter-spacing:1.3pt"> al </= span>momento de seleccionar la TRA e= mpleada. (2,5).Por</sp= an> otro lado, en lo </span= >que concierne a</= span> la tasa de nacidos </= span>vivos, se pudo= <span= class=3D"awspan">esclarecer que esta var= iable </span= >es indirectamente proporcional a la edad </span= >materna, puesto que = a mayor edad</sp= an> existe una menor tasa= de= natalidad independientemente= del procedimiento que</spa= n> haya sido utilizado como= manejo de la i= nfertilidad </= span>en las parejas.= Se concibe tambi=C3=A9n</s= pan> que el porcentaje de abortos espont=C3=A1neos= fue casi similar en ambos casos. (3).Con la propagaci=C3=B3n<= /span> y prevalencia de<= span class=3D"awspan" style=3D"letter-spacing:2.65pt"> la ICSI, y = con <s= pan class=3D"awspan">el prop=C3=B3sito = de <sp= an class=3D"awspan">minimizar las incidencias de = fallos en la<= span class=3D"awspan" style=3D"letter-spacing:2.2pt"> fecundaci=C3=B3n mediante la</span= > fertilizaci=C3=B3n in vitro,</s= pan> numerosos centros de ferti= lidad = eligen a la</spa= n> ICSI como la t=C3=A9cnica principal, incluso</sp= an> sin cumplir con<sp= an class=3D"awspan" style=3D"letter-spacing:-0.3pt"> laEsta revista <= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic">est=C3=A1<= /span> protegida bajo <= /span>una= licencia Creative Commons en la = 4.= 0 International. Copia de la licencia: </= span><a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D= "text-decoration:none"></a><= a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-= decoration:none">http://creativecommon= s.org/licenses/by-nc-sa/4.0/</a>D i a g n =C3=B3 <= /span>s t<= /span> i c o = M =C3=A9</s= pan> = d i = c oP =C3=A1 g<spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:0.45pt; color:#ffffff"> i n a </= span>13 | 18<img src=3D"data:image= /jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw= 8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4IC= A4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/= wAARCARhAxkDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECCAMGBwQF/8QAWBABAAE= DAwAECAsDBgsGAwkAAAECAwQFBhEHEiExExQXQVFVlNIIFiJUVmFxgZKT0TI3dBWRobGysyM1Nk= JSc3WChMHTGCQnM6LDJWJyJkNFRmOjwuHw/8QAGwEBAQEBAQEBAQAAAAAAAAAAAAECAwQFBgf/x= 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ght=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2= 000/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Ro= man'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs />= <g><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7= c" fill-rule=3D"evenodd" /></g></g></svg><a h= ref=3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none"><spa= n class=3D"awspan" style=3D"font-family:Ebrima; font-size:11pt; text-decora= tion:underline; letter-spacing:-0.1pt; color:#ffffff">www.anatomiadigital.o= rg</a>ISSN: 2697-3391<s= pan class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2= .1, pp.<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <s= pan class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </spa= n>mayo 2025 Revista en ciencias m=C3=A9dicas, = salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</span= >indicaci=C3=B3n espec=C3=ADfica. Los comit=C3=A9s</s= pan> de pr=C3=A1ctica de= la Sociedad Americana<= span class=3D"awspan" style=3D"letter-spacing:1.25pt"> de Medicina Reproductiva (ASRM= ) <span= class=3D"awspan">y la Sociedad<sp= an class=3D"awspan" style=3D"letter-spacing:0.5pt"> de </sp= an>Tecnolog=C3=ADa Reproductiva</spa= n> Asistida (SART) han llegado</sp= an> a la conclusi=C3=B3n de = que la evidencia disponible no respalda la utilizaci=C3=B3n rutinaria de la<= span class=3D"awspan" style=3D"letter-spacing:1.2pt"> ICSI = para mejorar = las <sp= an class=3D"awspan">tasas de embarazo</span= > cl=C3=ADnico en parejas,= debido a que a= mbos procedimientos mostraron resultado= s <sp= an class=3D"awspan">similares en base</= span> a las variables= establecidas, por lo que</sp= an> se recomienda la<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> realizaci=C3=B3n de una<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> FIV </= span>convencional como tratamiento de rutina y conservar la ICSI = como <= span class=3D"awspan">una alternativa ant= e <spa= n class=3D"awspan">un ciclo de<sp= an class=3D"awspan" style=3D"letter-spacing:-0.2pt"> FIV = fallido y = las <s= pan class=3D"awspan">condiciones que se = mencionaron <= /span>en esta revi= si=C3=B3n </s= pan>asociadas principalmente= a= la infertilidad<span= class=3D"awspan" style=3D"letter-spacing:1.75pt"> masculina. (9,11,13).<a id=3D"_._Conclusiones"></a><= span class=3D"awspan" style=3D"font-weight:bold; color:#767070">5.<s= pan class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.1pt; colo= r:#767070">Conclusiones=EF=82=B7Entre </span= >ambas t=C3=A9cnicas de = reproducci=C3=B3n asistida<s= pan class=3D"awspan" style=3D"letter-spacing:1.55pt"> existen diferencias en<sp= an class=3D"awspan" style=3D"letter-spacing:1.55pt"> cuanto al procedimiento que</span= > se lleva a = cabo <= span class=3D"awspan">para lograr la</spa= n> concepci=C3=B3n. Por un</sp= an> lado, la ICSI supone</span= > mayor intervencionismo debido= <span= class=3D"awspan">a que requiere<s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> la <= /span>manipulaci=C3=B3n enzim=C3=A1= tica del </sp= an>ovocito junto = con <s= pan class=3D"awspan">la selecci=C3=B3n = e <spa= n class=3D"awspan">inyecci=C3=B3n de un</= span> solo espermatozoide, por<= /span> lo que se considera= que debe reservarse<span= class=3D"awspan" style=3D"letter-spacing:1.3pt"> en </span= >casos en los= que existan tasas de = FIV nulas, evitando aplicar <= /span>esta t=C3=A9cnica<span= class=3D"awspan" style=3D"letter-spacing:-0.3pt"> en </sp= an>pacientes con infertilidad inexplicable, baja reserv= a <sp= an class=3D"awspan">ov=C3=A1rica y/o ed= ad <s= pan class=3D"awspan">materna avanzada. Por = otro lado, la</sp= an> FIV convencional se const= ituye como la t=C3=A9cnica preferida para el manejo rutinario de infertilid= ad.=EF=82=B7Se = examinaron </s= pan>los resultados o= btenidos </spa= n>revelando controversias<spa= n class=3D"awspan" style=3D"letter-spacing:4.9pt"> entre </= span>las variables bajo estudio. <= /span>Respecto a l= a <span= class=3D"awspan">tasa de fertilizaci=C3=B3= n, <spa= n class=3D"awspan">la FIV mostr=C3=B3</span= > cierta superioridad sobre la<= /span> ICSI, posicion=C3=A1ndola como </span= >una t=C3=A9cnica = viable </span= >en las TRA. Sin</= span> embargo, la capacidad= de= seleccionar un solo </span= >espermatozoide en la <sp= an class=3D"awspan">ICSI demostr=C3=B3 una tasa </sp= an>de embriones = de <sp= an class=3D"awspan">buena calidad, aunque= <span= class=3D"awspan">este aumento no<= span class=3D"awspan" style=3D"letter-spacing:1.05pt"> fue estad=C3=ADsticamente significativo= en comparaci=C3=B3n con</span= > la FIV. Por = lo <sp= an class=3D"awspan">tanto, esta variable n= o <spa= n class=3D"awspan">debe considerarse decisi= va <spa= n class=3D"awspan">al momento de<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> elegir= la TRA. En</= span> relaci=C3=B3n con la tasa<= /span> de nacidos vivos,= se evidenci=C3=B3 una<= span class=3D"awspan" style=3D"letter-spacing:2.55pt"> relaci=C3=B3n inversa con</sp= an> la edad materna, ya<= span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> que, a mayor edad, </sp= an>independientemente del<sp= an class=3D"awspan" style=3D"letter-spacing:-0.2pt"> procedimiento de manejo de</span= > la= infertilidad utilizado,</spa= n> se= observa una menor </span= >tasa de natalidad,<= /span> adem=C3=A1s, se observ=C3=B3 que el porcent= aje de abortos espont=C3=A1neos fue similar en ambos casos.= =EF=82=B7La fecundaci=C3=B3n<= /span> in vitro, inicialmente</spa= n> dise=C3=B1ada para tratar</span= > la= infertilidad tub=C3=A1rica, = ha <sp= an class=3D"awspan">evolucionado para con= vertirse </sp= an>en una t=C3=A9c= nica <= span class=3D"awspan">de reproducci=C3=B3n asistida </= span>de elecci=C3=B3n en<spa= n class=3D"awspan" style=3D"letter-spacing:-0.3pt"> diversas condiciones, como= la infertilidad inexplicada,= <span= class=3D"awspan">endometriosis, y problemas ov=C3=A1ricos y masculinos.<sp= an class=3D"awspan" style=3D"letter-spacing:1.25pt"> Aunque la FIV = presenta </sp= an>ventajas, como = la fertilizaci=C3=B3n de m=C3=BAltiples<= /span> <span= class=3D"awspan">ovocitos, conlleva el = riesgo de </s= pan>embarazos m=C3=BAltiples. En co= ntraste, </spa= n>la inyecci=C3=B3n = intracitoplasm=C3=A1tica de espermatozoides= (ICSI) se reserva para</sp= an> casos espec=C3=ADficos de</spa= n> infertilidad masculina, demostr= ando <s= pan class=3D"awspan">mayor eficacia en comp= araci=C3=B3n con t=C3=A9cnicas tradicionales, a pesar de su mayor intervenc= ionismo.Esta revista est=C3=A1 protegida</span= > bajo una <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">licencia</span= > Creative Commons </sp= an>en</sp= an> la 4.0 International. Co= pia de la licencia: <a href=3D"http://creativecomm= ons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:none"></a><a href=3D"http://creativecommons.or= g/licenses/by-nc-sa/4.0/" style=3D"text-decoration:none">http://creativecommons.org/licenses/by-nc-sa/4.0/= </a>D i a <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">g n =C3=B3<= /span> s t i c o M =C3=A9 = d i c oP =C3=A1 g = i n a<= /span> 14 | 18<= /p><img src=3D"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEA= YABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCE= YGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh= 4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/wAARCARhAxkDASIAAhEBAxEB/8QAHAABA= QACAwEBAAAAAAAAAAAAAAECCAMGBwQF/8QAWBABAAEDAwAECAsDBgsGAwkAAAECAwQFBhEHEiEx= ExQXQVFVlNIIFiJUVmFxgZKT0TI3dBWRobGysyM1NkJSc3WChMHTGCQnM6LDJWJyJkNFRmOjwuH= w/8QAGwEBAQEBAQEBAQAAAAAAAAAAAAECAwQFBgf/xAA1EQEAAQMCBQMBBgUEAwAAAAAAAQIDEQ= 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height:41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:xlink= =3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0 L209= ,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"evenodd" /></g></= g></svg><a href=3D"http://www.anatomiadigital= .org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>ISSN: 2697-<span= class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.2pt; color:#= ffffff">3391Vol. = 8 No. <spa= n class=3D"awspan" style=3D"color:#ffffff">2.1, pp. 6 =E2= =80=93 18,<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </span= >abril - mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblica Art=C3=ADcul= o de revisi=C3=B3n bibliogr=C3=A1fica.Cada enfoque tiene= sus propias indicaciones</spa= n> y consideraciones, destacand= o <spa= n class=3D"awspan">la importancia de una selecci=C3=B3n cuidadosa basada en= el diagn=C3=B3stico individual.<a id=3D"_._C= onflicto_de_intereses"></a>6.Conflicto de intere= sesLos autores </sp= an>declaran que = no <sp= an class=3D"awspan">existe conflicto de</= span> intereses en relaci=C3=B3n= <span= class=3D"awspan">con el art=C3=ADculo </= span>presentado.</sp= an><a id=3D"_._Declaraci=C3=B3n_de_contribuci=C3=B3n= _de_los_au"></a>7.Declaraci=C3=B3n de <sp= an class=3D"awspan" style=3D"font-weight:bold; color:#767070">contribuci=C3= =B3n de los autores</= span>Todos autores </sp= an>contribuyeron significativament= e <spa= n class=3D"awspan">en la elaboraci=C3=B3n= <span= class=3D"awspan">del art=C3=ADculo.<a id=3D"_._Costos_de_= financiamiento"></a>8.Costos de financiamientoLa presente investiga= ci=C3=B3n </s= pan>fue financiada en = su <s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt">totalidad con fondos pr= opios = de los autores.<a id=3D"_._Referencias_Bi= bliogr=C3=A1ficas"></a>9.Referencias Bibliog= r=C3=A1ficas1.Santa Ma= r=C3=ADa Ortiz J, =C3=81lvarez Silvares E, Berm=C3=BAdez Gonz=C3=A1lez M. I= nfluencia de la fecundaci=C3=B3n in vit= ro <s= pan class=3D"awspan">en los resultados<= /span> <span= class=3D"awspan">maternos y neonatales= <span= class=3D"awspan">en mujeres con= edad materna avanzada. Revista de Obstetricia y Ginecolog=C3=AD= a de Venezuela [Internet]. 2022 [citado 23 de marzo de 2025]; 82(3): 329-33= 9. Disponible en: <a href=3D"http://ve.scielo.org/scielo.php?script= =3Dsci_abstract&pid=3DS0048-77322022000300329&lng=3Des&nrm=3Dis= o&tlng=3Des" style=3D"text-decoration:none"></a>= <a href=3D"http://ve.scielo.org/scielo.php?script=3Dsci_abstract&pid=3D= S0048-77322022000300329&lng=3Des&nrm=3Diso&tlng=3Des" style=3D"= text-decoration:none">http://ve.scielo.org/scielo.php?script=3Dsci_a= bstract&pid=3DS0048-</a> <a href=3D"http://ve.scielo.org/scielo.p= hp?script=3Dsci_abstract&pid=3DS0048-77322022000300329&lng=3Des&= ;nrm=3Diso&tlng=3Des" style=3D"text-decoration:none"></a><a href=3D"http://ve.scielo.org/scielo.php?script=3Dsci_abstract= &pid=3DS0048-77322022000300329&lng=3Des&nrm=3Diso&tlng=3Des= " style=3D"text-decoration:none">77322022000300329&lng=3Des&= nrm=3Diso&tlng=3Des</a>2.Nabhan A, Salama M, Elsayed M, Nawara M, Kamel M, Abuelnaga Y, et al= . Indicators of infertility and fertility care: a systematic scoping review= . Human Reproduction Open [Internet]. 2022 [cited 2025 March 23]. Available= from: <a href=3D"https://academic.oup.com/hropen/article/2022/4/hoa= c047/6760263?searchresult=3D1" style=3D"text-decoration:none"></a><a href=3D"https://academic.oup.com/hropen/article/2022/4/hoa= c047/6760263?searchresult=3D1" style=3D"text-decoration:none">http= s://academic.oup.com/hropen/article/2022/4/hoac047/6760263?searchresult=3D1= </a>3.Cox CM, </= span>Thoma ME, Tchangalova= N, Mburu G, <= span class=3D"awspan">Bornstein MJ, Joh= nson = CL, et al. Infer= tility prevalence and the methods of estimation from 1990 to 2021: a system= atic review and meta-analysis. Human Reproduction Open [Internet]. 2022 [ci= ted 2025 March 23]; 2022(4): hoac051. 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Frontiers= in Reproductive Health</span= > [Internet].Esta</= span> revista est=C3=A1= p= rotegida bajo una licencia Creative Commons<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> en la 4.0 International. 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On </sp= an>estimating the prevalence= of use = of <s= pan class=3D"awspan">medically assisted reproduction in d= eveloped countries: a critical review of recent literature. Human Reproduct= ion Open [Internet]. 2021 [cited 2025 March 23]; 2021(1): hoaa065. Availabl= e from: <= a href=3D"https://doi.org/10.1093/hropen/hoaa065" style=3D"text-decoration:= none"></a><a href=3D"https://doi.org/10.1093/hropen/= hoaa065" style=3D"text-decoration:none">https://doi.org/10.1093/hropen/hoaa065</a></= p>Esta <spa= n class=3D"awspan" style=3D"font-size:8pt; font-style:italic">revista</span= > est=C3=A1 protegida <= /span>baj= o una licencia <= /span>Cre= ative Commons en= l= a 4.0 International. 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2.1, pp. 6<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </span= >=E2=80=93 18, abril - mayo</= span>= 2025 Revista en cien= cias m=C3=A9dicas, salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n biblio= gr=C3=A1fica.13.Yovich= JL, Conceicao JL, Wong J, Marjanovich N, Wicks R, Hinchliffe PM. Fertiliza= tion by ICSI generates a higher number of live births than IVF in a pioneer= facility applying >90% single blastocyst-stage embryo transfers. GSC Bi= ological </sp= an>and Pharmaceutical Sciences = [Internet]. 2021<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> [cited = 2025 March = 23]; 15(01): 087-103. 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Intracytoplasmic = sperm injection versus conventional in-vitro fertilisation in couples</span= > with infertility in= whom the male partner= has normal total </sp= an>sperm count and motility: = an open-label, randomised controlled trial.</spa= n> The Lancet [Internet]. 202= 1 [cited 2025 March 23]. 397(10284): 1554-1563. Avaible from: <a hre= f=3D"https://www.sciencedirect.com/science/article/pii/S0140673621005353" s= tyle=3D"text-decoration:none"></a><a href=3D"https:/= /www.sciencedirect.com/science/article/pii/S0140673621005353" style=3D"text= -decoration:none">https://www.sciencedirect.com/science/article/pii/= S0140673621005353</a>1= 5.Iwamoto A, Van Voorhis BJ, Summers KM, Sparks A, Mancuso AC. Intracytopla= smic sperm injection vs. conventional in vitro<spa= n class=3D"awspan" style=3D"letter-spacing:-0.05pt"> fertilization in patients with non-male<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> factor infertility. 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<spa= n class=3D"awspan" style=3D"font-size:18pt; font-weight:bold">Asistida: Fec= undaci=C3=B3n In Vitro (FIV) e Inyecci=C3=B3n Intracitoplasm=C3=A1tica de E= spermatozoides (ICSI)Efficac= y of Assisted Reproduction Techniques: = I= n Vitro Fertilization<sp= an class=3D"awspan" style=3D"font-size:14pt; font-style:italic; letter-spac= ing:-0.25pt"> (IVF) and Intracytoplasmic Sperm Injection (ICSI)<p= class=3D"awdiv" style=3D"font-size:10pt">Art=C3=ADculo </span= >de</span= > Investigaci=C3=B3n Cient=C3=ADfica</spa= n> y Tecnol=C3=B3gi= caEnviado: 17/02/2025 Revisado: 15/03/2025 Aceptado: 08/04/2025 Publicado:08/05/2025= DOI: <a href=3D"https://doi.org/10.33262/anatomi= adigital.v8i2.3373" style=3D"text-decoration:none"></a><a href=3D"https://doi.org/10.33262/anatomiadig= ital.v8i2.3373" style=3D"text-decoration:none">https://doi.org/ 1= 0.33262/anatomiadigital.v8i2.1.3388</a>C=C3=ADtese:Solano <= span class=3D"awspan" style=3D"font-size:10pt">Benalc=C3=A1zar,<span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.45pt"> = E. J., Sari Y=C3=A1nez, A. N.,<= /span> Pe=C3=B1afiel</s= pan>= Gaibor,<span= class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.45pt"> = V., & L=C3=B3pez Ullauri, V.G.</spa= n> </= span>(2025). <span= class=3D"awspan" style=3D"font-size:10pt">Eficacia de las t=C3=A9cnicas de reproducci=C3= =B3n asistida:</sp= an> <= /span>fecundaci=C3=B3n</spa= n> </= span>in vitro (FIV) e inyecci=C3=B3n intracitoplasm=C3=A1tica de espermatozoides (ICSI). Anatom=C3=ADa Digital, 8(2.1), 6-18. <a href=3D"https://doi.org/%2010.33262/anato= miadigital.v8i2.1.3388" style=3D"text-decoration:none"></a><a href=3D"https://doi.org/%2010.33262/anat= omiadigital.v8i2.1.3388" style=3D"text-decoration:none">https://doi.org/ 10.33262/anatomiadigital.v8i2.1.3388<= /a>ANATOM=C3=8DA DIGITAL, es una</sp= an> <= /span>Revista <span= class=3D"awspan" style=3D"font-size:8pt">Electr=C3=B3nica, Trimestral, que se publicar=C3=A1 en soporte= </sp= an>electr=C3=B3nico<s= pan class=3D"awspan" style=3D"font-size:8pt; letter-spacing:2pt"> <s= pan class=3D"awspan" style=3D"font-size:8pt">tiene como misi=C3=B3n contribuir a la= </spa= n>formaci=C3=B3n<span= class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.35pt"> <= span class=3D"awspan" style=3D"font-size:8pt">de profesionales competentes con visi=C3=B3n human=C3=ADstica y cr=C3=ADtica</= span> </= span>que sean capaces de exp= oner sus<spa= n class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.55pt"> <= span class=3D"awspan" style=3D"font-size:8pt">resultados investigativos y cient=C3=ADficos en la misma<= span class=3D"awspan" style=3D"font-size:8pt; letter-spacing:1.55pt"> </spa= n>medida que se promueva mediante su intervenci=C3=B3n cambios positivos en la socieda= d. <a href=3D"https://anatomiadigital.org/" style=3D"text-decoration= :none"></a><a href=3D"https:= //anatomiadigital.org/" style=3D"text-decoration:none">https:= //anatomiadigital.org</a>La revista es editada por</= span> = la Editorial Ciencia Digital (Editorial de</s= pan> <= /span>prestigio <spa= n class=3D"awspan" style=3D"font-size:8pt">registrada en la C=C3=A1mara Ecuato= riana de Libro con No de Afiliaci=C3=B3n 663) <a href=3D"http://www.= celibro.org.ec/" style=3D"text-decoration:none"></a><a href=3D"http://www.celibro.org.ec/" style=3D"tex= t-decoration:none">www.celibro.org.ec</a>Esta revista= est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; letter-spacing:-0.45pt"> </spa= n>protegida bajo una licencia Creative Comm= ons Atribuci=C3=B3n= -NoComercial-CompartirIgual4.0 International. Copia de la licencia: <a h= ref=3D"https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es" style=3D"= text-decoration:none"></a><a= href=3D"https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es" style= =3D"text-decoration:none">https://crea= tivecommons.org/licenses/by-nc-sa/4.0/deed.es</a>Esta revista </s= pan>est= =C3=A1 protegida bajo una licencia Creative<span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spacing= :-0.2pt"> Commons en la 4.0 International. 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ns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L20= 9,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"evenodd" = /></g></g></svg><a href=3D"http://www.anatomi= adigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>ISSN:<spa= n class=3D"awspan" style=3D"letter-spacing:-0.15pt; color:#ffffff"> = 2697-</spa= n>3391Vol. 8 No.= </sp= an>2.1, pp. 6 =E2=80=93 18,<= /span> abril <spa= n class=3D"awspan" style=3D"color:#ffffff">- mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblica Art= =C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.Palabras claves: </span= >infertilidad, </spa= n>fertilizaci=C3=B3n in<spa= n class=3D"awspan" style=3D"letter-spacing:-0.75pt"> vitro, inyecci=C3=B3n intracitoplasm=C3=A1tica de<= /span> <span= class=3D"awspan">espermatozoides, inseminaci=C3=B3n, fac= tor masculino= .ResumenIntroducci=C3=B3n. = La infertilidad es una condici=C3=B3n relativ= amente com=C3=BAn en la poblaci=C3=B3n general que<sp= an class=3D"awspan" style=3D"letter-spacing:-0.6pt"> llega= a afectar hasta </span= >al 15% de las= parejas = a nivel mundial,<= /span> y = en la actualidad,= los procedimientos e intervencio= nes <span= class=3D"awspan">utilizadas para asistir</span= > la </sp= an>reproducci=C3=B3n no = son <span= class=3D"awspan">totalmente capaces de<= span class=3D"awspan" style=3D"letter-spacing:4pt"> cubrir </= span>por completo la<= /span> <span= class=3D"awspan">tasa de =C3=A9xito,</sp= an> generando alta controversia= <span= class=3D"awspan">en el uso de<spa= n class=3D"awspan" style=3D"letter-spacing:2pt"> FIV <= span class=3D"awspan">y/o ICSI. Objetivo. Evaluar la <span= class=3D"awspan">efectividad de la<span= class=3D"awspan" style=3D"letter-spacing:4pt"> fertilizaci=C3=B3n in vitro (FIV) y la inyecci=C3=B3n intracitoplasm=C3= =A1tica de</s= pan>espermatozoides(= ICSI)como</sp= an>tratamientos</spa= n>parala infertilidad, considerando la<s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> causa <= /span>probable, analizando<sp= an class=3D"awspan" style=3D"letter-spacing:2pt"> los mecanismos fundamentales de<spa= n class=3D"awspan" style=3D"letter-spacing:2pt"> cada = t=C3=A9cnica, sus ventaj= as, desventajas y las opciones terap=C3=A9uticas m=C3=A1s adecuadas seg=C3= =BAn las </s= pan>caracter=C3=ADsticas de= cada pareja. Metodolog=C3=ADa. Se</span= > realiz=C3=B3 una b=C3=BAsqueda en </sp= an>bases de dato= s <sp= an class=3D"awspan">cient=C3=ADficas seleccionando= art=C3=ADculos basados en confiabil= idad, <sp= an class=3D"awspan">validez y relevancia= cl=C3=ADnica, prio= rizando </spa= n>publicaciones en ingl=C3=A9s y espa=C3=B1ol<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> de </sp= an>los =C3=BAltimos 5 a=C3=B1os, se eligieron 15 art=C3=ADculos de alto nivel de evidencia qu= e cumplieron </s= pan>con los criterios</s= pan> establecidos. Resultad= os. La fecundaci=C3=B3n = in <s= pan class=3D"awspan">vitro mostr=C3=B3 cierto </sp= an>grado de supe= rioridad </sp= an>frente a la ICSI con relaci=C3=B3n a la tasa de f= ertilizaci=C3=B3n, sin embargo, esta =C3=BAltima tuvo <s= pan class=3D"awspan">una mayor tasa<span= class=3D"awspan" style=3D"letter-spacing:2pt"> de <sp= an class=3D"awspan">embriones de buena<s= pan class=3D"awspan" style=3D"letter-spacing:4pt"> calidad, aunque el resultado no fue significativamente mayor. Finalme= nte, = se pudo establecer= <span= class=3D"awspan">que la tasa<span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> de </sp= an>nacidos vivos = es indirectam= enteproporcionala = laedadmaterna, independientemente del </sp= an>procedimiento realizado.</span= > Conclusi=C3=B3n. La <= /span>fecundaci=C3=B3n in vitro <= span class=3D"awspan">se ha convertido<s= pan class=3D"awspan" style=3D"letter-spacing:2pt"> en = la t=C3=A9cnica de repro= ducci=C3=B3n </s= pan>asistida de elecci= =C3=B3n <= span class=3D"awspan">en diversas condiciones c= omo la infertilidad inexplicada, endometriosis, y problemas ov=C3=A1ricos y= masculinos, no as=C3=AD la ICSI, misma que se reserva para casos espec=C3= =ADficos de infertilidad masculina a pesar de su mayor interv= encionismo. </sp= an>Cada enfoque tiene</s= pan> sus = propias indicaciones y consider= aciones, destacando la importancia de una selecci=C3=B3n cuidadosa basada e= n el diagn=C3=B3stico individual. =C3=81rea de estudio general: Medicina=C3=81rea de estudio esp= ec=C3=ADfica: Ginecolog=C3=ADa<sp= an class=3D"awspan" style=3D"letter-spacing:-0.1pt"> y </= span>Obstetricia.</s= pan>Tipo de estudio:<= span class=3D"awspan" style=3D"font-weight:bold; letter-spacing:2.85pt; col= or:#333333"> Revisi= =C3=B3n Bibliogr=C3=A1fica.Keywords:</sp= an>AbstractEsta revista </spa= n>est=C3= =A1 protegida bajo una licencia Creative<span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spacing= :-0.2pt"> Commons en la 4.0 International. Copia de la licencia: <a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" st= yle=3D"text-decoration:none"></a><a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D= "text-decoration:none">http://creative= commons.org/licenses/by-nc-sa/4.0/</a>D </spa= n>i a</span= > g n =C3=B3 s <spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#fff= fff">t i c o </s= pan>M =C3= =A9 d i <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">c oP = =C3=A1 g</sp= an> i n a 7 | <spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:-0.25pt; color:#ffffff">18<img src=3D"data= :image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwI= BwcHBw8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQc= GBw4ICA4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh= 4eHh7/wAARCARhAxkDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECCAMGBwQF/8QAW= 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dth=3D"77" height=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:a= bsolute" /><svg font-family=3D"Times New Roman" font-size=3D"1= 6" height=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3= .org/2000/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times = New Roman'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><d= efs /><g><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"= #7c7c7c" fill-rule=3D"evenodd" /></g></g></svg><a href=3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none= ">www.anatomiadig= ital.org</a>ISSN: 2697-3391Vol. 8 No. 2.1, pp.</sp= an> <= /span>6 =E2=80=93 18, abril -= mayo <spa= n class=3D"awspan" style=3D"color:#ffffff">2025 Revista en ciencias m=C3=A9= dicas, salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica= .Infertility, in vitro= fertilizatio= n, intracytoplasmic sperm injection, insemina= tion, </span= >male factor.Introduction. Infertility= is a relat= ively = common condition = in the </span= >general population, affecting = up to 15%</= span> of couples worldwide. Cur= rently, </sp= an>the procedures = and <= span class=3D"awspan">interventions used to assist </= span>reproduction are not </spa= n>fully capable = of <sp= an class=3D"awspan">achieving a complete = success </spa= n>rate, generating significant = controversy regarding the</s= pan> use of IVF and/or </= span>ICSI. Objective. To evalua= te the </span= >effectiveness of = in <sp= an class=3D"awspan">vitro fertilization = (IVF) = and intracytoplasmic sperm<s= pan class=3D"awspan" style=3D"letter-spacing:4.45pt"> injection (ICSI) as treatments for infertility, consideri= ng <spa= n class=3D"awspan">the probable cause.</spa= n> This includes analyzing the</= span> fundamental mechanisms of <= span class=3D"awspan">each technique, their advantages, disadvantages, and</sp= an> the most suitable<s= pan class=3D"awspan" style=3D"letter-spacing:1.65pt"> therapeutic options according = to <sp= an class=3D"awspan">the characteristics = of <sp= an class=3D"awspan">each couple. Methodology. A </sp= an>search was conducted<span= class=3D"awspan" style=3D"letter-spacing:-0.05pt"> in </s= pan>scientific databases, selecting= articles based on = reliability, </s= pan>validity, and clinic= al relevance, = prioritizing publications</sp= an> in English and Spanish from the last five </span= >years. Fifteen = high-evidence= articles that met the= established criteria= were selected. Results. In vitro fertilization showed some<sp= an class=3D"awspan" style=3D"letter-spacing:3.4pt"> degree = of superiority over = ICSI regarding fertilization= rates; however, ICSI<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> resulted in a = higher rate </= span>of high-quality embryos, </sp= an>although the diff= erence = was not statistically significant.= Ultimately, it was = determined that the = live <s= pan class=3D"awspan">birth rate is<s= pan class=3D"awspan" style=3D"letter-spacing:4.2pt"> indirectly proportional to<s= pan class=3D"awspan" style=3D"letter-spacing:4.2pt"> maternal age, regardless of= the procedure performed.</spa= n> Conclusion. In vitro fertilization has</sp= an> become the preferred<s= pan class=3D"awspan" style=3D"letter-spacing:2.8pt"> assisted reproductive technique = for <s= pan class=3D"awspan">various conditions = such <= span class=3D"awspan">as unexplained infertility,<s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt"> endometriosis, and ovarian</span= > and male factors.<span= class=3D"awspan" style=3D"letter-spacing:-0.1pt"> On </sp= an>the other hand, ICSI = is reserved for</s= pan> specific cases of<s= pan class=3D"awspan" style=3D"letter-spacing:-0.7pt"> male= infertility despite its</spa= n> higher level of intervention.= Each approach has <= span class=3D"awspan">its own indications and <= span class=3D"awspan">considerations, emphasizing<s= pan class=3D"awspan" style=3D"letter-spacing:9.45pt"> the importance of careful<s= pan class=3D"awspan" style=3D"letter-spacing:0.5pt"> selection based on individual </= span>diagnosis. General Area of Study: = MedicineSpecific area of study:<= /span> Gynecology and<= span class=3D"awspan" style=3D"letter-spacing:-0.05pt"> Obstetrician.Type of study: </sp= an>Bibliography Review.</s= pan><a id=3D"_._Introducci=C3=B3n"></a>1.Introducci=C3=B3nLa<= /span> infertilidad, seg=C3=BAn la = Sociedad Europea = para <= span class=3D"awspan">la Reproducci=C3=B3n Humana </s= pan>y Embriolog=C3=ADa se<s= pan class=3D"awspan" style=3D"letter-spacing:1pt"> define = como una c= ondici=C3=B3n= en la que<= /span> existe imposibilidad para= <span= class=3D"awspan">lograr un embarazoEst= a revista est=C3=A1 protegida bajo una licencia Creative Commons<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> en la 4.0 International. Copia de la licencia: <a href=3D"h= ttp://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:= none"></a><a href=3D"http://= creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoration:none">= http://creativecommons.org/licenses/by= -nc-sa/4.0/</a><span= class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ffff= ff">D i a g <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-sp= acing:0.5pt; color:#ffffff">n </spa= n>=C3=B3 s<= /span> t i c o M<= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-= spacing:0.45pt; color:#ffffff"> =C3=A9 d = i c oP =C3=A1<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-s= pacing:0.5pt; color:#ffffff"> g i </span= >n <= /span>a 8 = | 18<img src=3D"data:image/jpeg;base64,/9j/= 4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw8LCwkMEQ8SEhEPERE= TFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4ICA4eFBEUHh4eHh4eHh= 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KXb1pxtxg82F3r0B4843AZZG6E4fizS/GDyRQzepB7/AAamMIDNxjF9MCmG6LMkOBDZ3tKaq3YS= DdkUTsOs7FD6CsJRvd85enP3ks7b8kGLCqePUFyzPUYtHBUmMwuxGBR63PjnskGR5XUGLeakUip= QQkRWPOWaOmj79KLKOGOrhyho2VhXMaSrifN4k0mYkxJW8Fj5CLRBMtNJu6wAjxWay6xiQphtvI= /fo1fTmeTGUOdd9t91S8iJudt85X9NV2rawiNMF8yKqdJJADuXgF/+3jE6nQx/h5GTjORgXGrlC= SYV1UFnB7Mk1zrtj2uW+mdsba+7XM5IXeUvv56YX0vHd5I2c1rx/wAMSGsLvK7PHu2RUjlJ8PRG= eHcif7fC6wikxHTAGIkYnSSwwgfOLR8WDKDpJHV2RtmzDyQquLSetUCrNg9wogi4OffK71p5AJH= KqKWqrlR8xRhD+Yv4/ZwaSn2EqQHHY6CRj0aiTBnITEvlaz6SsyDYIEDviqQQaeON0FEwy+uY6W= HG2VsRYDCbHISqYxWNkHhIMGNTeZuG7R883Wyo4331P6OHe6WrhdFlh6s51GtllGo/Vq23yllCq= isIZSZ97J6sYk4abJiVQBJ4NlEqW1IB1iA0v9B60fmnjJ0igYDhzLLK7ZTdgZECy7HduRHM3KLy= R00NNTDfHBczEs0Hn5pg6T7ubp3x5x+qLAZ8gcm1mn0FGjhYUQhMLNBjaGI0WQYkYrJ13TMWSYl= UGD2OSNQFsptq2ESEGq8SbPt1WrfXr/Fu67nvbvPHWd12GHj8dkX/ACIARHZhGk3Wo3LIDUkNWa= r41drKrYXUySVwr/v7c4109uMemfXFvacXZ3SNbjLaMTexB7A44kg9nLbGsA0gNNvhYwG+IDU3k= mUwOVfCw4tq+0ZfAi8+g2WcpKuEtVfzZ5/FUraF1lyF0YLhAbIRiR6Ry/eIYJFiXzO8VjBm+Ffl= LP36yfoiknp8aSmiX+vu9nvzttkyR3ovDIRi5gpqr5r+sf/Z" width=3D"77" height=3D"27= " alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /><span= ><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.33" ver= sion=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" style=3D= "width:209.31px; height:41.33px; font-family:'Times New Roman'; font-size:1= 6px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"= M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"e= venodd" /></g></g></svg><a href=3D"http://www= .anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>= ISSN:</sp= an> = 269= 7-3391Vol. 8 No.= 2.1, <spa= n class=3D"awspan" style=3D"color:#ffffff">pp. 6 =E2=80=93 18, abril<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </spa= n>- mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblic= a Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.despu=C3=A9s de<span= class=3D"awspan" style=3D"letter-spacing:-0.25pt"> haber= mantenido relaciones</span= > sexuales regulares sin</sp= an> protecci=C3=B3n por al</= span> menos 12 meses, en</span= > donde intervienen factores</s= pan> que producen alteraciones<= /span> de la reproducci=C3=B3n= <span= class=3D"awspan">en uno o ambos<spa= n class=3D"awspan" style=3D"letter-spacing:1.8pt"> integrantes de la p= areja, = estim=C3=A1ndose que aproximadamente un 15% d= e parejas </s= pan>a escala mundi= al <spa= n class=3D"awspan">padecen infertilidad, = siendo </span= >esta afecci=C3=B3n m=C3=A1s </= span>prevalente en las mujeres. (1,2).= Desde = la d=C3=A9cada de<= /span> los 80 se han </span= >planteado y perfe= ccionado </sp= an>t=C3=A9cnicas de reproducci=C3=B3n asistida (TRA) que<= /span> han permitido lograr</s= pan> la concepci=C3=B3n, actua= lmente </span= >el tratamiento = que <= span class=3D"awspan">ha presentado altas tasas </span= >de =C3=A9xito es<= /span> la fertilizaci=C3=B3n = in <sp= an class=3D"awspan">vitro (FIV), raz=C3= =B3n <= span class=3D"awspan">por la cual<= span class=3D"awspan" style=3D"letter-spacing:0.35pt"> Robert Edwards fue galardonad= o <spa= n class=3D"awspan">con el Premio<s= pan class=3D"awspan" style=3D"letter-spacing:2.15pt"> Nobel de Medicina en = el 2010 al<= span class=3D"awspan" style=3D"letter-spacing:2.15pt"> lograr el nacimiento de la primera beb=C3=A9 p= robeta en el a=C3=B1o 1978. (2,3).Actualmente existen diversas</s= pan> t=C3=A9cnicas de reproducci= =C3=B3n </span= >asistida e incluso<= /span> se considera el surgimiento= de la NPT (Natural </s= pan>Procreative Technology),</span= > la= misma que s= e <span= class=3D"awspan">basa en identificar la</= span> causa de la infertilidad y buscar solucionarla mediante tratamientos</sp= an> m=C3=A9dicos convencionales para<spa= n class=3D"awspan" style=3D"letter-spacing:-0.55pt"> evitar recurrir a t=C3=A9cnicas de concepci=C3=B3n<= /span> <span= class=3D"awspan">artificiales, por su<= /span> <span= class=3D"awspan">parte entre las TRA</s= pan> se mencionan las<sp= an class=3D"awspan" style=3D"letter-spacing:0.85pt"> siguientes: inseminaci=C3=B3n art= ificial </spa= n>(IA), fecundaci=C3=B3n<spa= n class=3D"awspan" style=3D"letter-spacing:0.85pt"> in </s= pan>vitro convencional (FIV),= inyecci=C3=B3n intracitoplasm=C3=A1tica<= span class=3D"awspan" style=3D"letter-spacing:8.4pt"> de </= span>espermatozoides (ICSI), transfe= rencia </span= >de embriones y</s= pan> diagn=C3=B3stico gen=C3=A9tico preimplantacional (DGP), en particul= ar, <= span class=3D"awspan">en este texto</sp= an> se pretende evaluar</spa= n> la eficacia de<span= class=3D"awspan" style=3D"letter-spacing:-0.35pt"> dos </= span>de las t=C3= =A9cnicas </= span>com=C3=BAnmente utilizadas busc= ando <s= pan class=3D"awspan">identificar bajo qu=C3= =A9 <sp= an class=3D"awspan">par=C3=A1metros se pref= iere <s= pan class=3D"awspan">la utilizaci=C3=B3n d= e <span= class=3D"awspan">una t=C3=A9cnica en com= paraci=C3=B3n= a la otra<= /span> para el manejo<sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> de </= span>la infertilidad, identificando riesgos prenatales y</sp= an> perinatales entre las<s= pan class=3D"awspan" style=3D"letter-spacing:0.5pt"> parejas que optaron por <s= pan class=3D"awspan">un tratamiento de</spa= n> FIV o ICSI. (4=E2=80=936).La fertilizaci=C3= =B3n = in vitro es</spa= n> una t=C3=A9cnica basada</sp= an> en la fecundaci=C3=B3n</spa= n> extracorp=C3=B3rea, en prim= era instancia= es necesario ejercer </= span>acciones que = permitan </sp= an>conseguir la = estimulaci=C3=B3n ov=C3=A1rica controlada mediante </s= pan>el uso de</spa= n> medicamentos como la<= span class=3D"awspan" style=3D"letter-spacing:0.45pt"> gonadotropina cori=C3=B3nica = humana, administrados por v=C3=ADa= subcut=C3=A1nea o intramuscul= ar, <s= pan class=3D"awspan">para de esta<= span class=3D"awspan" style=3D"letter-spacing:1.35pt"> manera obtener varios fol=C3= =ADculos </sp= an>a partir de los cuales se extraer=C3=A1n ovocitos, mis= mos <s= pan class=3D"awspan">que ser=C3=A1n fertilizados y<= span class=3D"awspan" style=3D"letter-spacing:-0.1pt"> una vez que =C3=A9stos= progresen sean transferidos</= span> a la cavidad uterina = en un tiemp= o <spa= n class=3D"awspan">aproximado de tres a<= span class=3D"awspan" style=3D"letter-spacing:3pt"> cinco </s= pan>d=C3=ADas, optando p= or realizar dicha transferencia</= span> cuando el cultivo se= encuentre en= etapa de blastocisto.</span= > Finalmente, se menciona que= el <= span class=3D"awspan">ciclo completo de= <span= class=3D"awspan">FIV dura alrededor de dos semanas. (3,7).En un inicio </s= pan>se planteaba = que <s= pan class=3D"awspan">la FIV fue<sp= an class=3D"awspan" style=3D"letter-spacing:0.35pt"> ideada con el = objetivo </sp= an>de brindar trat= amiento </spa= n>a mujeres con = diagn=C3=B3stico de infertilidad<s= pan class=3D"awspan" style=3D"letter-spacing:0.35pt"> tub=C3=A1rica, sin embargo,</spa= n> al d=C3=ADa de hoy </spa= n>se reconoce como = una <sp= an class=3D"awspan">TRA de elecci=C3=B3n</s= pan> en casos de infertilidad = inexplicada, endometriosis, d= isfunci=C3=B3n ov=C3=A1rica resistente</s= pan> a la inducci=C3=B3n= farmacol=C3=B3gica de la</spa= n> ovulaci=C3=B3n, crio preservaci=C3=B3n= de= ovocitos en pacientes </s= pan>oncol=C3=B3gicos, preservaci=C3= =B3n <s= pan class=3D"awspan">de la fertilidad</span= > e infertilidad por factores</sp= an> masculinos por ejemplo,</span= > recuento de espermatozoides</s= pan> m=C3=B3viles<3 millones,<= span class=3D"awspan" style=3D"letter-spacing:0.35pt"> cabe mencionar que<span= class=3D"awspan" style=3D"letter-spacing:0.4pt"> en </spa= n>un ciclo com=C3=BA= n <span= class=3D"awspan">de FIV se fertilizan <= /span>alrededor de 8Esta revista est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spac= ing:-0.2pt"> protegida bajo <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">una<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> licencia Creative </spa= n>Commons= en la <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">4.0<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:2pt"> International. Copia de la licencia: <a h= ref=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-dec= oration:none"></a><a href=3D= "http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoratio= n:none">http://creativecommons.org/lic= enses/by-nc-sa/4.0/</a>D i</spa= n> a g </= span>n =C3=B3 <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">s t<spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:0.4pt; color:#ffffff"> i c <= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#= ffffff">o M<= /span> =C3=A9 d<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#f= fffff"> i c<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-s= pacing:0.5pt; color:#ffffff"> o</spa= n>P =C3=A1<= /span> g i n a <= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#= ffffff">9 | 18<img src=3D"data:image/jpeg;b= 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3Wo3LIDUkNWar41drKrYXUySVwr/v7c4109uMemfXFvacXZ3SNbjLaMTexB7A44kg9nLbGsA0gN= NvhYwG+IDU3kmUwOVfCw4tq+0ZfAi8+g2WcpKuEtVfzZ5/FUraF1lyF0YLhAbIRiR6Ry/eIYJFi= XzO8VjBm+FflLP36yfoiknp8aSmiX+vu9nvzttkyR3ovDIRi5gpqr5r+sf/Z" width=3D"77" = height=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" />= <svg font-family=3D"Times New Roman" font-size=3D"16" height= =3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000= /svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Roman= '; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g>= <g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" = fill-rule=3D"evenodd" /></g></g></svg><a href= =3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org<= /span></a>ISSN: 2697-3391<span= class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2.1,= pp. <span= class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <= span class=3D"awspan" style=3D"color:#ffffff">mayo 2025 Revista en ciencias m=C3=A9dicas, salu= d p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</p= >ovocitos y</spa= n> se transfieren de<spa= n class=3D"awspan" style=3D"letter-spacing:0.45pt"> 3 </sp= an>a 5 por<= span class=3D"awspan" style=3D"letter-spacing:0.45pt"> lo que, la = tasa <= span class=3D"awspan">de embarazos m=C3= =BAltiples </= span>incrementa considerablemente en pacientes que s= e han sometido a esta t=C3=A9cnica. (8,9).<sp= an class=3D"awspan">En contraste, la= inyecci=C3=B3n intracitoplasm=C3=A1tica<= span class=3D"awspan" style=3D"letter-spacing:0.6pt"> de </= span>espermatozoides (ICSI)<s= pan class=3D"awspan" style=3D"letter-spacing:0.6pt"> es </s= pan>una t=C3=A9cnica en la </spa= n>cual se selecci= ona <s= pan class=3D"awspan">un solo espermatozoi= de <sp= an class=3D"awspan">y se inserta<= span class=3D"awspan" style=3D"letter-spacing:-0.45pt"> directamente en el<sp= an class=3D"awspan" style=3D"letter-spacing:-0.35pt"> citoplasma de un ovocito<sp= an class=3D"awspan" style=3D"letter-spacing:0.4pt"> maduro,= pese a que</= span> este procedimiento forma</sp= an> parte de un c= iclo <s= pan class=3D"awspan">de FIV se considera</s= pan> que debe ser reservado </= span>en casos de</sp= an> infertilidad masculina en</spa= n> los que se haya= detectado </= span>alteraciones en las </span= >caracter=C3=ADsticas del<sp= an class=3D"awspan" style=3D"letter-spacing:6.35pt"> semen= como oligozoospermia, asten= ozoospermia, = teratozoospermia, ausencia</= span> de conductos deferentes,<= /span> anticuerpos anti espermatozoides<s= pan class=3D"awspan" style=3D"letter-spacing:2.25pt"> o </= span>que han exper= imentado </sp= an>tasas de =C3=A9= xito <= span class=3D"awspan">nulas o bajas</span= > en ciclos de fertilizaci=C3= =B3n <= span class=3D"awspan">in vitro previas,</= span> asociada a mayor<s= pan class=3D"awspan" style=3D"letter-spacing:1.85pt"> tasa= de =C3=A9xito en </span= >comparaci=C3=B3n con las t=C3=A9cnicas tradicionales de</s= pan> fertilizaci=C3=B3n. Esta = t=C3=A9cnica = supone mayor intervencionismo debido a que<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt"> el ovocito se somete = a manipulaci=C3=B3n<s= pan class=3D"awspan" style=3D"letter-spacing:-0.15pt"> enzim=C3=A1tica que promueva= <spa= n class=3D"awspan">un estado de madurez,= <span= class=3D"awspan">luego se inyecta= un espermatozoide inmovilizad= o <spa= n class=3D"awspan">con ayuda de<sp= an class=3D"awspan" style=3D"letter-spacing:1.75pt"> una <= /span>pipeta. (9,10).Las <= /span>t=C3=A9cnicas de reproducci=C3=B3n asistida han<sp= an class=3D"awspan" style=3D"letter-spacing:1.6pt"> sido </= span>objeto de contr= oversia </span= >en los aspectos =C3= =A9ticos </sp= an>y morales, sin<= /span> embargo, dichos conflict= os <sp= an class=3D"awspan">no han impedido</span= > el avance, mejora<spa= n class=3D"awspan" style=3D"letter-spacing:1.15pt"> y perfeccionamiento de las<sp= an class=3D"awspan" style=3D"letter-spacing:2.2pt"> mismas,= es por =C3= =A9ste = motivo que la= fertilizaci=C3=B3n in vitro</sp= an> se considera la t=C3=A9cnica= <span= class=3D"awspan">artificial de elecci=C3= =B3n <= span class=3D"awspan">para el manejo</spa= n> de la infertilidad,<s= pan class=3D"awspan" style=3D"letter-spacing:4.95pt"> el procedimiento por la<spa= n class=3D"awspan" style=3D"letter-spacing:0.5pt"> cual </s= pan>se opte depender= =C3=A1 = de las condiciones</= span> de la pareja inf=C3=A9rtil, por tal raz=C3=B3n,</spa= n> se analizaran distintas</= span> variables con relaci= =C3=B3n </sp= an>a la tasa</sp= an> de fertilizaci=C3=B3n, embriones de = buena calidad, nacidos </sp= an>vivos y el= porcentaje de abortos<sp= an class=3D"awspan" style=3D"letter-spacing:0.6pt"> espont=C3=A1neos, con el<span= class=3D"awspan" style=3D"letter-spacing:0.6pt"> objetivo de identificar cual deber=C3=A1 ser la t=C3=A9cnica de elecci= =C3=B3n rutinaria en estos casos. (11,12).<sp= an class=3D"awspan">Objetivo generalEvaluar la<= /span> efectividad de la fertil= izaci=C3=B3n = in vitro = (FIV) = y la inyecci=C3=B3= n <sp= an class=3D"awspan">intracitoplasm=C3=A1tica de espermatoz= oides = (ICSI) como tratam= ientos </span= >para la infertili= dad, <= span class=3D"awspan">analizando los mecanismos<spa= n class=3D"awspan" style=3D"letter-spacing:2.1pt"> fundamentales de cada t=C3=A9cnica, sus ventajas, desventajas y las opcio= nes terap=C3=A9uticas para establecer un m=C3=A9todo de fertilizaci=C3=B3n = seguro.Objetivos</span= > espec=C3=ADficos= =EF=82=B7Analizar los= pilares b=C3=A1sicos de</span= > cada procedimiento a<s= pan class=3D"awspan" style=3D"letter-spacing:1.05pt"> realizar con relaci=C3=B3n</sp= an> a las parejas sometidas al estudio para demo= strar la efectividad de cada intervenci=C3=B3n.=EF=82=B7</spa= n>Realizar una compa= raci=C3=B3n </= span>entre las varia= bles <s= pan class=3D"awspan">de ambos procedimiento= s, <spa= n class=3D"awspan">para identificar cu=C3=A1l es <= span class=3D"awspan">la t=C3=A9cnica que</= span> representa menor riesgo</spa= n> y = mayor tasa d= e efectividad= .=EF=82=B7Evalu= ar <s= pan class=3D"awspan">los resultados y</= span> caracter=C3=ADsticas de parejas </= span>sometidas a estas </spa= n>intervenciones con el<span= class=3D"awspan" style=3D"letter-spacing:0.35pt"> prop=C3=B3sito de identificar</span= > la incidencia de nacidos = vivos sin = complicaciones a corto y largo plazoEsta revista est=C3=A1<s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spac= ing:-0.2pt"> protegida bajo <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">una<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> licencia Creative </spa= n>Commons= en la <s= pan class=3D"awspan" style=3D"font-size:8pt; font-style:italic">4.0<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:2pt"> International. Copia de la licencia: <a h= ref=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-dec= oration:none"></a><a href=3D= "http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-decoratio= n:none">http://creativecommons.org/lic= enses/by-nc-sa/4.0/</a>D i</spa= n> a g </= span>n =C3=B3 <sp= an class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ff= ffff">s t<spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:0.4pt; color:#ffffff"> i c <= span class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#= ffffff">o M<= /span> =C3=A9 d<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#f= fffff"> i c<s= pan class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-s= pacing:0.5pt; color:#ffffff"> o</spa= n>P =C3=A1</= span> g i= n a <span= class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; color:#ffff= ff">10 | 18<img src=3D"data:image/jpeg;base= 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IDUkNWar41drKrYXUySVwr/v7c4109uMemfXFvacXZ3SNbjLaMTexB7A44kg9nLbGsA0gNNvhYw= G+IDU3kmUwOVfCw4tq+0ZfAi8+g2WcpKuEtVfzZ5/FUraF1lyF0YLhAbIRiR6Ry/eIYJFiXzO8V= jBm+FflLP36yfoiknp8aSmiX+vu9nvzttkyR3ovDIRi5gpqr5r+sf/Z" width=3D"77" heigh= t=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></spa= n><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.= 33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" s= tyle=3D"width:209.31px; height:41.33px; font-family:'Times New Roman'; font= -size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><pat= h d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-ru= le=3D"evenodd" /></g></g></svg><a href=3D"htt= p://www.anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org<= /a>IS= SN: 2697-3391Vol. 8 No. 2.1,</span= > </s= pan>pp. 6 =E2=80=93 18, abril= - mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3= =BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.<a id=3D"_._Metodolog=C3=ADa"></a>2.Metodolog=C3=AD= aSe e= jecut=C3=B3 </= span>una b=C3=BAsqueda de <= span class=3D"awspan">art=C3=ADculos en v= arias <= span class=3D"awspan">bases de datos= reconocidas en el campo cient=C3=ADfico y m=C3=A9dico</s= pan> como: Science Direct,</spa= n> Web of Science, Elsevier, PubMed y Scielo. La = elecci=C3=B3n de<span= class=3D"awspan" style=3D"letter-spacing:2.55pt"> los </s= pan>art=C3=ADculos se bas=C3=B3= en criterios de = elegibilidad, que = incluyeron: <= /span>la confiabilidad de<sp= an class=3D"awspan" style=3D"letter-spacing:0.65pt"> las <= /span>fuentes, validez metodol=C3=B3gica, pertinencia tem= =C3=A1tica </= span>y relevancia = en el <= span class=3D"awspan">=C3=A1mbito cl=C3=ADnico.<span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> El </span= >proceso de selecci= =C3=B3n </span= >se realiz=C3=B3 e= n <span= class=3D"awspan">dos fases: la<span= class=3D"awspan" style=3D"letter-spacing:0.8pt"> primera, = mediante una revisi=C3=B3n = de t=C3=ADtulos y res=C3=BAmenes y, en<= /span> <span= class=3D"awspan">la segunda, se efectu=C3=B3<span= class=3D"awspan" style=3D"letter-spacing:-0.05pt"> una evaluaci=C3=B3n completa de los = art=C3=ADculos preseleccionados.</= span> Se dio prioridad</span= > a las publicaciones= en ingl=C3=A9s y<spa= n class=3D"awspan" style=3D"letter-spacing:-0.25pt"> espa=C3=B1ol de los =C3=BAltimos</s= pan> 5 a=C3=B1os (entre<spa= n class=3D"awspan" style=3D"letter-spacing:1.4pt"> 2020 </s= pan>y 2025). En</spa= n> el= proceso investigativo,</sp= an> se incluyeron metaan=C3=A1lisis, art=C3=ADculos de revisi=C3=B3n<s= pan class=3D"awspan" style=3D"letter-spacing:1.3pt"> y </sp= an>art=C3=ADculos originales<= span class=3D"awspan" style=3D"letter-spacing:1.3pt"> que <= /span>se encuentren = en <spa= n class=3D"awspan">ingl=C3=A9s y espa=C3=B1ol, adem=C3=A1s estos deb=C3=ADan</span= > ser publicados dentro<= span class=3D"awspan" style=3D"letter-spacing:3.75pt"> de los =C3=BAltimos<sp= an class=3D"awspan" style=3D"letter-spacing:3.75pt"> 5 </s= pan>a=C3=B1os, estos documentos,</s= pan> deb=C3=ADan contener informaci=C3= =B3n <spa= n class=3D"awspan">sobre la Fertilizaci=C3=B3n<= /span> in= vitro y la</span= > inyecci=C3=B3n intracitoplasm=C3=A1tica de= espermatozoides, as=C3=AD como sus </span= >ventajas, desventajas, indicaciones y tasa </= span>de =C3=A9xito. Por </sp= an>otro lado, lo= s <sp= an class=3D"awspan">criterios de exclusi= =C3=B3n </sp= an>tuvieron varios puntos, </= span>entre ellos: que los </spa= n>documentos tengan una = fecha de publicaci= =C3=B3n </spa= n>superior a 5</sp= an> a=C3=B1os y que<span= class=3D"awspan" style=3D"letter-spacing:0.45pt"> contengan t=C3=A9cnicas diferentes a la FIV o ICSI.<a id=3D"_._Resultados"></a>3.Resultados<p= class=3D"awdiv">En un<span= class=3D"awspan" style=3D"letter-spacing:-0.15pt"> metaan=C3=A1lisis realizado por<= /span> <span= class=3D"awspan">Huang et al.<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> (5) = es posible comparar <= /span>la efectividad de </sp= an>la inyecci=C3=B3n intracitoplasm= =C3=A1tica </= span>de espermatozoides<span= class=3D"awspan" style=3D"letter-spacing:0.65pt"> y </spa= n>de la fertilizac= i=C3=B3n </sp= an>in vitro median= te el <= span class=3D"awspan">estudio de cuatro</sp= an> variables: tasa de<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> fertilizaci=C3=B3n, tasa total<= span class=3D"awspan" style=3D"letter-spacing:0.5pt"> de </= span>fracaso de fert= ilizaci=C3=B3n, tasa de embriones<= span class=3D"awspan" style=3D"letter-spacing:0.75pt"> de buena calidad y </span= >tasa de implantac= i=C3=B3n, </s= pan>en donde se</s= pan> obtuvieron los siguientes resultados:</span= >Tabla = 1.= Efectividad de </= span>la<= /span> inyecci=C3=B3n intracitoplasm= =C3=A1tica de espermatozoides</s= pan> y de = la</span= > fertilizaci=C3=B3n in vitro ICSIFIVVARIABLE= EVENTOSTOTAL%EVENTOS<= /p>TOTAL%Tasa de fertilizaci=C3=B3n</spa= n>1696361846,882659</= p>431161,68Tasa <spa= n class=3D"awspan" style=3D"font-size:10pt">total de fracaso de fertilizaci=C3=B3n166<spa= n class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.2pt">3618</sp= an>4,5916343113,78</= p>Tasa de embr= iones de<= span class=3D"awspan" style=3D"font-size:10pt; letter-spacing:-0.1pt"> </sp= an>buena calidad</s= pan>1846361851,022118= 431149,13Tasa <s= pan class=3D"awspan" style=3D"font-size:10pt">de implantaci=C3=B3n</= span>817361822,581021</span= >431123,68Fuente: Elaboraci=C3=B3n Propia.<span= class=3D"awspan">Del total de<spa= n class=3D"awspan" style=3D"letter-spacing:0.55pt"> la </s= pan>muestra, 3618 = mujeres </spa= n>optaron por la</= span> ICSI y 4311 por </sp= an>la FIV; la</spa= n> tasa de fertilizaci=C3=B3n = es <sp= an class=3D"awspan">de 46,88% (ICSI)</spa= n> y de 61,68% (FIV); </spa= n>la tasa total</s= pan> de fracaso de fertilizaci= =C3=B3n </spa= n>tiene un porcentaje de 4,59% (IC= SI) <= span class=3D"awspan">y 3,78% (FIV); la tasa de embriones= <span= class=3D"awspan">de buena calidad es</span= > de= 51,02% (ICSI) y <sp= an class=3D"awspan">49,13% (FIV); finalment= e, <spa= n class=3D"awspan">la tasa de implantaci=C3=B3n es de 22,58%</span= > (ICSI) y 23,68%<sp= an class=3D"awspan" style=3D"letter-spacing:-0.15pt"> (FIV). As=C3=AD tambi=C3=A9n,<= /span> <span= class=3D"awspan">en un estudio<= span class=3D"awspan" style=3D"letter-spacing:-0.15pt"> realizado por Yovich= et al. (13) a = una <sp= an class=3D"awspan">poblaci=C3=B3n de 2343<= /span> mujeres, en donde,<s= pan class=3D"awspan" style=3D"letter-spacing:1.4pt"> una </= span>muestra de 125<= /span> opt=C3=B3 por un tratamient= o <spa= n class=3D"awspan">con fertilizaci=C3=B3n in <s= pan class=3D"awspan">vitro, una muestra</= span> de 1981 por inyecci=C3=B3n intracitoplasm=C3=A1tica y las <= span class=3D"awspan">237 mujeres restant= es <sp= an class=3D"awspan">siguieron otros tipos= <span= class=3D"awspan">de trata= mientos,Esta revista est=C3=A1 protegida</span= > bajo una <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">licencia</span= > Creative Commons </sp= an>en</sp= an> la 4.0 International. 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9+m8OHD7NkyRJmzZpVqW2pX78+aWlpXLx4kfj4eN566y1tnaenJ+Hh4ZX6+uL2kpHHPa5Tp04cO= HDghjHu7u44OjpWeltKb9O5ZMmSKnOvWKGfjDzuce3ataOwsJCxY8dq9zVt3rw5ZrOZ06dPAyV3= ox8+fHilt8XGxoYhQ4YwZswYwsLCKv31ROWSn2qFELrIYYsQQhdJHkIIXSR5CCF0keQhhNBFkoc= QQhdJHkIIXSR5CCF0keQhhNBFkocQQhdJHkIIXSR5CCGEEOLO+X/HTqOAf/1oYQAAAABJRU5Erk= Jggg=3D=3D" width=3D"271" height=3D"190" alt=3D"" style=3D"margin-left:195.= 4pt; position:absolute" />ISSN: 2697-3391<span= class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2.1,= pp. <span= class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<spa= n class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <= span class=3D"awspan" style=3D"color:#ffffff">mayo 2025 Revista en ciencias m=C3=A9dicas, salu= d p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</p= >muestra un</span= > an=C3=A1lisis en el<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> cual </sp= an>es posible determ= inar <s= pan class=3D"awspan">la tasa de<span= class=3D"awspan" style=3D"letter-spacing:0.5pt"> nacidos <= /span>vivos de acuer= do con </span= >el grupo etario</= span> de la madre<span= class=3D"awspan" style=3D"letter-spacing:4.55pt"> y </spa= n>al m=C3=A9todo = seleccionado,= es decir = inyecci=C3=B3n intracitoplasm=C3=A1tica o fertilizaci=C3=B3n in vitro. (5,1= 3).Figura 1. Tasa de Nacidos Vivos<= p class=3D"awdiv">El gr=C3=A1fico</= span> muestra la tasa de = nacidos vivos regis= trados = en los estudios</spa= n> de Yovich et al.(13) & Dang et al. (14= ) <sp= an class=3D"awspan">se aprecia que en el grupo<spa= n class=3D"awspan" style=3D"letter-spacing:-0.05pt"> <35 a=C3=B1os corresponde al= 85,2% </spa= n>(ICSI) y al 77%<= /span> (FIV); en el<span= class=3D"awspan" style=3D"letter-spacing:0.65pt"> grupo <= /span>de 35-39 a= =C3=B1os </sp= an>es de 55,4%</sp= an> (ICSI) y al 42,3% </sp= an>(FIV); en el gr= upo <= span class=3D"awspan">de 40-44 a=C3=B1o= s, <s= pan class=3D"awspan">19% (ICSI) y= al 14% (FIV); y, </sp= an>en el grupo</= span> >45 a=C3=B1os corres= ponde = al 13,3% (ICSI) y al 5,5% (FIV). (13,14).= Iwamoto et= al. (15) presentaron<spa= n class=3D"awspan" style=3D"letter-spacing:0.1pt"> un </spa= n>an=C3=A1lisis retrospectivo</spa= n> en= donde particip=C3=B3<= span class=3D"awspan" style=3D"letter-spacing:0.1pt"> una <= /span>muestra de 46967<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> pacientes, al igual que<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> en </sp= an>el estudio de Yovich<span= class=3D"awspan" style=3D"letter-spacing:0.05pt"> et </sp= an>al. (13) es</sp= an> posible determinar la tasa<= /span> de nacidos vivos<= span class=3D"awspan" style=3D"letter-spacing:3.15pt"> y, adem=C3=A1s, tambi=C3=A9n<= /span> es posible divisar</span= > la tasa de = abortos espont=C3=A1neos que se<sp= an class=3D"awspan" style=3D"letter-spacing:2.95pt"> presentaron tras la aplicaci=C3=B3n de cada una </sp= an>de las t=C3=A9c= nicas, </span= >los resultados se presentan en el siguiente cuadro:= Tabla </= span>2.</= span> Tasa de </sp= an>Nacid= os Vivos y Abortos Espont=C3=A1neosVARIABLEICSIFIVNACIDOS VIVOS</sp= an>60,9%64,3%ABORTOS ESPONT=C3=81NEOS</sp= an>11,3%11,8%Fuente: Elaboraci=C3=B3n Propia<sp= an class=3D"awspan">El porcentaje de= nacidos vivos para la = ICSI es de<sp= an class=3D"awspan" style=3D"letter-spacing:0.9pt"> 69,9%, = por su parte,= la FIV tiene un porcentaje de 64,3%, adem=C3=A1s se evidencia que </sp= an>la tasa de</spa= n> abortos espont=C3=A1neos en<= /span> la ICSI es de 11,3%, mientras que, para l= a FIV es de 11,8%. (13=E2=80=9315).<a id=3D"_= ._Discusi=C3=B3n"></a>4.Discusi=C3=B3nLa imposibilidad para </span= >lograr un embara= zo <sp= an class=3D"awspan">despu=C3=A9s de mante= ner <= span class=3D"awspan">una vida sexual</sp= an> activa sin el uso<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> de </sp= an>ning=C3=BAn m=C3=A9todo<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> de </sp= an>planificaci=C3=B3n familiar</span= > durante al menos<span= class=3D"awspan" style=3D"letter-spacing:0.1pt"> 12 </span= >meses se traduceE= sta revista est=C3=A1 protegida bajo una licencia Creative <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">Commons= en la 4.0 International. 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=3D"27" alt=3D"" style=3D"margin-left:441.05pt; position:absolute" /></span= ><svg font-family=3D"Times New Roman" font-size=3D"16" height=3D"41.3= 3" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2000/svg" st= yle=3D"width:209.31px; height:41.33px; font-family:'Times New Roman'; font-= size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs /><g><g><path= d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rul= e=3D"evenodd" /></g></g></svg><a href=3D"http= ://www.anatomiadigital.org/" style=3D"text-decoration:none">www.anatomiadigital.org</= a>ISS= N: 2697-3391Vol. 8 No. 2.1,</span= > </s= pan>pp. 6 =E2=80=93 18, abril= - mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3= =BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.en un diagn=C3=B3stico de infertilidad,</sp= an> problema que afecta<= span class=3D"awspan" style=3D"letter-spacing:2.05pt"> hasta el 15% de <s= pan class=3D"awspan">la poblaci=C3=B3n mundial,<spa= n class=3D"awspan" style=3D"letter-spacing:1pt"> y <sp= an class=3D"awspan">cuya prevalencia var=C3=ADa= entre los diferentes<sp= an class=3D"awspan" style=3D"letter-spacing:1pt"> grupos </sp= an>etarios de las= parejas.= Se debe recalcar<s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> que = existen diferentes<sp= an class=3D"awspan" style=3D"letter-spacing:0.25pt"> etiolog=C3=ADas que se<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> asocian a este = problema, </s= pan>dentro de las = cuales </span= >pueden estar rela= cionadas </sp= an>con diferentes = factores </sp= an>que involucran = alteraciones tanto en el sexo </s= pan>masculino como en </span= >el sexo femenin= o, <s= pan class=3D"awspan">raz=C3=B3n por la<= /span> cual es imprescindible = realizar </spa= n>una evaluaci=C3=B3n completa </s= pan>de la pareja</sp= an> inf=C3=A9rtil, tomando en</spa= n> cuenta todos aquellos anteceden= tes <sp= an class=3D"awspan">de inter=C3=A9s que</sp= an> pueda orientar al uso </span= >de una u<spa= n class=3D"awspan" style=3D"letter-spacing:0.6pt"> otra </s= pan>t=C3=A9cnica de reproducci=C3=B3n asistida disponibles en la actualidad. (2,15).</p= >Las terapias</span= > de </sp= an>reproducci=C3=B3n asistida<s= pan class=3D"awspan" style=3D"letter-spacing:3pt"> han </span= >ido mejorando con</span= > el </sp= an>paso de los<sp= an class=3D"awspan" style=3D"letter-spacing:3pt"> a=C3=B1os. Inicialmente, la fecundaci= =C3=B3n </span= >in vitro era= un= procedimiento limitado</span= > al= manejo de l= a infertilidad de origen femenino,= sin embargo, actualmente es la t= =C3=A9cnica <= /span>m=C3=A1s utilizada<sp= an class=3D"awspan" style=3D"letter-spacing:-0.45pt"> para la concepci=C3=B3n extracor= p=C3=B3rea. <= /span>En contraste a <sp= an class=3D"awspan">ello, la inyecci=C3= =B3n <= span class=3D"awspan">intracitoplasm=C3=A1tica de espermat= ozoides </spa= n>se orienta princ= ipalmente </s= pan>a la posibilid= ad <sp= an class=3D"awspan">de lograr la<s= pan class=3D"awspan" style=3D"letter-spacing:2.95pt"> concepci=C3=B3n cuando el afectado= es el factor<span= class=3D"awspan" style=3D"letter-spacing:0.4pt"> masculino= en dependencia de <= span class=3D"awspan">diferentes alteraciones que interfieren en la producci=C3=B3n adecuada de gametos masculinos. (6= ) (16)Actualmente,</sp= an> debido a los diferentes conflictos =C3=A9ticos</sp= an> y morales, algunos<s= pan class=3D"awspan" style=3D"letter-spacing:3.15pt"> expertos consideran una alternativa</s= pan> viable el uso de</spa= n> la <= /span>=E2=80=9Cnaprotecnolog=C3=ADa=E2=80=9D,= como </s= pan>m=C3=A9todo de reproducci=C3=B3n= <span= class=3D"awspan">basado en identificar= <spa= n class=3D"awspan">la probable causa</s= pan> de infertilidad y<= span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> buscar solucionarla a trav=C3= =A9s <= span class=3D"awspan">de tratamientos m= =C3=A9dicos <= /span>convencionales para<sp= an class=3D"awspan" style=3D"letter-spacing:3.15pt"> evitar recurrir a t=C3=A9cnicas de concepci=C3=B3n artificiales. (6,7,12).= En l= os <spa= n class=3D"awspan">estudios previos se</spa= n> analizaron los resultados</span= > obtenidos, en donde<span= class=3D"awspan" style=3D"letter-spacing:3.4pt"> se </span= >pudo identificar varias<sp= an class=3D"awspan" style=3D"letter-spacing:-0.4pt"> controversias entre las<sp= an class=3D"awspan" style=3D"letter-spacing:-0.4pt"> variables sujetas a estudio.= Por un lado, </span= >en lo que corre= sponde </span= >a la tasa<= span class=3D"awspan" style=3D"letter-spacing:0.25pt"> de fertilizaci=C3=B3n, la</sp= an> FIV muestra cierto<s= pan class=3D"awspan" style=3D"letter-spacing:0.25pt"> grado de superioridad<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> frente a la ICSI, c= oloc=C3=A1ndola como una t= =C3=A9cnica </= span>factible en c= uanto <= span class=3D"awspan">al objetivo de= las TRA, sin embargo,<sp= an class=3D"awspan" style=3D"letter-spacing:1.9pt"> debido = a que en</spa= n> la= ICSI es posi= ble <sp= an class=3D"awspan">seleccionar un solo</sp= an> espermatozoide, se identific=C3=B3<span= class=3D"awspan" style=3D"letter-spacing:1.45pt"> que </s= pan>la tasa de</sp= an> embriones de buena<s= pan class=3D"awspan" style=3D"letter-spacing:1.45pt"> calidad fue ligeramente<s= pan class=3D"awspan" style=3D"letter-spacing:1.45pt"> superior en este grupo<sp= an class=3D"awspan" style=3D"letter-spacing:0.7pt"> de </sp= an>pacientes aunque = el <spa= n class=3D"awspan">porcentaje de superiorid= ad <spa= n class=3D"awspan">no fue significativo</sp= an> frente a la FIV, por = lo que esta<s= pan class=3D"awspan" style=3D"letter-spacing:1.3pt"> variable no deber=C3=ADa<spa= n class=3D"awspan" style=3D"letter-spacing:1.3pt"> considerarse como indicativo<= span class=3D"awspan" style=3D"letter-spacing:1.3pt"> al </= span>momento de seleccionar la TRA e= mpleada. (2,5).Por</sp= an> otro lado, en lo </span= >que concierne a</= span> la tasa de nacidos </= span>vivos, se pudo= <span= class=3D"awspan">esclarecer que esta var= iable </span= >es indirectamente proporcional a la edad </span= >materna, puesto que = a mayor edad</sp= an> existe una menor tasa= de= natalidad independientemente= del procedimiento que</spa= n> haya sido utilizado como= manejo de la i= nfertilidad </= span>en las parejas.= Se concibe tambi=C3=A9n</s= pan> que el porcentaje de abortos espont=C3=A1neos= fue casi similar en ambos casos. (3).Con la propagaci=C3=B3n<= /span> y prevalencia de<= span class=3D"awspan" style=3D"letter-spacing:2.65pt"> la ICSI, y = con <s= pan class=3D"awspan">el prop=C3=B3sito = de <sp= an class=3D"awspan">minimizar las incidencias de = fallos en la<= span class=3D"awspan" style=3D"letter-spacing:2.2pt"> fecundaci=C3=B3n mediante la</span= > fertilizaci=C3=B3n in vitro,</s= pan> numerosos centros de ferti= lidad = eligen a la</spa= n> ICSI como la t=C3=A9cnica principal, incluso</sp= an> sin cumplir con<sp= an class=3D"awspan" style=3D"letter-spacing:-0.3pt"> laEsta revista <= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic">est=C3=A1<= /span> protegida bajo <= /span>una= licencia Creative Commons en la = 4.= 0 International. Copia de la licencia: </= span><a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D= "text-decoration:none"></a><= a href=3D"http://creativecommons.org/licenses/by-nc-sa/4.0/" style=3D"text-= decoration:none">http://creativecommon= s.org/licenses/by-nc-sa/4.0/</a>D i a g n =C3=B3 <= /span>s t<= /span> i c o = M =C3=A9</s= pan> = d i = c oP =C3=A1 g<spa= n class=3D"awspan" style=3D"font-family:Calibri; font-size:11pt; letter-spa= cing:0.45pt; color:#ffffff"> i n a </= span>13 | 18<img src=3D"data:image= /jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAUDBAQEAwUEBAQFBQUGBwwIBwcHBw= 8LCwkMEQ8SEhEPERETFhwXExQaFRERGCEYGh0dHx8fExciJCIeJBweHx7/2wBDAQUFBQcGBw4IC= A4eFBEUHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh4eHh7/= wAARCARhAxkDASIAAhEBAxEB/8QAHAABAQACAwEBAAAAAAAAAAAAAAECCAMGBwQF/8QAWBABAAE= DAwAECAsDBgsGAwkAAAECAwQFBhEHEiExExQXQVFVlNIIFiJUVmFxgZKT0TI3dBWRobGysyM1Nk= JSc3WChMHTGCQnM6LDJWJyJkNFRmOjwuHw/8QAGwEBAQEBAQEBAQAAAAAAAAAAAAECAwQFBgf/x= 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ght=3D"41.33" version=3D"1.1" width=3D"209.31" xmlns=3D"http://www.w3.org/2= 000/svg" style=3D"width:209.31px; height:41.33px; font-family:'Times New Ro= man'; font-size:16px" xmlns:xlink=3D"http://www.w3.org/1999/xlink"><defs />= <g><g><path d=3D"M0,0 L209,0 L209,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7= c" fill-rule=3D"evenodd" /></g></g></svg><a h= ref=3D"http://www.anatomiadigital.org/" style=3D"text-decoration:none"><spa= n class=3D"awspan" style=3D"font-family:Ebrima; font-size:11pt; text-decora= tion:underline; letter-spacing:-0.1pt; color:#ffffff">www.anatomiadigital.o= rg</a>ISSN: 2697-3391<s= pan class=3D"awspan" style=3D"color:#ffffff">Vol. 8 No. 2= .1, pp.<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> <s= pan class=3D"awspan" style=3D"color:#ffffff">6 =E2=80=93 18, abril -<= span class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </spa= n>mayo 2025 Revista en ciencias m=C3=A9dicas, = salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n bibliogr=C3=A1fica.</span= >indicaci=C3=B3n espec=C3=ADfica. Los comit=C3=A9s</s= pan> de pr=C3=A1ctica de= la Sociedad Americana<= span class=3D"awspan" style=3D"letter-spacing:1.25pt"> de Medicina Reproductiva (ASRM= ) <span= class=3D"awspan">y la Sociedad<sp= an class=3D"awspan" style=3D"letter-spacing:0.5pt"> de </sp= an>Tecnolog=C3=ADa Reproductiva</spa= n> Asistida (SART) han llegado</sp= an> a la conclusi=C3=B3n de = que la evidencia disponible no respalda la utilizaci=C3=B3n rutinaria de la<= span class=3D"awspan" style=3D"letter-spacing:1.2pt"> ICSI = para mejorar = las <sp= an class=3D"awspan">tasas de embarazo</span= > cl=C3=ADnico en parejas,= debido a que a= mbos procedimientos mostraron resultado= s <sp= an class=3D"awspan">similares en base</= span> a las variables= establecidas, por lo que</sp= an> se recomienda la<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> realizaci=C3=B3n de una<spa= n class=3D"awspan" style=3D"letter-spacing:0.25pt"> FIV </= span>convencional como tratamiento de rutina y conservar la ICSI = como <= span class=3D"awspan">una alternativa ant= e <spa= n class=3D"awspan">un ciclo de<sp= an class=3D"awspan" style=3D"letter-spacing:-0.2pt"> FIV = fallido y = las <s= pan class=3D"awspan">condiciones que se = mencionaron <= /span>en esta revi= si=C3=B3n </s= pan>asociadas principalmente= a= la infertilidad<span= class=3D"awspan" style=3D"letter-spacing:1.75pt"> masculina. (9,11,13).<a id=3D"_._Conclusiones"></a><= span class=3D"awspan" style=3D"font-weight:bold; color:#767070">5.<s= pan class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.1pt; colo= r:#767070">Conclusiones=EF=82=B7Entre </span= >ambas t=C3=A9cnicas de = reproducci=C3=B3n asistida<s= pan class=3D"awspan" style=3D"letter-spacing:1.55pt"> existen diferencias en<sp= an class=3D"awspan" style=3D"letter-spacing:1.55pt"> cuanto al procedimiento que</span= > se lleva a = cabo <= span class=3D"awspan">para lograr la</spa= n> concepci=C3=B3n. Por un</sp= an> lado, la ICSI supone</span= > mayor intervencionismo debido= <span= class=3D"awspan">a que requiere<s= pan class=3D"awspan" style=3D"letter-spacing:-0.6pt"> la <= /span>manipulaci=C3=B3n enzim=C3=A1= tica del </sp= an>ovocito junto = con <s= pan class=3D"awspan">la selecci=C3=B3n = e <spa= n class=3D"awspan">inyecci=C3=B3n de un</= span> solo espermatozoide, por<= /span> lo que se considera= que debe reservarse<span= class=3D"awspan" style=3D"letter-spacing:1.3pt"> en </span= >casos en los= que existan tasas de = FIV nulas, evitando aplicar <= /span>esta t=C3=A9cnica<span= class=3D"awspan" style=3D"letter-spacing:-0.3pt"> en </sp= an>pacientes con infertilidad inexplicable, baja reserv= a <sp= an class=3D"awspan">ov=C3=A1rica y/o ed= ad <s= pan class=3D"awspan">materna avanzada. Por = otro lado, la</sp= an> FIV convencional se const= ituye como la t=C3=A9cnica preferida para el manejo rutinario de infertilid= ad.=EF=82=B7Se = examinaron </s= pan>los resultados o= btenidos </spa= n>revelando controversias<spa= n class=3D"awspan" style=3D"letter-spacing:4.9pt"> entre </= span>las variables bajo estudio. <= /span>Respecto a l= a <span= class=3D"awspan">tasa de fertilizaci=C3=B3= n, <spa= n class=3D"awspan">la FIV mostr=C3=B3</span= > cierta superioridad sobre la<= /span> ICSI, posicion=C3=A1ndola como </span= >una t=C3=A9cnica = viable </span= >en las TRA. Sin</= span> embargo, la capacidad= de= seleccionar un solo </span= >espermatozoide en la <sp= an class=3D"awspan">ICSI demostr=C3=B3 una tasa </sp= an>de embriones = de <sp= an class=3D"awspan">buena calidad, aunque= <span= class=3D"awspan">este aumento no<= span class=3D"awspan" style=3D"letter-spacing:1.05pt"> fue estad=C3=ADsticamente significativo= en comparaci=C3=B3n con</span= > la FIV. Por = lo <sp= an class=3D"awspan">tanto, esta variable n= o <spa= n class=3D"awspan">debe considerarse decisi= va <spa= n class=3D"awspan">al momento de<sp= an class=3D"awspan" style=3D"letter-spacing:0.1pt"> elegir= la TRA. En</= span> relaci=C3=B3n con la tasa<= /span> de nacidos vivos,= se evidenci=C3=B3 una<= span class=3D"awspan" style=3D"letter-spacing:2.55pt"> relaci=C3=B3n inversa con</sp= an> la edad materna, ya<= span class=3D"awspan" style=3D"letter-spacing:-0.25pt"> que, a mayor edad, </sp= an>independientemente del<sp= an class=3D"awspan" style=3D"letter-spacing:-0.2pt"> procedimiento de manejo de</span= > la= infertilidad utilizado,</spa= n> se= observa una menor </span= >tasa de natalidad,<= /span> adem=C3=A1s, se observ=C3=B3 que el porcent= aje de abortos espont=C3=A1neos fue similar en ambos casos.= =EF=82=B7La fecundaci=C3=B3n<= /span> in vitro, inicialmente</spa= n> dise=C3=B1ada para tratar</span= > la= infertilidad tub=C3=A1rica, = ha <sp= an class=3D"awspan">evolucionado para con= vertirse </sp= an>en una t=C3=A9c= nica <= span class=3D"awspan">de reproducci=C3=B3n asistida </= span>de elecci=C3=B3n en<spa= n class=3D"awspan" style=3D"letter-spacing:-0.3pt"> diversas condiciones, como= la infertilidad inexplicada,= <span= class=3D"awspan">endometriosis, y problemas ov=C3=A1ricos y masculinos.<sp= an class=3D"awspan" style=3D"letter-spacing:1.25pt"> Aunque la FIV = presenta </sp= an>ventajas, como = la fertilizaci=C3=B3n de m=C3=BAltiples<= /span> <span= class=3D"awspan">ovocitos, conlleva el = riesgo de </s= pan>embarazos m=C3=BAltiples. En co= ntraste, </spa= n>la inyecci=C3=B3n = intracitoplasm=C3=A1tica de espermatozoides= (ICSI) se reserva para</sp= an> casos espec=C3=ADficos de</spa= n> infertilidad masculina, demostr= ando <s= pan class=3D"awspan">mayor eficacia en comp= araci=C3=B3n con t=C3=A9cnicas tradicionales, a pesar de su mayor intervenc= ionismo.Esta revista est=C3=A1 protegida</span= > bajo una <span= class=3D"awspan" style=3D"font-size:8pt; font-style:italic">licencia</span= > Creative Commons </sp= an>en</sp= an> la 4.0 International. 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height:41.33px; font-family:'Times New Roman'; font-size:16px" xmlns:xlink= =3D"http://www.w3.org/1999/xlink"><defs /><g><g><path d=3D"M0,0 L209,0 L209= ,0 L209,41 L209,41 L0,41 Z" fill=3D"#7c7c7c" fill-rule=3D"evenodd" /></g></= g></svg><a href=3D"http://www.anatomiadigital= .org/" style=3D"text-decoration:none">www.anatomiadigital.org</a>ISSN: 2697-<span= class=3D"awspan" style=3D"font-weight:bold; letter-spacing:-0.2pt; color:#= ffffff">3391Vol. = 8 No. <spa= n class=3D"awspan" style=3D"color:#ffffff">2.1, pp. 6 =E2= =80=93 18,<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </span= >abril - mayo 2025 Revista en ciencias m=C3=A9dicas, salud p=C3=BAblica Art=C3=ADcul= o de revisi=C3=B3n bibliogr=C3=A1fica.Cada enfoque tiene= sus propias indicaciones</spa= n> y consideraciones, destacand= o <spa= n class=3D"awspan">la importancia de una selecci=C3=B3n cuidadosa basada en= el diagn=C3=B3stico individual.<a id=3D"_._C= onflicto_de_intereses"></a>6.Conflicto de intere= sesLos autores </sp= an>declaran que = no <sp= an class=3D"awspan">existe conflicto de</= span> intereses en relaci=C3=B3n= <span= class=3D"awspan">con el art=C3=ADculo </= span>presentado.</sp= an><a id=3D"_._Declaraci=C3=B3n_de_contribuci=C3=B3n= _de_los_au"></a>7.Declaraci=C3=B3n de <sp= an class=3D"awspan" style=3D"font-weight:bold; color:#767070">contribuci=C3= =B3n de los autores</= span>Todos autores </sp= an>contribuyeron significativament= e <spa= n class=3D"awspan">en la elaboraci=C3=B3n= <span= class=3D"awspan">del art=C3=ADculo.<a id=3D"_._Costos_de_= financiamiento"></a>8.Costos de financiamientoLa presente investiga= ci=C3=B3n </s= pan>fue financiada en = su <s= pan class=3D"awspan" style=3D"letter-spacing:-0.1pt">totalidad con fondos pr= opios = de los autores.<a id=3D"_._Referencias_Bi= bliogr=C3=A1ficas"></a>9.Referencias Bibliog= r=C3=A1ficas1.Santa Ma= r=C3=ADa Ortiz J, =C3=81lvarez Silvares E, Berm=C3=BAdez Gonz=C3=A1lez M. I= nfluencia de la fecundaci=C3=B3n in vit= ro <s= pan class=3D"awspan">en los resultados<= /span> <span= class=3D"awspan">maternos y neonatales= <span= class=3D"awspan">en mujeres con= edad materna avanzada. Revista de Obstetricia y Ginecolog=C3=AD= a de Venezuela [Internet]. 2022 [citado 23 de marzo de 2025]; 82(3): 329-33= 9. 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Frontiers= in Reproductive Health</span= > [Internet].Esta</= span> revista est=C3=A1= p= rotegida bajo una licencia Creative Commons<= span class=3D"awspan" style=3D"font-size:8pt; font-style:italic; letter-spa= cing:-0.2pt"> en la 4.0 International. 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On </sp= an>estimating the prevalence= of use = of <s= pan class=3D"awspan">medically assisted reproduction in d= eveloped countries: a critical review of recent literature. Human Reproduct= ion Open [Internet]. 2021 [cited 2025 March 23]; 2021(1): hoaa065. Availabl= e from: <= a href=3D"https://doi.org/10.1093/hropen/hoaa065" style=3D"text-decoration:= none"></a><a href=3D"https://doi.org/10.1093/hropen/= hoaa065" style=3D"text-decoration:none">https://doi.org/10.1093/hropen/hoaa065</a></= p>Esta <spa= n class=3D"awspan" style=3D"font-size:8pt; font-style:italic">revista</span= > est=C3=A1 protegida <= /span>baj= o una licencia <= /span>Cre= ative Commons en= l= a 4.0 International. 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2.1, pp. 6<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt; color:#ffffff"> </span= >=E2=80=93 18, abril - mayo</= span>= 2025 Revista en cien= cias m=C3=A9dicas, salud p=C3=BAblica Art=C3=ADculo de revisi=C3=B3n biblio= gr=C3=A1fica.13.Yovich= JL, Conceicao JL, Wong J, Marjanovich N, Wicks R, Hinchliffe PM. Fertiliza= tion by ICSI generates a higher number of live births than IVF in a pioneer= facility applying >90% single blastocyst-stage embryo transfers. GSC Bi= ological </sp= an>and Pharmaceutical Sciences = [Internet]. 2021<span= class=3D"awspan" style=3D"letter-spacing:-0.2pt"> [cited = 2025 March = 23]; 15(01): 087-103. Available from: <a href=3D"https://gsconlinepr= ess.com/journals/gscbps/content/fertilization-icsi-generates-higher-number-= live-births-ivf-pioneer-facility-applying-90" style=3D"text-decoration:none= "></a><a href=3D"https://gsconlinepress.com/journals= /gscbps/content/fertilization-icsi-generates-higher-number-live-births-ivf-= pioneer-facility-applying-90" style=3D"text-decoration:none">https:/= /gsconlinepress.com/journals/gscbps/content/fertilization-icsi-generates-</= span></a> = 0;<a href=3D"https://gsconlinepress.com/journals/gscbps/content/fert= ilization-icsi-generates-higher-number-live-births-ivf-pioneer-facility-app= lying-90" style=3D"text-decoration:none"></a><a href= =3D"https://gsconlinepress.com/journals/gscbps/content/fertilization-icsi-g= enerates-higher-number-live-births-ivf-pioneer-facility-applying-90" style= =3D"text-decoration:none">higher-number-live-births-ivf-pioneer-faci= lity-applying-90</a>14= .Dang VQ, Vuong LN, Luu TM, Pham TD, Ho TM, Ha AN, et al. Intracytoplasmic = sperm injection versus conventional in-vitro fertilisation in couples</span= > with infertility in= whom the male partner= has normal total </sp= an>sperm count and motility: = an open-label, randomised controlled trial.</spa= n> The Lancet [Internet]. 202= 1 [cited 2025 March 23]. 397(10284): 1554-1563. Avaible from: <a hre= f=3D"https://www.sciencedirect.com/science/article/pii/S0140673621005353" s= tyle=3D"text-decoration:none"></a><a href=3D"https:/= /www.sciencedirect.com/science/article/pii/S0140673621005353" style=3D"text= -decoration:none">https://www.sciencedirect.com/science/article/pii/= S0140673621005353</a>1= 5.Iwamoto A, Van Voorhis BJ, Summers KM, Sparks A, Mancuso AC. Intracytopla= smic sperm injection vs. conventional in vitro<spa= n class=3D"awspan" style=3D"letter-spacing:-0.05pt"> fertilization in patients with non-male<s= pan class=3D"awspan" style=3D"letter-spacing:-0.2pt"> factor infertility. Fertility</= span> and Sterility [Internet]= . <spa= n class=3D"awspan">2022 [cited 2025 March= 23]. 118(3): 465-472. Available from: <a href=3D"https://www.scienc= edirect.com/science/article/pii/S0015028222003879" style=3D"text-decoration= :none"></a><a href=3D"https://www.sciencedirect.com/= science/article/pii/S0015028222003879" style=3D"text-decoration:none"><span= class=3D"awspan" style=3D"text-decoration:underline; letter-spacing:-0.1pt= ">https://www.sciencedirect.com/science/article/pii/S0015028222003879</span= ></a>Esta </span= >revista<= /span> est=C3=A1 protegida bajo una licencia Creative Commons en la 4.0 International. 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