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= Trasto= rnos de la función tiroidea en pacientes de consulta externa del Hospital IESS-M= acas período 2021

Thyroid function disorde= rs in outpatient patients of the IESS-Macas Hospital period 2021

 

1

Jackeline García Mejía                                            https://o= rcid.org/0000-0001-8061-21356

Universidad Cató= lica de Cuenca. Cuenca, Ecuador

jackeline.garcia.94@est.ucacue.edu.ec

2

 Edmundo Estevez Montalvo =                                        =          https://orcid.org/0000-0001-7865-5099

Universidad Cató= lica de Cuenca.  Cuenca, Ecuador

luis.estevez@uca= cue.edu.ec

 

 

 

 

 

 

 

Artículo de Investigación Científica y Tecnológica<= o:p>

Enviado: 10/08/2022

Revisado: 12/09/2022

Aceptado: 10/10/2022

Publicado:02/11/2022   

DOI: https://doi.org/10.33262/anatomiadigita= l.v5i4.1.2382      

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Cítese: <= o:p>

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García Mejía, J., & Estevez Montalvo, E. (2022). Trastornos de la función tiroidea en pacientes de consulta externa del Hospital IESS-Macas período 2021. Anatomía Digital, 5(4.1), 25-45. https://doi= .org/10.33262/anatomiadigital.v5i4.1.2382

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ANATOMÍA DIGITAL, es una Revista Electrónica, Trimestral, que se publicará en soporte electrónico tiene como misión contribuir a la   formación de profesion= ales competentes con visión humanística y crítica que sean capaces de exponer&= nbsp; sus resultados  investigativos y científicos en la misma medida que = se promueva mediante su intervención cambios positivos en  la sociedad. https://anatomiadigital.org  

La revist= a es editada por la Editorial Ciencia Digital (Editorial de prestigio registra= da en la Cámara Ecuatoriana de Libro con No de Afiliación 663) www.celibro.org.ec<= u>

 

 

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Palabras Clave: Enfermedades de la Tiroides, Hipotiroidismo; Hipertiroidismo

 

 

Resumen

Introducción. Las tiroideopatías  continúan siendo patologías muy frecuentes en la población a nivel mundial, constituyen un gran impacto en los sistemas de salud lo que se traduce en grandes rubros destinados para el tratamiento de la misma. Objetivo. Caracterizar las patologías de Hipotiroidismo e Hipertiroidismo a partir = de su prevalencia en pacientes que acuden al Área de Consulta Externa del Ce= ntro Clínico Quirúrgico Ambulatorio HD-IESS Macas período 2021. Método. Inv= estigación de tipo descriptiva, transversal, retrospectivo durante el período de Enero–Diciembre de 2021.La muestra correspondió a 620 registros de pacien= tes. Resultados. Se presentó una frecuencia = del 41,8% de alteraciones de la función tiroidea, además dentro de las principales características de los pacientes se incluyeron la edad (entre= 30 y 64 años) con 66,0%, Sexo (Femenino 83,4%). Solamente el 2,7 % de los pacientes presentaron valores bajos de TSH considerándolos pacientes Hipertiroideos, en contraste con valores altos de TSH en 39,1% de pacient= es Hipotiroideos y el 58,2% de los pacientes presentaron valores normales de= TSH, representando este porcentaje a pacientes sanos o Eutiroideos. Conclusión. Se determinó que el sexo femenino presentó mayor frecuencia de casos asociad= os a trastornos de la función tiroidea con mayor énfasis en hipotiroidismo.  El grupo etario que prevaleció fue el= de los adultos mayores.

 

 

Keywords: Thyroid Diseases, Hypothyroidism; hyperthyroidis= m<= /o:p>

 

Abstract

Introduction. Thyroid diseases continue to be very frequent pathologies in the population worldwide, they constitute a great impact on health systems, which translates into large items destined for its treatment. Objetive. Characterize the pathologies of Hypothyroidism and Hyperthyroidism based on their prevalen= ce in patients who attend the Outpatient Area of ​​the HD-IESS M= acas Ambulatory Surgical Clinical Center, period 2021. Method. Descript= ive, cross-sectional, quantitative research with a documentary and retrospecti= ve design during the period of January-December 2021. The sample corresponde= d to 620 patient records. Results. A frequency of 41,8% of alterations = in thyroid function was presented, in addition, the main characteristics of = the patients included age (between 30 and 64 years) with 66,0%, Sex (Female 8= 3,4%). Only 2,7% of the patients presented low TSH values, considering them Hyperthyroid patients, in contrast to high TSH values ​​in 39= ,1% of Hypothyroid patients and 58,2% of the patients presented normal TSH values, representing this percentage to healthy or Euthyroid patients. Conclusion. It was determined that the female sex presented a higher frequency of cas= es associated with thyroid function disorders with greater emphasis on hypothyroidism. The age group that prevailed was that of older adults.

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Introducción.

A manera de antecedente, culturas como la china o la egipcia describ= ían desde entonces al bocio y a su tratamiento por medio de la ingesta de algas marinas, también se menciona a procedimientos quirúrgicos poco exitos= os donde el paciente terminaba por fallecer. Según Roca, el proceso de descubrimiento y estudio de la tiroides estuvo limitado a los impedimentos y restricciones que existían. Las patologías tiroideas fueron descritas desde= el siglo XIX, razón por la cual se han acuñado términos como bocio y cretinism= o, mismos que permitieron la continuidad de la investigación basada en el yodo para la recuperación y disminución de las tasas de morbimortalidad de la ép= oca.  En los orígenes de las patologías podemos encontrar al cretinismo, palabra usada en los dialectos suizos, elaborada para referirse a los niños que sufrían retr= asos intelectuales o mentales producto del hipotiroidismo congénito.  Ya por los años 1797 entra en la comuni= dad científica las primeras investigaciones, en las que se describe a la “enfermedad de coto” y su tratamiento. En el documento publicado en Paris el científico comenta cómo los indígenas de la región andina trataban el bocio consumiendo el agua rica en minerales y sales.  Los años siguientes se comenzaron a real= izar autopsias y análisis a la forma y función de la tiroides, para los 1981 el científico George R. Murray luego de tratar a un paciente con cretinismo lo= gra una recuperación tanto intelectual como física, resultados interesantes tra= tando con extracto de glándula tiroides fresca proveniente de ovejas, así como también preparados de rábano con yodo para tratar este mismo bocio endémico. Otros avances dentro de la prevención de apariciones de patologías tiroidea= s se plantean en Colombia por 1950, en dónde se plantea incluir al yodo en la sa= l de consumo doméstico, práctica que fue replicado en todo el mundo (1). Para los últimos avances importantes dentro = del tratamiento en 1927 los químicos Harington y Barger logran sintetizar la tiroxina, así dejando atrás al uso de extractos animales de la glándula.

Ent= re las enfermedades producidas por trastornos de la función tiroidea está el hipotiroidismo, mismo que se produce por problemas dentro de la actividad d= e la hormona tiroidea a lo largo del organismo, efecto que producirá un ascenso gradual de los niveles de TSH para tratar de equilibrar la hormona tiroidea, seguido de un aumento en la producción de T3 (triyodotironina) con relación= al T3 y consecutivamente un aumento de T3 y T4 en dirección a los tejidos periféricos, procesos que subyacen en tipos de hipotiroidismo; clínico o manifiesto y en situaciones más graves coma mixedematoso (2).

La clasificación de las alteraciones tiroideas se realiza en función = del trastorno de la glándula tiroidea. Pues entonces, el hipotiroidismo primari= o, el cual se presenta en la mayor parte de casos se encuentra en la glándula tiroides. Otros como el hipotiroidismo secundario que se presenta en la hipófisis o el hipotiroidismo terciario en el hipotálamo son menos frecuent= es (2).

El hipotiroidismo primario se presenta por la disminución del tejido = de la glándula tiroidea y por la alteración a nivel de funcionamiento de la mi= sma. Al existir un descenso en los niveles de T4 y T3 se produce un efecto de compensación, en el que los niveles de TSH aumentan. En el hipotiroidismo clínico la TSH se mantiene elevada; mientras que T3 y T4 disminuyen, en tan= to que el hipotiroidismo subclínico la TSH se mantiene arriba mientras que T3 = y T4 permanecen con niveles normales, usualmente es un hipotiroidismo subclínico= que puede desembocar en un clínico (2). Y el hipotiroidismo central presenta niveles insuficientes de TSH, = una de las causas es la aparición de adenomas hipofisiarios, la presencia de ot= ras patologías como la tuberculosis o la sarcoidosis en el hipotálamo e hipófii= s, también puede ser causada por efecto secundario de fármacos o incluso por accidentes vasculares. En menor caso se ha visto fenómenos genéticos que impiden el adecuado desarrollo de TSH, T3 y T4.

La tiroiditis de Hashimoto o tiroiditis crónica autoinmune se da por = la infiltración de linfocitos sensibilizados en la glándula, lo que conlleva a= que la producción hormonal descienda paulatinamente, es decir se produce una destrucción autoinmune de la glándula.  Otras variaciones de este tipo de tiroiditis son la tiroiditis pospa= rto y la tiroiditis silente, en las cuales se puede dar el paso de una condició= n de hipotiroidismo a hipertiroidismo y viceversa (2).

Los tratamientos han evolucionado activamente, desde la preparación de medicamento en base a la glándula tiroidea de ciertos animales hasta la configuración de los parámetros de TSH en sangre. A pesar de ser un tratami= ento homogéneo, existen autores que consideran poco eficiente en casos donde exi= sten variaciones celulares como los tipos periféricos. Después de descubrir el síndrome de Allan- Herndon-Dudley que provoca alteraciones en el transporta= dor MCT8 afectando solo a varones, el cual causa discapacidad intelectual ha obligado a la comunidad científica a replantearse otra alternativa terapéut= ica que abarquen tipos menos comunes de problemas tiroideos (3).

Dentro del estudio de Garcés en el cual se investigó la relación entr= e la artritis reumatoidea y el hipotiroidismo se tomó información de 265 pacient= es con edades entre los 32 y 66 años de edad siendo el 76,98% de sexo femenino, destacándose el grupo de pacientes entre los 56 y 65 años. De los cuales el= 49,37% sobrepasa los 65 años, poseen artritis reumatoidea e hipotiroidismo, seguid= os de los grupos etarios de entre 56 - 65 años y 46 - 55 años, evidenciándose = que ningún paciente menor de 46 años con artritis reumatoide tuvo la asociación=  con hipotiroidismo (4).   A pesar de que existió un alto porcentaj= e de pacientes con los dos diagnósticos no se encontró evidencia de correlación.=

Por otro lado, se encuentra con menos frecuencia de  patologías tiroideas a la hiperfunción = de la glándula, en primer lugar, está el BTD (bocio tóxico difuso) el cual es la forma más común de manifestación hipertiroidea, las mujeres son las más afectadas (5).

El hipertiroidismo es causado por un aumento de los valores de las hormonas tiroideas que se presenta mayormente en mujeres adultas, se puede observar una aparición en 0,1 de cada 100.000 niños y 1 de cada 100.000 adolescentes. Así como en el hipotiroidismo, el hipertiroidismo también pue= de presentarse como respuesta autoinmune la Hashitoxicosis causada por la inflación glandular. Otro desorden común en el diagnóstico, es la enfermedad Basedow – Graves (EG) en la cual se producen dentro del organismo anticuerp= os que sobre estimulan al receptor de TSH. Para el diagnóstico se considera a = la supresión de la TSH mientras que la T3 y T4 se presentan elevadas.

En estudios conducentes que analizan los problemas en pacientes infan= tes y adolescentes, de los cuales el 84,6% fueron femeninos, se encontró que los síntomas comenzaron a la edad de 4 a 9 años y se obtuvo el diagnóstico entre los 3 y 10 años. Uno de los pacientes analizados de sexo masculino comenzó = sus síntomas a los dos meses de nacido, el síntoma más evidente fue el aumento = de peso, con respecto al resto de pacientes presentó una duración de los signo= s de entre 6 a 10 meses antes del diagnóstico. El 42% de los niños presentaba historial familiar de enfermedades tiroideas y los síntomas que más se presentaron fueron la taquicardia con el 77%, la sudoración con el 80,7% y = el más encontrado fue el bocio con presencia del 96,2% de los pacientes estudiados. Dentro del estudio en 23 pacientes se realizó ecotomografía, la misma que mostró 19 pacientes con bocio difuso y 3 con bocio nodular, a los cuales las pruebas de laboratorio constataron la presencia de anticuerpos T= RAb (6).

Uno de los problemas subyacentes del hipertiroidismo se encuentra en = el sistema cardiovascular en donde es imprescindible conocer cómo la hormona tiroidea trabaja sobre el miocito cardíaco, el estudio muestra que existe una alteración principalmente diastólica en pacientes que padecen hipertiroidismo subclínico, esto es debido a que mien= tras aumentan los valores de la hormona tiroidea a su vez origina un ascenso en = la contractilidad y frecuencia cardíaca; procesos que son causantes del deteri= oro en el miocardio para esto se conoce que = la síntesis de la T3 y T4 ocurre en la glándula tiroidea (7).

En pacientes en estado de gestación, los cambios hormonales dentro de= la glándula tiroidea pueden presentar disminución en las concentraciones de TS= H, niveles que suelen aumentar conforme evolucionan los trimestres. Otros valo= res funcionales que se encuentran, es el acrecentamiento proporcional de las concentraciones de TBH y T4T con el ascenso en los estrógenos, esta última llegando a 150% más. Algunas de las dificultades que puede presentarse en c= aso de que la madre sufra de hipertiroidismo pueden ser, abortos, preeclamsia, parto pretérmino, trombosis venosa, insuficiencia cardíaca o abruptio placentaria, para el feto las repercusiones puede ser un bajo peso de nacimiento, prematuridad, crecimiento intrauterino retrasado, muerte fetal, disfunción tiroidea o bocio fetal, en cuanto a riesgos para el recién nacid= o se encuentra el hipertiroidismo transitorio o permanente (8).

Otra población de estudio para el hipertiroidismo son aquellos pacien= tes con Síndrome de Down. En un estudio de 1832 personas se consiguió atender a= 12 pacientes con Síndrome de Down (SD) de los cuales 5 fueron hombres y 7 muje= res diagnosticados con padecimiento hipertiroideo, de esto se obtiene que la población con Síndrome de Down (SD) que parece es de 6,55 casos por cada mil personas atendidas en donde el rango de edad se ubicó entre los 11 a 29 año= s. Después del inicio del tratamiento algunos de los cambios que se observa, e= s el aumento en el peso y en la estatura. Dentro de este grupo se presentaron síntomas como la intolerancia al calor seguido de sudoración, pérdida de pe= so, 7 de ellos sufrían pérdida de sueño, 9 taquicardias e incluso irritación oftálmica (9).

Distintos padecimientos que se pueden diagnostic= ar por el trastorno de la glándula tiroidea son los nódulos, que en muchos de los casos entre 2 de 20 son malignos. Estos nódulos pueden ser causantes del hipotiroidismo y en ocasiones están llenos con líquidos u hormonas tiroidea= s, aquellos que tienen más densidad logran ser más propensos a ser cancerosos. Entre los factores de riesgo para presentar un nódulo está pertenecer al se= xo femenino, que, así como se ha visto a lo largo del documento, es más frecue= nte en mujeres. Haber estado expuesto a tratamientos radiactivos en especial en la cabeza o cuello. Y otros síndromes genéticos (10).

Entre los tipos de cáncer se encuentran cinco, el primero es el papilar tiroideo que se produce a partir de células folicular= es, en la mayoría de los casos se presenta en uno de los lóbulos también es importante mencionar que puede esparcirse hacia los ganglios linfáticos (10). El segundo tipo de cáncer folicular tiroideo n= ace a partir de células foliculares, sin embargo, este se desarrolló de una man= era más lenta; este tipo es menos probable que se disemine y tal como el anteri= or es diferenciado. El tercero es el cáncer de células Hurthle o también conoc= ido como carcinoma de células de Hurthle, este se disemina con más frecuencia h= acia los ganglios y se produce por algunas clases de células foliculares. El cua= rto es el cáncer medular de tiroides, que se produce en ciertas ocasiones por neoplasia endócrina múltiple tipo 2 o dentro de las células C; este tumor v= isto a través de un microscopio no tiene ninguna similitud con el tejido tiroideo normal. El último es el cáncer anaplásico de tiroides, en tipo menos frecue= nte, de crecimiento acelerado y puede ser la continuación de un tumor benigno, debido a la manera de crecimiento es más exitoso y fácil de tratar <= /span>(11).

Otros padecimientos tienen que ver con los trastornos psiquiátricos o enfermedades mentales, mismos que han llamado la atención dentro de las ciencias de estudio de la tiroides, debido a la existencia de padecimientos de trastorno bipolar en pacientes con hipotiroi= dismo o hipertiroidismo.

En la actualidad, las patologías de la función tiroidea cursan con enfermedades que aquejan al desarrollo biopsicosocial de las personas de ma= nera asintomática y pueden afectar desde la infancia. En el estudio de Vásqu= ez se describen algunos de los síntomas que presentan los pacientes hipertiroi= deos como taquicardias, pérdida de peso, alteraciones del sueño, palpitaciones, síntomas gastrointestinales y Bocio (12). La falta o exceso de yodo se encuentra directamente asociado a producir alteraciones de nódulos y enfermedades autoinmunes  (13).

En la ciudad española de Navarra, en un estudio realizado con informa= ción desde 1986 y 2010 se encontró un incremento en los casos diagnosticados de patologías tiroideas, así como el cáncer de tiroides en pacientes masculino= s y femeninos, con mayor incidencia en el sexo femenino. Se observa un aumento = del 4,7% anual en hombres y un 2,5% en mujeres. Dentro del estudio se encontró = que el 72,3% de los diagnósticos de cáncer de tiroides corresponden a carcinoma papilar, el cual es el más común, mientras que el 27,7% fue carcinoma folic= ular (14).

En Estados Unidos, las afectaciones tiroideas tienen una prevalencia = del 1,3% en la población, siendo más evidente en el sexo femenino. (15). Existen varios tipos de patologías tiroideas entre estas, el hipertiroidismo con un 0,3-0,4%, el hipotiroidismo subclínico con un 4,3%-8= ,5%, en mujeres de mediana edad se evidencian casos de alteraciones de la hormona estimulante de la tiroides (TSH) en un 6,2%, y otras alteraciones tiroideas crónicas se ubican en el 3,1% con mayor prevalencia en adultos hospitalizad= os (16). Cada vez es mayor el número de pacientes diagnosticados por enfermedades tiroideas y se estima que en el mundo existen más de 200 millo= nes de personas con trastornos de la tiroides (17).

En otr= os estudios se menciona que la propensión al diagnóstico se eleva en países del tercer mundo, así como en vías de desarrollo debido a la falta de yodo dent= ro de la alimentación (18). En América Latina y el Caribe existen hasta un 10% de población afec= tada siendo los tipos más frecuentes el hipotiroidismo secundario y subclínico, = este último influye desfavorablemente en mujeres de entre 60 a 65 años mientras = que el primero en mujeres de edad media, entre 30 a 50 años (19).

Dentro del estudio, direccionado a analizar el hipertiroidismo durant= e el embarazo, se encuentra que el desarrollo de la enfermedad durante la gestac= ión es menos común con un aproximado de 0,5% y también se menciona que aquellas autoinmunes pueden mejorar durante el embarazo (20).

El Ecuador según informes emitidos por el INEC (17), es considerado un lugar endémico de patologías de la glándula tiroi= dea, sobre todo en mujeres, encontrándose un predominio en la sierra, alcanzando hasta un 25% en zonas de la sierra central. Un estudio realizado en el 2010 mencionó que en Ecuador la aparición de cáncer de tiroides comparado con los registros mundiales disponibles revela una mayor incidencia relativa que el promedio mundial, ubicándonos en el primer cuartil en mujeres y en el segun= do cuartil en hombres; en varios años de análisis (21). El estudio concluye que las alteraciones de la glándula tiroidea de= ntro de la población se desencadenan por factores como el historial familiar del padecimiento, sedentarismo y estrés laboral (22).

En el estudio de tendencias epidemiológicas de cáncer de tiroides en = la zona centro de ecuador entre el 2012 y el 2016 se evidencia que en los años= de estudio el diagnóstico ha aumentado y, al igual que en muchos otros estudio= s, se evidencia que las mujeres tienen una probabilidad 6,7 veces mayor de presentar cáncer, así mismo se constata que un diagnóstico positivo es dire= ctamente proporcional con la edad, siendo los grupos más afectados, personas de entr= e 30 a 59 años  (22).

En este contexto, a nivel nacional las alteraciones tiroideas tienen incidencia variada, la morbilidad por hipotiroidismo e hipertiroidismo se encuentran cerca al 8% en personas adultas. La tasa de prevalencia de hipertiroidismo congénito es de 15% en recién nacidos. A nivel nacional el cáncer de tiroides ha crecido en los últimos años, siendo el segundo más frecuente en mujeres, después del cáncer de mama (23). Entre las patologías tiroideas más usuales en la Amazonía son el hipotiroidismo y el bocio, su incidencia es aproximadamente del 5-8% con ma= yor evidencia en mujeres y adultos mayores de 65 años (24).

En los últimos años se ha apreciado un incremento de estas Patologías= en el Servicio de Consulta Externa del Hospital del IESS-Macas, a pesar de lo mencionado anteriormente no se encuentran estudios referentes a la temática= en la Provincia de Morona Santiago, por lo que en la actualidad no se precisa = de manera cierta la incidencia; así como también las posibles causas que afect= an a los pacientes que acuden a esta unidad de atención médica.

Por estas razones expuestas anteriormente, el objetivo de la presente investigación fue; Caracterizar la Función Tiroidea para el cribado de hipotiroidismo, eutiroidismo e hipertiroidismo a partir de su prevalencia en pacientes que acuden al área de Consulta Externa del Hospital del IESS-Maca= s; en el período comprendido de Enero-Diciembre del año 2021; ya que a pesar de ser un problema frecuente, su manejo permanece aún controvertido.

Metodologia.

La presente investigación fue= de tipo descriptiva, transversal, cuantitativa con un diseño documental y retrospectivo. La población de estudio estuvo comprendida por 620 registros= de pacientes; quienes se realizaron análisis de pruebas para la Función tiroid= ea en el área de Laboratorio Clínico del Hospital IESS–Macas dentro del período Enero–Diciembre de 2021. Se utilizó un muestreo de tipo no probabilístico de cobertura total. Los datos fueron recopilados de fuentes secundarias de información, ingresados en los registros del área de Endocrinología dentro = del departamento de Laboratorio Clínico.

Criterios de inclusión: regis= tro de pacientes que se realizaron pruebas séricas hormonales de perfil tiroide= o: Triyodotiroxina Libre (FT3), Tetrayodotiroxina Libre (FT4), Hormona estimul= ante de la tiroides (TSH), registro de pacientes que fueron reportados como eutiroideos, hipotiroideos, e hipertiroideos, registro de pacientes de ambos sexos.

Criterios de exclusión: regis= tros clínicos que no tengan información completa, registros de pruebas de Función Tiroidea incompleta sin resultados en cualquier analito del perfil tiroideo. 

Tamaño muestra:  620 pacientes, cuyos registros estuvieron disponibles en la base de datos del departamento de endocrinología.

Las determinaciones fueron realizadas en el área de Laboratorio Clínico del Hospital del IESS-Macas mediante muestras sanguíneas de suero, obtenidas a través de venopunción. Se utilizó el Método de Quimioluminiscencia amplificada por enzimas del Equipo= IMMULITE que permite la medición de límites de detección más bajos comparados con la quimioluminiscencia "flash" convencional (25). Las pruebas hormonales de acuerdo = a la cuantificación de la función tiroidea se analizaron mediante un inmunoanáli= sis quimioluminiscente enzimático competitivo en fase sólida (26).

Para el análisis estadístico = se generó una base de datos en el programa IBM SPSS Statistics V21.0, se aplicó estadística descriptiva, análisis de frecuencia y prueba de chi-cuadrado, e= ntre las variables: servicio hospitalario, tipo de muestra, medición de la Funci= ón Tiroidea, sexo biológico y grupos etarios.

Aspectos éticos: esta investigación fue fundamentada en los principios y normas éticas establecid= as en la Declaración de Helsinki Adendum de Taiwán 2016 (27), garantizando protección y privacidad= a los derechos individuales de los datos de los pacientes; los cuales se obtuvier= on de los registros clínicos objeto de estudio; fueron manejados con estricta confidencialidad; y no se vulneró el derecho de ningún paciente.

Se protegió la base de datos = con clave de seguridad restringiendo su acceso; garantizando la dignidad, la integridad, el derecho a la autodeterminación, la intimidad y la confidencialidad de la información personal de las personas que participan = en la investigación. La información no se utilizó con otros fines que no sean = de carácter investigativo, no tuvo manejo público y no se harán nuevas investigaciones, respetando para lo que fueron usadas.

Resultados.

Los registros de mues= tras estudiadas que cumplieron los criterios de inclusión y exclusión fueron 620 pacientes atendidos en el área de Laboratorio Clínico del CCQ H-D IESS Maca= s; con individuos de ambos sexos, donde el 83,4% (N=3D 517) corresponde mayoritariamente al género femenino, seguido del masculino con un porcentaj= e de 16,6% (N=3D 103) existiendo una diferencia significativa. (Ver gráfico 1).<= o:p>

Gráfico1. <= /span>

Frecuencia de Sexo Biológico, CCQ H-D IESS Macas período enero – diciembre 2021.<= /o:p>

=  

La distribución por grupos etarios fue mayoritariamente del grupo de Adultos (= 30 a 64 años) correspondiente al 66,0% (N=3D 409); el grupo de Adulto Mayor (65 = años o más) con el 13,9% (N=3D 86); el grupo de Jóvenes (18-29 años) con el 9,2% (= N=3D 57); el grupo de Adolescentes (10-17 años) con el 8.7% (N=3D 54); por últim= o, el grupo de Niños (0-9 años) con el 2,3% (N=3D 14). (Ver gráfico 2).

Gráfico 2. 

Frecuencia de Grupo Etario, CCQ H-D IESS Macas período enero – diciembre 2021.

A continuación, en la tabla 1 se observa la distribución de los 620 pacientes= de acuerdo a la presencia de trastornos tiroideos en un período de seguimiento= de un año:

Tabla 1. =

Distribución de la muestra de acuerdo con las alteraciones de la glándula tiroidea

 =

Frecuencia

Porcentaje

Porcentaje válido

Porcentaje acumulad= o

Válidos

HIPOTIROIDISMO

242

39,0

39,0

39,0

EUTIROIDISMO

361

58,2

58,2

97,3

HIPERTIROIDISMO

17

2,7

2,7

100,0

Total

620

100,0

100,0

 =

Fuente: = IESS Macas período enero – diciembre 2= 021

Elaborado por: García y Ortiz (2022)

 

De manera similar, en la tabla 2 se muestra la relación entre estas enfermedad= es y el grupo etario de pacientes (niños, adolescentes, jóvenes, adulto, adulto mayor) de acuerdo a la edad de los individuos.

Tabla 2.

Distribución de enfermedades tiroideas de acuerd= o a la edad

 

GRUPO ETARIO

Total

Niños (0-9)=

Adolescentes (10-17)

Jóvenes (18-29)

Adulto (30-64)

Adulto mayor (65 o más)

= FUNCIÓN DE LA GLÁNDULA TIROIDEA

= HIPOTIROIDISMO

9a

30a

24a, b<= /span>

140b

39a, b<= /span>

242

64,3%

55,6%

42,1%

34,2%

45,3%

39,0%

= EUTIROIDISMO

5a

24a

31a, b<= /span>

257b

44a

361

35,7%

44,4%

54,4%

62,8%

51,2%

58,2%

= HIPERTIROIDISMO

0a

0a

2a

12a

3a

17

0,0%

0,0%

3,5%

2,9%

3,5%

2,7%

= Total

=  

14

54

57

409

86

620

100,0%

100,0%

100,0%

100,0%

100,0%

100,0%

Fuente: IESS Macas período enero – diciembre 2021

= Elaborado por: García y Ortiz (2022)

De acuerdo= a la incidencia de enfermedades tiroideas por grupos etarios, la incidencia de Hipertiroidismo fue similar para jóvenes (18-29) y adulto mayor (65 ó más),= en menor rango para adultos (30-64); sin importancia significativa para niños (0-9). Sin embargo, la incidencia de Hipotiroidismo es mayor en niños (64,3= %) que en adolescentes (55,6%) frente a adulto mayor (45,3%), jóvenes (42,1%) y adulto (34,2%); existiendo una diferencia significativa entre Hipotiroidism= o y grupo etario adulto. Considerando todas las disfunciones en conjunto y la relación con el grupo etario; los resultados mostraron una incidencia acumu= lada para Eutiroidismo (58,2%).

Según el s= exo biológico y la función tiroidea se evidencia una alta incidencia del sexo femenino frente al sexo masculino en los estratos para toda la muestra, existiendo mujeres eutiroideas con un 49,19%, hipotiroideas 32,10% e hipertiroideas 2,10%; mientras que al Sexo Masculino le corresponde un 9,03% para Eutiroideos. Como era de esperar, la incidencia de enfermedades de la tiroides es mayor en las mujeres en comparación con los hombres. (Ver gráfi= co 3).

 = ;

 = ;

 = ;

Gráfico 3.

Distribución de la funci= ón tiroidea de acuerdo con el sexo biológico


Discusión

A nivel mundial las patologías tiroideas en su mayoría son diagnosticadas en pacientes asintomáticos. La mismas aumentan conforme incrementa la edad, presentándose del 1 al 4% de predomino en pacientes de sexo femenino, al mi= smo tiempo es importante conocer los antecedentes familiares, personales y necesidad de exámenes de laboratorio y radiológicos (28).

En el País Vasco, al igual que en el resto de España y en otros países del mun= do, si bien ha sido claro desde el siglo XIX la situación de Déficit de Yodo, el panorama ha cambiado de forma significativa en las últimas décadas. Los cam= bios experimentados en los últimos 30 años se deben a diferentes factores, unos = de tipo legislativo, otros de adecuación de las diferentes administraciones, y otros asociados al papel desarrollado por las diferentes sociedades científ= icas en materia de Nutrición y alimentación (29).

Dentro del Ecuador varias provincias, entre ellas la de Tungurahua a razón del adelanto de procesos de desarrollo económico y desarrollo del sistema de sa= lud, ha presentado procesos de detección más eficientes, mismo que ha contribuido para que en la actualidad se detecte una alta tasa de diagnóstico de neoplasias, especialmente de tiroides, misma que se compara con países desarrollados (22)

Los resultados conseguidos a través de la presente investigación determinaron q= ue; un 83,4% corresponde mayoritariamente al sexo femenino, seguido del masculi= no con un porcentaje de 16,6%, observando una prevalencia de 32,10% de pacient= es femeninas con hipotiroidismo y un 2,10% con hipertiroidismo. Similar a los resultados alcanzados por Chaves et al. (30) en donde se determinó una mayor frec= uencia de pacientes de sexo femenino con el 57%. Al igual que el estudio de Excuer= et al. (31) en donde se observa un 52,2% de paci= entes femeninas. Así mismo, se encontró en el estudio de Maldonado (32), una prevalencia del 58,4% de sexo femenino y una prevalencia de hipertiroidismo del 14,4% en mujeres. De mane= ra similar, el estudio de Merchán et al. (33) determinó una mayor frecuencia del s= exo femenino con el 81%. En contraste con el estudio realizado por Castillo (34) en donde se observó una mayor frecue= ncia de pacientes de sexo masculino. Al igual que la investigación de Santana et= al. (35) en la cual se comprobó que existió una prevalencia de hipotiroidismo e hipertiroidismo de 1/3 de la población investigada, con un predominio del sexo femenino, así como en los estudios = de Álvarez (36) donde se observó mayor frecuencia de pacientes femeninas. De igual manera en el estudio de León et al. (37) se estableció una mayor frecuencia = del sexo femenino con el 63,3% y similar al estudio de López (38) en donde el 78,4% corresponde al sexo femenino.

En cuanto al grupo etario de pacientes, se encontró una mayor frecuencia de individuos dentro del grupo de adultos correspondiente al 66,0% seguido del grupo de adultos mayores con el 13,9%. Lo cual se relaciona con el estudio realizado por Villarreal (38) en donde se observa una media de 36,5= años en el grupo de pacientes entre 18-62 años. Y similar con el estudio realiza= do por Gordillo (39), en donde se estableció una edad pro= medio de 73,5 años y en el estudio de Castillo (34) en el cual se observó una mayor frecu= encia de individuos dentro de grupo de los adultos mayores con el 85,12%. Por otro lado, el estudio realizado guarda relación por una mayor frecuencia de pacientes hipertiroideos en el grupo de 51-60 años con el 5% y una prevalen= cia de pacientes hipotiroideos en el grupo de 61-70 años con el 21% (39). Así también, la edad promedio del estudio de Velásquez et al. (12) en donde se fijó una edad media de = 58 años y del estudio de Gutiérrez et al. (40) en el cual se observa una media de = 73,6 años. Es decir, todos los estudios que se enumeran y muchos otros, menciona= n de manera reiterada a la incidencia de las patologías tiroideas, mismas que se encuentran presente en pacientes de sexo femenino, de entre 30 a 59 años, siendo el grupo más frecuente las pacientes entre los 40 a 50 años de edad.=

En relación a los trastornos de la función tiroidea, se halló que existe un 39= ,0% de pacientes que presentaron hipotiroidismo y en menor frecuencia un 2,7% presentaron hipertiroidismo. A demás guardan relación con los resultados de León et al. en donde se identificó un 29% de la muestra con hipotiroiditis, frente a un 18% con hipotiriodismo. A diferencia de la investigación realiz= ada por Villarreal (41) en donde se determinó que un 86% pre= sentó eutiroidismo mientras que un 10,5% fue diagnosticado con hipertiroidismo y = un 3,5% con hipotiroidismo; en contraste con el estudio de Peñaloza (42) en donde se observó una prevalencia = de pacientes con hipertiroidismo asociado al 85% de los casos. De la misma for= ma dentro del estudio de Velásquez se encuentra que dentro de 159 pacientes 18= de ellos se diagnosticó con hipertiroidismo,  de los cuales se observa una diferencia en los síntomas presentados = (43).  <= /span>Así mismo los antecedentes de los pacientes incluyen diabetes, en el 40.5% de hipotiroideos y el 11.1% de hipertiroideos, diabetes en porcentajes similar= es en los dos grupos, entre el 11% y el 13%, osteoporosis en un rango de entre= 11% y 12% para ambos grupos, entre otras (12).

Sin embargo, el hipertiroidismo es mayor en niños (64,3%) que en adolescentes (55,6%) y en menor medida en adultos mayores (45,3%) y jóvenes (42,1%). A diferencia del estudio realizado por Gordillo et al. (25), en donde se determinó que el hipertiroidismo es más frecuente en el grupo etario de pacientes con edades comprendidas entre los 51-60 años con el 10,71%. A diferencia de la investigación realizada por Cando et al.(24) en donde se estableció un total de = casos de alteraciones tiroideas con el 78,57% en mujeres, dentro de las cuales 7 mujeres presentaron hipertiroidismo subclínico, mientras que 3 mujeres presentaron hipotiroidismo subclínico. A diferencia del estudio de Quintana= et al. (44) en donde se encontró una frecuencia del 32,4% de pacientes con disfunción tiroidea en el cual el grupo etario de ed= ad de entre 40-49 años son los más representativos.

Conclusiones

·      =    Dentro de las características sociodemográficas de los pacientes que conforman la muestra de estudio, se observa una mayor frecuencia de pacientes de sexo femenino correspondiente = al 83,4% y en menor medida, se encuentran los pacientes de sexo masculino con = un porcentaje de 16,6%. Así mismo, según el grupo etario se observa una mayor frecuencia en adultos de entre 30-64 años con el 66%, seguido de los adultos mayores (>65 años) con un 13,9%, el grupo de jóvenes (18-29 años) con el 9,2%.

·      =    En relación a la incidencia de las enfermedades, se observa que existe una mayor frecuencia de hipertiroidismo= en pacientes dentro del grupo etario jóvenes (18-29 años) y adultos mayores (&= gt; 65 años). Por otro lado, en relación con el hipertiroidismo es más frecuent= e en el grupo etario de los niños con un 64,3% de los casos, mientras que en los adultos mayores corresponde al 45,3%.

·         Finalmente, en relación al sexo, se observa una mayor frecuencia de pacientes femeninos en cada uno de los grup= os etarios, identificando a pacientes de sexo femenino hipotiroideas con el 32,10%, hipertiroideas con el 2,10% y mujeres eutiroideas con el 49,19%

 =

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40.      Martin E, Ocampo H, Elena S, C= abezas G, Martin Hernandez Ocampo E, Hugo V, et al. Características clínicas y epidemiológicas de pacientes mayores de 65 años con diagnóstico de hipotiroidismo. Anales de la Facultad de Medicina. UNMSM. Facultad de Medicina; 2019;80(2):264‑5. DOI: 10.15381/ANALES.802.16425

41.      Villareal M. Descripción de la= prevalencia de trastornos tiroideos en trastornos mentales graves. Monterrey: Tecnológ= ico de Monterrey; 2017 [cité le 28 septembre 2022]. Disponible: https://repositorio.tec.mx/bitstream/handle/11285/636272/TESIS%20PDF%20MAR= IANA%20VILLARREAL%20CALDERON%20918150.pdf?sequence=3D3&isAllowed=3Dy.

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43.      Mogrovejo D. Hipertiroidismo e Hipotiroidismo como factores de riesgo para el desarrollo de enfermedad cardiovascular en pacientes que acudieron al servicio de Endocrinología del Hospital del IESS Manuel Ygnacio Monteros Valdivieso de Loja. Loja; 2019 [= cité le 28 septembre 2022]. Disponible: https://dspace.unl.edu.ec/jspui/bitstream/123456789/21910/1/TESIS%20MOGROV= EJO%20PALACIOS%20DAVID%20RICARDO.pdf.

44.      Maffei MVM, Cabral SAB, Cruz F= VS. Disfunción tiroidea en pacientes con diabetes mellitus tipo 2 ¿Una asociac= ión frecuente? Revista Virtual de la Sociedad Paraguaya de Medicina Interna. 2016;33‑41. DOI: 10.18004/rvspmi/2016.03(01)33-041=

 

 

El artículo que se publica es= de exclusiva responsabilidad de los autores y no necesariamente reflejan el pensamiento de la Revista Anatomía Digital.

 


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El artículo queda en propiedad de= la revista y, por tanto, su publicación parcial y/o total en otro medio tiene = que ser autorizado por el director de la Revista Anatomía Digital.<= /o:p>

 

 


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ISSN: 2697-3391=

Vol. 5 No. 4.1, pp. 25= – 45, octubre 2022

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                                      Ingeniería Genética               Página 25 | 1

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