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Psicosis en el embarazo y posparto, manejo actua= l. Revision bibliografica

 

Psychosis in pregn= ancy and postpartum, current handling. Bibliographicalrevsion

 

Diana Estefania Salazar Flores. [1], Juan Carlos Salazar Flores. [2], Paul Roberto Salazar Robalino. [3] & Johanna Estefanía Suquilanda Toapanta. [4] =

 

Recibido: 11-05-2021 / Revisado: 22-05-2021 /Aceptado: 08-06-2021/ Publicado: 05-07-2021

 

DOI:  https://doi.org/10.33262/a= natomiadigital.v4i3.1792  

 

Abstract.

 <= /o:p>

Introduction. Mental illness is a challenge for medicine, sin= ce the doctor must trust what the patient tells him since there are no visib= le signs to reach a diagnosis. The best therapeutic option is necessary to t= reat the psychiatric pathology around pregnancy without harming neither its development nor the woman's own health. In the same way, it is to be able= to have management guidelines for women who develop psychosis in the puerper= al period in order to maintain an adequate quality of life for both the moth= er and the newborn and their families; An adequate and even more personalized management protocol has not been established for pregnant and postpartum patients who decline in their mental state, leading to the establishment = of a psychiatric pathology that, without adequate follow-up, triggers a serious health problem. The main objecti= ve is to promptly recognize the different psychosis disorders during pregnan= cy and postpartum to be able to give their appropriate treatment, since in o= ur environment it is very lightly taken by non-psychiatric professionals and thus initiate an awareness of general practitioners of the current proble= m of non-organic, but mental field of the patients. The methodology of this research work is carried out around bibliographic reviews in the medical literature on the psychiatric repercussion that occurs in certain pregnant women as well as in mothers = in the immediate, mediate and late puerperal period. Results. Post-traumatic stress syndrome shows a prevalence of= 1%, appears between 24 and 48 hours after a difficult delivery. Postpartum depression there is a prevalence of 50-70% or even 80% of births on the t= hird day postpartum, but it does not usually exceed a week. Postpartum depress= ion in 10-15% of women in the first 2-3 months after delivery. Postpartum psychosis occurs in about 1-2 per 1,000 births, although other authors determine 3 per 1,000.

Keywords: Pathology. Therapy. Gestation. Woman. Puerperal. Neonate<= /span>

 

Resumen.

 

Introducción. La enfermedad= mental en un desafío para la medicina, ya que el médico debe confiar en lo que le dice el paciente ya que no hay signos visibles para llegar a un diagnósti= co. Es necesario la mejor opción terapéutica para tratar la patología psiquiátri= ca en torno a la gestación sin con ello perjudicar ni el desarrollo de la misma= ni la salud propia de la mujer. De igual manera es poder tener directrices de manejo para las mujeres que desarrollan psicosis en el periodo puerperal<= span style=3D'mso-spacerun:yes'>  en aras de mantener una adecuada cali= dad de vida tanto para la madre como para el neonato y sus familias; no se ha establecido un protocolo adecuado de manejo y más aún personalizado para aquellas pacientes gestantes y puérperas que declinan en su estado mental conllevando a establecer una patología psiquiátrica que sin un seguimiento adecuado desencadena en un grave problema de salud. El objetivo principal es reconocer con prontitud los diferent= es trastornos de psicosis durante el embarazo y posparto poder dar su tratamiento adecuado, ya que en nuestro medio es muy tomado a la ligera p= or los profesionales no psiquiátricos e iniciar así una concientización a los médicos generales de la problemática actual de ámbito no orgánico, sino mental de los pacientes. La metodología del presente trabajo investigativo se realiza en torno a revisiones bibliográfica en la literatura médica sobre la repercusión psiquiátrica que se presenta en determinados gestante= s así como en madres en periodo puerperal inmediato, mediato y tardío. Resultados. Síndrome de estrés postraumático muestra una prevalencia de 1 %,  aparece entre las 24 y 48 horas después de un parto dificultoso. Depresión del puerperio hay una prevalen= cia de 50-70 % o incluso 80 % de los nacimientos al tercer día del posparto, = pero no suele superar la semana. Depresión posparto entre 10-15 % de las mujer= es en los 2- 3 primeros meses luego del parto. Psicosis posparto se presenta= en alrededor de 1-2 por cada 1 000 nacimientos, aunque otros autores determi= nan 3 por cada 1 000.

Palabras claves: Patología. Terapéutica. Gestación. Mujer. Puerperal. Neonato

 

 

Introducción

El presente trabajo investigativo como revisión bibliográfica se ha instaurado con el fin de dar luces a un proble= ma que, siendo muy frecuente en nuestro medio, no se ha establecido un protoco= lo adecuado de manejo y más aún personalizado para aquellas pacientes gestante= s y puérperas que declinan en su estado mental conllevando a establecer una patología psiquiátrica que sin un seguimiento adecuado desencadena en un gr= ave problema de salud.

Por ende, la problemática a resolver es la determinación fisiopatológica que desencadena en una gestante la aparición = de eventos psicóticos que repercuten en un inadecuado control prenatal e inclu= sive con la pérdida del producto.  =

Desde los albores de la historia de la psiquiatría= , se ha sabido que el nacimiento de un hijo puede acarrear complicaciones psiquiátricas. Es así como, desde los principios de la edad clásica, en Lorete (2018) se indica que Hipócrates en la antigüed= ad ya describió las enfermedades mentales graves que aparecían después del parto,= a las que denominó "locura de las parturientas".<= /p>

Desde los finales del siglo XVI y en el siglo XVII, los expertos alemanes en Rechtsmedizin (medicina legal) produjeron múltiples estudios sobre el escabroso tema del neonaticidio, tan prevalente en Europa durante varios= siglos. En el ańo 1757 un médico inglés describió en los Proce= edings of the Royal Society, obsesiones de infanticidio. Esta fue la prim= era mención de un grupo de trastornos de ansiedad que ahora incluyen la tocofob= ia, el pánico puerperal, fobia hacia el bebé, miedo patológico de muerte súbita= del nińo, dismorfofobia pre y postparto, el trastorno por estrés postraumático = y el trastorno querulante (litigioso) que pueden ser consecuencia de un parto traumático. (Liji, 2019)

Pero es a partir del siglo XIX cuando las manifestaciones psíquicas unidas al puerperio se individualizan y en 1895, MARCE expone claramente el problema de la especificidad etiológica, clínica= y evolutiva de las psicosis puerperales. (Moure, = 1997)

Es imprtante saber el concepto de buena salud perinatal para prevenir alteraciones entre las buen= as relaciones sociales, psicológicas, ambientales y biológicas. Es imprtante agendar la cita postparto antes de las seis semanas en mujeres que reflejen síntomas depresivos o psicóticos en el postparto inmediato para detección temprana de quienes cursan con una depre= sión de base, o presenten historia de depresión o psicosis postparto previa. Una hospitalización temprana es el manejo principal del paciente para asegurar = su bienestar y el del neonato, además de tratamiento farmacológico con medicamentos antipsicóticos y terapia de cualquier trastorno subyacente. Au= nque los episodios de psicosis durante el embarazo son raros, las mujeres con historial de esta condición tienen un mayor riesgo de reincidencia.

Un estudio encontró que el embarazo parece empeora= r la salud mental de la madre con esquizofrenia. Algunas mujeres presentan negac= ión psicótica del embarazo, síntoma que de no ser abordado puede representar un factor de riesgo. En el postparto, estas mujeres pueden ser especialmente susceptibles a exacerbaciones agudas de la esquizofrenia. (Arrate, Molina, & Linares , 2016)

Por otro lado, un metaanálisis que contó con datos= de 12 estudios que incluyeron a 700 sujetos con esquizofrenia y 835 sujetos en= el grupo control, encontró asociaciones significativas entre el trastorno y la ruptura prematura de la membrana, edad gestacional menor a 37 semanas y uso= de incubadora y resucitación. Otra investigación también encontró que tenían m= ás riesgo de parto prematuro y, además, la esquizofrenia durante el embarazo se asociaba a bajo peso al nacer. (Bas, 2017)

En cuanto al tratamiento, la psicoeducación podría reducir el riesgo de complicaciones en el embarazo. Las terapias breves enfocadas también pueden ser útiles para algunas pacientes con dicha condic= ión psicológica. Con respecto al tratamiento farmacológico, un estudio de dos c= asos de mujeres medicadas con clozapina para la esquizofrenia durante el embaraz= o no observó riesgos en el embarazo, parto, la salud de la madre ni del bebé.

Para Fonseca (2018) “La psicosis postparto suele presentarse luego de dos semanas del nacimiento, siendo delirios y alucinaciones junto con pensamiento desorganizado los síntomas pivotes que caracterizan el cuadro. Durante este trastorno también se pueden presentar otras alteraciones del estado de ánimo entre los que se encuentran: ansieda= d, irritabilidad, agitación psicomotora y dificultad para conciliar el sueńo no asociado al recién nacido. Existen otros trastornos psiquiátricos que con frecuencia se relaciona a la psicosis postparto”.

La psicosis posparto puede presentarse como un est= ado maníaco, depresivo o mixto entre los pacientes con trastorno bipolar. Las mujeres con trastorno bipolar tienen un alto riesgo de recidiva en el embar= azo y después del parto, que puede presentarse como psicosis posparto. Las muje= res que dejan los medicamentos estabilizadores del ánimo antes o durante el embarazo pueden tener un mayor riesgo de psicosis posparto. Para las mujeres sin historia previa, un episodio psicótico después del parto puede ser la primera manifestación de un trastorno bipolar. (Fonsec= aVillanea, 2018)

La psicosis postparto requiere un reconocimiento temprano, con un manejo pluridisciplinario. Se debe tener claro que la psic= osis puerperal es una urgencia psiquiátrica, pues compromete el pronóstico de madre-hijo, por el riesgo de agresión que presenta el trastorno.=

Actualmente, se está desarrollando el concepto de psiquiatría perinatal que tiene como objetivo ayudar a las madres a preveni= r lo más precozmente posible las alteraciones psiquiátricas posteriores al parto= y garantizar un buen desarrollo mental del neonato. (Fon= secaVillanea, 2018)

En la actualidad se sabe que alrededor del 50% de = los episodios de depresión posparto comienza en realidad en el embarazo por lo cual; En 2013, la versión más reciente de la clasificación de enfermedades mentales de la Asociación Americana de Psiquiatría (DSM-5), recogió estos avances y, en los criterios para Depresión Mayor, sustituyó el antiguo espe= cificador “de comienzo en el posparto” por el especificador “con inicio en el peripar= to”. Esta denominación se puede utilizar para especificar que el episodio depres= ivo mayor se presentó durante el embarazo o en las cuatro semanas posteriores al parto. (Jadresic, 2017)

El desafío es enorme, pero podemos ser optimistas.= La ignorancia, el pesimismo ya no se justifican. Estamos en una posición mucho= más sólida para comprender lo que están padeciendo estas mujeres con trastornos= y para intervenir eficazmente. Actualmente se puede hacer mucho para restable= cer su salud mental plena. Todo esfuerzo que hagamos para mejorar el bienestar = y el ánimo de las madres es una contribución a la vida de la familia y la salud = de la generación siguiente. (Brockington I. , 2017)

Metodología

El presente trabajo investigativo se realiza en torno a revisiones bibliográfi= ca en la literatura médica sobre la repercusión psiquiátrica que se presenta en determinados gestantes, así como en madres en periodo puerperal inmediato, mediato y tardío.

Tras la revisión bibliográfica, se analizaron varios artículos, entre los ańos 2= 016 hasta la actualidad, de los cuales nos enfocamos alrededor de 15 artículos = por su pertinencia, los cuales muestran solilitud c= on el presente estudio. Se utilizaron para ello las bases de datos enfermeras Library, Medigrafic, Psiqu= iatria, Revista medica clinica Condes, psiquiatriafacmed, Revista Médica Siner= gia, Pubmed, Dialnet, Cochrane y Scielo. y el metabuscador Google Académico.

Se realizo una revisión de las referencias en los artículos seleccionados.

Se hizo una búsqueda específica en referecia a cad= a base de datos, empleando la combinación de operadores booleanos de los siguiente= s terminos controlados: "Embarazo" (Pregnancy), "Posparto" (Postpartum period), "Trastornos psicóticos" (Psychotic disorders).

Se utilizaron criterios de inclusion como son: est= udios que analizaran la etiología de la psicosis puerperal y ensayos clínicos controlados aleatorios que investigaran los efectos de las opciones de tratamiento donde esta incluida la atencion psicosocial estándar, fármacos antipsicótico= s, terapia cognitivo conductual y manejo actual integral en mujeres gestantes = y en periodo postparto con diagnósticos de trastornos psicóticos. Sin limitacion idiomatica ni temporal.

Resultados y discusió= n

Se seleccionaron 7 artículos científicos para la presente revisión bibliográfi= ca. En cuanto al diseńo de los artículos hubo 5 artículos de revisión, dos de l= os cuales constan en la base de datos COCHRANE, 2 de MEDIGRAFIC, PERINATOLOGIA REPRODUCCION HUMANA, 1 revisión de la ASOCIACION GALLEGA DE PSIQUIATRIA , un caso clínico en MEDISAN, 1 revision tomada del portal BIBLIOPSIQUIS.

Factores predisponentes

Los trastornos del estado de ánimo del puerperio: tristeza postparto, depresión= postparto y psicosis postparto tienen una alta prevalencia. Éstos afectan directament= e la salud física y emocional de la madre, al igual que la del recién nacido y la pareja, produciendo inestabilidad en el entorno familiar y social de quien = la padece.  (Medina-Serdán, 2013)=

De acuerdo a Arrete, Molina, L= inares(2016), existen factores predisopinentes que se pueden = menciohnar como:

Síndrome de estrés postraumático: Muestra una prevalencia de 1 % y aparece normalmente entre las 24 y 48 horas después de= un parto dificultoso. Se presenta con ansiedad asociada con pesadillas e imáge= nes recurrentes de la experiencia vivida. Es un cuadro pasajero; escasas veces = se cronifica. No necesita tratamiento específico.

Depresión del puerperio: Estado de ánimo melancóli= co, larvado, que puede pasar inadvertido. Se notifica una prevalencia de 50-70 = % o incluso 80 % de los nacimientos. Comienza alrededor del tercer día del posparto, pero no suele superar la semana. Si se intensifican los síntomas o duran más de un mes, se debe valorar el riesgo de cronificación.

Depresión posparto: Afecta entre 10-15 % de las mujeres en los 2- 3 primeros meses luego del parto; resulta la complicación médica más habitual de este período. El cuadro sintomático es el típico de = una depresión: sentimiento de culpa, trastornos del sueńo, cambios de humor con gran tendencia a la tristeza y ausencia de síntomas psicóticos. Mejor pronóstico que las depresiones de otra causa, pero en casos graves requiere hospitalización. Entre otros factores de riesgo se citan: edad materna (men= or de 20 ańos y mayor de 30), problemas psiquiátricos o psicológicos durante el embarazo, problemas psiquiátricos previos al embarazo, tensiones en la pare= ja durante el embarazo, acontecimientos desfavorables que generen ansiedad, vi= vidos durante el puerperio.

Psicosis posparto: se puede confundir con una depresión; su rasgo diferencial es la presencia de síntomas típicamente psicóticos, como delirios o alucinaciones. La duración es variable y en alg= unos casos se requiere la hospitalización. Se presenta en alrededor de 1-2 por c= ada 1 000 nacimientos, aunque otros autores elevan esta cifra a 3 por cada 1 00= 0. El cuadro clínico consiste en depresión e ideas delirantes que aparecen des= pués del parto, así como otras características dadas por el rápido cambio de los síntomas, la labilidad de humor y, con frecuencia, los signos de confusión.=

Los factores que aumentan el riesgo de psicosis posnatal incluyen madres primíp= aras solteras, mujeres mayores, o con antecedentes psiquiátricos previos y antecedentes familiares de psicosis afectiva, depresión prenatal y disfunci= ón tiroidea autoinmune.  (Adib, 2013)

Intervenciones preventivas para la psicosis posnatal

Ante la problemática establecida y estudiada en Latinoamérica se puede inferir q= ue la misma es un problema en común denominador que hace referencia a la idiosincrasia de cada pueblo y la practica sanitaria. Desde luego que con e= llo se evidencia la repercusión en el núcleo familiar a través de no solamente = el alto gasto para tratamiento medicamentoso y psicológico sino por el mismo h= echo hay una repercusión directa a nivel social ante ausentismo laborar, bajo rendimiento laboral entre otros factores.

El periodo gestaciona= l.

Durante el embarazo, y de forma fisiológica, aparecen en la mujer modificaciones afectivas debido a los cambios hormonales y a las expectativas vitales y las fantasías ante el nacimiento de un hijo. (Linares Despaigne, 2016)

Estos cambios son más aparentes en la primera gestación, aunque no son exclusivos= de esta y pueden reproducirse en cierta medida en cada nueva maternidad. (Linares Despaigne, 2016)

Las cifras de riesgo de presentar un trastorno psiquiátrico durante el embarazo= es, por ańo, de 7,1 cada 100 000 embarazadas. (Linares Despaigne, 2016)

El periodo puerperal.=  

La psicosis posnatal es una enfermedad global potencialmente mortal que afecta= de una a dos de cada 1000 nuevas madres. Tiene una aparición abrupta dentro del mes posterior al parto. Las nuevas madres afectadas desarrollan rápidamente psicosis manifiesta, deterioro cognitivo y comportamientos desorganizados. =

Se han descrito alrededor de 5000 casos de psicosis puerperal en la literatura mundial, aproximadamente 250, 5% han sido de etiología infecciosa. Una proporción de 7 a 9% se mantuvo estable hasta el descubrimiento de las sulfonamidas en 1936, desde entonces dicha cifra ha disminuido hasta que es= tas entidades casi se han olvidado.  CITATION Bro08 \l 12298 (Brockington I. , 2008)

El riesgo de una recurrencia posnatal futura es del 25% al 57%. Las intervenci= ones preventivas para la psicosis posnatal tienen como objetivo identificar a las pacientes con factores de riesgo, lograr el reconocimiento temprano de la psicosis inminente mediante el cribado, e incluyen el uso de tratamiento farmacológico preventivo. Los estabilizadores del estado de ánimo, los fárm= acos antipsicóticos y la terapia hormonal pueden tener efectos beneficiosos en la prevención de los episodios psicóticos posnatales en las pacientes con ries= go. (Adib, 2013)

La mayoría de las psicosis del posparto son psicosis afectivas, revestidas en = el 20% de los casos aproximadamente, de unas conductas de desorganización de la conciencia y de fluctuaciones del humor agudas y rápidas que debutan bruscamente en las primeras semanas del posparto. (Moure, 1997)

Manejo psicológico y psiquiátrico.

La morbilidad causada por la depresión puerperal es enorme. Varias intervencio= nes psicológicas y psicosociales parecieron ser efectivas para tratar este trastorno, aunque ninguna mostró un beneficio claro para prevenir el desarr= ollo de la depresión puerperal. Sin embargo, hasta ahora no se ha evaluado la efectividad de la hipnosis en relación con este trastorno. (Sado, 2012)

La litioterapia no debe ser iniciada según Stewart= antes del parto, por los posibles efectos secundarios en el recién nacido (hipoto= nía, cianosis, letargia...). Este tratamiento con litio necesita una vigilancia intensa de las litemias, por el riesgo de sobre= dosis unida a las modificaciones electrolíticas del posparto. (Moure, 1997)

Brew y Seidemberg recomiendan no utilizar la terapia  electroconvu= lsiva hasta después de las 4 semanas del parto, para evitar complicaciones como la movilización de un émbolo a partir de una tromboflebitis no diagnosticada <= w:Sdt Citation=3D"t" ID=3D"-2087056311">(Moure, 1997)

Este tipo de trastornos requiere una estrategia terapéutica para controlar de un modo integral varios aspectos, = como los síntomas maternos, por un lado, mediante el uso de técnicas psicológica= s, apoyadas, según lo requiera el caso, con medicación psicótropa, como los neurolépticos, junto con benzodiazepinas o antidepresivos si existe un mayor componente ansioso o depresivo. CITATION Lin16 \l 12298 (Linares Despaigne, 2016)

Pronostico

El pronóstico es generalmente favorable con una curación en el 70 a 80% de los= casos. Los estudios  d= e larga duración indican que de un 10 a un 15% de las psicosis puerperales evolucionan hacia una esquizofrenia crónica. (Moure, 1997)

Conclusiones

ˇ&nb= sp;        Los trastornos psiqui= átricos en el embarazo son tan frecuentes como 1-2 de cada 1000 nuevas madres y distribuido a nivel mundial

ˇ&nb= sp;        Existe un alto riesgo= de recurrencia en la presentación de psicosis en embarazos posteriores de hasta 57%

ˇ&nb= sp;        Hasta un 20% de las psicosis en el embarazo tienen como etiología conductas de desorganización = de conciencia

ˇ&nb= sp;        Los diagnósticos diferenciales hacia la psicosis posparto se los tiene con tristeza y depres= ión puerperales siendo el primero motivo de seguimiento hospitalario y motivo de tratamient= o pscico- farmacológico más complejo =

ˇ&nb= sp;        Se ha asociado hasta = un 5% de etiología infecciosa durante el parto para el aparecimiento de trasto= rno psiquiátrico.

Referencias bibliográficas <= /o:p>

Moure= , R. (1997). LAS PSICOSIS PUERPERALES . ASOCIACI= ON GALLEGA DE PSIQUIATRIA .

Medina-Serdán, E. (2013). Diferencias entre la depresión postparto, la psicosis postpart= o y la tristeza postparto. PERINATOLOGÍA Y REPRODUCCIÓN HUMANA, 185-193.=

Adib, E. e. (2013). Intervenciones preventivas para la psicosis posnatal. Cochr= ane Library .

Sado, M. e. (2012). Hipnosis durante el embarazo, el parto y el periodo posnatal para prevenir la depresión puerperal. Cochrane Library.=

Brockington, I. (2008). La importancia actual de las psicosis org= anicas duarente el embarazo, parto y puerperio . PERINATOLOGIA, REPRODUCCION HUMANA, 36-46.

Jadresic, E. (2017). DEPRESIÓN POSPARTO EN EL CONTEXTO DEL HOSPITAL GENERAL. Revista médica Clínica Las Condes, 28(6), 874–880. doi:10.101= 6/j.rmclc.2017.10.007

Bas, I. (23 de 03 de 2017). Psicosis Puerperales (2017). Obtenido de https://rdu.unc.edu.ar/bitstream/handle/11086/265/bas_isaia_sr.pdf?sequen= ce=3D1

Brockington, I. (12 de 02 de 2017). La importancia actual de la psicosis organicas durante el embarazo, parto, puerperio (20= 17). Obtenido de Revista Perinatal de Reproducion Humana: https://www.inper.mx/descargas/pdf/ImportanciaActualdelaspsicosisOrgasmic= asDuranteel.pdf

Liji, T. (19 de 02 de 2019). Psicosis postparto/postnatal (2019). Obtenido de N= ews Medical Life Sciences: https://www.news-medical.net/health/Postpartum-Postnatal-Psychosis-(Spani= sh).aspx

Lorete, G. (01 de 05 de 2018). CONOCER LA DEPRESIÓN Y LA PSICOSIS EN EL EMBARAZO Y PUERPERIO. Obtenido de Congreso Internacional de Salud Mental: https://ps= iquiatria.com/congresos/pdf/3-3-2017-4-pon2.pdf

Hernández, R. (2020). Psicosis postparto: a propósito de un caso. Psiquiatria, 24, 1137–3148. doi:http://psiqu.com/1-10496

FonsecaVillanea, C. (2018). PSICOSIS POSTPARTO. Revista Médica Sinergia, 3(8), 7–12. Recup= erado de https://revistamedicasinergia.com/index.php/rms/article/view/134/338

Arrate, M., Molina, V., & Linares, M. (2016). Tratamiento ambulatorio en una paciente con psicosis puerperal. MEDISAN, 20(11), 2390. Recuperado de http://scielo.sld.cu/pdf/san/v20n11/san102011.pdf

 

 

 

 

PARA CITAR EL ARTÍCULO INDEXADO.

 

 

Salazar Flores, D. E., Salazar Flores, J. C., Salazar Robalino, P. R., & Suquil= anda Toapanta, J. E. (2021). Psicosis en el embarazo y posparto, manejo actual. = Revision bibliografica. A= natomía Digital, 4(3), 127-136. https://doi.org/10.33262/anatomiadigital.v4i3.1792

 


 

 

 

El artículo que se publica es de exclusiva responsabilidad de los autores y no necesariamente reflejan el pensamiento de la Revi= sta Anatomía Digital.

 

El artículo qu= eda en propiedad de la revista y, por tanto, su publicación parcial y/o total en otro medio tiene que ser autorizado por el director de la Revista Anatomía Digital.

 

 

 

 



[1] Medico G= eneral, Universidad Técnica de Ambato, Medico de consulta particular, Correo: diansalazar96@hot= mail.com,  https://orcid.org/0000-0002-1206-8227

[2] Medico Posgradista de Medicina Int= erna, Universidad UESS Samborondón, Clínica Guayaquil, Correo: juank8sf@yahoo.es,  https://orcid.org/0000-0001-8079-0636<= /span>

[3] Medico G= eneral, Universidad Técnica de Ambato, Hospital IESS  Puyo, Correo: paulsr0988@gmail.c= om

<= v:shape id=3D"Imagen_x0020_8" o:spid=3D"_x0000_i1027" type=3D"#_x0000_t75" style= =3D'width:12.75pt; height:12.75pt;visibility:visible;mso-wrap-style:square'>  https= ://orcid.org/0000-0002-5387-4057

[4] Estudiante de Medicina, Univ= ersidad Uniandes,  Hosp= ital General Ambato IESS, Correo: chocoleyt03_09@hotmail.com,  https://orcid.org/0000-0003-1470-6277<= /p>

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www.anatomiadigital.org

                                                 =                                                                       ISSN: 2697-3391<= /p>

                                                   =                 Vol. 4, 3, p. 127-136, julio-septiemb= re, 20 21

Salud Publica                                                                       =                              =                                                 Página 125

 

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