Asma bronquial y ejercicio físico.
Manifestaciones en el adulto mayor
Adriana Mederos
González.
|
Abstract.
The
global prevalence of asthma varies between 1% and 18% depending on the
country, even within the same country it varies from region to region and
depending on the ethnic group analyzed. The prevalence traditionally acce=
pted
in our country is 8.2%, slightly higher in women than in men and in
individuals from urban and coastal areas.
It
is more frequent among children than among adults, with a male / female r=
atio
of approximately 1.5 in childhood, q in late adolescence and below, and 1
during adulthood. The maximum values, even with interregional differences,
come to be detected in the rich populations and those of Anglo-Saxon orig=
in
in both hemispheres, as well as certain countries in Central and South
America.
Keywords: global prevalence, bronchial asthma, exercise.
|
|
Resumen.
La prevalencia global de asma varía
entre 1% y 18% según países, incluso dentro de un mismo país varía de unas
regiones a otras y en función del grupo étnico analizado. La prevalencia
tradicionalmente aceptada en nuestro país es de 8.2%, ligeramente superio=
r en
el sexo femenino que en el masculino y en individuos de zonas urbanas y
costeras.
Resulta más frecuente entre los niños
que entre los adultos, con una relación varón/mujer aproximada de 1.5 en =
la
infancia, q en la adolescencia tardía e inferior y 1 durante la edad adul=
ta.
Los valores máximos, incluso con diferencias interregionales, vienen a
detectarse en las poblaciones ricas y de origen anglosajón de ambos hemis=
ferios,
así como determinados países de Centroamérica y Suramérica.
Palabras
claves: prevalencia global, asma bronquial, ejercicio.<=
/span>
|
=
Intro=
ducción.
El asma es una =
enfermedad
inflamatoria crónica de la vía aérea, en cuya patogenia intervienen diferen=
tes
células y mediadores inflamatorios, condicionada parcialmente por factores
genéticos, que cursa con hiperreactividad de la vía aérea a una gran varied=
ad
de estímulos y con obstrucción reversible del flujo aéreo, bien
espontáneamente, bien con tratamiento broncodilatador. Esta inflamación cau=
sa
episodios recurrentes de sibilancias, disnea, opresión torácica y tos. Es un
síndrome con fenotipos diferentes que comparten unas manifestaciones clínic=
as
similares, pero con etiologías probablemente distintas.
Historia
Desde los momen=
tos
más remotos de la historia de la medicina, los grandes maestros como
Hipócrates, Avicena y otros señalaron la importancia del aire para la vida y
señalaron los rudimentos de la fisiología pulmonar.
El asma bronqui=
al
ha ocupado ininterrumpidamente la atención médica desde la antigüedad (460-=
130
a.n.e), fue referida por Hipócrates, Galeno y Areteo de Capadocia. Celso en=
el
año 30 a.n.e le dio como nombre “falta de aire moderada” que presentaban los
soldados al hacer ejercicios.
Desde esos mome=
ntos
hasta hoy en día, esta condición respiratoria despierta el mayor interés en
todo el mundo, a pesar de la ausencia de una definición precisa de la
enfermedad, es uno de los problemas mayores en estudio y atención a los
pacientes que la sufren. El primer agente causal sigue siendo desconocido p=
or
lo que se eleva su dificultad, la anatomía patológica es de difícil obtenci=
ón y
las manifestaciones clínicas son variables y no pocas veces atípicas, lo que
precisamente sucede en el asma; por tanto, esta es una enfermedad fácil de
reconocer, pero difícil de definir.
Epidemiologia
Afecta a más de=
300
millones de personas en todo el mundo.
·&nb=
sp;
Prevalencia: la prevalencia global de asma v=
aría
entre 1% y 18% según países, incluso dentro de un mismo país varía de unas
regiones a otras y en función del grupo étnico analizado. La prevalencia
tradicionalmente aceptada en nuestro país es de 8.2%, ligeramente superior =
en
el sexo femenino que en el masculino y en individuos de zonas urbanas y
costeras.
Resulta más
frecuente entre los niños que entre los adultos, con una relación varón/muj=
er
aproximada de 1.5 en la infancia, q en la adolescencia tardía e inferior y 1
durante la edad adulta. Los valores máximos, incluso con diferencias
interregionales, vienen a detectarse en las poblaciones ricas y de origen
anglosajón de ambos hemisferios, así como determinados países de Centroamér=
ica
y Suramérica.
·&nb=
sp;
Mortalidad: en todo el mundo se producen 250=
000
muertes por asma al año, no existe relación entre la prevalencia y la
mortalidad por asma.
Causas
De entre las po=
sibles
causas consideradas, la que hoy goza de mayor predicamento es la vinculada =
con
la exposición a ciertos agentes infecciosos (hipótesis de la higiene).
En síntesis, la
hipótesis establece que determinadas infecciones comunes adquiridas en las
primeras etapas del desarrollo pueden prevenir la aparición de la atopia; el
origen del problema radica en la reducción de esas infecciones entre los
miembros más jóvenes de las familias, dicha reducción es consecuencia de la
mejoría de los estándares de vida, los programas de inmunización y/o el uso
indiscriminado de antibióticos. Hay pruebas crecientes de que el contexto
inmunológico durante la fase uterina se encuentra decantado de forma natural
hacia el fenotipo linfocitos T belper 2 (Th2) posiblemente para proteger la
placenta frente a los efectos tóxicos de las citosinas Th1, se mantiene así
durante un cierto tiempo tras el nacimiento, generando una “ventana de alto
riesgo” para la sensibilización alérgica temprana. El cierre de la “ventana”
solo tendrá lugar si el individuo entra en contacto con microorganismos que,
como los virus o los comensales del aparato digestivo, estimulan la respues=
ta
inmune del tipo Th1 y equilibran la relación Th1/Th2. La ausencia de exposi=
ción
ocasionará en definitiva que las respuestas de tipo Th2 frente a antígenos =
no
microbianos queden facilitadas en los sujetos predispuestos genéticamente.<=
/p>
Historia natural
Por lo general,=
el
asma comienza en las primeras etapas de la vida. En casi el 50% de los caso=
s,
el pico de inicio se localiza por debajo de los 10 años de edad, y en mayor
parte de los niños los síntomas aparecen antes de cumplir los 2 años.
Durante la
adolescencia, la incidencia de asma decrece para volver a repuntar de nuevo=
al
principio de la edad adulta. Sólo en menos del 25% de los individuos, el
diagnóstico se establece después de los 40 años. No obstante, en algunos de
ellos es posible identificar una sintomatología respiratoria previa, e incl=
uso
anormalidades espirográficas; muchos de esos sujetos han sido etiquetados de
“broncoquísticos crónicos” antes de ser categorizados de forma definitiva c=
omo
asmáticos.
Adopta un carác=
ter
agudo e intermitente en el 70-75% de los niños que la padecen; la duración y
gravedad de la crisis son variables y la función respiratoria tiende a volv=
er a
la normalidad entre los accesos. Por el contrario, en algo menos del 25% de=
los
casos de asma infantil, los episodios de sibilancias acostumbran a ser más
prolongadas y frecuentes, y en un pequeño número de pacientes el proceso
adquiere características de cronicidad y gravedad.
Con el comienzo=
de
la edad adulta, una gran proposición de asmáticos, aunque la recidiva poste=
rior
puede ocurrir. Las probabilidades de que la enfermedad persista aumentan en
función de la gravedad del asma en la infancia o si esta se acompañó de
sinusitis crónica, pólipos nasales o eccema.
De entre los ni=
ños
con asma leve e intermitente, más del 60% se encontrarían asintomáticos a l=
os
21 años; en el resto; las sibilancias persistirán de forma ocasional. Sin
embargo, en el grupo con sibilancias frecuentes, el 40% estará sustancialme=
nte
mejor a esa edad. Alrededor del 45% mantendrán su situación clínica y el 15%
empeorará. Cuando el asma comienza en la edad adulta tiene un peor pronósti=
co,
y son menores de las variaciones espontáneas y la posibilidad de remisiones
prolongadas. Si suceden, las recaídas resultan mucho más frecuentes que en =
el
asma infantil, máxime cuando el paciente mantiene síntomas respiratorios
residuales.
Patogenia
Es un trastorno
inflamatorio crónico de las vías áreas. La inflamación crónica se asocia a
hiperreactividad bronquial y a obstrucción reversible, aunque los mecanismos
que explican esta asociación no están completamente aclarados. El proceso
inflamatorio es bastante consistente entre pacientes y entre diferentes
momentos evolutivos de la enfermedad.
La inflamación =
en
el asma es similar a otros procesos alérgicos. Los factores implicados en la
diátesis inflamatoria se pueden clasificar en los tres aparatos siguientes:=
Células inflamatorias:<=
/p>
Linfocitos T:
elevados en la vía aérea, con un aumento de las células natural killer.
Mastocitos:
aumentados tanto en la vía aérea como en como en el músculo liso bronquial,=
lo
que reacciona con la hiperreactividad bronquial. Su activación da lugar a la
liberación de mediadores broncodilatadores y proinflamatorios.
Eosinófilos:
elevados en la vía aérea de la mayoría de los asmáticos y su número se
relaciona con la gravedad del asma. Su activación libera enzimas responsabl=
es
del daño epitelial y mediadores que amplifican la respuesta inflamatoria.
Neutrófilos:
aparecen en cantidad aumentada en la vía aérea de algunos pacientes con asma
grave, en exacerbaciones, en asmáticos fumadores y en algunos casos de asma
profesional.
Células
dendríticas: estimulan el desarrollo de linfocitos Th2.
Macrófagos:
contienen receptores de baja afinidad para la IgE que cuando son estimulados
por alérgenos liberan mediadores que amplifican la respuesta inflamatoria.<=
/p>
Células y elementos estructurales de l=
a vía
aérea:
Epitelio bronqu=
ial:
el daño en el epitelio de la vía aérea es una característica del asma no
controlada, con pérdida de células ciliadas y secretoras. A la vez intervie=
ne
activamente en el proceso inflamatorio, liberando mediadores proinflamatori=
os
en relación con diferentes estímulos que contribuyen a aumentar más el daño
epitelial. El proceso de reparación de estas lesiones es anómalo, dando lug=
ar a
un componente de obstrucción irreversible que en ocasiones aparece en el as=
ma,
en un proceso conocido como remodelado de la vía aérea.
Músculo liso
bronquial: contribuye a la obstrucción al flujo aéreo por su hipertrofia,
contracción aumentada e incluso liberación de mediadores inflamatorios igual
que las células epiteliales.
Células
endoteliales: la expresión de moléculas de adhesión en las células del
endotelio de la circulación bronquial es necesaria para el reclutamiento de
células inflamatorias en la vía aérea.
Fibroblastos y
miofibroblastos: estimulados por mediadores inflamatorios y factores de
crecimiento, contribuyen mediante la producción anómala de tejido fibroso al
remodelado de la vía aérea.
Terminaciones
nerviosas colinérgicas de las vías aéreas: si se activan por vía refleja,
causan broncoconstricción y secreción de moco. Producen síntomas como la to=
s y
la opresión pericordal.
Moléculas:
Quimiotoxinas:
expresadas por las células epiteliales, actúan reclutando células inflamato=
rias
en las vías aéreas.
Cistenil-leucot=
rienos:
sustancias liberadas por mastocitos y eosinófilos con fuerte efecto
broncoconstrictor.
Citosinas:
producidas por linfocitos y macrófagos, controlan el proceso inflamatorio e=
n el
asma y probablemente determinan su gravedad, las más importantes son las
derivadas de los linfocitos Th2; interleucina IL-5, favorece la producción y
activación de eosinófilos, y la IL-4 e IL-3, necesarias para la producción =
de
IgE por los linfocitos B.
IgE:
inmunoglobulina responsable de los fenómenos alérgicos, se une a receptores=
de alta
afinidad presentes en mastocitos, eosinófilos y células dendríticas. En
presencia del alérgeno específico esta unión desencadena la liberación de
mediadores en dichas células.
Óxido nítrico:
potente vasodilatador producido en el epitelio bronquial por la acción de la
enzima óxido nítrico-sintetasa. Su determinación en el aire espirado se pue=
de
emplear como prueba diagnóstica, por ser un marcador no invasivo de la vía
aérea.
Fisiopatología
Las alteraciones
estructurales de la mucosa y de la pared bronquial dan como resultado dos
consecuencias: la obstrucción y la hiperrespuesta de la vía aérea ante
estímulos contracturantes (metacolina, adenosina, etc.). La obstrucción, di=
fusa
pero no uniforme, condiciona una serie de modificaciones en la mecánica res=
piratoria,
con cambios sustanciales en las relaciones entre la profusión, flujo y volu=
men
pulmonar que pueden llegar a traducirse en una alteración de la relación
ventilación/perfusión y del intercambio gaseoso.
La hiperrespues=
ta
se origina por una suma de factores. El aumento de espesor de las diferentes
capas de la vía aérea o la reducción de las cargas elásticas debidas a los
cambios en la matriz del tejido conectivo provocan que, ante un mismo grado=
de
acortamiento del MLVA, la reducción de la luz bronquial sea mayor. Además, =
el
MLVA del asmático tiene una mayor sensibilidad frente a los agentes bronco
constrictores, ya que los mediadores inflamatorios determinan un incremento=
de
la disponibilidad del mensajero intracelular regulador de su tono: e Ca2+ i=
ntracitoplasmático.
Para otros, la hiperrespuesta es el resultado, sobre todo, de la pérdida de
algún factor operativo en los individuos normales encargado de modular y
limitar la contractilidad del miocito. El dilatador endógeno sería la propia
respiración y el estiramiento clínico a que se ve sometido el músculo de la
pared bronquial con los cambios de volumen pulmonar. El fracaso de ese
mecanismo broncoprotector, tal vez relacionado con un aumento en la longitu=
d de
los filamentos de actina y un comportamiento del MLVA más elástico que
plástico, condicionaría finalmente una mayor capacidad de contracción y una
mayor velocidad de acortamiento.
Manifestaciones clínicas
El diagnostico =
de
asma se instaura combinando la historia clínica y la funcional respiratoria,
los síntomas típicos son tos, disnea, sibilancias audibles y opresión torác=
ica,
de carácter variable y en diferentes combinaciones, con predominio nocturno=
o
durante las primeras horas de la mañana. El 80% de los asmáticos alérgicos =
y el
50% de los no alérgicos refieren también clínica rinosinusal. La anamnesis
rastreará igualmente la presencia o ausencia de antecedentes familiares y
personales de atopía y/o asma. La espirometría y las pruebas broncomotoras
permitirán finalmente confirmar o descartar el diagnóstico de sospecha. La
fluctuación de la función pulmonar en el tiempo, incluso en un mismo día, es
una característica de esa entidad que puede observarse con la medida diaria=
del
flujo respiratorio máximo. Por otro lado, la utilidad práctica de marcadore=
s de
inflamación (óxido nítrico en el aire exhalado o determinación de eosinófil=
os
en el esputo) está aún por establecer con exactitud, aunque, con razonable
seguridad, una clínica compatible y valores de óxido nítrico en el aire
espirado superiores a 30 partes por billón en no fumadores son muy sugestiv=
os
de la enfermedad asmática. Una vez establecido el diagnóstico, el estudio d=
el
perfil alérgico, sospechado a partir de la historia clínica, se establecerá
mediante las pruebas cutáneas de punción epidérmica en prick o midiendo la =
IgE
específica circulante. La selección de los aeroalergenos sospechosos (polen,
ácaros, epitelio de animales, etc.) variaría según la zona específica.
Medidas preventivas
La eliminación
total o parcial de los alérgenos más comunes del entorno del asmático plant=
ea
diversas dificultades, aunque debe siempre intentarse. Asimismo, es importa=
nte
evitar el tabaquismo activo o pasivo y la exposición a los alérgenos y
sustancias irritantes existentes en el lugar de trabajo que empeoran el asm=
a,
de no ser posible, con el cambio de actividad laboral. Algunos asmáticos, en
especial los que cursan con poliposis nasosinusal, desarrollan broncoespasmo
grave cuando toman ácido acetilsalicílico u otros antiinflamatorios no
esteroideos (AINE). Es pues capital que otros enfermos sean correctamente
diagnosticados, ya sea mediante una historia clínica (antecedentes de
reacciones a distintos AINE) o mediante provocación oral o nasal. Los
intolerantes a AINE que requieran analgesia deben tratarse con paracetamol =
sin
que la dosis exceda los 650 mg. Para una analgesia más potente, cabe recurr=
ir,
de forma progresiva, a asociación de codeína y paracetamol, el uso de
dextropropoxifeno o la administración de pentazocina y derivados mórficos.
Cuando se necesite de un tratamiento antiinflamatorio, pueden emplearse como
alternativa los inhibidores selectivos (meloxicam) o específicos de la
ciclooxigenasa-2 (etoricoxib y celecoxib) confirmado previamente la toleran=
cia
a los mismos.
Tratamiento farmacológico<=
/b>
Los antiasmátic=
os
disponibles se agrupan bajo dos grandes categorías: los fármacos de
mantenimiento y los fármacos de rescate. Los primeros (glucocorticoides
inhalados y sistémicos, antagonistas de los LT, agonistas adrenérgicos ^=
6;2
de acción prolongada, anticuerpos monoclonales anti-IgE (omalizumab y teofi=
lina
de liberación retardada) se utilizan de manera pautada, buscando estabiliza=
r la
enfermedad a largo plazo. Los segundos (agonistas adrenérgicos β2 de
acción corta inhalados y el bromuro de ipratropio), usados a demanda, actúan
rápidamente para revertir la obstrucción bronquial y aliviar los síntomas.<=
/p>
Educación del paciente=
Como sucede con
cualquier otra patología crónica, la colaboración del paciente constituye u=
na
pieza clave dentro de la estrategia terapéutica global. Se pretende que el
enfermo conozca cuándo y cómo manejar los fármacos y las medidas preventiva=
s,
cuáles son las estrategias a seguir=
para
evitar las exacerbaciones, qué hacer ante ellas y cuándo debe buscar ayuda
médica. El plan permitirá al paciente tomar conciencia del estado de su pro=
ceso
a través de la valoración de los síntomas, necesidades de medicación
broncodilatadora y variaciones en el FEM. Los programas de educación
específicos facilitan el aprendizaje de estas habilidades.
Objetivos:
1. Analizar
el asma bronquial como un síndrome respiratorio que azota a la humanidad.
2. Describir
la enfermedad, manifestaciones clínicas, fisiopatología, tratamiento y
clasificaciones.
3. Analizar
el comportamiento de esta enfermedad en el adulto mayor.
4. Relacionar
el asma bronquial con el ejercicio físico.
Desarrollo
Estadísticas
en nuestro país
En nuestro país, un estudio realizado en el munici=
pio
Guantánamo entre 2000 y 2001 en una empresa metalmecánica, encontró una
prevalencia de 2 % de asma ocupacional, aunque el 58,3 % de los trabajadores
presentó hiperreactividad bronquial, 25 % tos, 14,2 % disnea y 2,3 %
sibilancias 24.
Otro estudio realizado en el Instituto Nacional de
Salud de los Trabajadores (INSAT) sobre las enfermedades respiratorias
diagnosticadas en el período 1988-2006, muestra resultados que se correspon=
den
con las tendencias actuales reportadas a nivel internacional, donde los
procesos alérgicos han superado a los procesos por exposición prolongada a
polvos inorgánicos, las neumoconiosis, que pueden ser evitadas al disminuir=
la
exposición en el medio ambiente laboral. Estas enfermedades fueron, en orde=
n de
frecuencia, las siguientes:
·
Asma
ocupacional: 12 (42,8 %)
·
Neumoconiosis:
9 (32,1 %)
·
Alveolitis
alérgica extrínseca: 5 (17,8 %)
·
Bronquitis
ocupacional: 2 (7,1 %)
El tiempo promedio de exposición para el asma
ocupacional fue de 16 años, y de 12 para la bronquitis, existiendo
necesariamente un tiempo de latencia de meses o años hasta que se produzca =
la
sensibilización a la sustancia causal, tiempo que será menor en los individ=
uos
atópicos.
Otro dato recogido en el INSAT que puede llevarnos=
a
dirigir nuestra mirada al problema del asma relacionada con el trabajo, son=
los
casos de invalidez total (448 casos) por enfermedad respiratoria en nuestro
país en el año 2007. En 8 provincias (Pinar del Río, Mayabeque, Artemisa, La
Habana, Cienfuegos, Camagüey, Granma, Santiago y Guantánamo) más del 30 % de
los casos eran asmáticos.
Actualmente se requiere un cambio en la organizaci=
ón
de la actividad de seguridad y salud en el trabajo hacia un sistema de gest=
ión
de seguridad, salud y medio ambiente en el trabajo, que se ajuste a los cam=
bios
que se producen en la sociedad cubana. Es necesario crear una cultura
relacionada con la seguridad del trabajador, con el cuidado de su salud y e=
n la
conservación del medio ambiente laboral, bajo el principio de que “la segur=
idad
de todos es obligación de todos”.
Clasificaciones
Según la clínica, la enfermedad se puede clasifica=
r en
cuatro grupos, dependiendo del estado basal del paciente, la frecuencia de =
las
crisis, la función pulmonar y la variación.
Asma
intermitente:
·
Crisis
de disnea breves, menos de una vez a la semana.
·
Menos
de dos dosis nocturnas al mes.
·
Periodo
intercrítico asintomático y con función normal (PEF o VEMS >80% del
teórico).
·
Variabilidad
<20%.
·
Incluye
el asma por ejercicio.
Asma
persistente leve:
·
Más
de una crisis semanal, pero menos de una diaria.
·
Más
de dos crisis nocturnas al mes.
·
A
veces hay limitación de la actividad y del sueño.
·
Situación
basal: PEF o VEMS >80% del teórico.
·
Variabilidad
>30%.
Asma
persistente moderada:
·
Síntomas
continuos.
·
Más
de una crisis nocturna a la semana.
·
Limitación
de la actividad y del sueño.
·
Situación
basal de PEF o VEMS 60-80% del teórico.
·
Variabilidad
>30%.
Asma
persistente grave:
·
Síntomas
continuos.
·
Exacerbaciones
y crisis nocturnas frecuentes y graves.
·
Ingresos
hospitalarios frecuentes.
·
Limitación
de la actividad y del sueño.
·
Situación
basal: PEF o VEMS <60% del teórico.
·
Variabilidad:
>30%.
Esta clasificación es útil solo en pacientes no
tratados. Sin embargo, resulta más adecuado establecer la gravedad teniendo=
en
cuenta la medicación necesaria para controlar la enfermedad. Así, el asma g=
rave
es aquella que necesita un tratamiento de alta intensidad para conseguir el
control.
Tabla
2. Características de los tipos de Asma
|
Características
|
Controlada
|
Parcialmente
controlada
|
No
controlada
|
|
Síntomas
diurnos
|
Dos
o menos veces por semana<=
/span>
|
Más
de dos veces por semana<=
/span>
|
Al
menos tres veces por semana<=
/span>
|
|
Uso
de medicación de rescate<=
/span>
|
Dos
o menos veces por semana<=
/span>
|
Más
de dos veces por semana<=
/span>
|
Parcialmente
controladas presentes en una semana<=
/span>
|
|
Síntomas
nocturnos
|
Ninguno
|
Alguna
vez
|
|
|
Limitación
de la actividad<=
/span>
|
Ninguna
|
Alguna
vez
|
|
|
Función
pulmonar (FEV, PEF)<=
/span>
|
Normal
(>80%)
|
<80%
|
|
|
Exacerbaciones
|
Ninguna
|
Una
o más al año
|
Una
exacerbación convierte por definición el asma en no controlada.
|
------=_NextPart_01D60A22.F8817D90
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